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Review April 2021

Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020

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Ying Kai Chan; Andrew D. Dick; Sara Mary Hall; Thomas Langmann; Curtis L. Scribner; Brian C. Mansfield; for the Ocular Gene Therapy Inflammation Working Group
TAGS: blindness, gene therapy, inflammation, spatial vectors, disease vectors
Trans. Vis. Sci. Tech.. 2021; 10(4):3. doi: https://doi.org/10.1167/tvst.10.4.3

ARVO Annual Meeting Abstract July 2019

Phenotype of innate immune cells in uveitis associated with axial spondyloarthritis- versus juvenile idiopathic arthritis- associated uveitis

Maren Kasper; Karoline Walscheid; Björn Laffer; Dirk Bauer; Martin Busch; Karin Loser; Thomas Vogl; Thomas Langmann; Gerd Ganser; Thomas Rath; Arnd Heiligenhaus

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):808. doi:

ARVO Annual Meeting Abstract July 2019

Extended electrophysiological characterization of the retinal degeneration in CLN6 nclf mice

Cornelia Volz; Myriam Mirza; Thomas Langmann; Herbert Jaegle

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3118. doi:

Retina September 2018

Neuroprotective Effects of FGF2 and Minocycline in Two Animal Models of Inherited Retinal Degeneration

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Johnny Di Pierdomenico; Rebecca Scholz; F. Javier Valiente-Soriano; Maria C. Sánchez-Migallón; Manuel Vidal-Sanz; Thomas Langmann; Marta Agudo-Barriuso; Diego García-Ayuso; María Paz Villegas-Pérez
TAGS: animal model, fibroblast growth factor 2, minocycline, neuroprotective effect, photoreceptors, retinal degeneration, ciliary neurotrophic factor, rats
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4392-4403. doi: https://doi.org/10.1167/iovs.18-24621

ARVO Annual Meeting Abstract July 2018

Loss of Translocator Protein 18 kDa (TSPO) in the retinal pigment epithelium (RPE) of mice may lead to impaired visual function and abnormal RPE morphology

Katrin Klee; Federica Storti; Joshua L Dunaief; Thomas Langmann; Christian Grimm

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2460. doi:

ARVO Annual Meeting Abstract July 2018

PolySia avDP20 modulates macrophage-associated corneal hem- and lymphangiogenesis

Felix Bock; Ann-Charlott Schneider; Alexander Aslanidis; Marcus Karlstetter; Harald Neumann; Thomas Langmann; Claus Cursiefen

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3318. doi:

ARVO Annual Meeting Abstract July 2018

Microglia-specific expression of Translocator Protein (18kDa)

Khalid Rashid; Anne Wolf; Marcus Karlstetter; Thomas Langmann

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5390. doi:

ARVO Annual Meeting Abstract July 2018

Leveraging consanguinity in inherited retinal diseases uncovers missing genetic variation: rare novel disease genes and a multitude of novel pathogenic variants in known disease genes

Kristof Van Schil; Sarah Naessens; Stijn Van de Sompele; Marjolein Carron; Laurens Lambrechts; Núria Gruartmoner Roura; Katharina Dannhausen; Frauke Coppieters; Marcus Karlstetter; Thomas Langmann; Reza Maroofian; Andrew Webster; Michel Michaelides; Bart P Leroy; Elfride De Baere

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5404. doi:

ARVO Annual Meeting Abstract September 2016

Multifunctional OCT Imaging Facility for Rodent Eye Imaging

Jens Horstmann; Uta Gehlsen; Sebastian E Siebelmann; Deniz Hos; Felix Bock; Rafael S Grajewski; Sascha Fauser; Thomas Langmann; Gereon Huttmann; Claus Cursiefen; Philipp Steven

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2193. doi:

ARVO Annual Meeting Abstract September 2016

Genetic variants in ARMS2/HTRA1 and APOE loci are associated with hyperreflective foci present in early forms of age-related macular degeneration

Lebriz Ersoy; Paula Scholz; Carel C B Hoyng; Anneke I Den Hollander; Thomas Langmann; Sascha Fauser

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2628. doi:

ARVO Annual Meeting Abstract September 2016

Hypomorphic mutations in RCBTB1 cause autosomal recessive isolated and syndromic inherited retinal dystrophy

Frauke Coppieters; Giulia Ascari; Konstantinos Nikopoulos; Mingchu Xu; Thomas Langmann; Rui Chen; Carlo Rivolta; Christian P Hamel; Bart Peter Leroy; Elfride De Baere

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):637. doi:

ARVO Annual Meeting Abstract September 2016

Correlation of extracellular matrix-related gene expression with objective Fuchs Endothelial Corneal Dystrophy severity

Mario Matthaei; Christoph Leitl; Rebecca Scholz; Björn Bachmann; Thomas Langmann; Claus Cursiefen; Ludwig M Heindl

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5275. doi:

ARVO Annual Meeting Abstract September 2016

Investigating the pathomechanism of FAM161A -associated retinal disease in primary ciliated cells

Heidi Barbara Stoehr; Marlene Schwarzfischer; Lisa-Marie Braun; Alexander Aslanidis; Thomas Langmann; Ulrich Kellner

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3192. doi:

Retina August 2016

Association of Hyperreflective Foci Present in Early Forms of Age-Related Macular Degeneration With Known Age-Related Macular Degeneration Risk Polymorphisms

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Lebriz Altay; Paula Scholz; Tina Schick; Moritz Felsch; Carel B. Hoyng; Anneke I. den Hollander; Thomas Langmann; Sascha Fauser
TAGS: age-related macular degeneration, heart failure, polymorphism, single nucleotide polymorphism
Invest. Ophthalmol. Vis. Sci.. 2016; 57(10):4315-4320. doi: https://doi.org/10.1167/iovs.15-18855

Research Highlight November 2015

Intracellular Toll-Like Receptors Help Retinal Microglia Sense Corneal Infections

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Thomas Langmann

Invest. Ophthalmol. Vis. Sci.. 2015; 56(12):7387. doi: https://doi.org/10.1167/iovs.15-18268

ARVO Annual Meeting Abstract June 2015

SF3B2 , a novel candidate gene for autosomal dominant retinitis pigmentosa, encodes a component of the U2 small nuclear ribonucleoprotein

Caroline Van Cauwenbergh; Kris Vleminckx; Frauke Coppieters; Marcus Karlstetter; Thomas Langmann; Gael Manes; Christian P Hamel; Bart Peter Leroy; Elfride De Baere; adRP Study Group

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2873. doi:

ARVO Annual Meeting Abstract June 2015

Recessive RHO mutation E150K and SAMD7 regulatory variants in a consanguineous family with retinitis pigmentosa

Kristof Van Schil; Marcus Karlstetter; Alexander Aslanidis; Bart Peter Leroy; Frauke Coppieters; Fanny Depasse; Thomas Langmann; Elfride De Baere

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2876. doi:

ARVO Annual Meeting Abstract June 2015

Targeting the translocator protein (18kDa) (TSPO) prevents microglia reactivity and protects from from light induced retinal degeneration

Rebecca Scholz; Alexander Aslanidis; Marcus Karlstetter; Khalid Rashid; Christian Grimm; Thomas Langmann; Experimental Immunology of the eye (Langmann)

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):430. doi:

ARVO Annual Meeting Abstract June 2015

Mutation of RCBTB1 in a severe syndromic retinal ciliopathy

Frauke Coppieters; Miriam Bauwens; Marcus Karlstetter; Kris Vleminckx; Morgane Van der Eecken; Thomas Langmann; Bart Peter Leroy; Françoise Meire; Elfride De Baere

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5990. doi:

ARVO Annual Meeting Abstract June 2015

Polysialic acid attenuates alternative complement activation, inhibits microglial reactivity and reduces vascular leakage after retinal laser-damage

Marcus Karlstetter; Janine Claude; Albert Caramoy; Bettina Linnartz-Gerlach; Jens Kopatz; Anika Lückoff; Yiner Wang; Christine Skerka; Harald Neumann; Thomas Langmann

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):885. doi:

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Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020

Phenotype of innate immune cells in uveitis associated with axial spondyloarthritis- versus juvenile idiopathic arthritis- associated uveitis

Extended electrophysiological characterization of the retinal degeneration in CLN6 nclf mice

Neuroprotective Effects of FGF2 and Minocycline in Two Animal Models of Inherited Retinal Degeneration

Loss of Translocator Protein 18 kDa (TSPO) in the retinal pigment epithelium (RPE) of mice may lead to impaired visual function and abnormal RPE morphology

PolySia avDP20 modulates macrophage-associated corneal hem- and lymphangiogenesis

Microglia-specific expression of Translocator Protein (18kDa)

Leveraging consanguinity in inherited retinal diseases uncovers missing genetic variation: rare novel disease genes and a multitude of novel pathogenic variants in known disease genes

Multifunctional OCT Imaging Facility for Rodent Eye Imaging

Genetic variants in ARMS2/HTRA1 and APOE loci are associated with hyperreflective foci present in early forms of age-related macular degeneration

Hypomorphic mutations in RCBTB1 cause autosomal recessive isolated and syndromic inherited retinal dystrophy

Correlation of extracellular matrix-related gene expression with objective Fuchs Endothelial Corneal Dystrophy severity

Investigating the pathomechanism of FAM161A -associated retinal disease in primary ciliated cells

Association of Hyperreflective Foci Present in Early Forms of Age-Related Macular Degeneration With Known Age-Related Macular Degeneration Risk Polymorphisms

Intracellular Toll-Like Receptors Help Retinal Microglia Sense Corneal Infections

SF3B2 , a novel candidate gene for autosomal dominant retinitis pigmentosa, encodes a component of the U2 small nuclear ribonucleoprotein

Recessive RHO mutation E150K and SAMD7 regulatory variants in a consanguineous family with retinitis pigmentosa

Targeting the translocator protein (18kDa) (TSPO) prevents microglia reactivity and protects from from light induced retinal degeneration

Mutation of RCBTB1 in a severe syndromic retinal ciliopathy

Polysialic acid attenuates alternative complement activation, inhibits microglial reactivity and reduces vascular leakage after retinal laser-damage

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