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ARVO Annual Meeting Abstract July 2019

Targeting TFEB (transcription factor EB) as a novel approach for AMD therapy

Stacey L Hose; Sayan Ghosh; Nadezda A. Stepicheva; Sara Jabalameli; Imran Ahmed Bhutto; Peng Shang; Meysam Yazdankhah; Joseph Weiss; Gerard A Lutty; J Samuel Zigler, Jr; Leah Byrne; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1238. doi:

ARVO Annual Meeting Abstract July 2019

Autophagy is required for maintaining of oligodendrocyte precursor cells in optic nerve

Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Peng Shang; Nadezda A. Stepicheva; Stacey L Hose; Joseph Weiss; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6388. doi:

ARVO Annual Meeting Abstract July 2019

Role of Lipocalin-2 in iron homeostasis and inflammasome activation in pathogenesis of age-related macular degeneration (AMD)

Sayan Ghosh; Peng Shang; Meysam Yazdankhah; Imran Ahmed Bhutto; Nadezda A. Stepicheva; Joseph Weiss; Stacey L Hose; Gerard A Lutty; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1345. doi:

ARVO Annual Meeting Abstract July 2019

A possible role of βA3/A1-crystallin in endocytosis and downstream signaling pathways in RPE cells

Peng Shang; Nadezda A. Stepicheva; Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Joseph Weiss; Stacey L Hose; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1918. doi:

ARVO Annual Meeting Abstract July 2019

Infiltrating immune cells and pathophysiology in Diabetic Retinopathy (DR)

Imran Ahmed Bhutto; Tanuja Vaidya; Sayan Ghosh; Archana Padmanabhan; Meysam Yazdankhah; Peng Shang; Nadezda A. Stepicheva; Stacey L Hose; J Samuel Zigler, Jr; Santosh GopiKrishna; Thirumalesh MB; Gerard A Lutty; Arkasubhra Ghosh; Swaminathan Sethu; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2683. doi:

ARVO Annual Meeting Abstract July 2019

Lysosomal distribution and function may be affected by the cell type and spatial localization of the cell within the tissue

Nadezda A. Stepicheva; Joseph Weiss; Peng Shang; Meysam Yazdankhah; Sayan Ghosh; Imran Ahmed Bhutto; Stacey L Hose; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5981. doi:

Special Issue July 2018

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

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Sayan Ghosh; Peng Shang; Hiroto Terasaki; Nadezda Stepicheva; Stacey Hose; Meysam Yazdankhah; Joseph Weiss; Taiji Sakamoto; Imran A. Bhutto; Shuli Xia; J. Samuel Zigler, Jr; Ram Kannan; Jiang Qian; James T. Handa; Debasish Sinha
TAGS: crystallins, epithelial to mesenchymal transition, retinal pigment cell, age-related macular degeneration
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD104-AMD113. doi: https://doi.org/10.1167/iovs.18-24132

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Loss of functional βA3/A1-crystallin upregulates the expression of colony stimulating factor 1 receptor (CSF-1R) and activates inflammation in Nuc1 rat retina

Stacey L Hose; Sayan Ghosh; Meysam Yazdankhah; Imran Ahmed Bhutto; J. Samuel Zigler, Jr.; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4594. doi:

ARVO Annual Meeting Abstract June 2017

Loss of βA3/A1-crystallin in astrocytes lead to persistent fetal vasculature (PFV) by activating EGFR/mTORC1 signaling and inhibiting autophagy

Meysam Yazdankhah; Tianqi Luo; Imran Ahmed Bhutto; Peng Shang; Subrata Mishra; Gerard A Lutty; Stacey L Hose; J. Samuel Zigler, Jr.; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1210. doi:

ARVO Annual Meeting Abstract June 2017

βA3/A1-Crystallin/SLC36A4/V-ATPase complex in the RPE is a novel therapeutic target for AMD

Peng Shang; Mallika Valapala; Stacey L Hose; Jun Wan; Jiang Qian; Yuri V Sergeev; J. Samuel Zigler, Jr.; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3384. doi:

ARVO Annual Meeting Abstract June 2017

βA3/A1-crystallin modulates endolysosomal acidification in astrocytes by preventing phosphorylation of the V 0 a1 subunit of V-ATPase

Subrata H Mishra; Meysam Yazdankhah; Peng Shang; J. Samuel Zigler, Jr.; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5243. doi:

ARVO Annual Meeting Abstract June 2015

Loss of β A3/A1-crystallin in astrocytes affects cell migration by downregulating Rho family of proteins

Debasish Sinha; Mallika Valapala; Stacey L Hose; Shang Peng; J. Samuel Zigler, Jr.

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5591. doi:

ARVO Annual Meeting Abstract June 2015

Activation of mTORC1 in RPE leads to RPE cell death by modulating PTEN and BAD

Mallika Valapala; Shang Peng; Stacey L Hose; J. Samuel Zigler, Jr.; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4206. doi:

ARVO Annual Meeting Abstract March 2012

A Mutation In βA3/A1 Crystallin Disrupts Astrocyte Template Formation And Retinal Vascularization

Mallika Valapala; Samuel J. Zigler, Jr.; Stacey Hose; Gerard A. lutty; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):4118. doi:

ARVO Annual Meeting Abstract March 2012

Update on Longitudinal study of cataract using the Dynamic Light Scattering: Cataracts progress with loss of the molecular chaperone, alpha crystallin proteins

Andrea I. Zambrano; Manuel B. Datiles, III; Rafat R. Ansari; Holly Brown; Junko Yoshida; Qing Pan; Samuel Zigler, Jr.; Frederick Ferris; Sheila West; Walter J. Stark

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3058. doi:

ARVO Annual Meeting Abstract March 2012

Evaluation of Supranuclear Lens Changes in Alzheimer's Disease Patients using Scheimpflug Imaging 3-Dimensional Densitometry

Margaret P. Liu; Manuel B. Datiles, III; Qing Pan; Holly Brown; Junko Yoshida; Andrea Zambrano; Samuel Zigler, Jr.; Walter J. Stark

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3664. doi:

ARVO Annual Meeting Abstract April 2011

Synergistic Effect of Two Independent Spontaneous Mutations on the Optic Nerve of the Rat

J S. Zigler, Jr.; C Zhang; R Grebe; S Hose; D Sinha

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2671. doi:

ARVO Annual Meeting Abstract April 2011

Defects in Optic Nerve Glia and in the Lens During Embryonic Development May Cause Persistent Fetal Vasculature (PFV) Disease

Stacey L. Hose; Laura Asnaghi; Cheng Zhang; Marisol Cano; Morton F. Goldberg; Charles G. Eberhart; Eric F. Wawrousek; J. S. Zigler, Jr.; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2356. doi:

ARVO Annual Meeting Abstract April 2011

βA3/A1-crystallin: A New Protein Involved In Degradation Of Rod Outer Segments During Rpe Phagocytosis

Debasish Sinha; J S. Zigler, Jr.; Cheng Zhang; Rhonda Grebe; Yuri V. Sergeev; Donald J. Zack; James T. Handa; Gerard A. Lutty

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):4786. doi:

ARVO Annual Meeting Abstract April 2010

Developmental Expression of βA3/a1-Crystallin in the Rat Eye: From Structure to Function

G. Parthasarathy; C. Zhang; C. Brayton; J. S. Zigler, Jr.; D. Sinha

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):4615. doi:

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Targeting TFEB (transcription factor EB) as a novel approach for AMD therapy

Autophagy is required for maintaining of oligodendrocyte precursor cells in optic nerve

Role of Lipocalin-2 in iron homeostasis and inflammasome activation in pathogenesis of age-related macular degeneration (AMD)

A possible role of βA3/A1-crystallin in endocytosis and downstream signaling pathways in RPE cells

Infiltrating immune cells and pathophysiology in Diabetic Retinopathy (DR)

Lysosomal distribution and function may be affected by the cell type and spatial localization of the cell within the tissue

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

Loss of functional βA3/A1-crystallin upregulates the expression of colony stimulating factor 1 receptor (CSF-1R) and activates inflammation in Nuc1 rat retina

Loss of βA3/A1-crystallin in astrocytes lead to persistent fetal vasculature (PFV) by activating EGFR/mTORC1 signaling and inhibiting autophagy

βA3/A1-Crystallin/SLC36A4/V-ATPase complex in the RPE is a novel therapeutic target for AMD

βA3/A1-crystallin modulates endolysosomal acidification in astrocytes by preventing phosphorylation of the V 0 a1 subunit of V-ATPase

Loss of β A3/A1-crystallin in astrocytes affects cell migration by downregulating Rho family of proteins

Activation of mTORC1 in RPE leads to RPE cell death by modulating PTEN and BAD

A Mutation In βA3/A1 Crystallin Disrupts Astrocyte Template Formation And Retinal Vascularization

Update on Longitudinal study of cataract using the Dynamic Light Scattering: Cataracts progress with loss of the molecular chaperone, alpha crystallin proteins

Evaluation of Supranuclear Lens Changes in Alzheimer's Disease Patients using Scheimpflug Imaging 3-Dimensional Densitometry

Synergistic Effect of Two Independent Spontaneous Mutations on the Optic Nerve of the Rat

Defects in Optic Nerve Glia and in the Lens During Embryonic Development May Cause Persistent Fetal Vasculature (PFV) Disease

βA3/A1-crystallin: A New Protein Involved In Degradation Of Rod Outer Segments During Rpe Phagocytosis

Developmental Expression of βA3/a1-Crystallin in the Rat Eye: From Structure to Function

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