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Cornea August 2011

Interferon-γ Exacerbates Dry Eye–Induced Apoptosis in Conjunctiva through Dual Apoptotic Pathways

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Xiaobo Zhang; Wei Chen; Cintia S. De Paiva; Rosa M. Corrales; Eugene A. Volpe; Andrew J. McClellan; William J. Farley; De-Quan Li; Stephen C. Pflugfelder
TAGS: apoptosis, conjunctiva, dry eye syndromes, interferons, mice, caspase-3
Invest. Ophthalmol. Vis. Sci.. 2011; 52(9):6279-6285. https://doi.org/10.1167/iovs.10-7081

Cornea May 2011

Entrapment of Conjunctival Goblet Cells by Desiccation-Induced Cornification

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Rosa Maria Corrales; Cintia Sade de Paiva; De-Quan Li; William Johnson Farley; Johanna Tukler Henriksson; Jan Per Gustav Bergmanson; Stephen Carl Pflugfelder
TAGS: conjunctiva, desiccation, entrapment (morphologic abnormality), goblet cells, keratinization, stress, mice, enzymes
Invest. Ophthalmol. Vis. Sci.. 2011; 52(6):3492-3499. https://doi.org/10.1167/iovs.10-5782

Immunology and Microbiology May 2011

Pharmacological Cholinergic Blockade Stimulates Inflammatory Cytokine Production and Lymphocytic Infiltration in the Mouse Lacrimal Gland

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John D. Pitcher, III; Cintia S. De Paiva; Flavia S. A. Pelegrino; Andrew J. McClellan; Jagdeep K. Raince; Solherny B. Pangelinan; Ehsan Rahimy; William J. Farley; Michael E. Stern; De-Quan Li; Stephen C. Pflugfelder
TAGS: cholinergic agents, cytokine, lacrimal gland, mice, pharmacology, lymphocytes
Invest. Ophthalmol. Vis. Sci.. 2011; 52(6):3221-3227. https://doi.org/10.1167/iovs.09-4212

ARVO Annual Meeting Abstract April 2011

Effects Of Desiccating Stress On Thrombospondin-1 Knock-out Mice

Niral B. Gandhi; Eugene Volpe; William J. Farley; De-Quan Li; Stephen C. Pflugfelder; Cintia S. De Paiva

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3760.

ARVO Annual Meeting Abstract April 2011

Characterization of Intraepithelial Lymphocyte Populations and Their Changes in Response to Experimental Desiccating Stress

Eugene A. Volpe; Solherny B. Pangelinan; Niral B. Ghandi; Scott D. Kelly; William J. Farley; De-Quan Li; Michael E. Stern; Jerry Y. Niederkorn; Stephen C. Pflugfelder; Cintia S. De Paiva

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3763.

ARVO Annual Meeting Abstract April 2011

Disruption of TGF-β Signaling Improves Dry Eye Disease

Cintia S. De Paiva; Eugene Volpe; Niral B. Ghandi; John D. Pitcher, III; William J. Farley; De-Quan Li; Michael E. Stern; Jerry Y. Niederkorn; Stephen C. Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3770.

ARVO Annual Meeting Abstract April 2011

Biodegradable PLGA-Based Drug Delivery Systems for Modulating Ocular Surface Disease in a Murine Model

Andrew J. McClellan; Emanuel Chang; Cintia S. De Paiva; William J. Farley; Stephen C. Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3777.

ARVO Annual Meeting Abstract April 2011

Dry Eye Mice are Resistant to Toll-Like Receptor Induced Inflammation

Rachel L. Redfern; William J. Farley; Nimesh Patel; Samuel Hanlon; Stephen C. Pflugfelder; Alison McDermott

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3778.

ARVO Annual Meeting Abstract April 2011

Spontaneous Autoimmune Inflammation of the Ocular Surface Mucosa in Aged CD4-DNTGFβRII Mice

Stephen C. Pflugfelder; Michael E. Stern; Jerry Y. Niederkorn; John D. Pitcher, III; Eugene Volpe; Niral Gandhi; William J. Farley; De-Quan Li; Cintia S. De Paiva

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2095.

Cornea November 2010

Altered Morphology and Function of the Lacrimal Functional Unit in Protein Kinase Cα Knockout Mice

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Zhuo Chen; Zhijie Li; Surendra Basti; William J. Farley; Stephen C. Pflugfelder
TAGS: cornea, epithelium, language morphology, mice, mice, knockout, morphology, protein kinase, wound healing, lacrimal gland, body weight
Invest. Ophthalmol. Vis. Sci.. 2010; 51(11):5592-5600. https://doi.org/10.1167/iovs.09-4562

Immunology and Microbiology June 2010

Desiccating Stress Promotion of Th17 Differentiation by Ocular Surface Tissues through a Dendritic Cell-Mediated Pathway

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Xiaofen Zheng; Cintia S. de Paiva; De-Quan Li; William J. Farley; Stephen C. Pflugfelder
TAGS: body tissue, conjunctiva, cornea, cytokine, dendrites, interleukin-17, interleukin-6, mice, stress, t-lymphocytes
Invest. Ophthalmol. Vis. Sci.. 2010; 51(6):3083-3091. https://doi.org/10.1167/iovs.09-3838

Cornea February 2010

Association between High Tear Epidermal Growth Factor Levels and Corneal Subepithelial Fibrosis in Dry Eye Conditions

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Kavita Rao; William J. Farley; Stephen C. Pflugfelder
TAGS: cornea, dry eye syndromes, epidermal growth factor, fibrosis, metaplasia, signs and symptoms, mass or substance concentration per volume, drug clearance, conjunctiva
Invest. Ophthalmol. Vis. Sci.. 2010; 51(2):844-849. https://doi.org/10.1167/iovs.09-3875

Cornea July 2009

Production and Activity of Matrix Metalloproteinase-9 on the Ocular Surface Increase in Dysfunctional Tear Syndrome

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Suksri Chotikavanich; Cintia S. de Paiva; De Quan Li; Joseph J. Chen; Fang Bian; William J. Farley; Stephen C. Pflugfelder
TAGS: gelatinase b, syndrome
Invest. Ophthalmol. Vis. Sci.. 2009; 50(7):3203-3209. https://doi.org/10.1167/iovs.08-2476

Cornea June 2007

Expression of Th-1 Chemokines and Chemokine Receptors on the Ocular Surface of C57BL/6 Mice: Effects of Desiccating Stress

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Kyung-Chul Yoon; Cintia S. De Paiva; Hong Qi; Zhuo Chen; William J. Farley; De-Quan Li; Stephen C. Pflugfelder
TAGS: chemokine receptors, chemokines, mice, mice, inbred c57bl, stress, conjunctiva, cornea, chemokine (c-c motif) receptor 5, dry eye syndromes
Invest. Ophthalmol. Vis. Sci.. 2007; 48(6):2561-2569. https://doi.org/10.1167/iovs.07-0002

Cornea June 2007

Dry Eye–Induced Conjunctival Epithelial Squamous Metaplasia Is Modulated by Interferon-γ

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Cintia S. De Paiva; Arturo L. Villarreal; Rosa M. Corrales; Hassan T. Rahman; Victor Y. Chang; William J. Farley; Michael E. Stern; Jerry Y. Niederkorn; De-Quan Li; Stephen C. Pflugfelder
TAGS: conjunctiva, dry eye syndromes, epithelium, human leukocyte interferon, interferons, metaplasia, mice, mice, inbred c57bl, stress, t-lymphocytes
Invest. Ophthalmol. Vis. Sci.. 2007; 48(6):2553-2560. https://doi.org/10.1167/iovs.07-0069

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Interferon-γ Exacerbates Dry Eye–Induced Apoptosis in Conjunctiva through Dual Apoptotic Pathways

Entrapment of Conjunctival Goblet Cells by Desiccation-Induced Cornification

Pharmacological Cholinergic Blockade Stimulates Inflammatory Cytokine Production and Lymphocytic Infiltration in the Mouse Lacrimal Gland

Effects Of Desiccating Stress On Thrombospondin-1 Knock-out Mice

Characterization of Intraepithelial Lymphocyte Populations and Their Changes in Response to Experimental Desiccating Stress

Disruption of TGF-β Signaling Improves Dry Eye Disease

Biodegradable PLGA-Based Drug Delivery Systems for Modulating Ocular Surface Disease in a Murine Model

Dry Eye Mice are Resistant to Toll-Like Receptor Induced Inflammation

Spontaneous Autoimmune Inflammation of the Ocular Surface Mucosa in Aged CD4-DNTGFβRII Mice

Altered Morphology and Function of the Lacrimal Functional Unit in Protein Kinase Cα Knockout Mice

Desiccating Stress Promotion of Th17 Differentiation by Ocular Surface Tissues through a Dendritic Cell-Mediated Pathway

Association between High Tear Epidermal Growth Factor Levels and Corneal Subepithelial Fibrosis in Dry Eye Conditions

Production and Activity of Matrix Metalloproteinase-9 on the Ocular Surface Increase in Dysfunctional Tear Syndrome

Expression of Th-1 Chemokines and Chemokine Receptors on the Ocular Surface of C57BL/6 Mice: Effects of Desiccating Stress

Dry Eye–Induced Conjunctival Epithelial Squamous Metaplasia Is Modulated by Interferon-γ

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