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Retina June 2025

Alteration of Tear Metabolomics Profiling in Infants With Retinopathy of Prematurity

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Zixin Fan; Shuo Yang; Xiaofeng Lu; Sifan Zhang; Xianlu Zeng; Lin Lin; Duo Yuan; Jian Zeng; Guoming Zhang
TAGS: biological markers, infant, metabolites, metabolomics, retinopathy of prematurity, birth weight
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):61. https://doi.org/10.1167/iovs.66.6.61

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology June 2025

Peripapillary Hyperreflective Ovoid Mass-Like Structures: Prevalence and Associations in the Adult Population of the Beijing Eye Study

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Jost B. Jonas; Songhomitra Panda-Jonas; Dan Milea; Cédric Lamirel; Jie Xu; Rahul A. Jonas; Ya Xing Wang
TAGS: adult, beijing, eye, prevalence, optic disk
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):63. https://doi.org/10.1167/iovs.66.6.63

Retina June 2025

BCAT1 Activation Reprograms Branched-Chain Amino Acid Metabolism and Epigenetically Promotes Inflammation in Diabetic Retinopathy

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Jingyi Wang; Zihan Yin; Jingxiao Yang; Sijun Sun; Xiaofang Tang; Shengjie Zhang; Yi-Ping Wang; Haiyan Wang
TAGS: amino acids, branched-chain, diabetic retinopathy, inflammation, metabolism, diabetes mellitus, retina, mice, inflammatory response, glucose
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):59. https://doi.org/10.1167/iovs.66.6.59

Includes: Supplemental Content

Visual Neuroscience June 2025

Associations Between Myopia and Brain Volumes: An Observational and Genetic Analysis

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Selena Wei Zhang; Jingze Guo; Yanxian Chen; Jiahao Liu; Yu Huang; Xianwen Shang; Mingguang He
TAGS: brain volume, myopia, genetic analysis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):57. https://doi.org/10.1167/iovs.66.6.57

Includes: Supplemental Content

Cornea June 2025

RIPK3-Mediated Necroptosis Drives Macrophage Infiltration and Corneal Neovascularization After Alkali Burn

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Yue Li; Boyu Yang; Qi Chen; Yuchen Zhou; Wen Hu; Xiaojia Huang; Guangyi Huang; Ningning Tang; Fen Tang; Hui Huang; Qianqian Lan; Wenjing He; Fan Xu; Yiming Ye; Li Jiang
TAGS: alkalies, burns, cornea, corneal neovascularization, macrophages, necroptosis, fluorescent antibody technique, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):54. https://doi.org/10.1167/iovs.66.6.54

Includes: Supplemental Content

Cornea June 2025

Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in Aspergillus fumigatus –Induced Fungal Keratitis

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Jingze Kan; Shiqi Song; Mengzhu Liu; Qiang Xu; Jieun Lee; Jintao Sun; Shasha Xue; Xiaoyan Sun; Chengye Che
TAGS: aspergillus fumigatus, caspase-3, cornea, fungal keratitis, infections, inflammation, keratitis, mice, pyroptosis, rna, small interfering
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):52. https://doi.org/10.1167/iovs.66.6.52

Lens June 2025

Novel Subclassification of Presbyopia Based on Lens Functional and Structural Features

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Xiangjia Zhu; Xin Liu; Wenwen He; Kaiwen Cheng; Jiaqi Meng; Jiao Qi; Jing Zhao; Yi Lu; Xingtao Zhou
TAGS: lens (device), lens, crystalline, presbyopia, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(6):26. https://doi.org/10.1167/tvst.14.6.26

Article June 2025

The latent mechanism behind binocular advantage in reading

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Zhenyu Zhang; Tingting Wang; Zile Wang; Jinmei Xiao; Qingshang Ma; Xianyuan Yang; Fang-Fang Yan; Chang-Bing Huang
TAGS: reading (activity), ocular dominance, saccades
Journal of Vision. 2025; 25(7):6. https://doi.org/10.1167/jov.25.7.6

Artificial Intelligence June 2025

Development of Deep Learning Models to Screen Posterior Staphylomas in Highly Myopic Eyes Using UWF-OCT Images

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Yining Wang; Changyu Chen; Ziye Wang; Yijin Wu; Hongshuang Lu; Jianping Xiong; Keigo Sugisawa; Koju Kamoi; Kyoko Ohno-Matsui
TAGS: datasets, deep learning, eye, staphyloma, retina, specialism
Trans. Vis. Sci. Tech.. 2025; 14(6):25. https://doi.org/10.1167/tvst.14.6.25

Includes: Supplemental Content

Retina June 2025

Relationship of Choroidal Thickness With Age-Related Macular Degeneration in Asians: An Asian Eye Epidemiology Consortium Meta-Analysis

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Mariko Sasaki; Kai Xiong Cheong; Crystal Chun Yuen Chong; Marco Yu; Akiko Hanyuda; Kenya Yuki; Kazuno Negishi; Sawako Hashimoto; Kohta Fujiwara; Kohei Sonoda; Ya Xing Wang; Fei Gao; Anyarak Amornpetchsathaporn; Methaphon Chainakul; Ramyaa Srinivasan; Rehana Khan; Rajiv Raman; Paisan Ruamviboonsuk; Sung Ho Kim; Su Jeong Song; Mohammad Hassan Emamian; Hassan Hashemi; Akbar Fotouhi; Juping Liu; Xiaorong Li; Jost B. Jonas; Chui Ming Gemmy Cheung; Tien Yin Wong; Ching-Yu Cheng; Yih Chung Tham; Yasuo Yanagi; Anna Cheng Sim Tan
TAGS: age-related macular degeneration, asian, epidemiology, eye, meta-analysis, choroid, smoking
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):36. https://doi.org/10.1167/iovs.66.6.36

Includes: Supplemental Content

Cornea June 2025

HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway

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Hua Yang; Mengzhu Liu; Shiqi Song; Qiang Xu; Jieun Lee; Jintao Sun; Shasha Xue; Xiaoyan Sun; Chengye Che
TAGS: aspergillus fumigatus, caspase-8, cornea, inflammatory response, keratitis, macrophages, mice, pyroptosis, infections, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):32. https://doi.org/10.1167/iovs.66.6.32

Cornea June 2025

Corneal Sensory Denervation Causes Epithelial Ferroptosis and Delayed Healing in Mice

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Ning Wang; Yizhou Li; Xiaolei Wang; Lingling Yang; Jing Zhang; Jun Cheng; Xiaoyue Jiang; Xia Qi; Chao Wei; Qingjun Zhou; Ya Li; Suxia Li

Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):28. https://doi.org/10.1167/iovs.66.6.28

Includes: Supplemental Content

Cornea June 2025

SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction

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Yizhou Li; Feijia Xie; Lingling Yang; Xiaolei Wang; Yangyang Zhang; Hongqi Ge; Min Wang; Rui Cao; Qingjun Zhou; Ya Li
TAGS: cornea, epithelium, mice, stem cells, taurine, wound healing, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):25. https://doi.org/10.1167/iovs.66.6.25

Includes: Supplemental Content

Cornea June 2025

Cornea Nerves Can Identify Different Types of Parkinson's Disease

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Dongyu Li; Xinyu Zhang; Fan Yang; Xin Jin; Shumin Li; Haonan Yuan; Lifen Yao; Hong Zhang
TAGS: cornea, nervousness, neurons, parkinson disease
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):21. https://doi.org/10.1167/iovs.66.6.21

Retina June 2025

Short-Chain Fatty Acids Are Potential Biomarkers of Immune Regulation in Diabetic Retinopathy

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Xinran Qin; Jiaqi Sun; Yi Xu; Lina Lu; Yingyan Ma; Fangzhou Lou; Haidong Zou
TAGS: acetates, biological markers, diabetic retinopathy, plasma, regulation, volatile fatty acids, diabetes mellitus, retina, cytokine, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):23. https://doi.org/10.1167/iovs.66.6.23

Includes: Supplemental Content

Immunology and Microbiology June 2025

Alterations of the Enteric Virome in Vogt-Koyanagi-Harada Disease

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Mingzhu Liu; Jiawei Geng; Siyan Jin; Ping Hu; Xia Wang; Xiaoli Liu
TAGS: uveomeningoencephalitic syndrome, virome, viruses
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):15. https://doi.org/10.1167/iovs.66.6.15

Includes: Supplemental Content

Cornea June 2025

Activation of Sympathetic Nervous System Drives Dry Eye Onset Via Norepinephrine-β2-Adrenergic Receptor Signaling in Mice

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Mingli Qu; Xiaofei Bai; Mengyao Zhang; Jingyi Wu; Lei Wan; Xiaoyu Li; Qun Wang; Lin Cong; Benxiang Qi; Qingjun Zhou
TAGS: cornea, dry eye syndromes, mice, norepinephrine, sympathetic nervous system, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):13. https://doi.org/10.1167/iovs.66.6.13

Includes: Supplemental Content

Glaucoma June 2025

Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG

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Jianqi Chen; Xiaohua Zhuo; Yangjiani Li; Yingting Zhu; Zhidong Li; Xinyue Shen; Yehong Zhuo; Hongmei Tan; Lei Lei
TAGS: body tissue, genes, open-angle glaucoma
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):7. https://doi.org/10.1167/iovs.66.6.7

Includes: Supplemental Content

Low Vision June 2025

The Efficiency and Safety of Oxygen-Supplemented Accelerated Scleral Cross-Linking in Rabbits

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Lingling Yan; Ce Wu; Xiaona Liu; Pengfei Han; Jie Zhang; Zhipeng Gao; Xiaona Li; Weiyi Chen
TAGS: cross-linking, oryctolagus cuniculus, oxygen, sclera, safety
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):10. https://doi.org/10.1167/iovs.66.6.10

Includes: Supplemental Content

Glaucoma June 2025

Genetic Spectrum and Genotype-Phenotype Correlations in a Chinese Cohort With Nanophthalmos With Secondary Angle-Closure Glaucoma

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Xiaowei Yu; Hanxue Zhao; Yan Gao; Tao Zhou; Lin Deng; Miao Zhang; Hongyu Zhong; Feng Mei; Zhijun Li; Longyan Sun; Tianrui Zhang; Yan Shi; Zhigang Fan
TAGS: angle closure glaucoma, chinese (other dialects), chinese people, cohort studies, genetics, genotype, microphthalmos, phenotype, genes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):9. https://doi.org/10.1167/iovs.66.6.9

Includes: Supplemental Content

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Alteration of Tear Metabolomics Profiling in Infants With Retinopathy of Prematurity

Peripapillary Hyperreflective Ovoid Mass-Like Structures: Prevalence and Associations in the Adult Population of the Beijing Eye Study

BCAT1 Activation Reprograms Branched-Chain Amino Acid Metabolism and Epigenetically Promotes Inflammation in Diabetic Retinopathy

Associations Between Myopia and Brain Volumes: An Observational and Genetic Analysis

RIPK3-Mediated Necroptosis Drives Macrophage Infiltration and Corneal Neovascularization After Alkali Burn

Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in Aspergillus fumigatus –Induced Fungal Keratitis

Novel Subclassification of Presbyopia Based on Lens Functional and Structural Features

The latent mechanism behind binocular advantage in reading

Development of Deep Learning Models to Screen Posterior Staphylomas in Highly Myopic Eyes Using UWF-OCT Images

Relationship of Choroidal Thickness With Age-Related Macular Degeneration in Asians: An Asian Eye Epidemiology Consortium Meta-Analysis

HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway

Corneal Sensory Denervation Causes Epithelial Ferroptosis and Delayed Healing in Mice

SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction

Cornea Nerves Can Identify Different Types of Parkinson's Disease

Short-Chain Fatty Acids Are Potential Biomarkers of Immune Regulation in Diabetic Retinopathy

Alterations of the Enteric Virome in Vogt-Koyanagi-Harada Disease

Activation of Sympathetic Nervous System Drives Dry Eye Onset Via Norepinephrine-β2-Adrenergic Receptor Signaling in Mice

Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG

The Efficiency and Safety of Oxygen-Supplemented Accelerated Scleral Cross-Linking in Rabbits

Genetic Spectrum and Genotype-Phenotype Correlations in a Chinese Cohort With Nanophthalmos With Secondary Angle-Closure Glaucoma

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