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Cornea June 2025

HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway

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Hua Yang; Mengzhu Liu; Shiqi Song; Qiang Xu; Jieun Lee; Jintao Sun; Shasha Xue; Xiaoyan Sun; Chengye Che
TAGS: aspergillus fumigatus, caspase-8, cornea, inflammatory response, keratitis, macrophages, mice, pyroptosis, infections, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):32. https://doi.org/10.1167/iovs.66.6.32

Retina June 2025

Retinal Vessel Geometry and Retinal Abnormalities in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

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Wenbo Zhang; Xuecong Zhou; Jiacheng Liu; Tian Tian; Yu Guo; Chen Ling; Jingjing Xu; Qijie Wei; Yang Liu; Yuan Wu
TAGS: arterial disease, brain, cadasil, infarction, leukoencephalopathies, retinal vessels, subcortical
Trans. Vis. Sci. Tech.. 2025; 14(6):17. https://doi.org/10.1167/tvst.14.6.17

Retina June 2025

Electroretinography With the RM Electrode: Normative Reference Ranges, Variation With Age, and Comparison With the Burian–Allen Electrode

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Brett G. Jeffrey; Xueyang Yin; Christina Appleman; Sobany Suy; Anna Papadogiannis; Daniel Claus; Brian P. Brooks; Marisa Boyle; Laryssa A. Huryn; Wadih M. Zein
TAGS: electroretinography, erg protein, human, reference values
Trans. Vis. Sci. Tech.. 2025; 14(6):13. https://doi.org/10.1167/tvst.14.6.13

Includes: Supplemental Content

Retina June 2025

Short-Chain Fatty Acids Are Potential Biomarkers of Immune Regulation in Diabetic Retinopathy

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Xinran Qin; Jiaqi Sun; Yi Xu; Lina Lu; Yingyan Ma; Fangzhou Lou; Haidong Zou
TAGS: acetates, biological markers, diabetic retinopathy, plasma, regulation, volatile fatty acids, diabetes mellitus, retina, cytokine, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):23. https://doi.org/10.1167/iovs.66.6.23

Includes: Supplemental Content

Cornea June 2025

Fatty Acid Desaturase 1 Knockdown Promotes Wound Healing and Functional Recovery of the Corneal Epithelium in Diabetes

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Yangqi Zhao; Yi Dong; Qingqing Zheng; Yue Zhao; Yingjie Ni; Peijin Qiu; Chuannan Chen; Mengyue Xu; Chaoyang Hong; Ting Shen
TAGS: cornea, diabetes mellitus, rna, small interfering, wound healing, fatty acid desaturases, stearoyl-coa desaturase, epithelium, recovery of function, corneal epithelium, corneal epithelial cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):6. https://doi.org/10.1167/iovs.66.6.6

Includes: Supplemental Content

Glaucoma June 2025

Interocular Asymmetry of OCT Retinal Nerve Fiber Layer Values in a Normative Population: The Framingham Heart Study

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Louay Almidani; Jasdeep Sabharwal; Anoush Shahidzadeh; Ana Collazo Martinez; Shu Jie Ting; Brinda Vaidya; Xuejuan Jiang; Tim Kowalczyk; Alexa Beiser; Lucia Sobrin; Sudha Seshadri; Pradeep Ramulu; Amir H. Kashani
TAGS: eye, framingham heart study, glaucoma, retinal nerve fiber layer, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2025; 14(6):7. https://doi.org/10.1167/tvst.14.6.7

Includes: Supplemental Content

Glaucoma May 2025

Ferroptosis Contributes to Retinal Ganglion Cell Loss in GLAST Knockout Mouse Model of Normal Tension Glaucoma

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Huiwen Ye; Yanlin Feng; Wu Xiang; Zihao Lin; Yue Li; Wen Hu; Keyu Liu; Shuya Tao; Qinmeng Shu; Jiawei Wang; Fan Xu; Yue Xu; Yantao Wei; Jingjing Huang
TAGS: ferroptosis, mice, glutamate, glutamates, excitotoxicity, low tension glaucoma, lipid peroxidation, retina, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):26. https://doi.org/10.1167/iovs.66.5.26

Includes: Supplemental Content

Retina May 2025

Clofarabine Enhances the Transduction Efficiency of Recombinant AAV2 in the Retina

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Yuyao Diao; Xuewei Xiong; Jiayan Liu; Xingbo Teng; Qi Shi; Shangli Jin; Yahui Lei; Shisi Ma; Guei-Sheung Liu; Lian Liu; Guocheng Yu; Jiang-Hui Wang; Jingxiang Zhong; Leilei Tu
TAGS: clofarabine, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):42. https://doi.org/10.1167/iovs.66.5.42

Includes: Supplemental Content

Refractive Intervention May 2025

Distance of Corneal Vertex and Effective Optical Zone Margin Following Keratorefractive Lenticule Extraction in Myopic Astigmatism

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Xuyun Meng; Hui Ding; Hong He; Zhenduo Yang; Xiaodan Chen; Shisi Hu; Anzhen Li; Xingxing Wang; Yuhan Luo; Xingwu Zhong
TAGS: astigmatism, cornea, crown of head, optics, postoperative care, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(5):21. https://doi.org/10.1167/tvst.14.5.21

Cornea May 2025

Autophagy Impairment-Derived SQSTM1 Accumulation Promotes Ferroptosis in Corneal Epithelial Cells Through ACSL4 in Dry Eye

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Runze Zhang; Lihong Liang; Kai Liao; Hao Zeng; Xue Yang; Xiaoran Wang; Bowen Wang; Jin Yuan
TAGS: corneal epithelial cells, dry eye syndromes, ferroptosis, stress, autophagy, western blotting, impairment
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):23. https://doi.org/10.1167/iovs.66.5.23

Includes: Supplemental Content

Biochemistry and Molecular Biology May 2025

Canonical and Truncated Transglutaminase-2 Drive TGF-β1 Autocrine Loop to Induce Fibrosis in Graves’ Orbitopathy

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Xiaoli Bao; Zhihui Xu; Xi Wang; Te Zhang; Xiaotong Sha; Anqi Sun; Huijing Ye; Huasheng Yang
TAGS: fibrosis, protein glutamine gamma glutamyltransferase 2, autocrine, genes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):22. https://doi.org/10.1167/iovs.66.5.22

Includes: Supplemental Content

Glaucoma May 2025

Normative Variability in Retinal Nerve Fiber Layer Thickness: Does It Matter Where the Peaks Are?

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Sowjanya Gowrisankaran; Ashkan Abbasi; Xubo Song; Joel S. Schuman; Gadi Wollstein; Bhavna J. Antony; Hiroshi Ishikawa
TAGS: glaucoma, optic disk, retinal nerve fiber layer, retinal vessels
Trans. Vis. Sci. Tech.. 2025; 14(5):13. https://doi.org/10.1167/tvst.14.5.13

Cornea May 2025

Targeting α7 Nicotinic Acetylcholine Receptor for Modulating the Neuroinflammation of Dry Eye Disease Via Macrophages

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Xujiao Zhou; Yuqing Wu; Yirou Zhang; Binbin Chu; Kan Yang; Jiaxu Hong; Yao He
TAGS: agonists, cornea, dry eye syndromes, inflammation, macrophages, neuroinflammatory diseases, nicotinic receptors, linear gingival erythema, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):13. https://doi.org/10.1167/iovs.66.5.13

Includes: Supplemental Content

Refractive Intervention May 2025

Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study

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Yue Xu; Xing-Xuan Dong; Yun Wang; Xin-Yu Zhuang; Ying-Jie Chen; Xiao-Feng Zhang; Chen-Wei Pan
TAGS: cytokine, mendelian randomization analysis, refractive errors, ciliary motility disorders
Trans. Vis. Sci. Tech.. 2025; 14(5):1. https://doi.org/10.1167/tvst.14.5.1

Includes: Supplemental Content

Retina May 2025

Complement C3/C3aR Signaling Pathway Inhibition Ameliorates Retinal Damage in Experimental Retinal Vein Occlusion

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Yanying Zhao; Zhengwei Ge; Tingting Guo; Hengwei Liu; Yufan Zhou; Juan Chen; Heping Xu; Zhongping Chen
TAGS: complement 3, lasers, mice, retinal vein occlusion, signal pathway, signal transduction pathways, complement system proteins, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):2. https://doi.org/10.1167/iovs.66.5.2

Includes: Supplemental Content

Retina April 2025

Microglia-Derived IL-6 Promotes Müller Glia Reprogramming and Proliferation in Zebrafish Retina Regeneration

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Jie Xu; Yi Li; Xiangyu Li; Xuan Tan; Lihua Liu; Lining Cao; Hui Xu
TAGS: interleukin-6, retina, zebrafish, microglia, signal transduction, stat3 protein
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):67. https://doi.org/10.1167/iovs.66.4.67

Includes: Supplemental Content

Clinical Trials April 2025

Effect of Repeated Low-Level Red Light Versus 0.01% Topical Atropine on Myopia Progression: A Randomized Crossover-Controlled Trial

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Xuena Pang; Xuemin Jin; Aicun Fu; Weiqun Wang; Bingxin Zhao; Lili Shang; Minghang Chang; Nana Ma; Guangying Zheng
TAGS: atropine, myopia, child, red light
Trans. Vis. Sci. Tech.. 2025; 14(4):22. https://doi.org/10.1167/tvst.14.4.22

Includes: Supplemental Content

Cornea April 2025

Enhanced Therapeutic Effect of IL-10-ADSCs on Rabbit Autoimmune Dacryoadenitis By Suppressing T Follicular Helper Cell Responses Via miR-142-5p/RC3H1 Axis

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Lu Zhao; Na Li; Xinrui Shi; Jiachen Zhang; Min Gao; Yankai Wei; Xuejia Li; Bei Du; Deming Sun; Hong Nian; Ruihua Wei
TAGS: autoimmunity, dacryoadenitis, dry eye syndromes, oryctolagus cuniculus, t follicular helper cells, attenuation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):66. https://doi.org/10.1167/iovs.66.4.66

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study

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Zi Xuan Lin; Xiu Juan Zhang; Fang Yao Tang; Yuzhou Zhang; Ka Wai Kam; Alvin L. Young; Patrick Ip; Carol Y. Cheung; Chi Pui Pang; Clement C. Tham; Li Jia Chen; Kyoko Ohno-Matsui; Jason C. Yam
TAGS: child, eye, myopia, retinal vasculature, hong kong
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):64. https://doi.org/10.1167/iovs.66.4.64

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology April 2025

The Influence of Changes in Microglia Development on the Plasticity of the Developing Visual Cortex Circuit in Juvenile Mice

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Xuechun Wang; Kuan Li; Lingzhi Guo; Xinlong Liu; Yatu Guo; Wei Zhang
TAGS: mice, microglia, visual cortex, interneurons, neurons, small nuclear rna, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):45. https://doi.org/10.1167/iovs.66.4.45

Includes: Supplemental Content

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HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway

Retinal Vessel Geometry and Retinal Abnormalities in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Electroretinography With the RM Electrode: Normative Reference Ranges, Variation With Age, and Comparison With the Burian–Allen Electrode

Short-Chain Fatty Acids Are Potential Biomarkers of Immune Regulation in Diabetic Retinopathy

Fatty Acid Desaturase 1 Knockdown Promotes Wound Healing and Functional Recovery of the Corneal Epithelium in Diabetes

Interocular Asymmetry of OCT Retinal Nerve Fiber Layer Values in a Normative Population: The Framingham Heart Study

Ferroptosis Contributes to Retinal Ganglion Cell Loss in GLAST Knockout Mouse Model of Normal Tension Glaucoma

Clofarabine Enhances the Transduction Efficiency of Recombinant AAV2 in the Retina

Distance of Corneal Vertex and Effective Optical Zone Margin Following Keratorefractive Lenticule Extraction in Myopic Astigmatism

Autophagy Impairment-Derived SQSTM1 Accumulation Promotes Ferroptosis in Corneal Epithelial Cells Through ACSL4 in Dry Eye

Canonical and Truncated Transglutaminase-2 Drive TGF-β1 Autocrine Loop to Induce Fibrosis in Graves’ Orbitopathy

Normative Variability in Retinal Nerve Fiber Layer Thickness: Does It Matter Where the Peaks Are?

Targeting α7 Nicotinic Acetylcholine Receptor for Modulating the Neuroinflammation of Dry Eye Disease Via Macrophages

Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study

Complement C3/C3aR Signaling Pathway Inhibition Ameliorates Retinal Damage in Experimental Retinal Vein Occlusion

Microglia-Derived IL-6 Promotes Müller Glia Reprogramming and Proliferation in Zebrafish Retina Regeneration

Effect of Repeated Low-Level Red Light Versus 0.01% Topical Atropine on Myopia Progression: A Randomized Crossover-Controlled Trial

Enhanced Therapeutic Effect of IL-10-ADSCs on Rabbit Autoimmune Dacryoadenitis By Suppressing T Follicular Helper Cell Responses Via miR-142-5p/RC3H1 Axis

Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study

The Influence of Changes in Microglia Development on the Plasticity of the Developing Visual Cortex Circuit in Juvenile Mice

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