Biochemistry and Molecular Biology

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Immunology and Microbiology June 2021

Retinal Pigment Epithelial Cells Express Antimicrobial Peptide Lysozyme – A Novel Mechanism of Innate Immune Defense of the Blood-Retina Barrier

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Jian Liu; Caijiao Yi; Wei Ming; Miao Tang; Xiao Tang; Chang Luo; Bo Lei; Mei Chen; Heping Xu
TAGS: muramidase, retinal pigment cell, antimicrobials, peptides
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):21. doi: https://doi.org/10.1167/iovs.62.7.21

Visual Neuroscience June 2021

Synaptosomal Actin Dynamics in the Developmental Visual Cortex Regulate Behavioral Visual Acuity in Rats

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Ai-Ling Bi; Yue-Ying Zhang; Zhi-Yuan Lu; Hong-Ying Tang; Xiu-Yan Zhang; Zi-Han Zhang; Bo-Qin Li; Da-Dong Guo; Sheng Gong; Qian Li; Xing-Rong Wang; Xiu-Zhen Lu; Hong-Sheng Bi
TAGS: actins, rats, visual acuity, visual cortex, mitochondria, primary visual cortex
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):20. doi: https://doi.org/10.1167/iovs.62.7.20

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2021

Age-Related Retinal Changes in Wild-Type C57BL/6J Mice Between 2 and 32 Months

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Salma Ferdous; Kristie L. Liao; Isabelle D. Gefke; Vivian R. Summers; Wenfei Wu; Kevin J. Donaldson; Yong-Kyu Kim; Jana T. Sellers; Jendayi A. Dixon; Debresha A. Shelton; Shanu Markand; Somin M. Kim; Nan Zhang; Jeffrey H. Boatright; John M. Nickerson
TAGS: eye, mice, mice, inbred c57bl, body weight, photoreceptors, aging, retina
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):9. doi: https://doi.org/10.1167/iovs.62.7.9

Includes: Supplemental Content

Cornea June 2021

IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium

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Evan D. Bogdan; Whitney L. Stuard; Rossella Titone; Danielle M. Robertson
TAGS: corneal epithelium, homeostasis, hyperosmolality, insulin-like growth factor binding protein 3, sodium chloride, stress, mosmol, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):11. doi: https://doi.org/10.1167/iovs.62.7.11

Includes: Supplemental Content

Retinal Cell Biology June 2021

Sigma 1 Receptor Modulates Optic Nerve Head Astrocyte Reactivity

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Jing Zhao; Graydon Gonsalvez; Manuela Bartoli; Barbara A. Mysona; Sylvia B. Smith; Kathryn E. Bollinger
TAGS: astrocytes, glial fibrillary acidic protein, optic disk, receptors, sigma, mice, stress, ischemia, cell culture techniques
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):5. doi: https://doi.org/10.1167/iovs.62.7.5

Retina May 2021

The Predictive Role of Thyroid Hormone Levels for Early Diabetic Retinal Changes in Experimental Rat and Human Diabetes

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Anna Énzsöly; Rozina I. Hajdú; Zsolt Turóczi; Irén Szalai; Erika Tátrai; Fanni Pálya; Zoltán Z. Nagy; Csaba Mátyás; Attila Oláh; Tamás Radovits; Klaudia Szabó; Bulcsú Dékány; Arnold Szabó; Ákos Kusnyerik; Petra Soltész; Dániel S. Veres; Anikó Somogyi; Gábor M. Somfai; Ákos Lukáts
TAGS: diabetes mellitus, thyroid hormones, retinal cone, retina, opsin
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):20. doi: https://doi.org/10.1167/iovs.62.6.20

Cornea May 2021

Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer

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James W. Foster; Rupin N. Parikh; Jiangxia Wang; Kraig S. Bower; Mario Matthaei; Shukti Chakravarti; Albert S. Jun; Charles G. Eberhart; Uri S. Soiberman
TAGS: epithelium, keratoconus, wnt10a gene, bowman's layer
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):16. doi: https://doi.org/10.1167/iovs.62.6.16

Includes: Supplemental Content

Glaucoma May 2021

Involvement of c-Jun N-terminal kinase 2 (JNK2) in Endothelin-1 (ET-1) Mediated Neurodegeneration of Retinal Ganglion Cells

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Bindu Kodati; Dorota L. Stankowska; Vignesh R. Krishnamoorthy; Raghu R. Krishnamoorthy
TAGS: endothelin-1, glaucoma, mice, nerve degeneration, neuroprotection, phosphotransferases, retinal ganglion cells, immunohistochemistry, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):13. doi: https://doi.org/10.1167/iovs.62.6.13

Biochemistry and Molecular Biology May 2021

In Vivo Molecular Changes in the Retina of Patients With Multiple Sclerosis

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Salut Alba-Arbalat; Magi Andorra; Bernardo Sanchez-Dalmau; Anna Camos-Carreras; Marina Dotti-Boada; Irene Pulido-Valdeolivas; Sara Llufriu; Yolanda Blanco; Maria Sepulveda; Albert Saiz; Oscar Batet; Iker Bilbao; Iratxe Torre; Ivan Amat-Roldan; Elena H. Martinez-Lapiscina; Pablo Villoslada
TAGS: molecule, multiple sclerosis, retina, spectrum analysis, raman
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):11. doi: https://doi.org/10.1167/iovs.62.6.11

Includes: Supplemental Content

Cornea May 2021

Role of IL-36γ/IL-36R Signaling in Corneal Innate Defense Against Candida albicans Keratitis

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Chenyang Dai; Rao Me; Nan Gao; Guanyu Su; Xinyi Wu; Fu-Shin X. Yu
TAGS: cornea, keratitis, mice, signal transduction, fungal keratitis, cytokine, infections, candida albicans, interleukin-33
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):10. doi: https://doi.org/10.1167/iovs.62.6.10

Review May 2021

Metabolomics in Glaucoma: A Systematic Review

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Ying Wang; Xiao-Wen Hou; Gang Liang; Chen-Wei Pan
TAGS: glaucoma, metabolomics, metabolites, systematic reviews, biological markers
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):9. doi: https://doi.org/10.1167/iovs.62.6.9

Includes: Supplemental Content

Biochemistry and Molecular Biology May 2021

Setd1a Plays Pivotal Roles for the Survival and Proliferation of Retinal Progenitors via Histone Modifications of Uhrf1

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Xiaoyue Deng; Toshiro Iwagawa; Masaya Fukushima; Yutaka Suzuki; Sumiko Watanabe
TAGS: apoptosis, histones, plasmids, retina, rna-seq, mice, immunohistochemistry, antibodies
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):1. doi: https://doi.org/10.1167/iovs.62.6.1

Includes: Supplemental Content

Letters to the Editor April 2021

Author Response: Surface Area of the Exposed Eye

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Ben J. Glasgow
TAGS: eye
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):19. doi: https://doi.org/10.1167/iovs.62.4.19

Cornea April 2021

The Dopaminergic Neuronal System Regulates the Inflammatory Status of Mouse Lacrimal Glands in Dry Eye Disease

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Yong Woo Ji; Hyun Goo Kang; Jong Suk Song; Ji Won Jun; Kyusun Han; Tae-im Kim; Kyoung Yul Seo; Hyung Keun Lee
TAGS: dopamine, dopamine receptors, dry eye syndromes, langer-giedion syndrome, mice, cornea
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):14. doi: https://doi.org/10.1167/iovs.62.4.14

Glaucoma April 2021

TGF-β2 Promotes Oxidative Stress in Human Trabecular Meshwork Cells by Selectively Enhancing NADPH Oxidase 4 Expression

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Vidhya R. Rao; Evan B. Stubbs, Jr
TAGS: nadph oxidase 4, oxidative stress, proteins, trabecular meshwork, nadph oxidases, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):4. doi: https://doi.org/10.1167/iovs.62.4.4

Biochemistry and Molecular Biology April 2021

Transcriptome Landscape of Epithelial to Mesenchymal Transition of Human Stem Cell–Derived RPE

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Srinivasa R. Sripathi; Ming-Wen Hu; Melissa M. Liu; Jun Wan; Jie Cheng; Yukan Duan; Joseph L. Mertz; Karl J. Wahlin; Julien Maruotti; Cynthia A. Berlinicke; Jiang Qian; Donald J. Zack
TAGS: epithelial to mesenchymal transition, dissociation, tumor necrosis factors, gene expression profiling
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):1. doi: https://doi.org/10.1167/iovs.62.4.1

Includes: Supplemental Content

Retina March 2021

Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime

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Eric Seifert; Svenja Rebecca Sonntag; Philipp Kleingarn; Dirk Theisen-Kunde; Salvatore Grisanti; Reginald Birngruber; Yoko Miura; Ralf Brinkmann
TAGS: lasers, pigment, epithelium, cell injury
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):32. doi: https://doi.org/10.1167/iovs.62.3.32

Visual Neuroscience March 2021

Altered Visual Function in a Larval Zebrafish Knockout of Neurodevelopmental Risk Gene pdzk1

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Jiaheng Xie; Patricia R. Jusuf; Bang V. Bui; Stefanie Dudczig; Tamar E. Sztal; Patrick T. Goodbourn
TAGS: electroretinography, genes, genetics, larva, spatial frequency, vision, zebrafish, serotonin, depression, post-stroke, persistent speech disorders
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):29. doi: https://doi.org/10.1167/iovs.62.3.29

Includes: Supplemental Content

Immunology and Microbiology March 2021

Murine Model of Primary Acquired Ocular Toxoplasmosis: Fluorescein Angiography and Multiplex Immune Mediator Profiles in the Aqueous Humor

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Kexin Li; Xue Feng; Kenji Hikosaka; Kazumi Norose
TAGS: aqueous humor, fluorescein angiography, hypertension, immune mediator, infections, mice, ocular toxoplasmosis, eye
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):9. doi: https://doi.org/10.1167/iovs.62.3.9

Immunology and Microbiology February 2021

Altered Corneal Epithelial Dendritic Cell Morphology and Phenotype Following Acute Exposure to Hyperosmolar Saline

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Kirthana Senthil; Haihan Jiao; Laura E. Downie; Holly R. Chinnery
TAGS: cornea, dendritic cells, epithelium, hyperosmolality, language morphology, morphology, phenotype, saline solutions, mosmol, mice
Invest. Ophthalmol. Vis. Sci.. 2021; 62(2):38. doi: https://doi.org/10.1167/iovs.62.2.38

Includes: Supplemental Content

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Retinal Pigment Epithelial Cells Express Antimicrobial Peptide Lysozyme – A Novel Mechanism of Innate Immune Defense of the Blood-Retina Barrier

Synaptosomal Actin Dynamics in the Developmental Visual Cortex Regulate Behavioral Visual Acuity in Rats

Age-Related Retinal Changes in Wild-Type C57BL/6J Mice Between 2 and 32 Months

IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium

Sigma 1 Receptor Modulates Optic Nerve Head Astrocyte Reactivity

The Predictive Role of Thyroid Hormone Levels for Early Diabetic Retinal Changes in Experimental Rat and Human Diabetes

Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer

Involvement of c-Jun N-terminal kinase 2 (JNK2) in Endothelin-1 (ET-1) Mediated Neurodegeneration of Retinal Ganglion Cells

In Vivo Molecular Changes in the Retina of Patients With Multiple Sclerosis

Role of IL-36γ/IL-36R Signaling in Corneal Innate Defense Against Candida albicans Keratitis

Metabolomics in Glaucoma: A Systematic Review

Setd1a Plays Pivotal Roles for the Survival and Proliferation of Retinal Progenitors via Histone Modifications of Uhrf1

Author Response: Surface Area of the Exposed Eye

The Dopaminergic Neuronal System Regulates the Inflammatory Status of Mouse Lacrimal Glands in Dry Eye Disease

TGF-β2 Promotes Oxidative Stress in Human Trabecular Meshwork Cells by Selectively Enhancing NADPH Oxidase 4 Expression

Transcriptome Landscape of Epithelial to Mesenchymal Transition of Human Stem Cell–Derived RPE

Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime

Altered Visual Function in a Larval Zebrafish Knockout of Neurodevelopmental Risk Gene pdzk1

Murine Model of Primary Acquired Ocular Toxoplasmosis: Fluorescein Angiography and Multiplex Immune Mediator Profiles in the Aqueous Humor

Altered Corneal Epithelial Dendritic Cell Morphology and Phenotype Following Acute Exposure to Hyperosmolar Saline

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