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ARVO Annual Meeting Abstract June 2024

SORTILIN INHIBITION PROTECTS THE RETINA BY REDUCING INFLAMMATION AND LYSOSOMAL ACTIVITY

Jena J Steinle; Li Liu; youde Jiang

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3839.

ARVO Annual Meeting Abstract June 2022

TNFAIP3 may be key to TLR4-activation of the inflammasome in the retinal vasculature

Li Liu; Youde Jiang; Jena Jean Steinle

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):276 – F0321.

Retinal Cell Biology January 2022

PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature

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Li Liu; Youde Jiang; Jena J. Steinle
TAGS: inflammasomes, nlr family, pyrin domain-containing 3 protein, proteins, mice, dna, complementary, retinal vasculature
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):14. https://doi.org/10.1167/iovs.63.1.14

Retinal Cell Biology September 2020

Epac1 Requires AMPK Phosphorylation to Regulate HMGB1 in the Retinal Vasculature

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Youde Jiang; Jena J. Steinle
TAGS: ampk, hmgb1 protein, phosphorylation, retina, retinal vasculature, glucose
Invest. Ophthalmol. Vis. Sci.. 2020; 61(11):33. https://doi.org/10.1167/iovs.61.11.33

ARVO Annual Meeting Abstract July 2018

miRNA15 Regulates Insulin Signal Transduction in the Retinal Vasculature

Youde Jiang; Li Liu; Jena J Steinle

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3540.

ARVO Annual Meeting Abstract July 2018

Loss of TLR4 in Mouse Müller cells inhibits both MyD88-dependent and –independent signaling

Li Liu; Youde Jiang; Jena J Steinle

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3541.

ARVO Annual Meeting Abstract July 2018

miR15a Regulates NLRP3 Inflammasome Actions in the Retinal Vasculature

Elizabeth Curtiss; Li Liu; Youde Jiang; Jena J Steinle

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3547.

ARVO Annual Meeting Abstract June 2017

TLR4 inhibits insulin signaling, leading to increased apoptosis in mouse retina

Youde Jiang; Li Liu; Elizabeth Curtiss; Jena J Steinle

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4045.

ARVO Annual Meeting Abstract June 2017

TLR4 plays an important role in regulating ZO-1 and occludin levels, as well as retinal damage following ischemia-reperfusion injury

Li Liu; Youde Jiang; Elizabeth Curtiss; Jena J Steinle

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5203.

Retinal Cell Biology January 2017

Compound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature

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Youde Jiang; Li Liu; Jena J. Steinle
TAGS: endothelial cells, mice, proteins, retinal vasculature, vascular endothelial growth factor a, permeability, glucose, rna, small interfering, western blotting
Invest. Ophthalmol. Vis. Sci.. 2017; 58(1):185-189. https://doi.org/10.1167/iovs.16-20412

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Epac1 is required for Beta-Adrenergic Receptor Regulation of VEGF in Retinal Endothelial Cells Grown in High Glucose

Youde Jiang; Jena J Steinle

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3212.

ARVO Annual Meeting Abstract June 2015

IGFBP-3 Regulates VEGF through PKCzeta in retinal endothelial cells cultured in high glucose

Youde Jiang; Jena Steinle

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5177.

ARVO Annual Meeting Abstract June 2015

IGFBP-3 is not required for Compound 49b’s reduction of TNFa-induced insulin resistance in the diabetic rat retina

Bradley T Gao; Youde Jiang; Qiuhua Zhang; Vanessa Marie Morales; Jena J Steinle

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5187.

ARVO Annual Meeting Abstract April 2014

Modulation of Cytoskeletal Adaptor Proteins in Uveal Melanoma to Control Metastasis

Vanessa Marie Morales; Ryan Yates; Jordan J Toutounchian; Mercy W Kibe; Duane Miller; Youde Jiang; Jena J Steinle; Pia R. Mendoza; Hans E Grossniklaus; Matthew W Wilson

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3578.

ARVO Annual Meeting Abstract April 2014

Intravitreal injection of IGFBP-3 restores normal insulin signaling in diabetic rat retina

Qiuhua Zhang; Youde Jiang; Jena J Steinle

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5826.

ARVO Annual Meeting Abstract April 2014

Serine 307 on Insulin Receptor Substrate 1 is Key to Tumor Necrosis Factor alpha and Suppressor of Cytokine Signaling 3 Action in Müller cells

Youde Jiang; Qiuhua Zhang; Jena J Steinle

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5828.

Translational Research September 2013

Novel Quinic Acid Derivative KZ-41 Prevents Retinal Endothelial Cell Apoptosis Without Inhibiting Retinoblastoma Cell Death Through p38 Signaling

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Qiuhua Zhang; Youde Jiang; Jordan Toutounchian; Matthew W. Wilson; Vanessa Morales-Tirado; Duane D. Miller; C. Ryan Yates; Jena J. Steinle
TAGS: apoptosis, cell death, intercellular adhesion molecule 1, melphalan, quinic acid, retinoblastoma, endothelial cells, mitogen-activated protein kinase p38, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2013; 54(9):5937-5943. https://doi.org/10.1167/iovs.13-12326

Retinal Cell Biology August 2013

IGFBP-3 and TNF-α Regulate Retinal Endothelial Cell Apoptosis

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Qiuhua Zhang; Youde Jiang; Matthew J. Miller; Bonnie Peng; Li Liu; Carl Soderland; Jie Tang; Timothy S. Kern; John Pintar; Jena J. Steinle
TAGS: insulin-like growth factor binding protein 3, tumor necrosis factors, mice
Invest. Ophthalmol. Vis. Sci.. 2013; 54(8):5376-5384. https://doi.org/10.1167/iovs.13-12497

ARVO Annual Meeting Abstract June 2013

Compound 49b protects against blast-induced retinal injury

Youde Jiang; Jena Steinle

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):1183.

ARVO Annual Meeting Abstract June 2013

KNOCKOUT OF IGFBP-3 IN MICE PRODUCES CHANGES SIMILAR TO CHRONIC DIABETES IN THE RETINA

Jena Steinle; Youde Jiang; Qiuhua Zhang; Li Liu; Bonnie Peng; John Pintar; Timothy Kern

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):5559.

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SORTILIN INHIBITION PROTECTS THE RETINA BY REDUCING INFLAMMATION AND LYSOSOMAL ACTIVITY

TNFAIP3 may be key to TLR4-activation of the inflammasome in the retinal vasculature

PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature

Epac1 Requires AMPK Phosphorylation to Regulate HMGB1 in the Retinal Vasculature

miRNA15 Regulates Insulin Signal Transduction in the Retinal Vasculature

Loss of TLR4 in Mouse Müller cells inhibits both MyD88-dependent and –independent signaling

miR15a Regulates NLRP3 Inflammasome Actions in the Retinal Vasculature

TLR4 inhibits insulin signaling, leading to increased apoptosis in mouse retina

TLR4 plays an important role in regulating ZO-1 and occludin levels, as well as retinal damage following ischemia-reperfusion injury

Compound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature

Epac1 is required for Beta-Adrenergic Receptor Regulation of VEGF in Retinal Endothelial Cells Grown in High Glucose

IGFBP-3 Regulates VEGF through PKCzeta in retinal endothelial cells cultured in high glucose

IGFBP-3 is not required for Compound 49b’s reduction of TNFa-induced insulin resistance in the diabetic rat retina

Modulation of Cytoskeletal Adaptor Proteins in Uveal Melanoma to Control Metastasis

Intravitreal injection of IGFBP-3 restores normal insulin signaling in diabetic rat retina

Serine 307 on Insulin Receptor Substrate 1 is Key to Tumor Necrosis Factor alpha and Suppressor of Cytokine Signaling 3 Action in Müller cells

Novel Quinic Acid Derivative KZ-41 Prevents Retinal Endothelial Cell Apoptosis Without Inhibiting Retinoblastoma Cell Death Through p38 Signaling

IGFBP-3 and TNF-α Regulate Retinal Endothelial Cell Apoptosis

Compound 49b protects against blast-induced retinal injury

KNOCKOUT OF IGFBP-3 IN MICE PRODUCES CHANGES SIMILAR TO CHRONIC DIABETES IN THE RETINA

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