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ARVO Annual Meeting Abstract June 2024

Long term maintenance of cone structure and function in Rhodopsin knockout pig retina

Maureen A McCall; Archana Jalligampala; Kristin Whitworth; Kevin Wells

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3926.

ARVO Annual Meeting Abstract June 2024

The Rho1-2 meganuclease targeted to the human P23H human rhodopsin allele in a transgenic pig model of Autosomal Dominant Retinitis Pigmentosa (adRP) generates wide variety of inactivating mutations.

Jacob Michael Young; Archana Jalligampala; Maureen A McCall; Ronald G Gregg

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6073.

ARVO Annual Meeting Abstract June 2023

Mobility task shows rescue of scotopic vision in a swine model for autosomal dominant Retinitis Pigmentosa after treatment with the meganuclease Rho 1-2

Kautuk Kamboj; Jack E. Feist; Francesca Barone; Gita Jaikumar; Archana Jalligampala; Wei Wang; Jeff Smith; Dave Morris; Jantz Derek; Victor Bartsevich; Kristi Viles; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5240.

ARVO Annual Meeting Abstract June 2023

A ribozyme-mediated RNA replacement gene therapy shows efficacy in a pig model of Autosomal Dominant Retinitis Pigmentosa (adRP).

Archana Jalligampala; Kautuk Kamboj; Jennifer M. Noel; Elyse Frye; Joseph Prestigiacomo; Olivia Noelle Jacobs; Stephen Nash; Wei Wang; Ji-Hyun Kim; Seong-Wook Lee; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):803.

ARVO Annual Meeting Abstract June 2023

Semantic segmentation of OCT retinal layers in pigs using a trained U-Net network

David Alston; Archana Jalligampala; Joseph Prestigiacomo; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1116.

ARVO Annual Meeting Abstract June 2022

Successful late-stage disease treatment of P23H human RHO (hRHO) using ARCUS nuclease gene editing in a pig model of Autosomal Dominant Retinitis Pigmentosa (adRP)

Archana Jalligampala; Jennifer M. Noel; Olivia Noelle Jacobs; Alec Lynn Bradley; Wei Wang; Maha Haleem Jabbar; Nazarul Hasan; Joseph Prestigiacomo; Jeff Smith; Victor Bartsevich; Kristi Viles; Derek Jantz; Maureen Ann McCall

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1107.

ARVO Annual Meeting Abstract June 2022

The generation and characterization of a large animal model of USH3 disease

Astra Dinculescu; Maureen A McCall; Ronald G Gregg; Archana Jalligampala; Jennifer M. Noel; Rebecca Whiting; Kevin Donnelly; Kristin Whitworth; Randall S Prather; Kevin D Wells; Bethany Redel; J. Hugh McDowell

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1926 – A0072.

ARVO Annual Meeting Abstract June 2022

Stereopure oligonucleotide treatment results in durable rescue of disease phenotype in a P23H hRHO pig model of human autosomal dominant retinitis pigmentosa (adRP)

Jennifer M. Noel; Archana Jalligampala; Olivia N Jacobs; Joseph Prestigiacomo; Hailin Yang; Qianli Pan; Fangjun Liu; Yuan Yin; Richard Looby; Chandra Vargeese; Michael Byrne; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4289.

ARVO Annual Meeting Abstract June 2021

Allele-selective reduction of P23H-mutant rhodopsin with stereopure oligonucleotides rescues phenotype associated with retinitis pigmentosa in preclinical models

Michael Byrne; Vinod Vathipadickal; Lankai Guo; Yuan Yin; Hailin Yang; Richard Looby; Lauren Norwood; James W Fransen; archana jalligampala; Jennifer Noel; Chandra Vargeese; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):185.

ARVO Annual Meeting Abstract June 2021

Rho 1-2 meganuclease, an allele-specific gene-editing therapy, rejuvenates rod photoreceptor structure and function in a pig model of autosomal dominant Retinitis Pigmentosa (adRP).

archana jalligampala; Jennifer Noel; James W Fransen; Wei Wang; Maha Jabbar; Nazarul Hasan; Gobinda Pangeni; Bhubanananda Sahu; Whitney Lewis; Jeff Smith; Victor Bartsevich; Kristi Viles; Derek Jantz; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1478.

ARVO Annual Meeting Abstract June 2021

SPVN06, a Novel Mutation-Independent AAV-based Gene Therapy, Protects Cone Degeneration in a Pig Model of Retinitis Pigmentosa

Jennifer Noel; archana jalligampala; Myriam Marussig; Pierre-Axel VINOT; Melanie MARIE; Melanie Butler; Florence LORGET; Stephane Boissel; Thierry D Leveillard; Jose Alain Sahel; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1189.

ARVO Annual Meeting Abstract June 2020

Stereopure oligonucleotides achieve allele-selective reduction of P23H mutant rhodopsin

Vinod Vathipadiekal; Lankai Guo; Yuan Yin; Qiong Shen; Hailin Yang; Richard Looby; Lauren Norwood; James Fransen; archana jalligampala; Jennifer Noel; Chandra Vargeese; Maureen A McCall; Michael Byrne

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1912.

ARVO Annual Meeting Abstract June 2020

Allele-specific Homing Endonuclease (HE) Gene Editing Induces Rod Function in a P23H Transgenic Swine Model of Retinitis Pigmentosa

James W Fransen; archana jalligampala; Jennifer Noel; Wei Wang; Jeff Smith; Victor Bartsevich; Kristi Viles; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1915.

ARVO Annual Meeting Abstract June 2020

An Allele-Independent Gene Therapy Strategy Induces Rod Function in a Transgenic Swine Model of Autosomal Dominant Retinitis Pigmentosa

archana jalligampala; James Fransen; Jennifer Noel; Gobinda Pangeni; Maha Haleem Jabbar; William W Hauswirth; Alfred S Lewin; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4484.

ARVO Annual Meeting Abstract July 2019

Allele-specific Gene Editing Induces Rod Function in a Transgenic Swine Model of Autosomal Dominant Retinitis Pigmentosa

Maureen A McCall; Archana Jalligampala; gobinda Pangeni; Maha Jabbar; Henry J Kaplan; Wei Wang; Bhubanananda Sahu; Jon E Chatterton; Jeff Smith; Victor Bartsevich; Kristi Viles

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4229.

ARVO Annual Meeting Abstract September 2016

Electrical and Visual STA Types Correlate in Mouse Retina

Sudarshan Sekhar; Archana Jalligampala; Eberhart Zrenner; Daniel Llewellyn Rathbun

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3577.

ARVO Annual Meeting Abstract September 2016

Spatial aspects of electrical desensitization in mouse retina

Archana Jalligampala; Eberhart Zrenner; Daniel Llewellyn Rathbun

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3722.

ARVO Annual Meeting Abstract June 2015

Electrical stimulation alters light responses in mouse retinal ganglion cells.

Archana Jalligampala; Daniel Llewellyn Rathbun; Eberhart Zrenner

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):763.

ARVO Annual Meeting Abstract June 2015

Modeled direct and indirect activation of retinal ganglion cells during subretinal stimulation

Paul Werginz; Jörg Encke; Archana Jalligampala; Daniel Llewellyn Rathbun; Frank Rattay

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):771.

ARVO Annual Meeting Abstract June 2015

Characterization of indirect ganglion cell responses to electrical stimulation in the mouse retina.

Daniel Llewellyn Rathbun; Archana Jalligampala; Eberhart Zrenner

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):775.

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Long term maintenance of cone structure and function in Rhodopsin knockout pig retina

The Rho1-2 meganuclease targeted to the human P23H human rhodopsin allele in a transgenic pig model of Autosomal Dominant Retinitis Pigmentosa (adRP) generates wide variety of inactivating mutations.

Mobility task shows rescue of scotopic vision in a swine model for autosomal dominant Retinitis Pigmentosa after treatment with the meganuclease Rho 1-2

A ribozyme-mediated RNA replacement gene therapy shows efficacy in a pig model of Autosomal Dominant Retinitis Pigmentosa (adRP).

Semantic segmentation of OCT retinal layers in pigs using a trained U-Net network

Successful late-stage disease treatment of P23H human RHO (hRHO) using ARCUS nuclease gene editing in a pig model of Autosomal Dominant Retinitis Pigmentosa (adRP)

The generation and characterization of a large animal model of USH3 disease

Stereopure oligonucleotide treatment results in durable rescue of disease phenotype in a P23H hRHO pig model of human autosomal dominant retinitis pigmentosa (adRP)

Allele-selective reduction of P23H-mutant rhodopsin with stereopure oligonucleotides rescues phenotype associated with retinitis pigmentosa in preclinical models

Rho 1-2 meganuclease, an allele-specific gene-editing therapy, rejuvenates rod photoreceptor structure and function in a pig model of autosomal dominant Retinitis Pigmentosa (adRP).

SPVN06, a Novel Mutation-Independent AAV-based Gene Therapy, Protects Cone Degeneration in a Pig Model of Retinitis Pigmentosa

Stereopure oligonucleotides achieve allele-selective reduction of P23H mutant rhodopsin

Allele-specific Homing Endonuclease (HE) Gene Editing Induces Rod Function in a P23H Transgenic Swine Model of Retinitis Pigmentosa

An Allele-Independent Gene Therapy Strategy Induces Rod Function in a Transgenic Swine Model of Autosomal Dominant Retinitis Pigmentosa

Allele-specific Gene Editing Induces Rod Function in a Transgenic Swine Model of Autosomal Dominant Retinitis Pigmentosa

Electrical and Visual STA Types Correlate in Mouse Retina

Spatial aspects of electrical desensitization in mouse retina

Electrical stimulation alters light responses in mouse retinal ganglion cells.

Modeled direct and indirect activation of retinal ganglion cells during subretinal stimulation

Characterization of indirect ganglion cell responses to electrical stimulation in the mouse retina.

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