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Retina April 2025

Microglia-Derived IL-6 Promotes Müller Glia Reprogramming and Proliferation in Zebrafish Retina Regeneration

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Jie Xu; Yi Li; Xiangyu Li; Xuan Tan; Lihua Liu; Lining Cao; Hui Xu
TAGS: interleukin-6, retina, zebrafish, microglia, signal transduction, stat3 protein
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):67. https://doi.org/10.1167/iovs.66.4.67

Includes: Supplemental Content

Cornea April 2025

Enhanced Therapeutic Effect of IL-10-ADSCs on Rabbit Autoimmune Dacryoadenitis By Suppressing T Follicular Helper Cell Responses Via miR-142-5p/RC3H1 Axis

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Lu Zhao; Na Li; Xinrui Shi; Jiachen Zhang; Min Gao; Yankai Wei; Xuejia Li; Bei Du; Deming Sun; Hong Nian; Ruihua Wei
TAGS: autoimmunity, dacryoadenitis, dry eye syndromes, oryctolagus cuniculus, t follicular helper cells, attenuation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):66. https://doi.org/10.1167/iovs.66.4.66

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study

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Zi Xuan Lin; Xiu Juan Zhang; Fang Yao Tang; Yuzhou Zhang; Ka Wai Kam; Alvin L. Young; Patrick Ip; Carol Y. Cheung; Chi Pui Pang; Clement C. Tham; Li Jia Chen; Kyoko Ohno-Matsui; Jason C. Yam
TAGS: child, eye, myopia, retinal vasculature, hong kong
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):64. https://doi.org/10.1167/iovs.66.4.64

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

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Wenxu Wang; Rui Ren; Yue Liu; Xingyue Ye; Ru Zhang; Linze Xi; Liying Wang; Yao Zhang; Yi Zhang; Difei Wang
TAGS: age-related macular degeneration, genetic predisposition to disease, genetics, health, polygenic risk score, prospective studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):54. https://doi.org/10.1167/iovs.66.4.54

Includes: Supplemental Content

Cornea April 2025

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

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Haiqi Xiao; Li Hu; Xiongshi Lin; Linchang Liu; Xing Dong; Liting Yang; Ying Liu; Zhichong Wang; Ying Tian; Shuangyong Wang
TAGS: pax6 transcription factor, soluble fms-like tyrosine kinase 1
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):52. https://doi.org/10.1167/iovs.66.4.52

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology April 2025

The Influence of Changes in Microglia Development on the Plasticity of the Developing Visual Cortex Circuit in Juvenile Mice

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Xuechun Wang; Kuan Li; Lingzhi Guo; Xinlong Liu; Yatu Guo; Wei Zhang
TAGS: mice, microglia, visual cortex, interneurons, neurons, small nuclear rna, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):45. https://doi.org/10.1167/iovs.66.4.45

Includes: Supplemental Content

Glaucoma April 2025

Targeted Neuroprotection of Retinal Ganglion Cells Via AAV2-hSyn-NGF Gene Therapy in Glaucoma Models

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Xinlei Zhu; Benxiang Qi; Zhongmei Ren; Lin Cong; Xiaojing Pan; Qingjun Zhou; Bi Ning Zhang; Lixin Xie
TAGS: glaucoma, injections, gene therapy, neuroprotection, retinal ganglion cells, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):48. https://doi.org/10.1167/iovs.66.4.48

Includes: Supplemental Content

Cornea April 2025

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

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Xiaoqi Li; Anqi Liu; Yannan Zhou; Haolan Qi; Junyi Wang; Mingxiong Chen; Tunan Sun; Jie Wu; Yifei Huang; Liqiang Wang
TAGS: cornea, endothelium, mice, ppar alpha, chronic exertional compartment syndrome, fenofibrate, hereditary corneal dystrophy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):36. https://doi.org/10.1167/iovs.66.4.36

Includes: Supplemental Content

Genetics April 2025

Clinical and Molecular Landscape of GLRA2 in X-Linked Early-Onset High Myopia

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Xiaoxia Li; Siyu Wang; Yuhan Wang; Ruru Chen; Xinjie Mao; Ying Mei; Meiping Xu; Lan Hu; Chuan Qin; Shilai Xing; Xiaoguang Yu; Liya Qiao
TAGS: genes, myopia, x-linked inheritance, rna splicing, genetics, validity of results, mutation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):30. https://doi.org/10.1167/iovs.66.4.30

Includes: Supplemental Content

Biochemistry and Molecular Biology April 2025

Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling

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Shuting Lu; Qian Liu; Fan Ye; Ziran Zhang; Lianjun Shi; Xiumiao Li; Wan Mu; Qin Jiang; Biao Yan
TAGS: cholesterol metabolism, lymphangiogenesis, lymphatic vessels, rna, cornea, sutures, circular rna, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):26. https://doi.org/10.1167/iovs.66.4.26

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics April 2025

Temporal Contour Integration Deficits in Children With Amblyopia

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Yan-Ru Chen; Shu-Qi Jiang; Xiang-Yun Liu; Jun-Yun Zhang
TAGS: amblyopia, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):27. https://doi.org/10.1167/iovs.66.4.27

Pediatric Ophthalmology & Strabismus March 2025

The Peripheral Defocus Designed Spectacle Lenses Might Increase Astigmatism in Myopic Children

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Wenyan Xu; Xiaoman Li; Jianing Zhang; Hongyi Li; Xuewen Ding; Xiaoyue Hu; Xinyue Quan; Yue Su; Fan Lu; Jie Chen
TAGS: astigmatism, child, lens (device), lens, crystalline, myopia, refractive errors
Trans. Vis. Sci. Tech.. 2025; 14(3):8. https://doi.org/10.1167/tvst.14.3.8

Includes: Supplemental Content

Public Health March 2025

Visual Deficits in Type 2 Diabetes Mellitus Without Retinopathy: From Retinal Structure to Higher-Level Visual Functions

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Sha Luo; Lin Xia; Yue Wang; Yong Tang; Jiong Dong; Rong Liu; Lixia Feng
TAGS: diabetes mellitus, diabetes mellitus, type 2, retina, retinal diseases, vision, vision disorders
Trans. Vis. Sci. Tech.. 2025; 14(3):10. https://doi.org/10.1167/tvst.14.3.10

Includes: Supplemental Content

Glaucoma March 2025

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

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Jiayong Li; Yuncheng Ma; Lingling Xie; Kaichen Zhuo; Yuxian He; Xin Ma; Shufen Zheng; Shicheng Guo; Yizhen Tang; Guzainuer Muhetaer; Mireayi Aizezi; Dan Zhang; Aizezi Wumaier; Xu Zhang; Chao Tang; Wei Wang; Wenyong Huang; Xinbo Gao
TAGS: biological markers, exfoliation syndrome, mass spectrometry, mendelian randomization analysis, plasma, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):19. https://doi.org/10.1167/iovs.66.3.19

Includes: Supplemental Content

Immunology and Microbiology March 2025

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis

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Zhuang Li; Xiuxing Liu; Zuoyi Li; Zhiqiang Xiao; Guanyu Chen; Yangyang Li; Jun Huang; Yunwei Hu; Haixiang Huang; Wenjie Zhu; Yuxun Shi; Minzhen Wang; Yanyan Xie; Wenru Su; Xiaoqing Chen; Dan Liang
TAGS: autoimmunity, flow cytometry, interleukin-17, mice, rna, small cytoplasmic, t follicular helper cells, uveitis, genes, t-lymphocytes, phenotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):8. https://doi.org/10.1167/iovs.66.3.8

Includes: Supplemental Content

Refractive Intervention March 2025

Evaluation of the Long-Term Corneal Biomechanics Following SMILE With Different Residual Stromal Bed Thickness in Rabbits

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Hongwei Qin; Xin Yang; Rui He; Yaowen Song; Junchao Wei; Xiaona Liu; Chenyan Wang; Ce Wu; Jie Hou; Zhipeng Gao; Lingfeng Chen; Xiaona Li; Weiyi Chen
TAGS: cornea, oryctolagus cuniculus, biomechanics, stress, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(3):3. https://doi.org/10.1167/tvst.14.3.3

Includes: Supplemental Content

Public Health February 2025

The Relationship Between Serum Biochemical Variables and Corneal Biomechanics Measured by Corvis ST Among Healthy Young Adults

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Dan-Lin Li; Min-Xin Liu; Ya-Jie Zheng; Yu Qin; Rong Ma; Gang Liang; Chen-Wei Pan
TAGS: biomechanics, cornea, young adult
Trans. Vis. Sci. Tech.. 2025; 14(2):19. https://doi.org/10.1167/tvst.14.2.19

Cornea February 2025

Stiffness Regulates the Morphology and Stemness of Limbal Niche Cells Through Unique nYAP/cYAP Translocation

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Xiao Zhou; Lingjuan Xu; Yongyao Tan; Wei Wang; Xiaoyu Huang; Guigang Li
TAGS: language morphology, morphology, phenotype, translocation (genetics), diffuse idiopathic skeletal hyperostosis, cornea, stem cells, proteins, western blotting, patient isolation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):43. https://doi.org/10.1167/iovs.66.2.43

Includes: Supplemental Content

Retina February 2025

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

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Xiaoyan Ding; Xiaodi Zhou; Xinyu Liu; Yanting Lai; Wenjia Yan; Yizhe Cheng; Aohan Hou; Limei Chen; Limei Sun
TAGS: angiogenesis, hypoxia, mice, neovascularization, pathologic, 1-phosphatidylinositol 3-kinase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):40. https://doi.org/10.1167/iovs.66.2.40

Includes: Supplemental Content

Biochemistry and Molecular Biology February 2025

Extracellular Matrix Stiffness Modulates Myopia Scleral Remodeling Through Integrin/F-Actin/YAP Axis

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Xin Liu; Ying Yuan; Yue Wu; Chengcheng Zhu; Yuying Liu; Bilian Ke
TAGS: actins, integrins, myopia, sclera, fibroblasts, extracellular matrix, caviidae
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):22. https://doi.org/10.1167/iovs.66.2.22

Includes: Supplemental Content

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Microglia-Derived IL-6 Promotes Müller Glia Reprogramming and Proliferation in Zebrafish Retina Regeneration

Enhanced Therapeutic Effect of IL-10-ADSCs on Rabbit Autoimmune Dacryoadenitis By Suppressing T Follicular Helper Cell Responses Via miR-142-5p/RC3H1 Axis

Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

The Influence of Changes in Microglia Development on the Plasticity of the Developing Visual Cortex Circuit in Juvenile Mice

Targeted Neuroprotection of Retinal Ganglion Cells Via AAV2-hSyn-NGF Gene Therapy in Glaucoma Models

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

Clinical and Molecular Landscape of GLRA2 in X-Linked Early-Onset High Myopia

Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling

Temporal Contour Integration Deficits in Children With Amblyopia

The Peripheral Defocus Designed Spectacle Lenses Might Increase Astigmatism in Myopic Children

Visual Deficits in Type 2 Diabetes Mellitus Without Retinopathy: From Retinal Structure to Higher-Level Visual Functions

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis

Evaluation of the Long-Term Corneal Biomechanics Following SMILE With Different Residual Stromal Bed Thickness in Rabbits

The Relationship Between Serum Biochemical Variables and Corneal Biomechanics Measured by Corvis ST Among Healthy Young Adults

Stiffness Regulates the Morphology and Stemness of Limbal Niche Cells Through Unique nYAP/cYAP Translocation

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

Extracellular Matrix Stiffness Modulates Myopia Scleral Remodeling Through Integrin/F-Actin/YAP Axis

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