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ARVO Annual Meeting Abstract June 2022

Evaluation of ampyrone (4-aminoantipyrine), an activator of the intra-melanosomal domain of human tyrosinase, as a potential therapeutic agent for oculocutaneous albinism type 1B

VIJAY KUMAR KALASKAR; Monika Dolinska; Nathan Coussens; Sunit Dutta; Ighovie F Onojafe; Yingyos Jittayasothorn; Ramakrishna Prasad alur; Dhyanam Shukla; Robin Kee; Maria M Campos; Mones Abu-Asab; Tiziana Cogliati; YURI SERGEEV; Brian Patrick Brooks

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):676 – F0130.

ARVO Annual Meeting Abstract June 2022

Genetic analysis of familial AMD cohort identifies genes associated with disease susceptibility

Lina Zelinger; Tammy M Martin; Jayshree Advani; Milton English; Alan Kwong; Claire Malley; Jennifer Maykoski; YURI SERGEEV; Robert N Fariss; Emily Y Chew; Michael L Klein; Anand Swaroop

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2626.

ARVO Annual Meeting Abstract June 2021

Tyrosinase Immobilized to Ni-NTA Magnetic Beads Shows Improved Protein Thermostability

Paul Varghese; Mones Abu-Asab; Emilios Dimitriadis; Monika B. Dolinska; George Morcos; Yuri V. Sergeev

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2995.

ARVO Annual Meeting Abstract June 2021

Characterization of Temperature-Dependent Kinetics of Oculocutaneous Albinism-Causing Mutant of Tyrosinase

Samuel Wachamo; Paul Varghese; Monika B. Dolinska; Yuri V. Sergeev

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2988.

ARVO Annual Meeting Abstract June 2021

In silico Characterization of Tyrp1 Molecular Docking and Associated OCA3 Mutants

Milan H. Patel; Monika B. Dolinska; Yuri V. Sergeev

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2975.

ARVO Annual Meeting Abstract June 2020

Functional I n Silico Analysis of Human Tyrosinase and OCA1 Associated Mutations

Milan Patel; Claudi Kassouf; Yuri V Sergeev

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5010.

ARVO Annual Meeting Abstract June 2020

Isolation of DOPAchrome by characterizing and utilizing Tyrosinase bound Ni-NTA Magnetic Beads

Paul Varghese; Yuri V Sergeev; Emilios Dimitriadis; George Morcos; Monika Dolinska

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5022.

ARVO Annual Meeting Abstract July 2019

NEI Ocular Proteome Database: A Description of Inherited Eye Disease Proteins and Their Stability Changes by a Computational Global Mutagenesis.

Claudia Kassouf; Caitlyn McCafferty; Yuri V Sergeev; Francisca Wood Ortiz

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):386.

ARVO Annual Meeting Abstract July 2019

Molecular modeling and global computational mutagenesis of ABCA4 protein show a role of missense changes in Stargardt’s disease.

Yuri V Sergeev; Kaoru Fujinami; Benedetto Falsini; Wadih M Zein; Kerry Goetz; Yu Yokokawa Fujinami; Se Joon Woo; Shiying Li; Matteo Bertelli; Winston Lee; Jana Zernant; Rando Allikmets; Andrew Webster; Michel Michaelides; Brian Patrick Brooks; Paul A Sieving

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3872.

ARVO Annual Meeting Abstract July 2019

Title: Human Tyrosinase: Temperature-dependent Estimation of Gibbs Energies of Oxidase Activity

Kenneth Lee Young II; Claudia Kassouf; Monika Dolinska; David Anderson; Yuri V. Sergeev

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5684.

ARVO Annual Meeting Abstract July 2018

The Tyrp1 protection of human tyrosinase activity do not involve interaction between tyrosinase domains.

Monika Barbara Dolinska; Kenneth Young; Paul Wingfield; Brian Patrick Brooks; Yuri Sergeev

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2359.

ARVO Annual Meeting Abstract July 2018

Global computational mutagenesis of ocular proteome indicates a role of protein destabilization in inherited eye disease.

Yuri Sergeev; Francisca Wood Ortiz; Mikhail Laryukhin; Caitlyn McCafferty

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2365.

ARVO Annual Meeting Abstract June 2017

Purification and Characterization of Recombinant Human Tyrosinase Related Protein 1

Kenneth Lee Young II; Monika Dolinksa; Paul Wingfield; Eugenia Poliakov; Yuri V Sergeev

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):626.

ARVO Annual Meeting Abstract June 2017

Frequent hypomorphic alleles solve 80% of late-onset ABCA4 disease and distinguish it from age-related macular degeneration

Rando Allikmets; Jana Zernant; Frederick T Collison; Gerald A Fishman; Yuri V Sergeev; Kaspar Schuerch; Janet R Sparrow; Stephen Tsang; Winston Lee

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1240.

ARVO Annual Meeting Abstract June 2017

βA3/A1-Crystallin/SLC36A4/V-ATPase complex in the RPE is a novel therapeutic target for AMD

Peng Shang; Mallika Valapala; Stacey L Hose; Jun Wan; Jiang Qian; Yuri V Sergeev; J. Samuel Zigler, Jr.; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3384.

ARVO Annual Meeting Abstract September 2016

The National Eye Institute Prospective ABCA4 Retinopathy Natural History Study: Autofluorescence Imaging Analysis

Laryssa Huryn; Brett G Jeffrey; Aarti Hinduja; Catherine A Cukras; Wadih M Zein; Robert B Hufnagel; Yuri V Sergeev; Benedetto Falsini; Amy Turriff; Denise Cunningham; Brian Patrick Brooks

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):140.

ARVO Annual Meeting Abstract September 2016

A Computational Analysis of Human Tyrosinase to Further Understanding of Oculocutaneous Albinism Type 1

Katie Farney; Monika B Dolinska; Yuri V Sergeev

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):670.

ARVO Annual Meeting Abstract September 2016

Purification and biochemical characterization of full-length human tyrosinase

Nicole Joanne Kus; Monika B Dolinska; Yuri V Sergeev

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1723.

ARVO Annual Meeting Abstract September 2016

Unfolding mutation screen for inherited eye disease

Caitlyn McCafferty; Yuri V Sergeev

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3162.

ARVO Annual Meeting Abstract September 2016

In-silico unfolding: a role of missense changes in Stargardt’s disease.

Yuri V Sergeev; Caitlyn McCafferty; Kaoru Fujinami; Benedetto Falsini; Wadih M Zein; Kanishka Thiran Jayasundera; Michel Michaelides; Brian Patrick Brooks; Paul A Sieving

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3163.

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Evaluation of ampyrone (4-aminoantipyrine), an activator of the intra-melanosomal domain of human tyrosinase, as a potential therapeutic agent for oculocutaneous albinism type 1B

Genetic analysis of familial AMD cohort identifies genes associated with disease susceptibility

Tyrosinase Immobilized to Ni-NTA Magnetic Beads Shows Improved Protein Thermostability

Characterization of Temperature-Dependent Kinetics of Oculocutaneous Albinism-Causing Mutant of Tyrosinase

In silico Characterization of Tyrp1 Molecular Docking and Associated OCA3 Mutants

Functional I n Silico Analysis of Human Tyrosinase and OCA1 Associated Mutations

Isolation of DOPAchrome by characterizing and utilizing Tyrosinase bound Ni-NTA Magnetic Beads

NEI Ocular Proteome Database: A Description of Inherited Eye Disease Proteins and Their Stability Changes by a Computational Global Mutagenesis.

Molecular modeling and global computational mutagenesis of ABCA4 protein show a role of missense changes in Stargardt’s disease.

Title: Human Tyrosinase: Temperature-dependent Estimation of Gibbs Energies of Oxidase Activity

The Tyrp1 protection of human tyrosinase activity do not involve interaction between tyrosinase domains.

Global computational mutagenesis of ocular proteome indicates a role of protein destabilization in inherited eye disease.

Purification and Characterization of Recombinant Human Tyrosinase Related Protein 1

Frequent hypomorphic alleles solve 80% of late-onset ABCA4 disease and distinguish it from age-related macular degeneration

βA3/A1-Crystallin/SLC36A4/V-ATPase complex in the RPE is a novel therapeutic target for AMD

The National Eye Institute Prospective ABCA4 Retinopathy Natural History Study: Autofluorescence Imaging Analysis

A Computational Analysis of Human Tyrosinase to Further Understanding of Oculocutaneous Albinism Type 1

Purification and biochemical characterization of full-length human tyrosinase

Unfolding mutation screen for inherited eye disease

In-silico unfolding: a role of missense changes in Stargardt’s disease.

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