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ARVO Annual Meeting Abstract June 2020

Alu RNA exacerbates experimental choroidal neovascularization via an inflammasome-dependent pathway

Felipe Pereira; Ivana Apicella; Ryan Makin; Younghee Kim; Charles Wright; Tetsuhiro Yasuma; Reo Yasuma; Shuichiro Hirahara; Shinichi Fukuda; Siddharth Narendran; Romulo Albuquerque; Benjamin Fowler; Nagaraj Kerur; Jayakrishna Ambati; Bradley Gelfand

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5394. doi:

ARVO Annual Meeting Abstract July 2018

Nucleoside reverse transcriptase inhibitors are broad-spectrum RPE protectants

Shuichiro Hirahara; Shinichi Fukuda; Younghee Kim; Reo Yasuma; Kameshwari Ambati; Junichi Fukuhara; Dongxu Fu; DAIPAYAN BANERJEE; Benjamin J Fowler; Tetsuhiro Yasuma; Nagaraj Kerur; Bradley Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2459. doi:

ARVO Annual Meeting Abstract July 2018

Nucleoside reverse transcriptase inhibitors (NRTI) prevent inflammasome activation in retinal pigmented epithelium cells.

DAIPAYAN BANERJEE; Junichi Fukuhara; Dongxu Fu; Shinichi Fukuda; Shuichiro Hirahara; Younghee Kim; Benjamin J Fowler; Tetsuhiro Yasuma; Reo Yasuma; Kameshwari Ambati; Nagaraj Kerur; Bradley Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2475. doi:

ARVO Annual Meeting Abstract September 2016

Non-canonical NLRP3 Inflammasome activation in Geographic Atrophy

Nagaraj Kerur; Younghee Kim; Shinichi Fukuda; Reo Yasuma; Ana Bastos-Carvalho; Daipayan Banerjee; Benjamin Fowler; Tetsuhiro Yasuma; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):486. doi:

ARVO Annual Meeting Abstract September 2016

Role of interferon signaling in Alu RNA-induced AMD

Daipayan Banerjee; Younghee Kim; Shinichi Fukuda; Reo Yasuma; Ana Bastos-Carvalho; Benjamin Fowler; Tetsuhiro Yasuma; Bradley D Gelfand; Nagaraj Kerur; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):487. doi:

ARVO Annual Meeting Abstract September 2016

Subcutaneous IL-18 administration does not inhibit laser CNV in mice

Tetsuhiro Yasuma; Reo Yasuma; Bradley D Gelfand; Nagaraj Kerur; Ana Bastos-Carvalho; Younghee Kim; Charles B Wright; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4518. doi:

ARVO Annual Meeting Abstract September 2016

Nucleoside reverse transcriptase inhibitors prevent iron-induced retinal pigment epithelium cell death

Junichi Fukuhara; Younghee Kim; Tetsuhiro Yasuma; Reo Yasuma; Benjamin Fowler; Shinichi Fukuda; Takako Fukuhara; Nagaraj Kerur; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5005. doi:

ARVO Annual Meeting Abstract September 2016

Nucleoside reverse transcriptase inhibitors are anti-inflammatory and inhibit poly I:C-induced retinal pigment epithelium degeneration

Shinichi Fukuda; Junichi Fukuhara; Younghee Kim; Benjamin Fowler; Tetsuhiro Yasuma; Reo Yasuma; Takako Fukuhara; Nagaraj Kerur; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6551. doi:

ARVO Annual Meeting Abstract September 2016

Nucleoside reverse transcriptase inhibitors attenuate amyloid-beta-induced retinal pigment epithelium degeneration

Takako Fukuhara; Junichi Fukuhara; Younghee Kim; Tetsuhiro Yasuma; Reo Yasuma; Benjamin Fowler; Shinichi Fukuda; Nagaraj Kerur; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6552. doi:

Retinal Cell Biology November 2015

Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice

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Takeshi Mizutani; Benjamin J. Fowler; Younghee Kim; Reo Yasuma; Laura A. Krueger; Bradley D. Gelfand; Jayakrishna Ambati
TAGS: choroidal neovascularization, lasers, mice, nucleoside reverse transcriptase inhibitors, vascular endothelial growth factor a, p2rx7 gene
Invest. Ophthalmol. Vis. Sci.. 2015; 56(12):7122-7129. doi: https://doi.org/10.1167/iovs.15-17440

ARVO Annual Meeting Abstract June 2015

Nucleoside reverse transcriptase inhibitor (NRTI) protection against iron cytotoxicity

Charles B Wright; Younghee Kim; Tetsuhiro Yasuma; Reo Yasuma; Shengjian Li; Benjamin J Fowler; Ana Bastos-Carvalho; Mark Ellsworth Kleinman; Jayakrishna Ambati; Bradley D Gelfand

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4211. doi:

ARVO Annual Meeting Abstract April 2014

Intravenous immunoglobulin treatment inhibits choroidal and corneal neovascularization via FcyR1

Reo Yasuma; Sasha Bogdanovich; Younghee Kim; Tetsuhiro Yasuma; Takeshi Mizutani; Ana Bastos-Carvalho; Benjamin Fowler; shengjian li; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1190. doi:

ARVO Annual Meeting Abstract April 2014

The Fc fragments of Bevacizumab or IVIG suppress choroidal neovascularization

shengjian li; Nagaraj Kerur; Sasha Bogdanovich; Reo Yasuma; Younghee Kim; Takeshi Mizutani; Ana Bastos-Carvalho; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1191. doi:

ARVO Annual Meeting Abstract April 2014

Dideoxy-nucleosides are anti-inflammatory and inhibit RPE degeneration independent of reverse transcriptase inhibition

Benjamin Fowler; Younghee Kim; Yoshio Hirano; Nagaraj Kerur; Valeria Tarallo; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1735. doi:

ARVO Annual Meeting Abstract April 2014

Enhanced Alu RNA stability due to iron-mediated DICER1 impairment causes NLRP3 inflammasome priming

Charles B Wright; Younghee Kim; Tetsuhiro Yasuma; Shengjian Li; Benjamin J Fowler; Mark Ellsworth Kleinman; Jayakrishna Ambati; Bradley D Gelfand

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2187. doi:

ARVO Annual Meeting Abstract April 2014

Myd88 as a therapeutic target for choroidal neovascularization

Nagaraj Kerur; Younghee Kim; Yoshio Hirano; Valeria Tarallo; Ana Bastos-Carvalho; Benjamin Fowler; Tetsuhiro Yasuma; Reo Yasuma; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2195. doi:

ARVO Annual Meeting Abstract April 2014

Extracellular HMGB1 promotes choroidal angiogenesis

Younghee Kim; Nagaraj Kerur; Shengjian Li; Ana Bastos-Carvalho; Bradley D Gelfand; William W Hauswirth; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4459. doi:

ARVO Annual Meeting Abstract April 2014

Human therapeutic monoclonal antibodies inhibit corneal neovascularization via FcγRI in a target-independent manner

Ana Bastos-Carvalho; Sasha Bogdanovich; Younghee Kim; Reo Yasuma; Takeshi Mizutani; Nagaraj Kerur; Tetsuhiro Yasuma; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5049. doi:

ARVO Annual Meeting Abstract April 2014

Dual anti-angiogenic activity of Bevacizumab from its IgG1-Fc domain and VEGF neutralization

Takeshi Mizutani; Nagaraj Kerur; Shengjian Li; Younghee Kim; Reo Yasuma; Tetsuhiro Yasuma; Ana Bastos-Carvalho; Benjamin Fowler; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1936. doi:

ARVO Annual Meeting Abstract April 2014

Generic, target-independent suppression of choroidal neovascularization by human IgG1 antibodies via Fc gamma receptor I

Tetsuhiro Yasuma; Reo Yasuma; Younghee Kim; Takeshi Mizutani; Nagaraj Kerur; Ana Bastos-Carvalho; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1937. doi:

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Alu RNA exacerbates experimental choroidal neovascularization via an inflammasome-dependent pathway

Nucleoside reverse transcriptase inhibitors are broad-spectrum RPE protectants

Nucleoside reverse transcriptase inhibitors (NRTI) prevent inflammasome activation in retinal pigmented epithelium cells.

Non-canonical NLRP3 Inflammasome activation in Geographic Atrophy

Role of interferon signaling in Alu RNA-induced AMD

Subcutaneous IL-18 administration does not inhibit laser CNV in mice

Nucleoside reverse transcriptase inhibitors prevent iron-induced retinal pigment epithelium cell death

Nucleoside reverse transcriptase inhibitors are anti-inflammatory and inhibit poly I:C-induced retinal pigment epithelium degeneration

Nucleoside reverse transcriptase inhibitors attenuate amyloid-beta-induced retinal pigment epithelium degeneration

Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice

Nucleoside reverse transcriptase inhibitor (NRTI) protection against iron cytotoxicity

Intravenous immunoglobulin treatment inhibits choroidal and corneal neovascularization via FcyR1

The Fc fragments of Bevacizumab or IVIG suppress choroidal neovascularization

Dideoxy-nucleosides are anti-inflammatory and inhibit RPE degeneration independent of reverse transcriptase inhibition

Enhanced Alu RNA stability due to iron-mediated DICER1 impairment causes NLRP3 inflammasome priming

Myd88 as a therapeutic target for choroidal neovascularization

Extracellular HMGB1 promotes choroidal angiogenesis

Human therapeutic monoclonal antibodies inhibit corneal neovascularization via FcγRI in a target-independent manner

Dual anti-angiogenic activity of Bevacizumab from its IgG1-Fc domain and VEGF neutralization

Generic, target-independent suppression of choroidal neovascularization by human IgG1 antibodies via Fc gamma receptor I

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