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ARVO Annual Meeting Abstract June 2024

Brain-derived neurotrophic factor in retinal integrity under diabetic and hypoxic conditions

Yun-Zheng Le; Bei Xu; Ana J Chucair-Elliott; Huiru Zhang; Meili Zhu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3951.

ARVO Annual Meeting Abstract June 2023

VEGF as direct functional regulator of photoreceptors and major contributing factor for reduced retinal function in hypoxic and diabetic retinal disorders

Yun-Zheng Le; Meili Zhu

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):571.

Retina August 2022

Dependence of Retinal Pigment Epithelium Integrity on the NRF2–Heme Oxygenase-1 Axis

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Yida Jiang; Li-Juan Duan; Jingbo Pi; Yun-Zheng Le; Guo-Hua Fong
TAGS: body tissue, heme, mice, oxidative stress, oxygenases, painful bladder syndrome, personal integrity, retinal pigment cell, retinal pigment epithelium, eye
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):30. https://doi.org/10.1167/iovs.63.9.30

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2022

VEGF as a direct regulator of photoreceptor function and a major contributing factor for altering photoreceptor function in diabetes and hypoxia

Yun-Zheng Le; Jianyan Hu; Meili Zhu; Dai Li; Qiang Wu

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4111 – F0348.

ARVO Annual Meeting Abstract June 2020

GDNF and BDNF are positive regulators for Müller cell viability through similar but divergent mechanisms

Yun-Zheng Le; Meili Zhu

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1173.

ARVO Annual Meeting Abstract July 2019

The Contribution of Endoplasmic Reticulum Calcium Deficiency to Mistrafficking of Cone Outer Segment Proteins in CNG Channel Deficiency

Hongwei Ma; Fan Yang; Michael Robert Butler; Jacob Rapp; Yun-Zheng Le; Katsuhiko Mikoshiba; Martin Biel; Stylianos Michalakis; Xi-Qin Ding

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4207.

ARVO Annual Meeting Abstract July 2019

Mechanism of BDNF-mediated neuroprotection: critical role of Müller glia in diabetic retinopathy and age-related macular degeneration

Yun-Zheng Le; Fangfang Qiu; Meili Zhu

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4402.

ARVO Annual Meeting Abstract July 2019

The Role of Endoplasmic Reticulum (ER) Calcium Channels in ER Stress and Cone Death in CNG Channel Deficiency

Michael Robert Butler; Hongwei Ma; Fan Yang; Jacob Rapp; Yun-Zheng Le; Katsuhiko Mikoshiba; Martin Biel; Stylianos Michalakis; Xi-Qin Ding

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4864.

ARVO Annual Meeting Abstract July 2018

Mechanisms of Müller glia-mediated neuroprotection in diabetic retinopathy and hypoxic retinal diseases

Yun-Zheng Le; Meili Zhu

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2505.

ARVO Annual Meeting Abstract June 2017

Synergistic effect among BDNF, GDNF, or VEGF on protecting Müller cells in hypoxia: implication in neuroprotection in age-related macular degeneration and diabetic retinopathy and in anti-VEGF therapies

Yun-Zheng Le; Mei Zhu

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5398.

ARVO Annual Meeting Abstract June 2017

Elamipretide Protects RPE and Improves Mitochondrial Function in Models of AMD

Rebecca Kapphahn; Marcia Terluk; Mara Ebeling; Mark Pierson; Kevin Mar; Hwee Gong; Sandra Monetzuma; Yun-Zheng Le; Takuji Shirasawa; Takahiko Shimizu; Deborah A Ferrington

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1954.

ARVO Annual Meeting Abstract September 2016

RPE cell specific loss of ERK1/2 leads to retinal degeneration.

Aswin Pyakurel; Delphine Balmer; Mei L Zhu; Marck Saba El Leil; Jean Daraspe; Bruno Humbel; Laure Voisin; Yun-Zheng Le; Johannes Von Lintig; Sylvain Meloche; Raphael Roduit

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3176.

ARVO Annual Meeting Abstract September 2016

Neuroprotective role of GDNF and BDNF in diabetic retinopathy

Yun-Zheng Le; Mei L Zhu

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3232.

ARVO Annual Meeting Abstract June 2015

Uniqueness and significance of RPE barrier breakdown in diabetic retinopathy

Yun-Zheng Le; Meili Zhu

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4274.

ARVO Annual Meeting Abstract June 2015

RPE-specific deletion of murine Atg5 or Atg7 causes AMD-like features and retinal degeneration

Youwen Zhang; Samuel D Cross; Yong Lee; James Brett Stanton; Lori A Bachman; Yun-Zheng Le; Alan D Marmorstein; Lihua Y Marmorstein

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2397.

Biochemistry and Molecular Biology July 2014

Mitochondrial Oxidative Stress in the Retinal Pigment Epithelium Leads to Localized Retinal Degeneration

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Haoyu Mao; Soo Jung Seo; Manas R. Biswal; Hong Li; Mandy Conners; Arathi Nandyala; Kyle Jones; Yun-Zheng Le; Alfred S. Lewin
TAGS: atrophy, mice, oxidative stress, retinal degeneration, mitochondria, doxycycline, electroretinography, eye
Invest. Ophthalmol. Vis. Sci.. 2014; 55(7):4613-4627. https://doi.org/10.1167/iovs.14-14633

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

Molecular regulation in rhodopsin transport

Ya-Chu Hsu; Jen-Zen Chuang; Ching-Kang Jason Chen; Yu-Ting Yan; Yun-Zheng Le; Ching-Hwa Sung

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4377.

ARVO Annual Meeting Abstract April 2014

Efficient induction of productive Cre-mediated recombination in the retinal pigment epithelium

Yun-Zheng Le; Meili Zhu

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4563.

ARVO Annual Meeting Abstract June 2013

Testing the effect of RPE barrier function regulators in vitro and in vivo

Meili Zhu; Yun-Zheng Le

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):1770.

ARVO Annual Meeting Abstract June 2013

VEGF receptor-2 mediated neuro-protection is required for cone photoreceptor survival under hypoxic condition

Yun-Zheng Le; Meili Zhu

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):3261.

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Brain-derived neurotrophic factor in retinal integrity under diabetic and hypoxic conditions

VEGF as direct functional regulator of photoreceptors and major contributing factor for reduced retinal function in hypoxic and diabetic retinal disorders

Dependence of Retinal Pigment Epithelium Integrity on the NRF2–Heme Oxygenase-1 Axis

VEGF as a direct regulator of photoreceptor function and a major contributing factor for altering photoreceptor function in diabetes and hypoxia

GDNF and BDNF are positive regulators for Müller cell viability through similar but divergent mechanisms

The Contribution of Endoplasmic Reticulum Calcium Deficiency to Mistrafficking of Cone Outer Segment Proteins in CNG Channel Deficiency

Mechanism of BDNF-mediated neuroprotection: critical role of Müller glia in diabetic retinopathy and age-related macular degeneration

The Role of Endoplasmic Reticulum (ER) Calcium Channels in ER Stress and Cone Death in CNG Channel Deficiency

Mechanisms of Müller glia-mediated neuroprotection in diabetic retinopathy and hypoxic retinal diseases

Synergistic effect among BDNF, GDNF, or VEGF on protecting Müller cells in hypoxia: implication in neuroprotection in age-related macular degeneration and diabetic retinopathy and in anti-VEGF therapies

Elamipretide Protects RPE and Improves Mitochondrial Function in Models of AMD

RPE cell specific loss of ERK1/2 leads to retinal degeneration.

Neuroprotective role of GDNF and BDNF in diabetic retinopathy

Uniqueness and significance of RPE barrier breakdown in diabetic retinopathy

RPE-specific deletion of murine Atg5 or Atg7 causes AMD-like features and retinal degeneration

Mitochondrial Oxidative Stress in the Retinal Pigment Epithelium Leads to Localized Retinal Degeneration

Molecular regulation in rhodopsin transport

Efficient induction of productive Cre-mediated recombination in the retinal pigment epithelium

Testing the effect of RPE barrier function regulators in vitro and in vivo

VEGF receptor-2 mediated neuro-protection is required for cone photoreceptor survival under hypoxic condition

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