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Immunology and Microbiology May 2025

Comparative Efficacy of Interleukin-7 and -15 Blockade in Alleviating Experimental Chronic Uveitis and Suppressing Pathogenic Memory CD4 + T Cells

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Qiurong Zhu; Maryam Shayan; Rachel M. Huckfeldt; Yihe Chen
TAGS: interleukin-15, interleukin-7, memory, t-lymphocytes, uveitis, mice, neutralization
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):9. https://doi.org/10.1167/iovs.66.5.9

Includes: Supplemental Content

Immunology and Microbiology May 2025

Contribution of Leukocidin ED to the Pathogenesis of Staphylococcus aureus Endophthalmitis

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Luis Longoria-Gonzalez; Phillip S. Coburn; Roger Astley; Yan Chen; Michelle C. Callegan
TAGS: endophthalmitis, eye, infections, mice, pathogenesis, staphylococcus aureus
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):11. https://doi.org/10.1167/iovs.66.5.11

Glaucoma May 2025

Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use—A Prospective Study

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Yu-Ting Tsao; Hung-Chi Chen; Yi-Jen Hsueh; Yu-Chun Cheng; Eugene Yu-Chuan Kang; Chu-Yen Huang; Yung-Sung Lee
TAGS: antioxidants, aqueous humor, glaucoma, intraocular pressure, teller acuity cards, total arterial compliance, trigeminal autonomic cephalalgias, prospective studies, drug usage
Trans. Vis. Sci. Tech.. 2025; 14(5):7. https://doi.org/10.1167/tvst.14.5.7

Includes: Supplemental Content

Refractive Intervention May 2025

Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study

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Yue Xu; Xing-Xuan Dong; Yun Wang; Xin-Yu Zhuang; Ying-Jie Chen; Xiao-Feng Zhang; Chen-Wei Pan
TAGS: cytokine, mendelian randomization analysis, refractive errors, ciliary motility disorders
Trans. Vis. Sci. Tech.. 2025; 14(5):1. https://doi.org/10.1167/tvst.14.5.1

Includes: Supplemental Content

Retina April 2025

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

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Kao-Jung Chang; Ching-Yun Wang; Hsin-Yu Wu; Pei-Yu Weng; Chia-Hsin Lu; Wei Chiu; Wei-Chieh Fang; Chong-En Kao; Cheng-Yi Li; Yi-Ting Chung; Yu-Chun Chen; Ai-Ru Hsieh; Shih-Hwa Chiou; Chih-Chien Hsu; Tai-Chi Lin; Shih-Jen Chen; De-Kuang Hwang
TAGS: biological markers, polygenic risk score, retinal detachment, screening, ultrasonography, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(4):16. https://doi.org/10.1167/tvst.14.4.16

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics April 2025

Temporal Contour Integration Deficits in Children With Amblyopia

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Yan-Ru Chen; Shu-Qi Jiang; Xiang-Yun Liu; Jun-Yun Zhang
TAGS: amblyopia, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):27. https://doi.org/10.1167/iovs.66.4.27

Glaucoma April 2025

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

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Jinpeng Yang; Yangjiani Li; Qi Zhang; Simei Zeng; Haishun Huang; Caiqing Wu; Zhe Liu; Jiahui Tang; Siting Wu; Yuze Chen; Yehong Zhuo; Yangfan Yang; Yiqing Li
TAGS: glaucoma, language morphology, morphology, myopia, optic disk, optic nerve, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):18. https://doi.org/10.1167/iovs.66.4.18

Includes: Supplemental Content

Optica Fall Vision Meeting Abstract April 2025

Poster Session: Development of a natural wideview 3D scene fMRI dataset for modeling human spatial cognition

Joseph Obriot; Pei-Yin Chen; Atsushi Wada
TAGS: cognition, datasets, functional magnetic resonance imaging, posters
Journal of Vision. 2025; 25(5):16. https://doi.org/10.1167/jov.25.5.16

Genetics March 2025

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

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Qiu-Yi Huo; Rui-Zheng Zhang; Wan-Nan Jia; Ya-Lei Wang; Xin Shen; Xin-Yao Chen; Tian-Hui Chen; Yan Liu; Ling-Hao Song; Xinyue Wang; Yong Lv; Ze-Xu Chen; Yong-Xiang Jiang
TAGS: biomechanics, cornea, ectopia lentis, fibrillin-1, marfan syndrome, mutation, genotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):23. https://doi.org/10.1167/iovs.66.3.23

Includes: Supplemental Content

Retina February 2025

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

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Xiaoyan Ding; Xiaodi Zhou; Xinyu Liu; Yanting Lai; Wenjia Yan; Yizhe Cheng; Aohan Hou; Limei Chen; Limei Sun
TAGS: angiogenesis, hypoxia, mice, neovascularization, pathologic, 1-phosphatidylinositol 3-kinase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):40. https://doi.org/10.1167/iovs.66.2.40

Includes: Supplemental Content

Retina February 2025

Metabolomic Characteristics of Aqueous Humor in Wet Age-Related Macular Degeneration and the Impact of Anti-VEGF Treatment

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Yijing Chen; Xiaoya Zhang; Yanli Zhang; Shian Zhang; Yu Huo; Yubo Wu; Lijun Shen; Jianbo Mao
TAGS: anti-vascular endothelial growth factor therapy, aqueous humor, exudative age-related macular degeneration, metabolites, metabolomics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):37. https://doi.org/10.1167/iovs.66.2.37

Includes: Supplemental Content

Clinical and Epidemiologic Research February 2025

Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy

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Ying-Yi Chen; Chung-May Yang; Chang-Hao Yang; Tzyy-Chang Ho; Yi-Ting Hsieh; Tso-Ting Lai; Tzu-Hsun Tsai; Shu-Yi Huang
TAGS: ceramides, vitreous body, diabetic retinopathy, proliferative diabetic retinopathy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):28. https://doi.org/10.1167/iovs.66.2.28

Retinal Cell Biology January 2025

Inhibition of Retinal Neovascularization by BEZ235: Targeting the Akt/4EBP1/Cyclin D1 Pathway in Endothelial Cells

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Qi Liu; Ling-Xiao Xia; Wan-Zhao Yi; Ya-Ni Wu; Shuo-Shuo Gu; Jian-Ying Chen; Ting-Ting Liu; Ying-Hui Lu; Yu-Hong Cui; Jing Meng; Hong-Wei Pan
TAGS: cyclin d1, endothelial cells, proto-oncogene proteins c-akt, retinal neovascularization, cell cycle, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):66. https://doi.org/10.1167/iovs.66.1.66

Includes: Supplemental Content

Retina January 2025

Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens

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Deng Pan; Ge Hu; Jiayue Li; Zixu Wang; Yaoxing Chen; Jing Cao
TAGS: autophagy, chickens, stress, retina, blue light, endoplasmic reticulum, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):3. https://doi.org/10.1167/iovs.66.1.3

Includes: Supplemental Content

Clinical and Epidemiologic Research January 2025

Ten-Year Change in Visual Function and Incidence of Visual Impairment in Highly Myopic Children and Adults

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Yanping Chen; Ruilin Xiong; Jian Zhang; Shaopeng Yang; Huangdong Li; Ziyu Zhu; Peiyuan Wang; Mingguang He; Yingfeng Zheng; Wei Wang
TAGS: adult, child, eye, incidence, myopia, vision, visual impairment, blindness, world health organization
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):2. https://doi.org/10.1167/iovs.66.1.2

Includes: Supplemental Content

Genetics December 2024

Linking Iris Cis -Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics

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Jiaying Li; Yun Chen; Wenbin Wang; Ye Zhang; Guangsong Su; Sean K. Wang; Yuanyuan Zhang; Yilong Yao; Shen Wu; Wange Lu; Kunlin Zhang; Chunyan Qiao; Shuning Li; Hengtong Li; Ching-Yu Cheng; Yuwen Liu; Ningli Wang
TAGS: angle closure glaucoma, iris, pathogenesis, enhancer of transcription, diagnostic imaging, chromatin, alleles, multiomics
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):18. https://doi.org/10.1167/iovs.65.14.18

Includes: Supplemental Content

Retina December 2024

A Novel Grid Strategy for Correlating Focal Macular Anatomic Changes With Focal Changes in Choriocapillaris Perfusion

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Farhan E. Hiya; Yuxuan Cheng; Mengxi Shen; Jianqing Li; Alessandro Berni; Sandy Wenting Zhou; Gissel Herrera; Robert C. O'Brien; Giovanni Gregori; Ruikang K. Wang; Philip J. Rosenfeld
TAGS: chief complaint, drusen, eye, perfusion, reliability, diagnostic imaging, coronary arteriosclerosis, masks, computer assisted diagnosis, computer-aided detection systems
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):5. https://doi.org/10.1167/iovs.65.14.5

Artificial Intelligence November 2024

Associations of Metabolically Healthy Obesity and Retinal Age Gap

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Xiaomin Zeng; Ruiye Chen; Gabriella Bulloch; Qingsheng Peng; Ching-Yu Cheng; Mingguang He; Honghua Yu; Zhuoting Zhu
TAGS: obesity, obesity, metabolically benign, phenotype, body mass index procedure, body weight
Trans. Vis. Sci. Tech.. 2024; 13(11):26. https://doi.org/10.1167/tvst.13.11.26

Visual Psychophysics and Physiological Optics October 2024

Factors Affecting Stimulus Duration Threshold for Depth Discrimination of Asynchronous Targets in the Intermediate Distance Range

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Yiya Chen; Zijiang J. He; Teng Leng Ooi
TAGS: vision disparity, visual system, health disparity
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):36. https://doi.org/10.1167/iovs.65.12.36

Includes: Supplemental Content

Glaucoma October 2024

Normative Profile of Retinal Nerve Fiber Layer Thickness and Lamina Cribrosa-Related Parameters in a Healthy Non-Glaucoma Cynomolgus Monkey Colony

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Jian Wu; Ruyue Li; Sirui Zhu; Kezhe Chen; Caixia Lin; Jiaxin Tian; Lijie Pan; Hongyi Liu; Xu Jia; Ziyu Yu; Zhidong Li; Yingting Zhu; Wei Liu; Chenlong Yang; Chiwai Wong; Ningli Wang; Yehong Zhuo; for the Non-Human Primate Eye Study Group
TAGS: glaucoma, macaca fascicularis, retinal nerve fiber layer, eye, cercopithecidae, intraocular pressure
Trans. Vis. Sci. Tech.. 2024; 13(10):6. https://doi.org/10.1167/tvst.13.10.6

Includes: Supplemental Content

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Comparative Efficacy of Interleukin-7 and -15 Blockade in Alleviating Experimental Chronic Uveitis and Suppressing Pathogenic Memory CD4 + T Cells

Contribution of Leukocidin ED to the Pathogenesis of Staphylococcus aureus Endophthalmitis

Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use—A Prospective Study

Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

Temporal Contour Integration Deficits in Children With Amblyopia

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

Poster Session: Development of a natural wideview 3D scene fMRI dataset for modeling human spatial cognition

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

Metabolomic Characteristics of Aqueous Humor in Wet Age-Related Macular Degeneration and the Impact of Anti-VEGF Treatment

Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy

Inhibition of Retinal Neovascularization by BEZ235: Targeting the Akt/4EBP1/Cyclin D1 Pathway in Endothelial Cells

Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens

Ten-Year Change in Visual Function and Incidence of Visual Impairment in Highly Myopic Children and Adults

Linking Iris Cis -Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics

A Novel Grid Strategy for Correlating Focal Macular Anatomic Changes With Focal Changes in Choriocapillaris Perfusion

Associations of Metabolically Healthy Obesity and Retinal Age Gap

Factors Affecting Stimulus Duration Threshold for Depth Discrimination of Asynchronous Targets in the Intermediate Distance Range

Normative Profile of Retinal Nerve Fiber Layer Thickness and Lamina Cribrosa-Related Parameters in a Healthy Non-Glaucoma Cynomolgus Monkey Colony

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