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Cornea April 2025

Prox1 Protein in Corneal Limbal Lymphatic Vessels Maintains Limbal Stem Cell Stemness and Regulates Corneal Injury Repair

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An Wang; Zongyuan Li; Yilin Jiang; Mingxiong Chen; Hanrui Yu; Zhao Li; Shengshu Sun; Ge Bai; Qun Wang; Yifei Huang; Liqiang Wang
TAGS: alkalies, burns, cornea, corneal injuries, limbal stem cells, lymphatic vessels, prospero-related homeobox 1 protein, recovery of function, epithelium, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):81. https://doi.org/10.1167/iovs.66.4.81

Includes: Supplemental Content

Retina April 2025

Relationships Between Retinal Vascular Characteristics and Systemic Indicators in Patients With Diabetes Mellitus

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Xingyu Xiao; Jianchun Zhao; Shiqun Lin; Yajie Yang; Wenhui Li; Yan Zhou; Xiao Zhang; Rongping Dai
TAGS: diabetes mellitus, nonproliferative diabetic retinopathy, retinal vessels, renal function, biological markers
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):72. https://doi.org/10.1167/iovs.66.4.72

Retina April 2025

The Exponential Constriction Model of the Ellipsoid Zone in Taiwanese Individuals With RPGR-Related X-Linked Retinitis Pigmentosa

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Yi-Han Huang; Yu-Shu Huang; Chien-Yu Lin; Ying-Ju Lai; Chang-Hao Yang; Tzzy-Chang Ho; Yi-Ting Hsieh; Po-Ting Yeh; Tso-Ting Lai; Chao-Wen Lin; Chung-May Yang; Pei-Lung Chen; Ta-Ching Chen
TAGS: constriction procedure, disease progression, retinitis pigmentosa, taiwanese, x-linked inheritance, eye, phenotype, exons
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):59. https://doi.org/10.1167/iovs.66.4.59

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

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Wenxu Wang; Rui Ren; Yue Liu; Xingyue Ye; Ru Zhang; Linze Xi; Liying Wang; Yao Zhang; Yi Zhang; Difei Wang
TAGS: age-related macular degeneration, genetic predisposition to disease, genetics, health, polygenic risk score, prospective studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):54. https://doi.org/10.1167/iovs.66.4.54

Includes: Supplemental Content

Retina April 2025

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

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Xing Wei; Sisi Ma; Yunyu Zhou; Haoliang Cui; Shan Zhang; Duanyang Wang; Yingying Fu; Wei Li; Huihui Han; Yamei Li; Wuyi Li; Huixin Liu; Zixi Sun; Xiaoxu Han; Xuan Zou; Hui Li; Cheng Wang; Ruifang Sui
TAGS: electroretinography, mice, gene therapy, capsid
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):37. https://doi.org/10.1167/iovs.66.4.37

Includes: Supplemental Content

Anatomy and Pathology/Oncology April 2025

Novel OCT Angiography Features, von Hippel–Lindau Disease Association, and Genetic Characterization of Juxtapapillary Retinal Capillary Hemangiomas

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Xiaonan Zhuang; Fengjuan Gao; Yi Xuan; Zhongcui Sun; Xiaofeng Ye; Xin Huang; Rui Jiang; Jihong Wu; Min Wang; Qing Chang; Gezhi Xu; Wei Liu
TAGS: angiogram, atypical, eye, genetics, retinal capillary hemangioma, von hippel-lindau syndrome, follow-up
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):34. https://doi.org/10.1167/iovs.66.4.34

Includes: Supplemental Content

Cornea April 2025

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

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Xiaoqi Li; Anqi Liu; Yannan Zhou; Haolan Qi; Junyi Wang; Mingxiong Chen; Tunan Sun; Jie Wu; Yifei Huang; Liqiang Wang
TAGS: cornea, endothelium, mice, ppar alpha, chronic exertional compartment syndrome, fenofibrate, hereditary corneal dystrophy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):36. https://doi.org/10.1167/iovs.66.4.36

Includes: Supplemental Content

Cornea April 2025

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway

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Yuzhou Wang; Zhiqiang Xu; Linzhi Wei; Yang Lu; Yizhou Shi; Shiyu Wen; Xiujuan Lv; Kaiyan Huang; Fan Lu; Jia Qu; Liang Hu
TAGS: hmgb1 protein, mice, toll-like receptor 4, inflammation, dry eye syndromes, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):28. https://doi.org/10.1167/iovs.66.4.28

Includes: Supplemental Content

Optica Fall Vision Meeting Abstract April 2025

Invited Session III: Machine Learning and AI Approaches to Retinal Diagnostics: Towards more robust AI models in ophthalmology

Adam M Dubis; Mustafa Arikan; James Willoughby; Watjana Lilaonitkul
TAGS: machine learning, ophthalmology
Journal of Vision. 2025; 25(5):29. https://doi.org/10.1167/jov.25.5.29

Optica Fall Vision Meeting Abstract April 2025

Poster Session: Contrast polarity in photopic, mesopic, and scotopic vision

Lisa Widmayer; Alexander C. Schütz
TAGS: dark adaptation, polarity, posters
Journal of Vision. 2025; 25(5):47. https://doi.org/10.1167/jov.25.5.47

Biochemistry and Molecular Biology March 2025

LncRNA ENST00000581911 Regulates Extraocular Muscle Remodeling by Interacting With KHSRP in Thyroid Eye Disease

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Mingsu Shi; Rongmei Zhou; Weiai Shen; Yu Liang; Yihan Zhang; Lingyun Liu; Runyi Shao; Yanxi Fang; Chen Zhao; Lianqun Wu
TAGS: bodily secretions, genes, graves' ophthalmopathy, muscle of orbit, polymerase chain reaction, rna, sequence analysis, rna, sincalide, cell proliferation, enzyme-linked immunosorbent assay
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):46. https://doi.org/10.1167/iovs.66.3.46

Includes: Supplemental Content

Clinical and Epidemiologic Research March 2025

Orbital Clinicopathological Differences in Thyroid Eye Disease: An Analysis of Cytokines With Histopathological and Clinical Correlation

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Yue Li; Jiaqi Tang; Gaojing Jing; Yueyue Li; Rui Ma; Xin Kang; Liyuan Rong; Wenlu Liu; Lan Yao; Xiaohui Lv; Aijun Deng; Wei Wu; Xinji Yang
TAGS: connective tissue, cytokine, histopathology tests, graves' ophthalmopathy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):33. https://doi.org/10.1167/iovs.66.3.33

Includes: Supplemental Content

Immunology and Microbiology March 2025

Ocular Surface Involvements in the Development of Sjögren's Syndrome–Associated Dry Eye in the IL14α Transgenic Mouse

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Minjie Zhang; Yichen Liang; Han Wu; Rongrong Zong; Xiaobo Zhang; Hui He; Peter Sol Reinach; Zuguo Liu; Long Shen; Wei Li
TAGS: dry eye syndromes, mice, ocular surfaces, sjogren's syndrome, conjunctiva, mice, transgenic
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):2. https://doi.org/10.1167/iovs.66.3.2

Includes: Supplemental Content

Retina February 2025

Phenotypic Distinctions Between EYS - and USH2A -Associated Retinitis Pigmentosa in an Asian Population

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Ellis Y. H. Yeo; Taro Kominami; Tien-En Tan; Lathiksha Babu; Kevin G. S. Ong; Weilun Tan; Yasmin M. Bylstra; Kanika Jain; Rachael W. C. Tang; Saadia Z. Farooqui; Sylvia P. R. Kam; Choi-Mun Chan; Ranjana S. Mathur; Saumya S. Jamuar; Weng Khong Lim; Koji Nishiguchi; Beau J. Fenner
TAGS: asian, cohort studies, phenotype, retinitis pigmentosa, symptom onset, genotype
Trans. Vis. Sci. Tech.. 2025; 14(2):16. https://doi.org/10.1167/tvst.14.2.16

Includes: Supplemental Content

Retina February 2025

Preconception Paternal Alcohol Consumption Elicits Postnatal Changes in Neural Retinas of the Offspring

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Kofi Owusu-Ansah; Kara N. Thomas; Kelsey Cox; Dylan L. Pham; Wei-Lin Chen; Michael Lee Ko; Michael C. Golding; Gladys Yi-Ping Ko
TAGS: alcohol drinking, ethanol, neural retina, offspring, retina, mice, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):16. https://doi.org/10.1167/iovs.66.2.16

Retina January 2025

Relationship Between Axial Length and Retinal Oxygen Dynamics in Adults With Myopia

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Guocheng Xiao; Mei Ge; Guoqing Qiao; Shuyu Liu; Na Li; Feng Liu; Yanye Lu; Qiushi Ren; Liqiang Wang
TAGS: adult, myopia, oxygen
Trans. Vis. Sci. Tech.. 2025; 14(1):18. https://doi.org/10.1167/tvst.14.1.18

Cornea January 2025

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

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Ling Wang; Ye Tian; Hui Zhang; Yongxiao Dong; Xia Hua; Xiaoyong Yuan
TAGS: caspase-3, cornea, dry eye syndromes, epithelium, mice, proteins, pyroptosis, apoptosis, genes, western blotting
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):24. https://doi.org/10.1167/iovs.66.1.24

Includes: Supplemental Content

Retina January 2025

Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment

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Lisong Wang; Gaocheng Zou; Yuanye Yan; Ronghua Shi; Yue Guo; Mei Zhang; Li Lu; Kai Dong
TAGS: idebenone, mice, oxidative phosphorylation defect, photoreceptors, retinal detachment, body tissue, mitochondria, retina, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):17. https://doi.org/10.1167/iovs.66.1.17

Includes: Supplemental Content

Retina December 2024

Mettl3 -Mediated m 6 A Modification is Essential for Visual Function and Retinal Photoreceptor Survival

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Xiaoyan Jiang; Kuanxiang Sun; Yudi Fan; Qianchun Xiang; Rong Zou; Yeming Yang; Xianjun Zhu; Wenjing Liu
TAGS: mice, photoreceptors, proteins, rod photoreceptors, vision, retina, retinal cone, western blotting, candidate disease gene
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):40. https://doi.org/10.1167/iovs.65.14.40

Includes: Supplemental Content

Cornea November 2024

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

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Yang Huang; Lijun Wang; Haiying Jin
TAGS: bilirubin, cornea, dry eye syndromes, mice, mitophagy, nadph oxidase 4, nanoparticles, ocular surfaces, pink1 gene, nitric oxide synthase
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):55. https://doi.org/10.1167/iovs.65.13.55

Includes: Supplemental Content

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Prox1 Protein in Corneal Limbal Lymphatic Vessels Maintains Limbal Stem Cell Stemness and Regulates Corneal Injury Repair

Relationships Between Retinal Vascular Characteristics and Systemic Indicators in Patients With Diabetes Mellitus

The Exponential Constriction Model of the Ellipsoid Zone in Taiwanese Individuals With RPGR-Related X-Linked Retinitis Pigmentosa

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

Novel OCT Angiography Features, von Hippel–Lindau Disease Association, and Genetic Characterization of Juxtapapillary Retinal Capillary Hemangiomas

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway

Invited Session III: Machine Learning and AI Approaches to Retinal Diagnostics: Towards more robust AI models in ophthalmology

Poster Session: Contrast polarity in photopic, mesopic, and scotopic vision

LncRNA ENST00000581911 Regulates Extraocular Muscle Remodeling by Interacting With KHSRP in Thyroid Eye Disease

Orbital Clinicopathological Differences in Thyroid Eye Disease: An Analysis of Cytokines With Histopathological and Clinical Correlation

Ocular Surface Involvements in the Development of Sjögren's Syndrome–Associated Dry Eye in the IL14α Transgenic Mouse

Phenotypic Distinctions Between EYS - and USH2A -Associated Retinitis Pigmentosa in an Asian Population

Preconception Paternal Alcohol Consumption Elicits Postnatal Changes in Neural Retinas of the Offspring

Relationship Between Axial Length and Retinal Oxygen Dynamics in Adults With Myopia

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment

Mettl3 -Mediated m 6 A Modification is Essential for Visual Function and Retinal Photoreceptor Survival

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

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