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ARVO Annual Meeting Abstract June 2022

Detection and characterization of circular RNAs hosted by RPGR exon ORF15.

Tatyana Appelbaum; Leonardo Murgiano; Gustavo D Aguirre; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3890 – A0092. doi:

ARVO Annual Meeting Abstract June 2022

Surgical Procedure and Applicability of the Orbit Subretinal Delivery System (SDS)™ in the Normal Adult Canine Eye

Alexa P Gray; Yu Sato; Tom Meyer; Kirsten Stoner; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4118 – F0355. doi:

ARVO Annual Meeting Abstract June 2022

Disease-driven Prolactin Isoform Expression in Canine Inherited Retinopathies

Raghavi Sudharsan; Gustavo D Aguirre; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1964 – F0382. doi:

ARVO Annual Meeting Abstract June 2022

Triple drug immunosuppression for xenotransplantation of human photoreceptor precursor cells in the canine retina.

Ana Ripolles-Garcia; Natalia Dolgova; M. Joseph Phillips; Svetalana Savina; Allison Ludwig; Sara Stuedemann; John H Wolfe; Oliver Garden; David M Gamm; Gustavo D Aguirre; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):53 – A0026. doi:

ARVO Annual Meeting Abstract June 2022

Long-term follow up of gene therapy for NPHP5 -LCA in a canine model shows restoration of photoreceptor function and vision for > 5 years

William A Beltran; Artur V Cideciyan; Ana Ripolles-Garcia; Valerie L Dufour; Yu Sato; Alexa Gray; Malgorzata Swider; Sanford L Boye; William W Hauswirth; Samuel G. Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):454. doi:

ARVO Annual Meeting Abstract June 2020

Characterization of a Novel Prolactin Transcript in Photoreceptors of Degenerating Retina

Raghavi Sudharsan; Leonardo Murgiano; Gustavo D Aguirre; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):666. doi:

ARVO Annual Meeting Abstract June 2020

Subretinal transplantation and survival of hESC-derived photoreceptor precursor cells in normal canine eyes

Ana Ripolles Garcia; Valerie Dufour; Joe Phillips; Natalia Dolgova; Allison Ludwig; Sara Stuedemann; Svetlana Savina; John H Wolfe; Karina E Guziewicz; Oliver Garden; David M Gamm; Gustavo D Aguirre; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):796. doi:

ARVO Annual Meeting Abstract June 2020

AAV gene therapy restores ON-bipolar cell function in a canine model of LRIT3 -congenital stationary night blindness

Keiko Miyadera; Karolina Roszak; Ana Ripolles Garcia; Evelyn Santana; Sommer M Iffrig; Meike Visel; Leah Byrne; William A Beltran; John Gerard Flannery; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2298. doi:

ARVO Annual Meeting Abstract June 2020

A newly recognized canine phenotype of early-onset retinal degeneration

Karina E Guziewicz; Valerie Dufour; Lauren Lew; Brian Thomas Kendrick; Ana Ripolles Garcia; William A Beltran; Artur V Cideciyan; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2792. doi:

ARVO Annual Meeting Abstract June 2020

Azobenzene-based BENAQ photoswitch confers light-sensitivity to degenerating and WT canine retinas.

Sergei Nikonov; Roman Nikonov; Natalia Dolgova; Richard H Kramer; Russell Van Gelder; Gustavo D Aguirre; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4285. doi:

ARVO Annual Meeting Abstract June 2020

AAV capsid variants target canine and primate bipolar cells after subretinal and intravitreal delivery

William A Beltran; Natalia Dolgova; Valerie L Dufour; Iwabe Simone; Ryan F. Boyd; Joshua T Bartoe; Gustavo D Aguirre; David L schaffer; John Gerard Flannery; Leah Byrne

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4489. doi:

ARVO Annual Meeting Abstract June 2020

Differential expression of protein tyrosine phosphatases in canine models of retinal degeneration

Catharina Grubaugh; Leonardo Murgiano; Raghavi Sudharsan; Brian Thomas Kedrick; William A Beltran; Karina E Guziewicz; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5004. doi:

ARVO Annual Meeting Abstract July 2019

Long-term longitudinal assessment of functional rescue in mutant XLRP dogs after RPGR gene augmentation therapy

William A Beltran; Valerie L Dufour; Sommer M Ainsworth; Karolina Roszak; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4031. doi:

ARVO Annual Meeting Abstract July 2019

Prolactin Expression is Induced in Photoreceptors of Degenerating Retina

Raghavi Sudharsan; Leonardo Murgiano; Gustavo D Aguirre; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5991. doi:

ARVO Annual Meeting Abstract July 2019

Safety and long-term efficacy of AAV2- BEST1 gene augmentation therapy in canine model of Best vitelliform macular dystrophies

Karina E Guziewicz; Artur V Cideciyan; Brian T. Kendrick; Valerie L Dufour; Gordon Ruthel; Andras M Komaromy; Simone Iwabe; William Hauswirth; William A Beltran; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5200. doi:

New Developments in Vision Research September 2018

Translational Retinal Research and Therapies

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Alison J. Hardcastle; Paul A. Sieving; José-Alain Sahel; Samuel G. Jacobson; Artur V. Cideciyan; John G. Flannery; William A. Beltran; Gustavo D. Aguirre
TAGS: gene therapy, genes, mutation, optogenetics, photoreceptors, proteins, retina, retinal cone, retinitis pigmentosa, rhodopsin
Trans. Vis. Sci. Tech.. 2018; 7(5):8. doi: https://doi.org/10.1167/tvst.7.5.8

ARVO Annual Meeting Abstract July 2018

BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments

Karina E Guziewicz; Artur V Cideciyan; William A Beltran; Andras M Komaromy; Valerie Dufour; Malgorzata Swider; Simone Iwabe; Alexander Sumaroka; Brian T Kendrick; Gordon Ruthel; Vince A Chiodo; Elise Heon; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4522. doi:

ARVO Annual Meeting Abstract July 2018

AAV-mediated expression of X-linked Inhibitor of Apoptosis protects photoreceptors in two canine models of early onset RP

William A Beltran; Artur V Cideciyan; Simone Iwabe; Valerie Dufour; Jason Charng; Brianna Lisi; Jose-Manuel Guzman; Alireza Badiei; Catherine Tsilfidis; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4527. doi:

ARVO Annual Meeting Abstract July 2018

Association of long-term RPE65 expression and photoreceptor preservation in RPE65 -gene therapy-treated canines

Kristin Lee Gardiner; William A Beltran; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5318. doi:

ARVO Annual Meeting Abstract July 2018

Long-term preservation of photoreceptor function and structure following early-stage treatment by AAV-mediated gene augmentation in canine model of NPHP5 Leber congenital amaurosis

Gustavo D Aguirre; Artur V Cideciyan; Sanford L Boye; Simone Iwabe; Valerie Dufour; Malgorzata Swider; Karolina Roszak; William W Hauswirth; Samuel G Jacobson; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6006. doi:

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Detection and characterization of circular RNAs hosted by RPGR exon ORF15.

Surgical Procedure and Applicability of the Orbit Subretinal Delivery System (SDS)™ in the Normal Adult Canine Eye

Disease-driven Prolactin Isoform Expression in Canine Inherited Retinopathies

Triple drug immunosuppression for xenotransplantation of human photoreceptor precursor cells in the canine retina.

Long-term follow up of gene therapy for NPHP5 -LCA in a canine model shows restoration of photoreceptor function and vision for > 5 years

Characterization of a Novel Prolactin Transcript in Photoreceptors of Degenerating Retina

Subretinal transplantation and survival of hESC-derived photoreceptor precursor cells in normal canine eyes

AAV gene therapy restores ON-bipolar cell function in a canine model of LRIT3 -congenital stationary night blindness

A newly recognized canine phenotype of early-onset retinal degeneration

Azobenzene-based BENAQ photoswitch confers light-sensitivity to degenerating and WT canine retinas.

AAV capsid variants target canine and primate bipolar cells after subretinal and intravitreal delivery

Differential expression of protein tyrosine phosphatases in canine models of retinal degeneration

Long-term longitudinal assessment of functional rescue in mutant XLRP dogs after RPGR gene augmentation therapy

Prolactin Expression is Induced in Photoreceptors of Degenerating Retina

Safety and long-term efficacy of AAV2- BEST1 gene augmentation therapy in canine model of Best vitelliform macular dystrophies

Translational Retinal Research and Therapies

BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments

AAV-mediated expression of X-linked Inhibitor of Apoptosis protects photoreceptors in two canine models of early onset RP

Association of long-term RPE65 expression and photoreceptor preservation in RPE65 -gene therapy-treated canines

Long-term preservation of photoreceptor function and structure following early-stage treatment by AAV-mediated gene augmentation in canine model of NPHP5 Leber congenital amaurosis

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