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ARVO Annual Meeting Abstract June 2020

Serotype dependent Adeno-Associated Virus Hybrid Vector mediated gene therapy for Stargardt Disease

Frank M Dyka; Vince A. Chiodo; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2464. doi:

ARVO Annual Meeting Abstract July 2019

Dual Adeno-Associated Virus Vector mediated gene therapy for autosomal recessive Stargardt Disease

Frank M Dyka; Laurie L Molday; Vince A Chiodo; Robert S Molday; William Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3402. doi:

ARVO Annual Meeting Abstract July 2018

BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments

Karina E Guziewicz; Artur V Cideciyan; William A Beltran; Andras M Komaromy; Valerie Dufour; Malgorzata Swider; Simone Iwabe; Alexander Sumaroka; Brian T Kendrick; Gordon Ruthel; Vince A Chiodo; Elise Heon; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4522. doi:

ARVO Annual Meeting Abstract July 2018

Very long chain ceramides production mediated by ELOVL4 stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

Julia V Busik; Nermin Kady; Xuwen Liu; Todd Lydic; Sergey S Seregin; Andrea Amalfitano; Vince A Chiodo; Sanford L Boye; William W Hauswirth; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3002. doi:

ARVO Annual Meeting Abstract June 2017

Inhibiting complement C3 activation by gene therapy reduces glaucoma progression

Alejandra Bosco; Sarah Anderson; Kevin T Breen; Cesar O Romero; Michael R Steele; Vince A Chiodo; Sanford L Boye; William W Hauswirth; Stephen Tomlinson; Monica L Vetter

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2957. doi:

ARVO Annual Meeting Abstract June 2017

Overexpression of ELOVL4 stabilizes tight junctions and prevents VEGF-induced vascular permeability in diabetic retina and retinal cells.

Nermin Kady; Xuwen Liu; Todd Lydic; Segey Seregin; Andrea Amalfitano; Vince A Chiodo; Sanford L Boye; William Hauswirth; Maria B Grant; David Antonetti; Julia V Busik

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4034. doi:

ARVO Annual Meeting Abstract June 2017

Adeno-associated virus dual vector-mediated gene therapy for ABCA4 Stargardt Disease

Frank M Dyka; Vince A Chiodo; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4497. doi:

ARVO Annual Meeting Abstract June 2017

Gene augmentation therapy improves inner and outer segment morphology and preserves retinal structure in a large animal model of CNGB1 -retinitis pigmentosa

Laurence Mireille Occelli; Paige A Winkler; Vince A Chiodo; Sanford L Boye; William W Hauswirth; Simon M Petersen-Jones

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4508. doi:

ARVO Annual Meeting Abstract June 2017

Optimization of transgene expression in the trabecular meshwork (TM) by comparing capsid mutant AAV2 vectors

Christine Harman; Kristin Koehl; Annie Oh; Vince A Chiodo; Sanford L Boye; William W Hauswirth; Shannon Elizabeth Boye; Andras M Komaromy

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4611. doi:

Retinal Cell Biology June 2012

ER Stress Is Involved in T17M Rhodopsin-Induced Retinal Degeneration

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Mansi M. Kunte; Shreyasi Choudhury; Jessica F. Manheim; Vishal M. Shinde; Masayuki Miura; Vince A. Chiodo; William W. Hauswirth; Oleg S. Gorbatyuk; Marina S. Gorbatyuk
TAGS: gene expression, retina, retinal degeneration, rhodopsin, stress, genes, mice, proteins, apoptosis
Invest. Ophthalmol. Vis. Sci.. 2012; 53(7):3792-3800. doi: https://doi.org/10.1167/iovs.11-9235

Includes: Supplemental Content

Retina April 2012

Tyrosine-Mutant AAV8 Delivery of Human MERTK Provides Long-Term Retinal Preservation in RCS Rats

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Wen-Tao Deng; Astra Dinculescu; Qiuhong Li; Sanford L. Boye; Jie Li; Marina S. Gorbatyuk; Jijing Pang; Vince A. Chiodo; Michael T. Matthes; Douglas Yasumura; Li Liu; Fowzan S. Alkuraya; Kang Zhang; Douglas Vollrath; Matthew M. LaVail; William W. Hauswirth
TAGS: eye, mertk gene, rats, tyrosine, retina, photoreceptors, spatial vectors, did not receive therapy or drug
Invest. Ophthalmol. Vis. Sci.. 2012; 53(4):1895-1904. doi: https://doi.org/10.1167/iovs.11-8831

Includes: Supplemental Content

ARVO Annual Meeting Abstract March 2012

Selective Transduction Of Ground Squirrel Bipolar Cells With A Capsid Mutated AAV2

Steven H. DeVries; Yongling Zhu; Vince A. Chiodo; William W. Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):4317. doi:

ARVO Annual Meeting Abstract March 2012

Dual AAV vector system for Usher syndrome (USH1B) gene therapy

Frank M. Dyka; Shannon E. Boye; Sanford L. Boye; Vince A. Chiodo; William W. Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1906. doi:

ARVO Annual Meeting Abstract March 2012

Normalization of Fatty Acid Elongase ELOVL4 In Diabetic Retina Prevents Vascular Degeneration and Inflammation Through Modification of Sphingolipid Metabolism

Matthew S. Faber; Todd A. Lydic; Maria Tikhonenko; Svetlana N. Bozack; Sergey S. Seregin; Andrea Amalfitano; Vince A. Chiodo; Sanford L. Boye; William W. Hauswirth; Julia V. Busik

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):2407. doi:

ARVO Annual Meeting Abstract April 2011

Efficient Vision Rescue Using Self-complementary Capsid Mutant Aav8 In A Mouse Model For Severe Childhood Blindness

Cristy A. Ku; Cristoforo Larzo; Vince A. Chiodo; Sanford L. Boye; Tiansen Li; William W. Hauswirth; Visvanathan Ramamurthy

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1394. doi:

ARVO Annual Meeting Abstract April 2011

A Novel Method for Delivery of Recombinant Adeno-associated Virus to the Inner Retina of Non-human Primates

John J. Alexander; Clark D. Witherspoon; William W. Hauswirth; Mark E. Clark; Kristen J. Sandefer; Sanford L. Boye; Vince A. Chiodo; Christopher A. Girkin; Paul D. Gamlin

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1398. doi:

ARVO Annual Meeting Abstract April 2011

AAV-mediated SOD1 Antioxidant Gene Therapy Protects Against Retinal Degeneration in a Mouse Model of Retinitis Pigmentosa

Jianwen Liu; Alfred S. Lewin; Vince A. Chiodo; Min Ding; Santhi Mani; William W. Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1402. doi:

Biochemistry and Molecular Biology April 2011

Whirlin Replacement Restores the Formation of the USH2 Protein Complex in Whirlin Knockout Photoreceptors

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Junhuang Zou; Ling Luo; Zuolian Shen; Vince A. Chiodo; Balamurali K. Ambati; William W. Hauswirth; Jun Yang
TAGS: hrk protein, photoreceptors, proteins, retina, western blotting, mice, spatial vectors
Invest. Ophthalmol. Vis. Sci.. 2011; 52(5):2343-2351. doi: https://doi.org/10.1167/iovs.10-6141

ARVO Annual Meeting Abstract April 2011

Evaluation Of AAV-mediated BEST1 Expression In The Canine Retina

Karina E. Guziewicz; Andras M. Komaromy; William W. Hauswirth; Sanford L. Boye; Vincent A. Chiodo; Julianna Slavik; Simone Iwabe; Gustavo D. Aguirre; Barbara Zangerl

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):4378. doi:

Retinal Cell Biology June 2003

Structural and Functional Protection of Photoreceptors from MNU-Induced Retinal Degeneration by the X-Linked Inhibitor of Apoptosis

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Dino Petrin; Adam Baker; Stuart G. Coupland; Peter Liston; Monica Narang; Karim Damji; Brian Leonard; Vince A. Chiodo; Adrian Timmers; William Hauswirth; Robert G. Korneluk; Catherine Tsilfidis
TAGS: apoptosis inhibitor, birc4 gene, photoreceptors, retinal degeneration, x-linked inheritance, eye, in situ nick-end labeling, electroretinography, proteins
Invest. Ophthalmol. Vis. Sci.. 2003; 44(6):2757-2763. doi: https://doi.org/10.1167/iovs.02-0729

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Serotype dependent Adeno-Associated Virus Hybrid Vector mediated gene therapy for Stargardt Disease

Dual Adeno-Associated Virus Vector mediated gene therapy for autosomal recessive Stargardt Disease

BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments

Very long chain ceramides production mediated by ELOVL4 stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

Inhibiting complement C3 activation by gene therapy reduces glaucoma progression

Overexpression of ELOVL4 stabilizes tight junctions and prevents VEGF-induced vascular permeability in diabetic retina and retinal cells.

Adeno-associated virus dual vector-mediated gene therapy for ABCA4 Stargardt Disease

Gene augmentation therapy improves inner and outer segment morphology and preserves retinal structure in a large animal model of CNGB1 -retinitis pigmentosa

Optimization of transgene expression in the trabecular meshwork (TM) by comparing capsid mutant AAV2 vectors

ER Stress Is Involved in T17M Rhodopsin-Induced Retinal Degeneration

Tyrosine-Mutant AAV8 Delivery of Human MERTK Provides Long-Term Retinal Preservation in RCS Rats

Selective Transduction Of Ground Squirrel Bipolar Cells With A Capsid Mutated AAV2

Dual AAV vector system for Usher syndrome (USH1B) gene therapy

Normalization of Fatty Acid Elongase ELOVL4 In Diabetic Retina Prevents Vascular Degeneration and Inflammation Through Modification of Sphingolipid Metabolism

Efficient Vision Rescue Using Self-complementary Capsid Mutant Aav8 In A Mouse Model For Severe Childhood Blindness

A Novel Method for Delivery of Recombinant Adeno-associated Virus to the Inner Retina of Non-human Primates

AAV-mediated SOD1 Antioxidant Gene Therapy Protects Against Retinal Degeneration in a Mouse Model of Retinitis Pigmentosa

Whirlin Replacement Restores the Formation of the USH2 Protein Complex in Whirlin Knockout Photoreceptors

Evaluation Of AAV-mediated BEST1 Expression In The Canine Retina

Structural and Functional Protection of Photoreceptors from MNU-Induced Retinal Degeneration by the X-Linked Inhibitor of Apoptosis

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