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ARVO Annual Meeting Abstract June 2024

AAV2 gene therapy rescues rod photoreceptor functional recovery in the RDH5 -mutant cat

Laura Ford; Laurence Occelli; Kelian Sun; Mary Enfield; William Hauswirth; Simon M Petersen-Jones

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6080.

ARVO Annual Meeting Abstract June 2023

Maturation of synaptic ribbons and synaptogenesis occur after CaBP4 gene augmentation therapy

Billie Beckwith-Cohen; Paige A Winkler; Kelian Sun; Laurence M Occelli; Luis Felipe Marinho; Fabiano Montiani-Ferreira; William W Hauswirth; Simon M Petersen-Jones

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1915.

ARVO Annual Meeting Abstract June 2022

Long-term follow up of gene therapy for NPHP5 -LCA in a canine model shows restoration of photoreceptor function and vision for > 5 years

William A Beltran; Artur V Cideciyan; Ana Ripolles-Garcia; Valerie L Dufour; Yu Sato; Alexa Gray; Malgorzata Swider; Sanford L Boye; William W Hauswirth; Samuel G. Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):454.

ARVO Annual Meeting Abstract June 2022

Gene augmentation therapy restores vision in a CaBP4 -mutant canine model of cone-rod synaptic disorder

Billie Beckwith-Cohen; Paige A Winkler; Laurence M Occelli; Kelian Sun; Fabiano Montiani-Ferreira; Luis Felipe Marinho; Amy Lee; Maciej Parys; vilma Yuzbasiyan-Gurkan; William W Hauswirth; Simon Petersen-Jones

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1108.

Glaucoma February 2022

Neuroprotective Gene Therapy by Overexpression of the Transcription Factor MAX in Rat Models of Glaucomatous Neurodegeneration

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Rafael Lani-Louzada; Camila Marra; Mariana Santana Dias; Victor Guedes de Araújo; Carla Andreia Abreu; Vinícius Toledo Ribas; Daniel Adesse; Silvana Allodi; Vince Chiodo; William Hauswirth; Hilda Petrs-Silva; Rafael Linden
TAGS: gene therapy, glaucoma, intravitreal injections, nerve degeneration, optic nerve, protein overexpression, tissue degeneration, transcription factor, eye, retina
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):5. https://doi.org/10.1167/iovs.63.2.5

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Disease mechanisms of X-linked cone dystrophy caused by missense mutations in the red and green cone opsins

Wen-Tao Deng; Ping Zhu; Frank M Dyka; Wolfgang Baehr; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1554.

Articles May 2021

Examining Whether AOSLO-Based Foveal Cone Metrics in Achromatopsia and Albinism Are Representative of Foveal Cone Structure

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Katie M. Litts; Erica N. Woertz; Niamh Wynne; Brian P. Brooks; Alicia Chacon; Thomas B. Connor, Jr.; Deborah Costakos; Alina Dumitrescu; Arlene V. Drack; Gerald A. Fishman; William W. Hauswirth; Christine N. Kay; Byron L. Lam; Michel Michaelides; Mark E. Pennesi; Kimberly E. Stepien; Sasha Strul; C. Gail Summers; Joseph Carroll
TAGS: achromatopsia, albinism, retinal cone, diagnostic imaging, mosaicism
Trans. Vis. Sci. Tech.. 2021; 10(6):22. https://doi.org/10.1167/tvst.10.6.22

Includes: Supplemental Content

Articles January 2021

Optical Coherence Tomography Artifacts Are Associated With Adaptive Optics Scanning Light Ophthalmoscopy Success in Achromatopsia

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Katie M. Litts; Erica N. Woertz; Michalis Georgiou; Emily J. Patterson; Byron L. Lam; Gerald A. Fishman; Mark E. Pennesi; Christine N. Kay; William W. Hauswirth; Michel Michaelides; Joseph Carroll
TAGS: achromatopsia, artifacts, diagnostic imaging, ophthalmoscopy, optical coherence tomography, optics
Trans. Vis. Sci. Tech.. 2021; 10(1):11. https://doi.org/10.1167/tvst.10.1.11

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology July 2020

XIAP Protects Retinal Ganglion Cells in the Mutant ND4 Mouse Model of Leber Hereditary Optic Neuropathy

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Sarah J. Wassmer; Yves De Repentigny; Derek Sheppard; Pamela S. Lagali; Lijun Fang; Stuart G. Coupland; Rashmi Kothary; John Guy; William W. Hauswirth; Catherine Tsilfidis
TAGS: birc4 gene, gene therapy, mice, optic atrophy, hereditary, leber, axon, retinal ganglion cells, optic nerve
Invest. Ophthalmol. Vis. Sci.. 2020; 61(8):49. https://doi.org/10.1167/iovs.61.8.49

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Rescue of cone structure and function in Opn1mw/sw double knockout mice

Wen-Tao Deng; Ping Zhu; Tiffanie Dahl; Wolfgang Baehr; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2456.

ARVO Annual Meeting Abstract June 2020

Development of an Allele-Independent Gene Replacement Therapy for Best Vitelliform Macular Dystrophy Using RNAi Technology

Brianna Bowman Young; Karina E Guziewicz; Alfred S Lewin; william W hauswirth; Cristhian Ildefonso

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2457.

ARVO Annual Meeting Abstract June 2020

Serotype dependent Adeno-Associated Virus Hybrid Vector mediated gene therapy for Stargardt Disease

Frank M Dyka; Vince A. Chiodo; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2464.

ARVO Annual Meeting Abstract June 2020

An Allele-Independent Gene Therapy Strategy Induces Rod Function in a Transgenic Swine Model of Autosomal Dominant Retinitis Pigmentosa

archana jalligampala; James Fransen; Jennifer Noel; Gobinda Pangeni; Maha Haleem Jabbar; William W Hauswirth; Alfred S Lewin; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4484.

ARVO Annual Meeting Abstract June 2020

Optical coherence tomography artifacts predict adaptive optics scanning light ophthalmoscopy success in achromatopsia

Katie M Litts; Erica N. Woertz; Rachel E Linderman; Byron L Lam; Gerald A Fishman; Mark E Pennesi; Christine N Kay; William W Hauswirth; Joseph Carroll

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5271.

Retina August 2019

Rescue of M-cone Function in Aged Opn1mw −/− Mice, a Model for Late-Stage Blue Cone Monochromacy

PDF

Wen-Tao Deng; Jie Li; Ping Zhu; Beau Freedman; W. Clay Smith; Wolfgang Baehr; William W. Hauswirth
TAGS: gene therapy, mice, retinal cone, opsin
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3644-3651. https://doi.org/10.1167/iovs.19-27079

ARVO Annual Meeting Abstract July 2019

VMD2 Promoter-mediated Gene Therapy Optimizes Active Rap1a Expression in the Retinal Pigment Epithelium of Wild Type Mice

Haibo Wang; Aniket Ramshekar; Eric Kunz; William Hauswirth; M Elizabeth Hartnett

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1925.

ARVO Annual Meeting Abstract July 2019

Dual Adeno-Associated Virus Vector mediated gene therapy for autosomal recessive Stargardt Disease

Frank M Dyka; Laurie L Molday; Vince A Chiodo; Robert S Molday; William Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3402.

ARVO Annual Meeting Abstract July 2019

Successful rescue of M-cone function in aged M-opsin knock-out mice, a model for blue cone monochromacy

Wen-Tao Deng; Jie Li; Ping Zhu; Wolfgang Baehr; William Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3419.

ARVO Annual Meeting Abstract July 2019

Safety and long-term efficacy of AAV2- BEST1 gene augmentation therapy in canine model of Best vitelliform macular dystrophies

Karina E Guziewicz; Artur V Cideciyan; Brian T. Kendrick; Valerie L Dufour; Gordon Ruthel; Andras M Komaromy; Simone Iwabe; William Hauswirth; William A Beltran; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5200.

ARVO Annual Meeting Abstract July 2018

Very long chain ceramides production mediated by ELOVL4 stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

Julia V Busik; Nermin Kady; Xuwen Liu; Todd Lydic; Sergey S Seregin; Andrea Amalfitano; Vince A Chiodo; Sanford L Boye; William W Hauswirth; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3002.

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AAV2 gene therapy rescues rod photoreceptor functional recovery in the RDH5 -mutant cat

Maturation of synaptic ribbons and synaptogenesis occur after CaBP4 gene augmentation therapy

Long-term follow up of gene therapy for NPHP5 -LCA in a canine model shows restoration of photoreceptor function and vision for > 5 years

Gene augmentation therapy restores vision in a CaBP4 -mutant canine model of cone-rod synaptic disorder

Neuroprotective Gene Therapy by Overexpression of the Transcription Factor MAX in Rat Models of Glaucomatous Neurodegeneration

Disease mechanisms of X-linked cone dystrophy caused by missense mutations in the red and green cone opsins

Examining Whether AOSLO-Based Foveal Cone Metrics in Achromatopsia and Albinism Are Representative of Foveal Cone Structure

Optical Coherence Tomography Artifacts Are Associated With Adaptive Optics Scanning Light Ophthalmoscopy Success in Achromatopsia

XIAP Protects Retinal Ganglion Cells in the Mutant ND4 Mouse Model of Leber Hereditary Optic Neuropathy

Rescue of cone structure and function in Opn1mw/sw double knockout mice

Development of an Allele-Independent Gene Replacement Therapy for Best Vitelliform Macular Dystrophy Using RNAi Technology

Serotype dependent Adeno-Associated Virus Hybrid Vector mediated gene therapy for Stargardt Disease

An Allele-Independent Gene Therapy Strategy Induces Rod Function in a Transgenic Swine Model of Autosomal Dominant Retinitis Pigmentosa

Optical coherence tomography artifacts predict adaptive optics scanning light ophthalmoscopy success in achromatopsia

Rescue of M-cone Function in Aged Opn1mw −/− Mice, a Model for Late-Stage Blue Cone Monochromacy

VMD2 Promoter-mediated Gene Therapy Optimizes Active Rap1a Expression in the Retinal Pigment Epithelium of Wild Type Mice

Dual Adeno-Associated Virus Vector mediated gene therapy for autosomal recessive Stargardt Disease

Successful rescue of M-cone function in aged M-opsin knock-out mice, a model for blue cone monochromacy

Safety and long-term efficacy of AAV2- BEST1 gene augmentation therapy in canine model of Best vitelliform macular dystrophies

Very long chain ceramides production mediated by ELOVL4 stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

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