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Glaucoma March 2025

Fibrosis-Related Gene and Protein Expression in Normal and Glaucomatous Trabecular Meshwork Cells

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Yong-Feng Yang; Paul Holden; Ying Ying Sun; Jennifer A. Faralli; Donna M. Peters; Kate E. Keller
TAGS: fibrosis, genes, glaucoma, proteins, trabecular meshwork
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):48. https://doi.org/10.1167/iovs.66.3.48

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Thrombospondin-1 is a novel substrate for matrix metalloproteinase-1 (MMP-1)

Paul Holden; Joanne Murphy-Ullrich; Yong-Feng Yang; Ying Ying Sun; Kate E Keller

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3577.

ARVO Annual Meeting Abstract June 2024

Molecular analyses of glaucomatous trabecular meshwork cells harboring the N700S thrombospondin-1 variant

Kate E Keller; Yong-Feng Yang; Ying Ying Sun; Joanne Murphy-Ullrich; Paul Holden

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3553.

ARVO Annual Meeting Abstract June 2024

Profiling IOP-Responsive Genes in Anterior and Posterior Ocular Tissues following a Controlled Elevation of IOP.

Diana C Lozano; Kate E Keller; Yong-Feng Yang; Eliesa Ing; William O Cepurna; John C Morrison

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3548.

Glaucoma May 2024

Profiling IOP-Responsive Genes in the Trabecular Meshwork and Optic Nerve Head in a Rat Model of Controlled Elevation of Intraocular Pressure

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Diana C. Lozano; Yong-Feng Yang; William O. Cepurna; Barbara F. Smoody; Eliesa Ing; John C. Morrison; Kate E. Keller
TAGS: genes, intraocular pressure, optic disk, gene expression, trabecular meshwork, rna
Invest. Ophthalmol. Vis. Sci.. 2024; 65(5):41. https://doi.org/10.1167/iovs.65.5.41

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Influence of hyaluronan depletion on CD44 and tunneling nanotubes in trabecular meshwork cells

Kate E Keller; Yong-feng Yang; Ying YIng Sun

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3448.

ARVO Annual Meeting Abstract June 2022

Isolation of trabecular meshwork (TM) RNA and analysis of gene expression following serial bevacizumab injections in rat eyes.

Eliesa Ing; William Cepurna; Diana C Lozano; Virginia O'Callahan; Yong-Feng Yang; Fountane Chan; Kate E Keller; John C Morrison

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2703 – A0067.

ARVO Annual Meeting Abstract June 2022

Effects of biomechanical cues on filopodia, tunneling nanotubes, and myosin-X in trabecular meshwork cells

Kate E Keller; Ying YIng Sun; Yong-Feng Yang

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3300 – A0400.

ARVO Annual Meeting Abstract June 2020

Tunneling nanotube formation by normal and glaucomatous trabecular meshwork cells in response to mechanical stretch

Kate Keller; Ying Ying Sun; Yong-feng Yang

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2331.

ARVO Annual Meeting Abstract July 2019

Identification of extracellular matrix gene variants in a large glaucoma family and analysis of human trabecular meshwork cells harboring one or more of these variants.

Kate E Keller; Ying Ying Sun; Yong-Feng Yang; Renee Sykes; Douglas Keene; John R Samples; Mary Wirtz

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5145.

Glaucoma February 2019

Myosin-X Silencing in the Trabecular Meshwork Suggests a Role for Tunneling Nanotubes in Outflow Regulation

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Ying Ying Sun; Yong-Feng Yang; Kate E. Keller
TAGS: actins, lentivirus, myosins, perfusion, regulation, trabecular meshwork, phagocytosis, proteins, western blotting, matrix metalloproteinases
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):843-851. https://doi.org/10.1167/iovs.18-26055

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

The effect of substratum on trabecular meshwork cell morphology and cellular communication by tunneling nanotubes

Kate E Keller; Yong-Feng Yang; Justin Nguyen; Ying Ying Sun

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4720.

ARVO Annual Meeting Abstract July 2018

Substrate stiffness triggers an extracellular matrix response in human trabecular meshwork cells and tissues

Janice A Vranka; Julia Staverosky; Ying Ying Sun; Yong-Feng Yang; John Bradley; Kate E Keller; Ted S Acott

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4722.

Glaucoma October 2017

Tunneling Nanotubes are Novel Cellular Structures That Communicate Signals Between Trabecular Meshwork Cells

PDF

Kate E. Keller; John M. Bradley; Ying Ying Sun; Yong-Feng Yang; Ted S. Acott
TAGS: actins, body tissue, cellular structures, trabecular meshwork, transfer technique, vesicle, diagnostic imaging, software, cd44 antigens, homing-associated cell adhesion molecule
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5298-5307. https://doi.org/10.1167/iovs.17-22732

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

The role of Myosin-X in tunneling nanotube formation by trabecular meshwork cells

Kate E Keller; John Bradley; Ying Ying Sun; Yong-feng Yang; Ted S Acott

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4691.

ARVO Annual Meeting Abstract September 2016

The role of the interleukin-20 (IL-20) family of cytokines and receptors in the normal and glaucomatous aqueous outflow pathway

Mary Wirtz; Renee Sykes; Ying Ying Sun; Yong-feng Yang; Kate E Keller

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6016.

Glaucoma September 2014

Differential Effects of Caveolin-1 and -2 Knockdown on Aqueous Outflow and Altered Extracellular Matrix Turnover in Caveolin-Silenced Trabecular Meshwork Cells

PDF

Mini Aga; John M. Bradley; Rohan Wanchu; Yong-feng Yang; Ted S. Acott; Kate E. Keller
TAGS: catabolism, caveolins, extracellular matrix, fibronectins, perfusion, proteins, trabecular meshwork, genes, lentivirus, matrix metalloproteinases
Invest. Ophthalmol. Vis. Sci.. 2014; 55(9):5497-5509. https://doi.org/10.1167/iovs.14-14519

Includes: Supplemental Content

Glaucoma August 2013

The Effects of Tenascin C Knockdown on Trabecular Meshwork Outflow Resistance

PDF

Kate E. Keller; Janice A. Vranka; Ramez I. Haddadin; Min-Hyung Kang; Dong-Jin Oh; Douglas J. Rhee; Yong-feng Yang; Ying Ying Sun; Mary J. Kelley; Ted S. Acott
TAGS: tenascin, trabecular meshwork, proteins, rna, messenger, eye
Invest. Ophthalmol. Vis. Sci.. 2013; 54(8):5613-5623. https://doi.org/10.1167/iovs.13-11620

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2013

ADAMTS4 activity and TIMP3 levels are modulated in trabecular meshwork cells with decreased hyaluronan synthesis

Kate Keller; Yong-Feng Yang; Ying Ying Sun; Ted Acott

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):3546.

Glaucoma July 2012

Perturbation of Hyaluronan Synthesis in the Trabecular Meshwork and the Effects on Outflow Facility

PDF

Kate E. Keller; Ying Ying Sun; Yong-Feng Yang; John M. Bradley; Ted S. Acott
TAGS: enzyme-linked immunosorbent assay, eye, genes, hyaluronan, lentivirus, perfusion, perturbations, suidae, trabecular meshwork, body tissue
Invest. Ophthalmol. Vis. Sci.. 2012; 53(8):4616-4625. https://doi.org/10.1167/iovs.12-9500

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Fibrosis-Related Gene and Protein Expression in Normal and Glaucomatous Trabecular Meshwork Cells

Thrombospondin-1 is a novel substrate for matrix metalloproteinase-1 (MMP-1)

Molecular analyses of glaucomatous trabecular meshwork cells harboring the N700S thrombospondin-1 variant

Profiling IOP-Responsive Genes in Anterior and Posterior Ocular Tissues following a Controlled Elevation of IOP.

Profiling IOP-Responsive Genes in the Trabecular Meshwork and Optic Nerve Head in a Rat Model of Controlled Elevation of Intraocular Pressure

Influence of hyaluronan depletion on CD44 and tunneling nanotubes in trabecular meshwork cells

Isolation of trabecular meshwork (TM) RNA and analysis of gene expression following serial bevacizumab injections in rat eyes.

Effects of biomechanical cues on filopodia, tunneling nanotubes, and myosin-X in trabecular meshwork cells

Tunneling nanotube formation by normal and glaucomatous trabecular meshwork cells in response to mechanical stretch

Identification of extracellular matrix gene variants in a large glaucoma family and analysis of human trabecular meshwork cells harboring one or more of these variants.

Myosin-X Silencing in the Trabecular Meshwork Suggests a Role for Tunneling Nanotubes in Outflow Regulation

The effect of substratum on trabecular meshwork cell morphology and cellular communication by tunneling nanotubes

Substrate stiffness triggers an extracellular matrix response in human trabecular meshwork cells and tissues

Tunneling Nanotubes are Novel Cellular Structures That Communicate Signals Between Trabecular Meshwork Cells

The role of Myosin-X in tunneling nanotube formation by trabecular meshwork cells

The role of the interleukin-20 (IL-20) family of cytokines and receptors in the normal and glaucomatous aqueous outflow pathway

Differential Effects of Caveolin-1 and -2 Knockdown on Aqueous Outflow and Altered Extracellular Matrix Turnover in Caveolin-Silenced Trabecular Meshwork Cells

The Effects of Tenascin C Knockdown on Trabecular Meshwork Outflow Resistance

ADAMTS4 activity and TIMP3 levels are modulated in trabecular meshwork cells with decreased hyaluronan synthesis

Perturbation of Hyaluronan Synthesis in the Trabecular Meshwork and the Effects on Outflow Facility

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