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Glaucoma August 2024

Activation of the ROCK/MYLK Pathway Affects Complex Molecular and Morphological Changes of the Trabecular Meshwork Associated With Ocular Hypertension

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Chia-Chen Hsu; Fang-Pai Lin; Hao-Chen Tseng; Pin Kuan Ho; Yi-Hsun Chen; Yann-Guang Chen; Da-Wen Lu; Yi-Hao Chen; Jian-Liang Chou; Hsin-Chih Chen; Yu Chuan Huang
TAGS: intraocular pressure, microspheres, myosin light chain kinase, ocular hypertension, open-angle glaucoma, oryctolagus cuniculus, trabecular meshwork
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):17. https://doi.org/10.1167/iovs.65.10.17

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Lipid nanoparticle delivery of adenine base editors as a potential treatment for inherited retinal diseases

Victoria AC Palmgren; Miffy Hok Yan Cheng; Tiffany Carlaw; Tessa Morin; Colin JD Ross; Pieter R Cullis; Robert S Molday

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6056.

ARVO Annual Meeting Abstract June 2023

Transcriptional Immunological Adaptation of Human Retinal Pigment Epithelial Cells to Infection with Klebsiella pneumoniae in Diabetic Ocular Environment

Yi-Hsing Chen; yih-shiou Hwang; Chia-Rui shen

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):156.

Visual Neuroscience January 2023

Investigation of the Protective Effect of Extracellular Vesicle miR-124 on Retinal Ganglion Cells Using a Photolabile Paper-Based Chip

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Yi-Hsun Chen; Yu Chuan Huang; Chih-Hung Chen; Yao-Tseng Wen; Rong-Kung Tsai; Chihchen Chen
TAGS: cd63 antigen, extracellular vesicles, micrornas, neuroprotective effect, recovery of function, retinal ganglion cells, nonarteritic anterior ischemic optic neuropathy, rna, rats
Invest. Ophthalmol. Vis. Sci.. 2023; 64(1):17. https://doi.org/10.1167/iovs.64.1.17

Includes: Supplemental Content

Lens August 2022

Zebrafish ( Danio rerio ) Is an Economical and Efficient Animal Model for Screening Potential Anti-cataract Compounds

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Chun-Fu Liu; Yen Ou-Yang; Ching-Ying Huang; Shih-Wei Jao; Yu-Kai Kuo; Hung-Chi Chen; Shu-Chun Cheng; Nan-Kai Wang; Lan-Hsin Chuang; Yau-Hung Chen; Wei-Yi Chen
TAGS: cataract, lanosterol, zebrafish, screening, animal model, lens (device)
Trans. Vis. Sci. Tech.. 2022; 11(8):21. https://doi.org/10.1167/tvst.11.8.21

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2022

Diabetic ocular environment facilitates the invasion of Klebsiella pneumoniae to Human Retinal Pigment Epithelial Cells: via suppression of NFkB and MAPK pathway

Yi-Hsing Chen; Chia-Rui Shen; Yih-Shiou Hwang

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4130 – F0367.

New Developments in Vision Research October 2021

The Intraocular Pressure Lowering Effect of a Dual Kinase Inhibitor (ITRI-E-(S)4046) in Ocular Hypertensive Animal Models

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Yi-Hsun Chen; Wan-Ying Lin; Yu Chuan Huang; Wan Yu Ho; Chih-Wei Fu; Chia-Mu Tu; Chrong-Shiong Hwang; Chiu-Lien Hung; Ming-Chun Lin; Felice Cheng; Yen-Jen Wang; Chih-Hung Chen; Shuen-Hsiang Chou; Meng-Ping She; Chia-Yi Yang; Hui-Ling Cheng; Chih-Peng Liu; Da-Wen Lu
TAGS: animal model, intraocular pressure, kinase inhibitors, ocular hypertension, oryctolagus cuniculus, phosphotransferases
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):12. https://doi.org/10.1167/iovs.62.13.12

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology May 2021

Inhibition of Retinal Ganglion Cell Loss By a Novel ROCK Inhibitor (E212) in Ischemic Optic Nerve Injury Via Antioxidative and Anti-Inflammatory Actions

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Yao-Tseng Wen; Ching-Wen Huang; Chih-Peng Liu; Chih-Hung Chen; Chia-Mu Tu; Chrong-Shiong Hwang; Yi-Hsun Chen; Wan-Ru Chen; Keh-Liang Lin; Yu-Chieh Ho; Ta-Ching Chen; Rong-Kung Tsai
TAGS: anti-inflammatory agents, infarction, ischemia, neuroprotective effect, optic nerve injuries, painful bladder syndrome, retina, retinal ganglion cells, macrophages, fluoro-gold
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):21. https://doi.org/10.1167/iovs.62.6.21

Includes: Supplemental Content

Special Issue July 2020

Leveraging Multimodal Deep Learning Architecture with Retina Lesion Information to Detect Diabetic Retinopathy

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Vincent S. Tseng; Ching-Long Chen; Chang-Min Liang; Ming-Cheng Tai; Jung-Tzu Liu; Po-Yi Wu; Ming-Shan Deng; Ya-Wen Lee; Teng-Yi Huang; Yi-Hao Chen
TAGS: deep learning, diabetic retinopathy, retina, ophthalmologists
Trans. Vis. Sci. Tech.. 2020; 9(2):41. https://doi.org/10.1167/tvst.9.2.41

ARVO Annual Meeting Abstract June 2020

Effects of oxidative stress in retinal ganglion cells and possible relevance to acute glaucoma

Hsin-Yi Chen; Mei-Lan Ko

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):809.

ARVO Annual Meeting Abstract June 2020

Transforming Growth Factor beta-1 Protects Retinal ganglion cells in Hyperglycemia

Mei-Lan Ko; Hsin-Yi Chen

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1747.

Retina February 2020

Patchy Scotoma Observed in Chorioretinal Patchy Atrophy of Myopic Macular Degeneration

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Jung Lo; Linda Yi-Chieh Poon; Yi-Hao Chen; Hsi-Kung Kuo; Yung-Jen Chen; Wei-Yu Chiang; Pei-Chang Wu
TAGS: atrophy, eye, myopic macular degeneration, scotoma
Invest. Ophthalmol. Vis. Sci.. 2020; 61(2):15. https://doi.org/10.1167/iovs.61.2.15

ARVO Annual Meeting Abstract July 2019

ITRI-E-247, a novel selective Rho-associated kinase inhibitor, characterized with the potent intraocular pressure lowering effect and less conjunctival hyperemia.

Chiamu Tu; Chih-Peng Liu; ChihHung Chen; Yuan-Jang Tsai; Chrong-Shiong Hwang; Chiu-Lien Hung; Yi-Hsun Chen; Tsan-Lin Hu; Shuen-Hsiang Chou; Sung-En Chen

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3768.

ARVO Annual Meeting Abstract July 2019

A role of Th1/17 cells migrating across the blood-retinal-barrier in experimental autoimmune uveitis

Yi hsing Chen; Malihe Eskandarpour; Mahid Chaudhry; Xiaozhe Zhang; Susan Lightman; Virginia L Calder

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):785.

Glaucoma February 2019

A Highly Selective Rho-Kinase Inhibitor (ITRI-E-212) Potentially Treats Glaucoma Upon Topical Administration With Low Incidence of Ocular Hyperemia

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Cherng-Ru Hsu; Yi-Hsun Chen; Chih-Peng Liu; Chih-Hung Chen; Kuo-Kuei Huang; Jui-Wen Huang; Meng-Nan Lin; Chih-Lung Lin; Wan-Ru Chen; Yi-Ling Hsu; Tze-chung Lee; Shuen-Hsiang Chou; Chia-Mu Tu; Chrong-Shiong Hwang; Yu Chuan Huang; Da-Wen Lu
TAGS: administration, topical, erythema, glaucoma, hypertension, intraocular pressure, oryctolagus cuniculus, phosphotransferases, conjunctival injection, incidence
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):624-633. https://doi.org/10.1167/iovs.18-25252

ARVO Annual Meeting Abstract July 2018

Prospective study of the morphologic and functional parameter changes post treatment of macular oedema associated with different retinal disorders

Lazha Sharief; Yi-Hsing Chen; Susan Lightman; Oren Tomkins-Netzer

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):392.

ARVO Annual Meeting Abstract July 2018

Experimental immune-mediated conjunctivitis (EIC): downregulation by Coversin, a dual C5 and LTB4 inhibitor

Virginia Calder; Malihe Eskandarpour; Xiaozhe Zhang; Yi-Hsing Chen; Miles Nunn; Wynne Weston-Davies

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):507.

ARVO Annual Meeting Abstract July 2018

Effects of α4β1 Integrin Inhibitor on Leucocyte Subset Migration in Experimental Autoimmune Uveitis

Yi hsing Chen; Malihe Eskandarpour; Grazyna Galatowicz; Mahid Chaudhry; Xiaozhe Zhang; Susan Lightman; Virginia Calder

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2541.

ARVO Annual Meeting Abstract July 2018

Causes of vision loss and clinical outcomes over an 18 year period in patients with Vogt–Koyanagi–Harada Disease

Sophia Zagora; Yi-Hsing Chen; Susan Lightman; Oren Tomkins-Netzer

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4200.

ARVO Annual Meeting Abstract June 2017

Dependence of Flupirtine-resistant RGC oscillation in deafferentated mouse retinas on Connexin 36

Ching-Kang Jason Chen; Yu-Jiun Chen; Yu-Hsu Chen; Chih-Chun Hsu; Hung-Ya Tu

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2582.

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Activation of the ROCK/MYLK Pathway Affects Complex Molecular and Morphological Changes of the Trabecular Meshwork Associated With Ocular Hypertension

Lipid nanoparticle delivery of adenine base editors as a potential treatment for inherited retinal diseases

Transcriptional Immunological Adaptation of Human Retinal Pigment Epithelial Cells to Infection with Klebsiella pneumoniae in Diabetic Ocular Environment

Investigation of the Protective Effect of Extracellular Vesicle miR-124 on Retinal Ganglion Cells Using a Photolabile Paper-Based Chip

Zebrafish ( Danio rerio ) Is an Economical and Efficient Animal Model for Screening Potential Anti-cataract Compounds

Diabetic ocular environment facilitates the invasion of Klebsiella pneumoniae to Human Retinal Pigment Epithelial Cells: via suppression of NFkB and MAPK pathway

The Intraocular Pressure Lowering Effect of a Dual Kinase Inhibitor (ITRI-E-(S)4046) in Ocular Hypertensive Animal Models

Inhibition of Retinal Ganglion Cell Loss By a Novel ROCK Inhibitor (E212) in Ischemic Optic Nerve Injury Via Antioxidative and Anti-Inflammatory Actions

Leveraging Multimodal Deep Learning Architecture with Retina Lesion Information to Detect Diabetic Retinopathy

Effects of oxidative stress in retinal ganglion cells and possible relevance to acute glaucoma

Transforming Growth Factor beta-1 Protects Retinal ganglion cells in Hyperglycemia

Patchy Scotoma Observed in Chorioretinal Patchy Atrophy of Myopic Macular Degeneration

ITRI-E-247, a novel selective Rho-associated kinase inhibitor, characterized with the potent intraocular pressure lowering effect and less conjunctival hyperemia.

A role of Th1/17 cells migrating across the blood-retinal-barrier in experimental autoimmune uveitis

A Highly Selective Rho-Kinase Inhibitor (ITRI-E-212) Potentially Treats Glaucoma Upon Topical Administration With Low Incidence of Ocular Hyperemia

Prospective study of the morphologic and functional parameter changes post treatment of macular oedema associated with different retinal disorders

Experimental immune-mediated conjunctivitis (EIC): downregulation by Coversin, a dual C5 and LTB4 inhibitor

Effects of α4β1 Integrin Inhibitor on Leucocyte Subset Migration in Experimental Autoimmune Uveitis

Causes of vision loss and clinical outcomes over an 18 year period in patients with Vogt–Koyanagi–Harada Disease

Dependence of Flupirtine-resistant RGC oscillation in deafferentated mouse retinas on Connexin 36

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