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Anatomy and Pathology/Oncology March 2025

Whorl-Like Collagen Fiber Arrangement Around Emissary Canals in the Posterior Sclera

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Hongshuang Lu; Yijin Wu; Jianping Xiong; Nan Zhou; Masahiro Yamanari; Michiaki Okamoto; Keigo Sugisawa; Hiroyuki Takahashi; Changyu Chen; Yining Wang; Ziye Wang; Kyoko Ohno-Matsui
TAGS: collagen fiber, eye, sclera
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):35. https://doi.org/10.1167/iovs.66.3.35

Includes: Multimedia, Supplemental Content

Lens March 2025

Changes in Lens Thickness and Power Before and After Myopia Onset

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Jiaqing Zhang; Ling Jin; Qianyun Chen; Decai Wang; Xiang Chen; Yuting Li; Yabin Qu; Rong Lin; Mingguang He; Ian G. Morgan; Lixia Luo; Yangfa Zeng; Xiaotong Han
TAGS: lens, crystalline, myopia, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):36. https://doi.org/10.1167/iovs.66.3.36

Includes: Supplemental Content

Cornea March 2025

A Novel Model for Cornea Power Shift in Eyes Wearing Orthokeratology Lenses With Different Back Optic Zone Diameters for Myopia Control

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Ting Wang; Xiaoqin Chen; Mengdi Li; Hua Bi; Xiaoyan Yang; Muhan Sun; Yue Liu; Lihua Li; Bin Zhang
TAGS: cornea, eye, lens (device), lens, crystalline, myopia, orthokeratology contact lenses, optics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):29. https://doi.org/10.1167/iovs.66.3.29

Includes: Supplemental Content

Glaucoma March 2025

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

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Jing Wang; Yang Zhang; Huimin Zhong; Yumeng Zhang; Ruiqi Han; Yanzhi Guo; Shouyue Huang; Huan Yu; Yisheng Zhong
TAGS: ferroptosis, fibrosis, nadph oxidase 4, silicone oils, smad3 gene, trabecular meshwork, glaucoma, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):25. https://doi.org/10.1167/iovs.66.3.25

Public Health March 2025

Visual Deficits in Type 2 Diabetes Mellitus Without Retinopathy: From Retinal Structure to Higher-Level Visual Functions

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Sha Luo; Lin Xia; Yue Wang; Yong Tang; Jiong Dong; Rong Liu; Lixia Feng
TAGS: diabetes mellitus, diabetes mellitus, type 2, retina, retinal diseases, vision, vision disorders
Trans. Vis. Sci. Tech.. 2025; 14(3):10. https://doi.org/10.1167/tvst.14.3.10

Includes: Supplemental Content

Genetics March 2025

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

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Qiu-Yi Huo; Rui-Zheng Zhang; Wan-Nan Jia; Ya-Lei Wang; Xin Shen; Xin-Yao Chen; Tian-Hui Chen; Yan Liu; Ling-Hao Song; Xinyue Wang; Yong Lv; Ze-Xu Chen; Yong-Xiang Jiang
TAGS: biomechanics, cornea, ectopia lentis, fibrillin-1, marfan syndrome, mutation, genotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):23. https://doi.org/10.1167/iovs.66.3.23

Includes: Supplemental Content

Retina March 2025

Artificial Intelligence Versus Rules-Based Approach for Segmenting NonPerfusion Area in a DRCR Retina Network Optical Coherence Tomography Angiography Dataset

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Tristan T. Hormel; Wesley T. Beaulieu; Jie Wang; Jennifer K. Sun; Yali Jia
TAGS: nasopharyngeal aspirate, retina, angiogram, optical coherence tomography, datasets, artificial intelligence
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):22. https://doi.org/10.1167/iovs.66.3.22

Includes: Supplemental Content

Retina March 2025

Characteristics of Retina, Choroid, and Retrobulbar Blood Flow in Myopes With Posterior Staphyloma Using Ultra-Widefield OCTA and CDI

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Fang Liu; Yunzhe Wang; Lingling Niu; Jing Zhao; Kang Xue; Xingtao Zhou
TAGS: choroid, retina, staphyloma, vascular flow, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):21. https://doi.org/10.1167/iovs.66.3.21

Glaucoma March 2025

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

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Jiayong Li; Yuncheng Ma; Lingling Xie; Kaichen Zhuo; Yuxian He; Xin Ma; Shufen Zheng; Shicheng Guo; Yizhen Tang; Guzainuer Muhetaer; Mireayi Aizezi; Dan Zhang; Aizezi Wumaier; Xu Zhang; Chao Tang; Wei Wang; Wenyong Huang; Xinbo Gao
TAGS: biological markers, exfoliation syndrome, mass spectrometry, mendelian randomization analysis, plasma, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):19. https://doi.org/10.1167/iovs.66.3.19

Includes: Supplemental Content

Artificial Intelligence March 2025

An Intelligent Grading Model for Myopic Maculopathy Based on Long-Tailed Learning

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Bo Zheng; Chen Wang; Maotao Zhang; Shaojun Zhu; Maonian Wu; Tao Wu; Weihua Yang; Lu Chen
TAGS: learning, macular disorders, fundus photography, color, datasets
Trans. Vis. Sci. Tech.. 2025; 14(3):4. https://doi.org/10.1167/tvst.14.3.4

Includes: Supplemental Content

Immunology and Microbiology March 2025

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis

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Zhuang Li; Xiuxing Liu; Zuoyi Li; Zhiqiang Xiao; Guanyu Chen; Yangyang Li; Jun Huang; Yunwei Hu; Haixiang Huang; Wenjie Zhu; Yuxun Shi; Minzhen Wang; Yanyan Xie; Wenru Su; Xiaoqing Chen; Dan Liang
TAGS: autoimmunity, flow cytometry, interleukin-17, mice, rna, small cytoplasmic, t follicular helper cells, uveitis, genes, t-lymphocytes, phenotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):8. https://doi.org/10.1167/iovs.66.3.8

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology March 2025

One-Month-Old Rabbits Exhibit a Longer Postoperative Remodeling in Extraocular Muscles Compared to 3-Month-Old Rabbits

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Jiangtao Lou; Hailu Huang; Yiyi Peng; Chunxiao Wang; Meiping Xu; Xinping Yu
TAGS: muscle of orbit, oryctolagus cuniculus, postoperative care, surgical procedures, operative, embryo, russell-silver syndrome, surgery specialty, somatostatin receptor scintigraphy, preoperative care
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):12. https://doi.org/10.1167/iovs.66.3.12

Includes: Supplemental Content

Refractive Intervention March 2025

Evaluation of the Long-Term Corneal Biomechanics Following SMILE With Different Residual Stromal Bed Thickness in Rabbits

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Hongwei Qin; Xin Yang; Rui He; Yaowen Song; Junchao Wei; Xiaona Liu; Chenyan Wang; Ce Wu; Jie Hou; Zhipeng Gao; Lingfeng Chen; Xiaona Li; Weiyi Chen
TAGS: cornea, oryctolagus cuniculus, biomechanics, stress, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(3):3. https://doi.org/10.1167/tvst.14.3.3

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2025

Butyrate Ameliorates Graves’ Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota

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Pingbo Ouyang; Jia Qi; Boding Tong; Yunping Li; Jiamin Cao; Lujue Wang; Tongxin Niu; Xin Qi
TAGS: butyrates, fibroblasts, gastrointestinal microbiome, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):5. https://doi.org/10.1167/iovs.66.3.5

Includes: Supplemental Content

Retina March 2025

Photoreceptor Outer Segment Reflectivity With Ultrahigh-Resolution Visible-Light Optical Coherence Tomography in Systemic Hydroxychloroquine Use

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Anupam K. Garg; Jingyu Wang; Bailee Alonzo; Ji Yi; Amir H. Kashani
TAGS: hydroxychloroquine, optical coherence tomography, photoreceptors, vaccine information sheets, visible light, diagnostic imaging, toxic effect
Trans. Vis. Sci. Tech.. 2025; 14(3):2. https://doi.org/10.1167/tvst.14.3.2

Includes: Supplemental Content

Cornea February 2025

Identification of Wnt-5a Receptors Important in Diabetic and Non-Diabetic Corneal Epithelial Wound Healing

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Ruchi Shah; Cynthia Amador; Adam J. Poe; Tanya M. Spektor; Priyanka Bhandary; Yizhou Wang; Zhiping Paul Wang; Daniel J. Weisenberger; Vanessa F. Borges; Onkar B. Sawant; Ezra Maguen; Pedram Hamrah; Andrei A. Kramerov; Mehrnoosh Saghizadeh; Alexander V. Ljubimov
TAGS: cornea, diabetes mellitus, receptors, wnt, wnt-5a protein, wound healing, epithelium, receptor tyrosine kinase-like orphan receptor 2
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):64. https://doi.org/10.1167/iovs.66.2.64

Includes: Supplemental Content

Glaucoma February 2025

Evaluation of Serum and Aqueous Humor Neurofilament Light Chain as Markers of Neurodegeneration in Glaucoma

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Jonathan B. Lin; Hani El Helwe; Henisk Falah; Bruno L. Hammerschlag; Stephanie A. Schultz; George Baldwin; Yixi Xue; Ryan A. Vasan; Christian Song; Kristine Lo; Austin Meeker; Silas L. Wang; Pia Kivisäkk; David Solá-Del Valle; Milica A. Margeta
TAGS: aqueous humor, glaucoma, nerve degeneration, neurofilament protein l, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(2):24. https://doi.org/10.1167/tvst.14.2.24

Includes: Supplemental Content

Cornea February 2025

Melatonin Alleviates Age-Related Lacrimal Gland Dysfunction Via SIRT-1/NLRP3 Pathway

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Chao Wang; Yu-Zhi Li; Huan Guo; Shi-Rui Zhou; Xi Peng; Jia-Song Wang; Hua-Tao Xie; Ming-Chang Zhang
TAGS: lacrimal gland, nlr family, pyrin domain-containing 3 protein, sirt1 gene, melatonin, pathophysiology, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):51. https://doi.org/10.1167/iovs.66.2.51

Includes: Supplemental Content

Cornea & External Disease February 2025

Validation of the Ocular Pain Assessment Survey Instrument With Rasch Analysis

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Debbie Marie Ng; Xiu Wang; Chang Liu; MingYi Yu; Isabelle Xin Yu Lee; Jipson Hon Fai Wong; Regina Kay Ting Wong; Diana Xin Hui Chan; Yu-Chi Liu; Louis Hak Tien Tong
TAGS: ocular pain, pain, rasch model, reliability, surveys
Trans. Vis. Sci. Tech.. 2025; 14(2):20. https://doi.org/10.1167/tvst.14.2.20

Includes: Supplemental Content

Cornea February 2025

Stiffness Regulates the Morphology and Stemness of Limbal Niche Cells Through Unique nYAP/cYAP Translocation

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Xiao Zhou; Lingjuan Xu; Yongyao Tan; Wei Wang; Xiaoyu Huang; Guigang Li
TAGS: language morphology, morphology, phenotype, translocation (genetics), diffuse idiopathic skeletal hyperostosis, cornea, stem cells, proteins, western blotting, patient isolation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):43. https://doi.org/10.1167/iovs.66.2.43

Includes: Supplemental Content

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Whorl-Like Collagen Fiber Arrangement Around Emissary Canals in the Posterior Sclera

Changes in Lens Thickness and Power Before and After Myopia Onset

A Novel Model for Cornea Power Shift in Eyes Wearing Orthokeratology Lenses With Different Back Optic Zone Diameters for Myopia Control

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

Visual Deficits in Type 2 Diabetes Mellitus Without Retinopathy: From Retinal Structure to Higher-Level Visual Functions

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

Artificial Intelligence Versus Rules-Based Approach for Segmenting NonPerfusion Area in a DRCR Retina Network Optical Coherence Tomography Angiography Dataset

Characteristics of Retina, Choroid, and Retrobulbar Blood Flow in Myopes With Posterior Staphyloma Using Ultra-Widefield OCTA and CDI

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

An Intelligent Grading Model for Myopic Maculopathy Based on Long-Tailed Learning

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis

One-Month-Old Rabbits Exhibit a Longer Postoperative Remodeling in Extraocular Muscles Compared to 3-Month-Old Rabbits

Evaluation of the Long-Term Corneal Biomechanics Following SMILE With Different Residual Stromal Bed Thickness in Rabbits

Butyrate Ameliorates Graves’ Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota

Photoreceptor Outer Segment Reflectivity With Ultrahigh-Resolution Visible-Light Optical Coherence Tomography in Systemic Hydroxychloroquine Use

Identification of Wnt-5a Receptors Important in Diabetic and Non-Diabetic Corneal Epithelial Wound Healing

Evaluation of Serum and Aqueous Humor Neurofilament Light Chain as Markers of Neurodegeneration in Glaucoma

Melatonin Alleviates Age-Related Lacrimal Gland Dysfunction Via SIRT-1/NLRP3 Pathway

Validation of the Ocular Pain Assessment Survey Instrument With Rasch Analysis

Stiffness Regulates the Morphology and Stemness of Limbal Niche Cells Through Unique nYAP/cYAP Translocation

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