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Retina August 2019

Rescue of M-cone Function in Aged Opn1mw −/− Mice, a Model for Late-Stage Blue Cone Monochromacy

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Wen-Tao Deng; Jie Li; Ping Zhu; Beau Freedman; W. Clay Smith; Wolfgang Baehr; William W. Hauswirth
TAGS: gene therapy, mice, retinal cone, opsin
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3644-3651. doi: https://doi.org/10.1167/iovs.19-27079

ARVO Annual Meeting Abstract July 2019

Dual Adeno-Associated Virus Vector mediated gene therapy for autosomal recessive Stargardt Disease

Frank M Dyka; Laurie L Molday; Vince A Chiodo; Robert S Molday; William Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3402. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2019

Successful rescue of M-cone function in aged M-opsin knock-out mice, a model for blue cone monochromacy

Wen-Tao Deng; Jie Li; Ping Zhu; Wolfgang Baehr; William Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3419. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2019

VMD2 Promoter-mediated Gene Therapy Optimizes Active Rap1a Expression in the Retinal Pigment Epithelium of Wild Type Mice

Haibo Wang; Aniket Ramshekar; Eric Kunz; William Hauswirth; M Elizabeth Hartnett

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1925. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2019

Safety and long-term efficacy of AAV2- BEST1 gene augmentation therapy in canine model of Best vitelliform macular dystrophies

Karina E Guziewicz; Artur V Cideciyan; Brian T. Kendrick; Valerie L Dufour; Gordon Ruthel; Andras M Komaromy; Simone Iwabe; William Hauswirth; William A Beltran; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5200. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2018

Interocular symmetry of foveal cone topography in achromatopsia (ACHM)

Katie M Litts; Christopher S Langlo; Emily J Patterson; Rebecca Mastey; Jenna A Cava; Patrick May; Byron L Lam; Gerald A Fishman; Mark E Pennesi; Christine N. Kay; Alfredo Dubra; William W Hauswirth; Kathleen N Beasley; Jeffrey D Chulay; Joseph Carroll

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4992. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2018

Long-term preservation of photoreceptor function and structure following early-stage treatment by AAV-mediated gene augmentation in canine model of NPHP5 Leber congenital amaurosis

Gustavo D Aguirre; Artur V Cideciyan; Sanford L Boye; Simone Iwabe; Valerie Dufour; Malgorzata Swider; Karolina Roszak; William W Hauswirth; Samuel G Jacobson; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6006. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2018

Neuroprotection by overexpression of transcription factor Max in experimental glaucoma.

Rafael Lani; Mariana Santana Dias; Tabata Granja Araujo; William W Hauswirth; Adalmir Morterá Dantas; Mario Fiorani Junior; Hilda Petrs Silva; Rafael Linden

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6137. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2018

Very long chain ceramides production mediated by ELOVL4 stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

Julia V Busik; Nermin Kady; Xuwen Liu; Todd Lydic; Sergey S Seregin; Andrea Amalfitano; Vince A Chiodo; Sanford L Boye; William W Hauswirth; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3002. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2018

Phenotypic consequences of amino acid substitutions at the S163 position in C1QTNF5 protein following expression in murine RPE

Astra Dinculescu; Susan Bolch; Frank M Dyka; Manoj Kulkarni; Chiab Simpson; W Clay Smith; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3052. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2018

The expression pattern and pathological effects of CLRN1 mutant proteins in the mouse retina

Susan Bolch; Frank M Dyka; Manoj Kulkarni; Rachel Stupay; Chiab Simpson; W Clay Smith; William W Hauswirth; Astra Dinculescu

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3053. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2018

Assessment of cone outer segment defects and rescue in the Opn1mw/sw double knockout mouse

Tiffanie M. Dahl; Michelle Reed; Cecilia D. Gerstner; Guoxin Ying; Wentao Deng; William W Hauswirth; Wolfgang Baehr

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3054. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2018

BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments

Karina E Guziewicz; Artur V Cideciyan; William A Beltran; Andras M Komaromy; Valerie Dufour; Malgorzata Swider; Simone Iwabe; Alexander Sumaroka; Brian T Kendrick; Gordon Ruthel; Vince A Chiodo; Elise Heon; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4522. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2018

AAV-mediated expression of X-linked Inhibitor of Apoptosis protects photoreceptors in two canine models of early onset RP

William A Beltran; Artur V Cideciyan; Simone Iwabe; Valerie Dufour; Jason Charng; Brianna Lisi; Jose-Manuel Guzman; Alireza Badiei; Catherine Tsilfidis; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4527. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2018

Dual Adeno-Associated Virus Vector Treatment of Autosomal Recessive Stargardt Disease

Frank M Dyka; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4533. doi: https://doi.org/

ARVO Annual Meeting Abstract June 2017

Overexpression of ELOVL4 stabilizes tight junctions and prevents VEGF-induced vascular permeability in diabetic retina and retinal cells.

Nermin Kady; Xuwen Liu; Todd Lydic; Segey Seregin; Andrea Amalfitano; Vince A Chiodo; Sanford L Boye; William Hauswirth; Maria B Grant; David Antonetti; Julia V Busik

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4034. doi: https://doi.org/

ARVO Annual Meeting Abstract June 2017

Inhibiting complement C3 activation by gene therapy reduces glaucoma progression

Alejandra Bosco; Sarah Anderson; Kevin T Breen; Cesar O Romero; Michael R Steele; Vince A Chiodo; Sanford L Boye; William W Hauswirth; Stephen Tomlinson; Monica L Vetter

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2957. doi: https://doi.org/

ARVO Annual Meeting Abstract June 2017

Outcome measures for BEST1 gene augmentation therapy: restoration of RPE-photoreceptor interface homeostasis

Karina E Guziewicz; William A Beltran; Artur V Cideciyan; Valerie Liliane Dufour; Andras M Komaromy; Emily McTish; Alfred S Lewin; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2273. doi: https://doi.org/

ARVO Annual Meeting Abstract June 2017

Co-expression of human L- or M-opsin restores M-Cone Function in the Opn1mw Knock-out mouse, a model for blue cone monochromacy (BCM)

Wentao Deng; Ji-Jing Pang; Jie Li; Ping Zhu; Wolfgang Baehr; W. Clay Smith; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4477. doi: https://doi.org/

ARVO Annual Meeting Abstract June 2017

Restoration of M-cone function in an S-cone only mouse model of human blue cone monochromacy by AAV-mediated expression of human L- or M-opsin

Ji-Jing Pang; Wentao Deng; Yuxin Zhang; Jie Li; Ping Zhu; Wolfgang Baehr; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4478. doi: https://doi.org/

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Rescue of M-cone Function in Aged Opn1mw −/− Mice, a Model for Late-Stage Blue Cone Monochromacy

Dual Adeno-Associated Virus Vector mediated gene therapy for autosomal recessive Stargardt Disease

Successful rescue of M-cone function in aged M-opsin knock-out mice, a model for blue cone monochromacy

VMD2 Promoter-mediated Gene Therapy Optimizes Active Rap1a Expression in the Retinal Pigment Epithelium of Wild Type Mice

Safety and long-term efficacy of AAV2- BEST1 gene augmentation therapy in canine model of Best vitelliform macular dystrophies

Interocular symmetry of foveal cone topography in achromatopsia (ACHM)

Long-term preservation of photoreceptor function and structure following early-stage treatment by AAV-mediated gene augmentation in canine model of NPHP5 Leber congenital amaurosis

Neuroprotection by overexpression of transcription factor Max in experimental glaucoma.

Very long chain ceramides production mediated by ELOVL4 stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

Phenotypic consequences of amino acid substitutions at the S163 position in C1QTNF5 protein following expression in murine RPE

The expression pattern and pathological effects of CLRN1 mutant proteins in the mouse retina

Assessment of cone outer segment defects and rescue in the Opn1mw/sw double knockout mouse

BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments

AAV-mediated expression of X-linked Inhibitor of Apoptosis protects photoreceptors in two canine models of early onset RP

Dual Adeno-Associated Virus Vector Treatment of Autosomal Recessive Stargardt Disease

Overexpression of ELOVL4 stabilizes tight junctions and prevents VEGF-induced vascular permeability in diabetic retina and retinal cells.

Inhibiting complement C3 activation by gene therapy reduces glaucoma progression

Outcome measures for BEST1 gene augmentation therapy: restoration of RPE-photoreceptor interface homeostasis

Co-expression of human L- or M-opsin restores M-Cone Function in the Opn1mw Knock-out mouse, a model for blue cone monochromacy (BCM)

Restoration of M-cone function in an S-cone only mouse model of human blue cone monochromacy by AAV-mediated expression of human L- or M-opsin

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