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ARVO Annual Meeting Abstract June 2022

Discovery and preclinical development of VVN539，a novel ROCK and NO dual MOA agent for the treatment of glaucoma in normotensive rabbits model with minimal hyperemia.

Yong Li; Lili Yao; Kuifeng Dang; Qiao Han; Caroline Lu; Erning Xia; Wang Shen

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):150 – A0343. doi:

Vision Sciences Society Annual Meeting Abstract September 2021

Follow Because of Trust: Trust Modulates the Gaze Cueing Effect

Wang Shengyuan; Xu Luzi; Luo Xinyu; Sun Yanliang

Journal of Vision. 2021; 21(9):2366. doi: https://doi.org/10.1167/jov.21.9.2366

Glaucoma August 2021

iPSC-Derived Trabecular Meshwork Cells Stimulate Endogenous TM Cell Division Through Gap Junction in a Mouse Model of Glaucoma

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Shangru Sui; Hongxia Yu; Xiangji Wang; Wenyan Wang; Xuejiao Yang; Xiaojing Pan; Qingjun Zhou; Chen Xin; Rong Du; Shen Wu; Jingxue Zhang; Qilong Cao; Ningli Wang; Markus H. Kuehn; Wei Zhu
TAGS: cell growth, connexin 43, gap junction protein, glaucoma, medication therapy management, mice, trabecular meshwork, myoc gene, coculture techniques, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):28. doi: https://doi.org/10.1167/iovs.62.10.28

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

JR5558 transgenic mice are a reliable model to investigate subretinal fibrosis

Yashar Seyed-Razavi; So-Ra Lee; Jiawen Fan; Weiyong Shen; Mark C Gillies

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2253. doi:

ARVO Annual Meeting Abstract June 2021

Retina Specific Laminin 523 Drives Differentiation of Pluripotent Human Stem Cells to Photoreceptor Progenitors Promoting Retina Function

Hwee Tay; Helder Andre; Vicki Chrysostomou; Swarnaseetha Adusumalli; Jing Guo; Wei Sheng Tan; Zuhua Cai; Sai Bo Bo Tun; Veluchamy A Barathi; Gavin Siew Wei Tan; Li Yen Chong; Anders Kvanta; Enrico Petretto; Karl Tryggvason

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2934. doi:

ARVO Annual Meeting Abstract June 2021

A tetravalent bispecific anti-angiopoietin-2/anti-VEGF antibody suppresses neovascular lesion and leakage in a laser-induced rat choroidal neovascularization model

Zsolt Ablonczy; James Lulo; Shengqin Wan; Christopher Schillo; Ciara O'Connor; Raj Patil; Andy Whitlock; Marco Muda

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):444. doi:

ARVO Annual Meeting Abstract June 2021

Topical BRM421 Ophthalmic Solution improves signs and symptoms of moderate to severe dry eye patients in clinical trials

Ping-Yen Huang; Yeou-Ping Tsao; Conrad Tou; Frank Lee; George W Ousler; Blair Boehmer; Eugene B McLaurin; Gail Torkildsen; David Wirta; Tsung-Chuan Ho; Hsiao-Han Wang; Erin Chang; Sheng-Shin Wang; Shih-Ya Chang; Yilun Chiang; Haishan Jang

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1335. doi:

Articles May 2021

Xeno- and Feeder-Free Differentiation of Human iPSCs to Trabecular Meshwork-Like Cells by Recombinant Cytokines

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Wenyan Wang; Yongzhen Miao; Shangru Sui; Yanan Wang; Shen Wu; Qilong Cao; Haoyun Duan; Xia Qi; Qingjun Zhou; Xiaojing Pan; Jingxue Zhang; Xuehong Chen; Yantao Han; Ningli Wang; Markus H. Kuehn; Wei Zhu
TAGS: cytokine, culture media, conditioned, reverse transcriptase polymerase chain reaction
Trans. Vis. Sci. Tech.. 2021; 10(6):27. doi: https://doi.org/10.1167/tvst.10.6.27

Includes: Supplemental Content

Articles October 2020

Laser Capture Microdissection-Based RNA Microsequencing Reveals Optic Nerve Crush-Related Early mRNA Alterations in Retinal Ganglion Cell Layer

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Dongyan Pan; Mengqiao Xu; Xin Chang; Mao Xia; Yibin Fang; Yinghua Fu; Wei Shen; Yue Wang; Xiaodong Sun
TAGS: lasers, microdissection, optic nerve, rna, rna, messenger, retinal ganglion cells, genes, sequence analysis, rna
Trans. Vis. Sci. Tech.. 2020; 9(11):30. doi: https://doi.org/10.1167/tvst.9.11.30

Includes: Supplemental Content

Articles July 2020

Mutation Screening of mtDNA Combined Targeted Exon Sequencing in a Cohort With Suspected Hereditary Optic Neuropathy

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Jian-Kang Li; Wei Li; Feng-Juan Gao; Shou-Fang Qu; Fang-Yuan Hu; Sheng-Hai Zhang; Li-Li Li; Zi-Wei Wang; Yong Qiu; Lu-Sheng Wang; Jie Huang; Ji-Hong Wu; Fang Chen
TAGS: cohort studies, dna, mitochondrial, exons, mutation, optic atrophy, hereditary, leber, optic nerve disorders, screening, optic atrophy, autosomal dominant
Trans. Vis. Sci. Tech.. 2020; 9(8):11. doi: https://doi.org/10.1167/tvst.9.8.11

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Comparison of glucose metabolism in human macula and peripheral retina

Ting Zhang; Shaoxue Zeng; Michele C Madigan; Meidong Zhu; Jianhai Du; Weiyong Shen; Ling Zhu; Mark C Gillies

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3539. doi:

ARVO Annual Meeting Abstract June 2020

Efficacy of Complement C3 Inhibition in Preclinical Models of Wet Age-related Macular Degeneration (AMD)

Wei-Sheng Chen; Benbo Song; Mary-Kamala Isoka; Maria Bogachek; Betty Li; Kalyani Mondal; Yan Wang; Serena Leong; Darrin Lindhout; Bin Fan; Raj Haldankar; Jie Tang; David Shen; Hui Tian; Zhonghao Liu; Alexander Loktev

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1799. doi:

Glaucoma May 2020

Time-Dependent Effects of Reduced Cerebrospinal Fluid Pressure on Optic Nerve Retrograde Axonal Transport

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Zheng Zhang; Shen Wu; Kegao Liu; Jingxue Zhang; Qian Liu; Lei Li; Ningli Wang
TAGS: axon, axonal transport, cerebrospinal fluid pressure, optic nerve, fluoro-gold
Invest. Ophthalmol. Vis. Sci.. 2020; 61(5):6. doi: https://doi.org/10.1167/iovs.61.5.6

ARVO Annual Meeting Abstract July 2019

The discovery of novel LFA-1 antagonist VVN001 to treat Dry Eye Disease (DED)

Yong Li; Erning Xia; wang shen

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):293. doi:

ARVO Annual Meeting Abstract July 2019

Selectively knocking down insulin receptor in rods disrupts glucose flux and leads to photoreceptor degeneration

Rui Zhang; Weiyong Shen; Victoria Pye; Ashish Easow Mathai; So-Ra Lee; Michelle Yam; Ling Zhu; Ching-Kang Jason Chen; Jianhai Du; Mark C Gillies

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1670. doi:

ARVO Annual Meeting Abstract July 2019

Comparison of Serine Biosynthesis in Human Retinal Pigment Epithelium from the Macula and Periphery

Ting Zhang; Shaoxue Zeng; Ling Zhu; Weiyong Shen; Jiawen Fan; Mark C Gillies

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1701. doi:

ARVO Annual Meeting Abstract July 2019

The dysregulation of interphotoreceptor retinoid binding protein (IRBP) under hyperglycemic conditions in Akita mice and human retinal explant culture

Shaoxue Zeng; Ting Zhang; Ling Zhu; Weiyong Shen; Junjun Zhang; Mark Gilles

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2670. doi:

ARVO Annual Meeting Abstract July 2019

A bioenergetic crisis in the retinal pigment epithelium contributes to photoreceptor degeneration

Weiyong Shen; Ashish Easow Mathai; Victoria Pye; So-Ra Lee; Michelle X. Yam; Rui Zhang; Ling Zhu; Pankaj Seth; Joshua L Dunaief; Mark C Gillies

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3866. doi:

ARVO Annual Meeting Abstract July 2019

Defined- and Xeno-free differentiation of human iPSCs to functional trabecular meshwork cells

Wei Zhu; Yongzhen Miao; Haoyun Duan; Qingjun Zhou; Shen Wu; jingxue zhang; Ningli Wang; Kewei Wang

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5212. doi:

ARVO Annual Meeting Abstract July 2019

Intravitreal injection of bortezomib attenuates choroidal neovascularization by antagonizing VEGF and PDGF-mediated signaling

Shengzhou Wu; Yimei Liu; Meiling Feng

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2991. doi:

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Discovery and preclinical development of VVN539，a novel ROCK and NO dual MOA agent for the treatment of glaucoma in normotensive rabbits model with minimal hyperemia.

Follow Because of Trust: Trust Modulates the Gaze Cueing Effect

iPSC-Derived Trabecular Meshwork Cells Stimulate Endogenous TM Cell Division Through Gap Junction in a Mouse Model of Glaucoma

JR5558 transgenic mice are a reliable model to investigate subretinal fibrosis

Retina Specific Laminin 523 Drives Differentiation of Pluripotent Human Stem Cells to Photoreceptor Progenitors Promoting Retina Function

A tetravalent bispecific anti-angiopoietin-2/anti-VEGF antibody suppresses neovascular lesion and leakage in a laser-induced rat choroidal neovascularization model

Topical BRM421 Ophthalmic Solution improves signs and symptoms of moderate to severe dry eye patients in clinical trials

Xeno- and Feeder-Free Differentiation of Human iPSCs to Trabecular Meshwork-Like Cells by Recombinant Cytokines

Laser Capture Microdissection-Based RNA Microsequencing Reveals Optic Nerve Crush-Related Early mRNA Alterations in Retinal Ganglion Cell Layer

Mutation Screening of mtDNA Combined Targeted Exon Sequencing in a Cohort With Suspected Hereditary Optic Neuropathy

Comparison of glucose metabolism in human macula and peripheral retina

Efficacy of Complement C3 Inhibition in Preclinical Models of Wet Age-related Macular Degeneration (AMD)

Time-Dependent Effects of Reduced Cerebrospinal Fluid Pressure on Optic Nerve Retrograde Axonal Transport

The discovery of novel LFA-1 antagonist VVN001 to treat Dry Eye Disease (DED)

Selectively knocking down insulin receptor in rods disrupts glucose flux and leads to photoreceptor degeneration

Comparison of Serine Biosynthesis in Human Retinal Pigment Epithelium from the Macula and Periphery

The dysregulation of interphotoreceptor retinoid binding protein (IRBP) under hyperglycemic conditions in Akita mice and human retinal explant culture

A bioenergetic crisis in the retinal pigment epithelium contributes to photoreceptor degeneration

Defined- and Xeno-free differentiation of human iPSCs to functional trabecular meshwork cells

Intravitreal injection of bortezomib attenuates choroidal neovascularization by antagonizing VEGF and PDGF-mediated signaling

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