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ARVO Annual Meeting Abstract June 2025

Conditional Deletion of Na/K-ATPase β2 Subunit Affects Retinal Structural Integrity and Function

Saravanan Kolandaivelu; Emily Sechrest; Boyden Myers; Wen-Tao Deng; Jianhai Du

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):3057.

ARVO Annual Meeting Abstract June 2025

Rab6a regulates rhodopsin trafficking in the trans -Golgi network of mouse rod photoreceptors

Samantha Thompson; Maryam Hekmatara; Brooke Brothers; Wen-Tao Deng; Michael Robichaux

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):4284.

ARVO Annual Meeting Abstract June 2025

Molecular Mechanisms Limiting the Therapeutic Window of AAV Gene Therapy in Mouse Models of Blue Cone Monochromacy

Wen-Tao Deng; Brooke Brothers; Emily Sechrest

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):4270.

ARVO Annual Meeting Abstract June 2024

Subcellular analysis of the rhodopsin-ER biosynthesis network and ER dynamics in response to light exposure in mouse rod photoreceptors.

Shannon Eshelman; Lauren Sexton; Hunter Aliff; Visvanathan Ramamurthy; Wen-Tao Deng; Michael Robichaux

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4717.

ARVO Annual Meeting Abstract June 2024

P307L and R330Q cone opsin missense mutant knock-in mice display a dominant negative blue cone monochromacy phenotype

Brooke Brothers; Robert Barbera; Emily Sechrest; Wen-Tao Deng

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4707.

ARVO Annual Meeting Abstract June 2024

Side-by-side comparison of high transduction AAV8-Y733F-mediated gene therapy in two BCM mouse models

Emily Sechrest; Robert Barbera; Brooke Brothers; Marion Easton Cahill; Wen-Tao Deng

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5355.

ARVO Annual Meeting Abstract June 2024

Gene therapy rescued cones in an all-cone mouse model of blue cone monochromacy with the most common cone opsin missense mutation

Marion Easton Cahill; Kathryn Chmelik; Emily Sechrest; Daniel Markovitz; Wen-Tao Deng

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6090.

ARVO Annual Meeting Abstract June 2023

Gene therapy rescues cone function and structure in a novel mouse model of blue cone monochromacy with the most common C203R missense mutation

Emily R. Sechrest; Robert J. Barbera; Kathryn Chmelik; Marion Cahill; Wen-Tao Deng

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):797.

ARVO Annual Meeting Abstract June 2023

Gene therapy restores vision to the all-cone Nrl -/- /Opn1mw -/- /Opn1sw -/- mouse model of blue cone monochromacy

Marion Cahill; Kathryn Chmelik; Emily R. Sechrest; Robert J. Barbera; Wolfgang Baehr; Wen-Tao Deng

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):769.

ARVO Annual Meeting Abstract June 2023

Mapping the Endoplasmic Reticulum and Rhodopsin Biosynthesis in Rod Photoreceptor Neurons Using Super-Resolution Microscopy

Shannon Eshelman; Kristen Haggerty; Matthew Humbert; Wen-Tao Deng; Michael Robichaux

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3228.

ARVO Annual Meeting Abstract June 2022

Characterization of cone structure and function in a mouse model for blue cone monochromacy patients with a C203R mutation

Emily Sechrest; Xiajie Ma; Wen-Tao Deng

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1789 – F0338.

ARVO Annual Meeting Abstract June 2021

Disease mechanisms of X-linked cone dystrophy caused by missense mutations in the red and green cone opsins

Wen-Tao Deng; Ping Zhu; Frank M Dyka; Wolfgang Baehr; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1554.

ARVO Annual Meeting Abstract June 2020

Rescue of cone structure and function in Opn1mw/sw double knockout mice

Wen-Tao Deng; Ping Zhu; Tiffanie Dahl; Wolfgang Baehr; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2456.

Retina August 2019

Rescue of M-cone Function in Aged Opn1mw −/− Mice, a Model for Late-Stage Blue Cone Monochromacy

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Wen-Tao Deng; Jie Li; Ping Zhu; Beau Freedman; W. Clay Smith; Wolfgang Baehr; William W. Hauswirth
TAGS: gene therapy, mice, retinal cone, opsin
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3644-3651. https://doi.org/10.1167/iovs.19-27079

ARVO Annual Meeting Abstract July 2019

Successful rescue of M-cone function in aged M-opsin knock-out mice, a model for blue cone monochromacy

Wen-Tao Deng; Jie Li; Ping Zhu; Wolfgang Baehr; William Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3419.

ARVO Annual Meeting Abstract September 2016

Gene therapy in the Opn1mw Knock-out mouse, a model for blue cone monochromacy, leads to long-term M-cone restoration

Ji-Jing Pang; Yuxin Zhang; Ping Zhu; Wen-Tao Deng; Jie Li; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1166.

ARVO Annual Meeting Abstract September 2016

Long term restoration of cone function following AAV-mediated gene therapy in CNGA3 -/- Nrl -/- Mice

Yuxin Zhang; Wei Du; Ping Zhu; Jie Li; Wen-Tao Deng; Chen Zhao; William Hauswirth; Ji-Jing Pang

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1175.

Retina October 2015

Pathological Effects of Mutant C1QTNF5 (S163R) Expression in Murine Retinal Pigment Epithelium

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Astra Dinculescu; Seok-Hong Min; Frank M. Dyka; Wen-Tao Deng; Rachel M. Stupay; Vince Chiodo; W. Clay Smith; William W. Hauswirth
TAGS: antibodies, eye, immunohistochemistry, injections, mice, photoreceptors, proteins, retinal pigment epithelium, spatial vectors, tissue membrane
Invest. Ophthalmol. Vis. Sci.. 2015; 56(11):6971-6980. https://doi.org/10.1167/iovs.15-17166

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Localization of Clarin-1 in Photoreceptor Cells and Optimized AAV Gene Delivery of Clarin-1 to the Mouse Retina

William W Hauswirth; Rachel M Stupay; Ping Zhu; Wen-Tao Deng; Vince Chiodo; Sanford L Boye; Qiuhong Li; Astra Dinculescu

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3630.

ARVO Annual Meeting Abstract June 2015

AAV-mediated Long Term Rescue of Cone Function in the CNGA3 -/- Nrl -/- Mice Following Intravitreal Injection

Yuxin Zhang; Wei Du; Ping Zhu; Jie Li; Wen-Tao Deng; Sanford L Boye; Xi-Qin Ding; Shannon Elizabeth Boye; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5468.

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Conditional Deletion of Na/K-ATPase β2 Subunit Affects Retinal Structural Integrity and Function

Rab6a regulates rhodopsin trafficking in the trans -Golgi network of mouse rod photoreceptors

Molecular Mechanisms Limiting the Therapeutic Window of AAV Gene Therapy in Mouse Models of Blue Cone Monochromacy

Subcellular analysis of the rhodopsin-ER biosynthesis network and ER dynamics in response to light exposure in mouse rod photoreceptors.

P307L and R330Q cone opsin missense mutant knock-in mice display a dominant negative blue cone monochromacy phenotype

Side-by-side comparison of high transduction AAV8-Y733F-mediated gene therapy in two BCM mouse models

Gene therapy rescued cones in an all-cone mouse model of blue cone monochromacy with the most common cone opsin missense mutation

Gene therapy rescues cone function and structure in a novel mouse model of blue cone monochromacy with the most common C203R missense mutation

Gene therapy restores vision to the all-cone Nrl -/- /Opn1mw -/- /Opn1sw -/- mouse model of blue cone monochromacy

Mapping the Endoplasmic Reticulum and Rhodopsin Biosynthesis in Rod Photoreceptor Neurons Using Super-Resolution Microscopy

Characterization of cone structure and function in a mouse model for blue cone monochromacy patients with a C203R mutation

Disease mechanisms of X-linked cone dystrophy caused by missense mutations in the red and green cone opsins

Rescue of cone structure and function in Opn1mw/sw double knockout mice

Rescue of M-cone Function in Aged Opn1mw −/− Mice, a Model for Late-Stage Blue Cone Monochromacy

Successful rescue of M-cone function in aged M-opsin knock-out mice, a model for blue cone monochromacy

Gene therapy in the Opn1mw Knock-out mouse, a model for blue cone monochromacy, leads to long-term M-cone restoration

Long term restoration of cone function following AAV-mediated gene therapy in CNGA3 -/- Nrl -/- Mice

Pathological Effects of Mutant C1QTNF5 (S163R) Expression in Murine Retinal Pigment Epithelium

Localization of Clarin-1 in Photoreceptor Cells and Optimized AAV Gene Delivery of Clarin-1 to the Mouse Retina

AAV-mediated Long Term Rescue of Cone Function in the CNGA3 -/- Nrl -/- Mice Following Intravitreal Injection

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