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Cornea & External Disease April 2025

A Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing

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Mark Dibbs; Mitchelle Matesva; Despoina Theotoka; Christina Jayaraj; Beruk Metiku; Patrick Demkowicz; Jacob S. Heng; Yvonne Wang; Christine Y. Bakhoum; Jessica Chow; Mathieu F. Bakhoum
TAGS: bacteria, corneal ulcer, nanopore sequencing, pathogenic organism, ulcer, eye, cornea
Trans. Vis. Sci. Tech.. 2025; 14(4):19. https://doi.org/10.1167/tvst.14.4.19

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics April 2025

The Relationship Between Binocular Imbalance and Myopic Shift in Unoperated Eyes After Unilateral SMILE and tPRK

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Kaiyan Huang; Mi Xia; Qianwen Gong; Kexin Li; Yijie Xu; Hui Wang; Yuzhou Wang; Jiawei Zhou; Liang Hu
TAGS: eye, imbalance, spatial frequency
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):32. https://doi.org/10.1167/iovs.66.4.32

Includes: Supplemental Content

Genetics April 2025

Clinical and Molecular Landscape of GLRA2 in X-Linked Early-Onset High Myopia

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Xiaoxia Li; Siyu Wang; Yuhan Wang; Ruru Chen; Xinjie Mao; Ying Mei; Meiping Xu; Lan Hu; Chuan Qin; Shilai Xing; Xiaoguang Yu; Liya Qiao
TAGS: genes, myopia, x-linked inheritance, rna splicing, genetics, validity of results, mutation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):30. https://doi.org/10.1167/iovs.66.4.30

Includes: Supplemental Content

Cornea April 2025

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway

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Yuzhou Wang; Zhiqiang Xu; Linzhi Wei; Yang Lu; Yizhou Shi; Shiyu Wen; Xiujuan Lv; Kaiyan Huang; Fan Lu; Jia Qu; Liang Hu
TAGS: hmgb1 protein, mice, toll-like receptor 4, inflammation, dry eye syndromes, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):28. https://doi.org/10.1167/iovs.66.4.28

Includes: Supplemental Content

Retina April 2025

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

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Kao-Jung Chang; Ching-Yun Wang; Hsin-Yu Wu; Pei-Yu Weng; Chia-Hsin Lu; Wei Chiu; Wei-Chieh Fang; Chong-En Kao; Cheng-Yi Li; Yi-Ting Chung; Yu-Chun Chen; Ai-Ru Hsieh; Shih-Hwa Chiou; Chih-Chien Hsu; Tai-Chi Lin; Shih-Jen Chen; De-Kuang Hwang
TAGS: biological markers, polygenic risk score, retinal detachment, screening, ultrasonography, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(4):16. https://doi.org/10.1167/tvst.14.4.16

Includes: Supplemental Content

Visual Neuroscience April 2025

Enlarged Blind Spot Linked to Gamma Zone and Peripapillary Hyperreflective Ovoid Mass-Like Structures in Non-Pathological Highly Myopic Eyes

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Qiuyan Wu; Ruihan Hu; Qihong Liu; Fang Li; Yuanyuan Wang; Zuohuizi Yi; Jiajia Yuan; Yilei Shao; Meixiao Shen; Hongmei Zheng; Changzheng Chen
TAGS: eye, retinal blind spot, glaucoma, myopia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):5. https://doi.org/10.1167/iovs.66.4.5

Includes: Supplemental Content

Lens April 2025

In Vivo Brillouin Analysis of Lens Nucleus and Cortex in Adult Myopic Eyes and Their Correlation With Accommodation

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Le Chang; Fen Song; Shijia Qu; Huazheng Cao; Yanan Wu; Lulu Xu; Jing Wang; Ruirui Zhang; Chao Xue; Yan Wang
TAGS: cell nucleus, eye, lens (device), lens, crystalline, myopia, visual accommodation, adult, regression analysis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):6. https://doi.org/10.1167/iovs.66.4.6

Includes: Supplemental Content

Artificial Intelligence March 2025

Multimodal Artificial Intelligence Models Predicting Glaucoma Progression Using Electronic Health Records and Retinal Nerve Fiber Layer Scans

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Abigail Koornwinder; Youchen Zhang; Rohith Ravindranath; Robert T. Chang; Isaac A. Bernstein; Sophia Y. Wang
TAGS: artificial intelligence, electronic medical records, glaucoma, retinal nerve fiber layer, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(3):27. https://doi.org/10.1167/tvst.14.3.27

Includes: Supplemental Content

Anatomy and Pathology/Oncology March 2025

Whorl-Like Collagen Fiber Arrangement Around Emissary Canals in the Posterior Sclera

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Hongshuang Lu; Yijin Wu; Jianping Xiong; Nan Zhou; Masahiro Yamanari; Michiaki Okamoto; Keigo Sugisawa; Hiroyuki Takahashi; Changyu Chen; Yining Wang; Ziye Wang; Kyoko Ohno-Matsui
TAGS: collagen fiber, eye, sclera
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):35. https://doi.org/10.1167/iovs.66.3.35

Includes: Multimedia, Supplemental Content

Public Health March 2025

Visual Deficits in Type 2 Diabetes Mellitus Without Retinopathy: From Retinal Structure to Higher-Level Visual Functions

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Sha Luo; Lin Xia; Yue Wang; Yong Tang; Jiong Dong; Rong Liu; Lixia Feng
TAGS: diabetes mellitus, diabetes mellitus, type 2, retina, retinal diseases, vision, vision disorders
Trans. Vis. Sci. Tech.. 2025; 14(3):10. https://doi.org/10.1167/tvst.14.3.10

Includes: Supplemental Content

Retina March 2025

Characteristics of Retina, Choroid, and Retrobulbar Blood Flow in Myopes With Posterior Staphyloma Using Ultra-Widefield OCTA and CDI

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Fang Liu; Yunzhe Wang; Lingling Niu; Jing Zhao; Kang Xue; Xingtao Zhou
TAGS: choroid, retina, staphyloma, vascular flow, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):21. https://doi.org/10.1167/iovs.66.3.21

Genetics March 2025

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

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Qiu-Yi Huo; Rui-Zheng Zhang; Wan-Nan Jia; Ya-Lei Wang; Xin Shen; Xin-Yao Chen; Tian-Hui Chen; Yan Liu; Ling-Hao Song; Xinyue Wang; Yong Lv; Ze-Xu Chen; Yong-Xiang Jiang
TAGS: biomechanics, cornea, ectopia lentis, fibrillin-1, marfan syndrome, mutation, genotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):23. https://doi.org/10.1167/iovs.66.3.23

Includes: Supplemental Content

Cornea February 2025

Identification of Wnt-5a Receptors Important in Diabetic and Non-Diabetic Corneal Epithelial Wound Healing

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Ruchi Shah; Cynthia Amador; Adam J. Poe; Tanya M. Spektor; Priyanka Bhandary; Yizhou Wang; Zhiping Paul Wang; Daniel J. Weisenberger; Vanessa F. Borges; Onkar B. Sawant; Ezra Maguen; Pedram Hamrah; Andrei A. Kramerov; Mehrnoosh Saghizadeh; Alexander V. Ljubimov
TAGS: cornea, diabetes mellitus, receptors, wnt, wnt-5a protein, wound healing, epithelium, receptor tyrosine kinase-like orphan receptor 2
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):64. https://doi.org/10.1167/iovs.66.2.64

Includes: Supplemental Content

Clinical and Epidemiologic Research February 2025

Comprehensive Visualization of Choroidal Alterations in Thyroid Eye Disease With Ultra-Widefield OCT Angiography

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Yi Wang; Tengbo Rao; Jichao Zhou; Debo You; Jiarui Yang; Lingge Suo
TAGS: angiogram, eye, graves' ophthalmopathy, optic disk, cortical blindness, vascular flow, cardiovascular imaging
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):25. https://doi.org/10.1167/iovs.66.2.25

Includes: Supplemental Content

Lens February 2025

Advanced Artificial-Intelligence-Based Jiang Formula for Intraocular Lens Power in Congenital Ectopia Lentis

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Yan Liu; Xinyue Wang; Linghao Song; Yang Sun; Zexu Chen; Wannan Jia; Xin Shen; Yalei Wang; Xinyao Chen; Qiuyi Huo; Pranav Prakash Edavi; Tianhui Chen; Yongxiang Jiang
TAGS: ectopia lentis, eye, intelligence, intraocular lens implant device, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(2):5. https://doi.org/10.1167/tvst.14.2.5

Includes: Supplemental Content

Retina January 2025

ABCA4 Deep Intronic Variants Contributed to Nearly Half of Unsolved Stargardt Cases With a Milder Phenotype

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Yingwei Wang; Pangfeng Wang; Zhen Yi; Jiamin Ouyang; Yi Jiang; Shiqiang Li; Xiaoyun Jia; Xueshan Xiao; James Fielding Hejtmancik; Wenmin Sun; Qingjiong Zhang
TAGS: abca4 gene, introns, phenotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):65. https://doi.org/10.1167/iovs.66.1.65

Includes: Supplemental Content

Retina January 2025

Age- and Sex-Specific Regulation of Serine Racemase in the Retina of an Alzheimer's Disease Mouse

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Yan Wang; Dehuan Xu; Yuhang Zhao; Haiyu Zhu; Xiaoyu Xiu; Haiyan Jiang; Yimei Liu; Ge Shan; Shengzhou Wu
TAGS: mice, proteins, retina, serine, alzheimer's disease, regulation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):36. https://doi.org/10.1167/iovs.66.1.36

Includes: Supplemental Content

Retinal Cell Biology January 2025

Retinal Müller Cell-Released Exosomal MiR-92a-3p Delivers Interleukin-17A Signal by Targeting Notch-1 to Promote Diabetic Retinopathy

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Ao-Wang Qiu; Ning-Yu Wang; Wen-Jie Yin; Zhao-Qi Zhu; Qing-Huai Liu; Wei-Wei Zhang
TAGS: cardiac support procedures, exosomes, interleukin-17, mast-cell sarcoma, millennium cohort study, minimally conscious state, diabetic retinopathy, interleukins, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):1. https://doi.org/10.1167/iovs.66.1.1

Glaucoma December 2024

A Pattern-Based OCT Metric for Glaucoma Detection

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Donald C. Hood; Sol La Bruna; Mary Durbin; Chris Lee; Anya Guzman; Tayna Gebhardt; Yujia Wang; Arin L. Stowman; Carlos Gustavo De Moraes; Michael Chaglasian; Emmanouil Tsamis
TAGS: eye, glaucoma, cohort studies
Trans. Vis. Sci. Tech.. 2024; 13(12):21. https://doi.org/10.1167/tvst.13.12.21

Includes: Supplemental Content

Retina December 2024

Early Diabetic Retinopathy Evaluation With OCTA: A Study on Vascular Branching and Fragmentation

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Yao Yu; Shiwei Cui; Yang He; Jiahao Zhang; Nan Lu; Yanqiu Yang; Jian Liu; Yi Wang; Zhenhe Ma
TAGS: diabetic retinopathy, human placental lactogen, embolic protection devices, diabetes mellitus, fovea centralis
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):21. https://doi.org/10.1167/iovs.65.14.21

Includes: Supplemental Content

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A Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing

The Relationship Between Binocular Imbalance and Myopic Shift in Unoperated Eyes After Unilateral SMILE and tPRK

Clinical and Molecular Landscape of GLRA2 in X-Linked Early-Onset High Myopia

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

Enlarged Blind Spot Linked to Gamma Zone and Peripapillary Hyperreflective Ovoid Mass-Like Structures in Non-Pathological Highly Myopic Eyes

In Vivo Brillouin Analysis of Lens Nucleus and Cortex in Adult Myopic Eyes and Their Correlation With Accommodation

Multimodal Artificial Intelligence Models Predicting Glaucoma Progression Using Electronic Health Records and Retinal Nerve Fiber Layer Scans

Whorl-Like Collagen Fiber Arrangement Around Emissary Canals in the Posterior Sclera

Visual Deficits in Type 2 Diabetes Mellitus Without Retinopathy: From Retinal Structure to Higher-Level Visual Functions

Characteristics of Retina, Choroid, and Retrobulbar Blood Flow in Myopes With Posterior Staphyloma Using Ultra-Widefield OCTA and CDI

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

Identification of Wnt-5a Receptors Important in Diabetic and Non-Diabetic Corneal Epithelial Wound Healing

Comprehensive Visualization of Choroidal Alterations in Thyroid Eye Disease With Ultra-Widefield OCT Angiography

Advanced Artificial-Intelligence-Based Jiang Formula for Intraocular Lens Power in Congenital Ectopia Lentis

ABCA4 Deep Intronic Variants Contributed to Nearly Half of Unsolved Stargardt Cases With a Milder Phenotype

Age- and Sex-Specific Regulation of Serine Racemase in the Retina of an Alzheimer's Disease Mouse

Retinal Müller Cell-Released Exosomal MiR-92a-3p Delivers Interleukin-17A Signal by Targeting Notch-1 to Promote Diabetic Retinopathy

A Pattern-Based OCT Metric for Glaucoma Detection

Early Diabetic Retinopathy Evaluation With OCTA: A Study on Vascular Branching and Fragmentation

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