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ARVO Annual Meeting Abstract June 2025

Identification of disease-responsive neuronal promoters and enhancers for glaucoma gene therapy

Yuyang Zeng; Xue Feng; Wenjun Yan; Liang Liu; Haoliang Huang; Fuyun Bian; Yang Hu

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):2661.

ARVO Annual Meeting Abstract June 2025

The OPTN-H486R Mutation Induces Early Onset of Glaucomatous Neurodegeneration

Dong Liu; Hannah Webber; Manjari Prakash; Xue Feng; Haoliang Huang; Zdenek Lansky; Yang Hu

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):4867.

ARVO Annual Meeting Abstract June 2025

Enhancing Axonal Mitochondria by Actin Depolymerization In Optic Nerve Regeneration and Glaucomatous Neuroprotection

Yang Hu; Liang Li; Xue Feng; Fang Fang; Michaela Zdímalová; Zdenek Lansky

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1856.

ARVO Annual Meeting Abstract June 2025

Injury-responsive gene therapy for neuroprotection of retinal ganglion cells

Lucie Guo; Runxia Rain Wen; Xin Xia; Haoliang Huang; Yinglin Situ; Christina Tsien; Heather V Chang; Eeshika Mitra; Liang Li; Sui Wang; Michael Kapiloff; Lei Stanley Qi; Yang Hu; Jeffrey L Goldberg

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):2479.

ARVO Annual Meeting Abstract June 2025

Integrated visible-light OCT and fluorescence SLO to image retinal ganglion cell axons

Tianyu Xu; Weijia Fan; Roman Kuranov; Junghun Kweon; Raymond Atkinson; Cheng Sun; Yang Hu; Hao Zhang

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1936.

ARVO Annual Meeting Abstract June 2025

Spatial Transcriptomic Analysis of Mouse Glaucoma Retinas Reveals Unique Patterns of RGC Death and Microglial Infiltration

Fuyun Bian; Xue Feng; Ming Yang; Wenjun Yan; Yuyang Zeng; Yan Lin; Yang Hu

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):4004.

ARVO Annual Meeting Abstract June 2025

Delineate the functional changes of RGC subtypes in glaucomatous retinas by in vivo Ca2+ imaging at single-cell level

Liang Li; Xue Feng; Zheng Jiang; Yang Hu

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):3407.

ARVO Annual Meeting Abstract June 2025

ROCK inhibitor suppressed choroidal neovascularization by inhibiting the activation of microglia and macrophages

Jiahui Wu; Weijia Fan; Lei Xu; Mingna Liu; Shichu Chang; Emma Smith; Hu Yang; Hao Zhang; Xiaorong Liu

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):2743.

ARVO Annual Meeting Abstract June 2025

Retinal Pathoconnectome 2: Persistent Rewiring in Retinal Degeneration

Rebecca Pfeiffer; Jia-Hui Yang; James Anderson; Bryan W Jones

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):4093.

Biochemistry and Molecular Biology June 2025

Three-Dimensional Culture of Orbital Fibroblasts From Thyroid Eye Disease Induce In Vivo-Like Tissue Remodeling and Fibrosis

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Xiaoli Bao; Zhihui Xu; Xi Wang; Te Zhang; Huijing Ye; Huasheng Yang
TAGS: body tissue, fibroblasts, fibrosis, graves' ophthalmopathy, tissue remodeling, spheroids, cellular, genes, polymerase chain reaction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):67. https://doi.org/10.1167/iovs.66.6.67

Includes: Supplemental Content

Cornea June 2025

HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway

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Hua Yang; Mengzhu Liu; Shiqi Song; Qiang Xu; Jieun Lee; Jintao Sun; Shasha Xue; Xiaoyan Sun; Chengye Che
TAGS: aspergillus fumigatus, caspase-8, cornea, inflammatory response, keratitis, macrophages, mice, pyroptosis, infections, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):32. https://doi.org/10.1167/iovs.66.6.32

Biochemistry and Molecular Biology May 2025

Canonical and Truncated Transglutaminase-2 Drive TGF-β1 Autocrine Loop to Induce Fibrosis in Graves’ Orbitopathy

PDF

Xiaoli Bao; Zhihui Xu; Xi Wang; Te Zhang; Xiaotong Sha; Anqi Sun; Huijing Ye; Huasheng Yang
TAGS: fibrosis, protein glutamine gamma glutamyltransferase 2, autocrine, genes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):22. https://doi.org/10.1167/iovs.66.5.22

Includes: Supplemental Content

Cornea November 2024

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

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Yang Huang; Lijun Wang; Haiying Jin
TAGS: bilirubin, cornea, dry eye syndromes, mice, mitophagy, nadph oxidase 4, nanoparticles, ocular surfaces, pink1 gene, nitric oxide synthase
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):55. https://doi.org/10.1167/iovs.65.13.55

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

A novel function of optineurin in axonal mitochondria transport for axon integrity and regeneration

Yang Hu; Dong Liu; Hannah Webber; Fuyun Bian; Manjari Prakash; Liang Li; In Jee You; Xue Feng; Hang Yang; Liping Liu; Pingting Liu; Ming Yang; Haoliang Huang; Zdenek Lansky

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):944.

ARVO Annual Meeting Abstract June 2024

High-throughput Screening of ATF4/CHOP inhibitors as Neuroprotectants for Glaucoma

Dong Liu; Wei Chen; Hang Yang; Liang Liu; Steve Schow; Robert Lum; Yang Hu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):674.

ARVO Annual Meeting Abstract June 2024

Longitudinal Dynamic Changes of RGC Axon Bundles in Mouse Silicone Oil-Induced Ocular Hypertension Glaucoma Model Revealed by Visible-light OCT Fibergraphy

Mingshen Ma; Weijia Fan; Liang Li; Hao F Zhang; Yang Hu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2520.

ARVO Annual Meeting Abstract June 2024

Anti-lipid peroxidation promotes significant optic nerve regeneration and neuroprotection in mouse glaucoma models

Ming Yang; Liang Li; Xue Feng; Haoliang Huang; Liang Liu; Dong Liu; Fuyun Bian; Roopa Dalal; Hang Yang; Frank Cao; Petrina Ong; Alexandria Luo; Yang Hu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3255.

ARVO Annual Meeting Abstract June 2024

Diseased RGC-specific targeting with gene therapy

Yang Hu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5598.

ARVO Annual Meeting Abstract June 2024

Nme2Cas9-mediated Pten knockdown in RGCs promotes potent optic nerve regeneration after crush injury

Fuyun Bian; Xue Feng; Liang Li; Liang Liu; Yang Hu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6065.

ARVO Annual Meeting Abstract June 2024

Complement Factor D Expression in Normal and Age-Related Macular Degeneration Human Eyes

Aixu Sun; Hua Yang; Ying Hu; Jingtai Cao; Botir T Sagdullaev

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):559.

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Identification of disease-responsive neuronal promoters and enhancers for glaucoma gene therapy

The OPTN-H486R Mutation Induces Early Onset of Glaucomatous Neurodegeneration

Enhancing Axonal Mitochondria by Actin Depolymerization In Optic Nerve Regeneration and Glaucomatous Neuroprotection

Injury-responsive gene therapy for neuroprotection of retinal ganglion cells

Integrated visible-light OCT and fluorescence SLO to image retinal ganglion cell axons

Spatial Transcriptomic Analysis of Mouse Glaucoma Retinas Reveals Unique Patterns of RGC Death and Microglial Infiltration

Delineate the functional changes of RGC subtypes in glaucomatous retinas by in vivo Ca2+ imaging at single-cell level

ROCK inhibitor suppressed choroidal neovascularization by inhibiting the activation of microglia and macrophages

Retinal Pathoconnectome 2: Persistent Rewiring in Retinal Degeneration

Three-Dimensional Culture of Orbital Fibroblasts From Thyroid Eye Disease Induce In Vivo-Like Tissue Remodeling and Fibrosis

HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway

Canonical and Truncated Transglutaminase-2 Drive TGF-β1 Autocrine Loop to Induce Fibrosis in Graves’ Orbitopathy

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

A novel function of optineurin in axonal mitochondria transport for axon integrity and regeneration

High-throughput Screening of ATF4/CHOP inhibitors as Neuroprotectants for Glaucoma

Longitudinal Dynamic Changes of RGC Axon Bundles in Mouse Silicone Oil-Induced Ocular Hypertension Glaucoma Model Revealed by Visible-light OCT Fibergraphy

Anti-lipid peroxidation promotes significant optic nerve regeneration and neuroprotection in mouse glaucoma models

Diseased RGC-specific targeting with gene therapy

Nme2Cas9-mediated Pten knockdown in RGCs promotes potent optic nerve regeneration after crush injury

Complement Factor D Expression in Normal and Age-Related Macular Degeneration Human Eyes

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