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ARVO Annual Meeting Abstract July 2018

Nucleoside reverse transcriptase inhibitors are broad-spectrum RPE protectants

Shuichiro Hirahara; Shinichi Fukuda; Younghee Kim; Reo Yasuma; Kameshwari Ambati; Junichi Fukuhara; Dongxu Fu; DAIPAYAN BANERJEE; Benjamin J Fowler; Tetsuhiro Yasuma; Nagaraj Kerur; Bradley Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2459. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2018

Nucleoside reverse transcriptase inhibitors (NRTI) prevent inflammasome activation in retinal pigmented epithelium cells.

DAIPAYAN BANERJEE; Junichi Fukuhara; Dongxu Fu; Shinichi Fukuda; Shuichiro Hirahara; Younghee Kim; Benjamin J Fowler; Tetsuhiro Yasuma; Reo Yasuma; Kameshwari Ambati; Nagaraj Kerur; Bradley Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2475. doi: https://doi.org/

ARVO Annual Meeting Abstract September 2016

Nucleoside reverse transcriptase inhibitors are anti-inflammatory and inhibit poly I:C-induced retinal pigment epithelium degeneration

Shinichi Fukuda; Junichi Fukuhara; Younghee Kim; Benjamin Fowler; Tetsuhiro Yasuma; Reo Yasuma; Takako Fukuhara; Nagaraj Kerur; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6551. doi: https://doi.org/

ARVO Annual Meeting Abstract September 2016

Nucleoside reverse transcriptase inhibitors attenuate amyloid-beta-induced retinal pigment epithelium degeneration

Takako Fukuhara; Junichi Fukuhara; Younghee Kim; Tetsuhiro Yasuma; Reo Yasuma; Benjamin Fowler; Shinichi Fukuda; Nagaraj Kerur; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6552. doi: https://doi.org/

ARVO Annual Meeting Abstract September 2016

Non-canonical NLRP3 Inflammasome activation in Geographic Atrophy

Nagaraj Kerur; Younghee Kim; Shinichi Fukuda; Reo Yasuma; Ana Bastos-Carvalho; Daipayan Banerjee; Benjamin Fowler; Tetsuhiro Yasuma; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):486. doi: https://doi.org/

ARVO Annual Meeting Abstract September 2016

Role of interferon signaling in Alu RNA-induced AMD

Daipayan Banerjee; Younghee Kim; Shinichi Fukuda; Reo Yasuma; Ana Bastos-Carvalho; Benjamin Fowler; Tetsuhiro Yasuma; Bradley D Gelfand; Nagaraj Kerur; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):487. doi: https://doi.org/

ARVO Annual Meeting Abstract September 2016

Subcutaneous IL-18 administration does not inhibit laser CNV in mice

Tetsuhiro Yasuma; Reo Yasuma; Bradley D Gelfand; Nagaraj Kerur; Ana Bastos-Carvalho; Younghee Kim; Charles B Wright; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4518. doi: https://doi.org/

ARVO Annual Meeting Abstract September 2016

Nucleoside reverse transcriptase inhibitors prevent iron-induced retinal pigment epithelium cell death

Junichi Fukuhara; Younghee Kim; Tetsuhiro Yasuma; Reo Yasuma; Benjamin Fowler; Shinichi Fukuda; Takako Fukuhara; Nagaraj Kerur; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5005. doi: https://doi.org/

Retinal Cell Biology November 2015

Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice

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Takeshi Mizutani; Benjamin J. Fowler; Younghee Kim; Reo Yasuma; Laura A. Krueger; Bradley D. Gelfand; Jayakrishna Ambati
TAGS: vascular endothelial growth factor a, choroidal neovascularization, lasers, mice, nucleoside reverse transcriptase inhibitors, p2rx7 gene
Invest. Ophthalmol. Vis. Sci.. 2015; 56(12):7122-7129. doi: https://doi.org/10.1167/iovs.15-17440

ARVO Annual Meeting Abstract June 2015

Nucleoside reverse transcriptase inhibitor (NRTI) protection against iron cytotoxicity

Charles B Wright; Younghee Kim; Tetsuhiro Yasuma; Reo Yasuma; Shengjian Li; Benjamin J Fowler; Ana Bastos-Carvalho; Mark Ellsworth Kleinman; Jayakrishna Ambati; Bradley D Gelfand

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4211. doi: https://doi.org/

ARVO Annual Meeting Abstract April 2014

Dideoxy-nucleosides are anti-inflammatory and inhibit RPE degeneration independent of reverse transcriptase inhibition

Benjamin Fowler; Younghee Kim; Yoshio Hirano; Nagaraj Kerur; Valeria Tarallo; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1735. doi: https://doi.org/

ARVO Annual Meeting Abstract April 2014

Dual anti-angiogenic activity of Bevacizumab from its IgG1-Fc domain and VEGF neutralization

Takeshi Mizutani; Nagaraj Kerur; Shengjian Li; Younghee Kim; Reo Yasuma; Tetsuhiro Yasuma; Ana Bastos-Carvalho; Benjamin Fowler; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1936. doi: https://doi.org/

ARVO Annual Meeting Abstract April 2014

Generic, target-independent suppression of choroidal neovascularization by human IgG1 antibodies via Fc gamma receptor I

Tetsuhiro Yasuma; Reo Yasuma; Younghee Kim; Takeshi Mizutani; Nagaraj Kerur; Ana Bastos-Carvalho; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1937. doi: https://doi.org/

ARVO Annual Meeting Abstract April 2014

Enhanced Alu RNA stability due to iron-mediated DICER1 impairment causes NLRP3 inflammasome priming

Charles B Wright; Younghee Kim; Tetsuhiro Yasuma; Shengjian Li; Benjamin J Fowler; Mark Ellsworth Kleinman; Jayakrishna Ambati; Bradley D Gelfand

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2187. doi: https://doi.org/

ARVO Annual Meeting Abstract April 2014

Myd88 as a therapeutic target for choroidal neovascularization

Nagaraj Kerur; Younghee Kim; Yoshio Hirano; Valeria Tarallo; Ana Bastos-Carvalho; Benjamin Fowler; Tetsuhiro Yasuma; Reo Yasuma; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2195. doi: https://doi.org/

ARVO Annual Meeting Abstract April 2014

Human therapeutic monoclonal antibodies inhibit corneal neovascularization via FcγRI in a target-independent manner

Ana Bastos-Carvalho; Sasha Bogdanovich; Younghee Kim; Reo Yasuma; Takeshi Mizutani; Nagaraj Kerur; Tetsuhiro Yasuma; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5049. doi: https://doi.org/

ARVO Annual Meeting Abstract April 2014

Extracellular HMGB1 promotes choroidal angiogenesis

Younghee Kim; Nagaraj Kerur; Shengjian Li; Ana Bastos-Carvalho; Bradley D Gelfand; William W Hauswirth; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4459. doi: https://doi.org/

ARVO Annual Meeting Abstract April 2014

Intravenous immunoglobulin treatment inhibits choroidal and corneal neovascularization via FcyR1

Reo Yasuma; Sasha Bogdanovich; Younghee Kim; Tetsuhiro Yasuma; Takeshi Mizutani; Ana Bastos-Carvalho; Benjamin Fowler; shengjian li; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1190. doi: https://doi.org/

ARVO Annual Meeting Abstract April 2014

The Fc fragments of Bevacizumab or IVIG suppress choroidal neovascularization

shengjian li; Nagaraj Kerur; Sasha Bogdanovich; Reo Yasuma; Younghee Kim; Takeshi Mizutani; Ana Bastos-Carvalho; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1191. doi: https://doi.org/

Retinal Cell Biology November 2013

TLR-Independent and P2X7-Dependent Signaling Mediate Alu RNA-Induced NLRP3 Inflammasome Activation in Geographic Atrophy

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Nagaraj Kerur; Yoshio Hirano; Valeria Tarallo; Benjamin J. Fowler; Ana Bastos-Carvalho; Tetsuhiro Yasuma; Reo Yasuma; Younghee Kim; David R. Hinton; Carsten J. Kirschning; Bradley D. Gelfand; Jayakrishna Ambati
TAGS: signal transduction, atrophy, atrophic condition of skin, rna, p2rx7 gene, tissue degeneration, inflammasomes
Invest. Ophthalmol. Vis. Sci.. 2013; 54(12):7395-7401. doi: https://doi.org/10.1167/iovs.13-12500

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Nucleoside reverse transcriptase inhibitors are broad-spectrum RPE protectants

Nucleoside reverse transcriptase inhibitors (NRTI) prevent inflammasome activation in retinal pigmented epithelium cells.

Nucleoside reverse transcriptase inhibitors are anti-inflammatory and inhibit poly I:C-induced retinal pigment epithelium degeneration

Nucleoside reverse transcriptase inhibitors attenuate amyloid-beta-induced retinal pigment epithelium degeneration

Non-canonical NLRP3 Inflammasome activation in Geographic Atrophy

Role of interferon signaling in Alu RNA-induced AMD

Subcutaneous IL-18 administration does not inhibit laser CNV in mice

Nucleoside reverse transcriptase inhibitors prevent iron-induced retinal pigment epithelium cell death

Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice

Nucleoside reverse transcriptase inhibitor (NRTI) protection against iron cytotoxicity

Dideoxy-nucleosides are anti-inflammatory and inhibit RPE degeneration independent of reverse transcriptase inhibition

Dual anti-angiogenic activity of Bevacizumab from its IgG1-Fc domain and VEGF neutralization

Generic, target-independent suppression of choroidal neovascularization by human IgG1 antibodies via Fc gamma receptor I

Enhanced Alu RNA stability due to iron-mediated DICER1 impairment causes NLRP3 inflammasome priming

Myd88 as a therapeutic target for choroidal neovascularization

Human therapeutic monoclonal antibodies inhibit corneal neovascularization via FcγRI in a target-independent manner

Extracellular HMGB1 promotes choroidal angiogenesis

Intravenous immunoglobulin treatment inhibits choroidal and corneal neovascularization via FcyR1

The Fc fragments of Bevacizumab or IVIG suppress choroidal neovascularization

TLR-Independent and P2X7-Dependent Signaling Mediate Alu RNA-Induced NLRP3 Inflammasome Activation in Geographic Atrophy

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