Biochemistry and Molecular Biology

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Glaucoma December 2018

Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma

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Emily Mathieu; Neeru Gupta; Luz A. Paczka-Giorgi; Xun Zhou; Amir Ahari; Rafael Lani; Joseph Hanna; Yeni H. Yücel
TAGS: glaucoma, cerebrospinal fluid, optic nerve
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5876-5884. doi: 10.1167/iovs.18-24521

Biochemistry and Molecular Biology December 2018

Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease

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Anastasia Marie Litke; Sarah Samuelson; Kerry R. Delaney; Yves Sauvé; Robert L. Chow
TAGS: mutation, corneal diseases, electroretinography, keratoconus, luciferases, missense mutation, cornea, diagnostic imaging, mice, pathogenicity
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5824-5835. doi: 10.1167/iovs.18-25490

Includes: Supplemental Content

Lens December 2018

Epithelial-Mesenchymal Transdifferentiation in Pediatric Lens Epithelial Cells

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Laura Wernecke; Susanne Keckeis; Nadine Reichhart; Olaf Strauß; Daniel J. Salchow
TAGS: epithelium, cataract, child, pediatrics, patient characteristics, lens epithelial cell, cell transdifferentiation, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5785-5794. doi: 10.1167/iovs.18-23789

Includes: Supplemental Content

Biochemistry and Molecular Biology December 2018

Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs

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Miaozhen Pan; Shiming Jiao; Peter S. Reinach; Jiaofeng Yan; Yanan Yang; Qihang Li; Nethrajeith Srinivasalu; Jia Qu; Xiangtian Zhou
TAGS: bezafibrate, caviidae, injections, myopia, apolipoprotein a-ii, eye, ppar alpha
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5803-5815. doi: 10.1167/iovs.17-22297

Includes: Supplemental Content

Retinal Cell Biology November 2018

Self-Formation of RPE Spheroids Facilitates Enrichment and Expansion of hiPSC-Derived RPE Generated on Retinal Organoid Induction Platform

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Shengxu Liu; Bingbing Xie; Xiaojing Song; Dandan Zheng; Liwen He; Guilan Li; Guanjie Gao; Fuhua Peng; Minzhong Yu; Jian Ge; Xiufeng Zhong
TAGS: retinal pigment cell, spheroids, cellular, organoids
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5659-5669. doi: 10.1167/iovs.17-23613

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2018

The Effect of Corticosteroids on Human Choroidal Endothelial Cells: A Model to Study Central Serous Chorioretinopathy

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Joost Brinks; Elon H. C. van Dijk; Mahmoud Habeeb; Aikaterini Nikolaou; Roula Tsonaka; Hendrika A. B. Peters; Hetty C. M. Sips; Arjanneke F. van de Merbel; Eiko K. de Jong; Robbert G. E. Notenboom; Szymon M. Kielbasa; Silvère M. van der Maarel; Paul H. A. Quax; Onno C. Meijer; Camiel J. F. Boon
TAGS: hydrocortisone, endothelial cells, adrenal corticosteroids, glucocorticoids, patient isolation, mineralocorticoids, agonists, antagonists, central serous chorioretinopathy, chronic exertional compartment syndrome
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5682-5692. doi: 10.1167/iovs.18-25054

Includes: Supplemental Content

Cornea November 2018

Downregulation of IL-7 and IL-7R Reduces Membrane-Type Matrix Metalloproteinase 14 in Granular Corneal Dystrophy Type 2 Keratocyte

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So Young Kim; Areum Yeo; Hyemi Noh; Yong Woo Ji; Jong Suk Song; Hyeon Chang Kim; Lark Kyun Kim; Hyung Keun Lee
TAGS: matrix metalloproteinases, keratocytes, interleukin-7, hereditary corneal dystrophy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5693-5703. doi: 10.1167/iovs.18-25161

Includes: Supplemental Content

Retina November 2018

Morphologic, Biomechanical, and Compositional Features of the Internal Limiting Membrane in Pathologic Myopic Foveoschisis

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Lu Chen; Yantao Wei; Xuezhi Zhou; Zhaotian Zhang; Wei Chi; Li Gong; Xintong Jiang; Shaochong Zhang
TAGS: western blotting, astrocytes, collagen, collagen type iv, fluorescent antibody technique, gliosis, tissue membrane, microscopy, atomic force, surgical procedures, operative, body tissue, eye, proteins, mass or substance concentration per volume, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5569-5578. doi: 10.1167/iovs.18-24676

Cornea November 2018

Altered Signaling Pathways in Aniridia-Related Keratopathy

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André Vicente; Berit Byström; Fátima Pedrosa Domellöf
TAGS: epithelium, antibodies, cornea, signal pathway, signal transduction pathways, notch1 gene, beta catenin, pax6 transcription factor, pannus, aniridia
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5531-5541. doi: 10.1167/iovs.18-25175

Genetics November 2018

Genome-Wide Association Study to Identify a New Susceptibility Locus for Central Serous Chorioretinopathy in the Japanese Population

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Akiko Miki; Yoichi Sakurada; Koji Tanaka; Kentaro Semba; Yoshinori Mitamura; Mitsuko Yuzawa; Atsushi Tajima; Masahiro Nakatochi; Ken Yamamoto; Keitaro Matsuo; Issei Imoto; Shigeru Honda
TAGS: disease susceptibility, single nucleotide polymorphism, central serous chorioretinopathy, genome-wide association study, japanese
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5542-5547. doi: 10.1167/iovs.18-25497

Includes: Supplemental Content

Cornea November 2018

Sleep Deprivation Induces Dry Eye Through Inhibition of PPARα Expression in Corneal Epithelium

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Liying Tang; Xue Wang; Jieli Wu; San Ming Li; Zhaoqiang Zhang; Sangang Wu; Ting Su; Zhirong Lin; Xueting Chen; Xulin Liao; Ting Bai; Yan Qiu; Peter Sol Reinach; Wei Li; Yongxiong Chen; Zuguo Liu
TAGS: dry eye syndromes, corneal epithelium, microvilli, sleep deprivation, cornea, lipids, mice, sleep, morphology, ppar alpha, language morphology
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5494-5508. doi: 10.1167/iovs.18-24504

Glaucoma November 2018

Mesenchymal Stem Cell–Derived Small Extracellular Vesicles Promote Neuroprotection in a Genetic DBA/2J Mouse Model of Glaucoma

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Ben Mead; Zubair Ahmed; Stanislav Tomarev
TAGS: glaucoma, ocular hypertension, genetics, mice, stem cell, mesenchymal, neuroprotection, exosomes, extracellular vesicles
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5473-5480. doi: 10.1167/iovs.18-25310

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2018

SIRT1 Deletion Impairs Retinal Endothelial Cell Migration Through Downregulation of VEGF-A/VEGFR-2 and MMP14

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Yong Lin; Li Li; Junjie Liu; Xiaoting Zhao; Juxiu Ye; Peter S. Reinach; Jia Qu; Dongsheng Yan
TAGS: angiogenesis, vascular endothelial growth factor a, western blotting, endothelial cells, vascular endothelial growth factor receptor-2, down-regulation, mice, rna, small interfering
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5431-5440. doi: 10.1167/iovs.17-23558

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2018

CD40 Enhances Sphingolipids in Orbital Fibroblasts: Potential Role of Sphingosine-1-Phosphate in Inflammatory T-Cell Migration in Graves' Orbitopathy

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Svenja Plöhn; Bärbel Edelmann; Lukasz Japtok; Xingxuan He; Matthias Hose; Wiebke Hansen; Edward H. Schuchman; Anja Eckstein; Utta Berchner-Pfannschmidt
TAGS: fibroblasts, cd40 antigens, cd40 ligand, sphingolipids, t-lymphocyte, sphingosine-1-phosphate phosphatase
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5391-5397. doi: 10.1167/iovs.18-25466

Includes: Supplemental Content

Retina November 2018

An iTRAQ-Based Quantitative Proteomic Analysis of Plasma Proteins in Preterm Newborns With Retinopathy of Prematurity

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Magdalena Zasada; Maciej Suski; Renata Bokiniec; Monika Szwarc-Duma; Maria Katarzyna Borszewska-Kornacka; Józef Madej; Beata Bujak-Giżycka; Anna Madetko-Talowska; Cecilie Revhaug; Lars O. Baumbusch; Ola D. Saugstad; Jacek Józef Pietrzyk; Przemko Kwinta
TAGS: fibrinogen, child, gestational age, hospitalization, newborn, plasma, proteome, retinopathy of prematurity, proteins, plasma proteins
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5312-5319. doi: 10.1167/iovs.18-24914

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology October 2018

Loss of CXCR4/CXCL12 Signaling Causes Oculomotor Nerve Misrouting and Development of Motor Trigeminal to Oculomotor Synkinesis

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Mary C. Whitman; Elaine H. Nguyen; Jessica L. Bell; Alan P. Tenney; Alon Gelber; Elizabeth C. Engle
TAGS: signal transduction, axon, embryo, motor neurons, oculomotor nerve, cxcr4 receptors, synkinesis, oculomotor synkinesis, stromal cell-derived factor 1
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5201-5209. doi: 10.1167/iovs.18-25190

Includes: Multimedia, Supplemental Content

Biochemistry and Molecular Biology October 2018

Lacrimal Gland Denervation Alters Tear Protein Composition and Impairs Ipsilateral Eye Closures and Corneal Nociception

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Deborah M. Hegarty; Larry L. David; Sue A. Aicher
TAGS: cornea, denervation, eye, proteins, rats, sensory perception, lacrimal gland, lacrimal nerve, pain perception
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5217-5224. doi: 10.1167/iovs.18-25267

Includes: Supplemental Content

Anatomy and Pathology/Oncology October 2018

Induction of Apoptosis in Pterygium Cells by Antagonists of Growth Hormone–Releasing Hormone Receptors

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Yong Jie Qin; Wai Kit Chu; Li Huang; Clara Hoi Yen Ng; Tommy Chung Yan Chan; Di Cao; Cheng Yang; Liang Zhang; Shao Ping Huang; Juan Li; Hong Liang Lin; Wen Qian Li; Li Chen; Andrew V. Schally; Sun On Chan; Hong Yang Zhang; Chi Pui Pang
TAGS: apoptosis, signal transduction, growth hormone-releasing factor, sermorelin, pterygium, antagonists, picture exchange communication system, pectoral compartment nerve block type 1
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5060-5066. doi: 10.1167/iovs.18-24751

Includes: Supplemental Content

Retina October 2018

The Carnitine Shuttle Pathway is Altered in Patients With Neovascular Age-Related Macular Degeneration

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Sabrina L. Mitchell; Karan Uppal; Samantha M. Williamson; Ken Liu; L. Goodwin Burgess; ViLinh Tran; Allison C. Umfress; Kelli L. Jarrell; Jessica N. Cooke Bailey; Anita Agarwal; Margaret Pericak-Vance; Jonathan L. Haines; William K. Scott; Dean P. Jones; Milam A. Brantley, Jr
TAGS: carnitine, plasma, exudative age-related macular degeneration, metabolites, metabolomics
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4978-4985. doi: 10.1167/iovs.18-25137

Includes: Supplemental Content

Retinal Cell Biology October 2018

Altered Decorin Biology in Proliferative Vitreoretinopathy: A Mechanistic and Cohort Study

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Ghazala Begum; Jenna O'Neill; Rishika Chaudhary; Karen Blachford; David R. J. Snead; Martin Berry; Robert A. H. Scott; Ann Logan; Richard J. Blanch
TAGS: cell culture techniques, fibronectins, cohort studies, vitreoretinopathy, proliferative, vitreous body, epithelial to mesenchymal transition, laminin, collagen, fibrosis, enzyme-linked immunosorbent assay, radiation recall dermatitis
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4929-4936. doi: 10.1167/iovs.18-24299

Includes: Supplemental Content

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Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma

Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease

Epithelial-Mesenchymal Transdifferentiation in Pediatric Lens Epithelial Cells

Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs

Self-Formation of RPE Spheroids Facilitates Enrichment and Expansion of hiPSC-Derived RPE Generated on Retinal Organoid Induction Platform

The Effect of Corticosteroids on Human Choroidal Endothelial Cells: A Model to Study Central Serous Chorioretinopathy

Downregulation of IL-7 and IL-7R Reduces Membrane-Type Matrix Metalloproteinase 14 in Granular Corneal Dystrophy Type 2 Keratocyte

Morphologic, Biomechanical, and Compositional Features of the Internal Limiting Membrane in Pathologic Myopic Foveoschisis

Altered Signaling Pathways in Aniridia-Related Keratopathy

Genome-Wide Association Study to Identify a New Susceptibility Locus for Central Serous Chorioretinopathy in the Japanese Population

Sleep Deprivation Induces Dry Eye Through Inhibition of PPARα Expression in Corneal Epithelium

Mesenchymal Stem Cell–Derived Small Extracellular Vesicles Promote Neuroprotection in a Genetic DBA/2J Mouse Model of Glaucoma

SIRT1 Deletion Impairs Retinal Endothelial Cell Migration Through Downregulation of VEGF-A/VEGFR-2 and MMP14

CD40 Enhances Sphingolipids in Orbital Fibroblasts: Potential Role of Sphingosine-1-Phosphate in Inflammatory T-Cell Migration in Graves' Orbitopathy

An iTRAQ-Based Quantitative Proteomic Analysis of Plasma Proteins in Preterm Newborns With Retinopathy of Prematurity

Loss of CXCR4/CXCL12 Signaling Causes Oculomotor Nerve Misrouting and Development of Motor Trigeminal to Oculomotor Synkinesis

Lacrimal Gland Denervation Alters Tear Protein Composition and Impairs Ipsilateral Eye Closures and Corneal Nociception

Induction of Apoptosis in Pterygium Cells by Antagonists of Growth Hormone–Releasing Hormone Receptors

The Carnitine Shuttle Pathway is Altered in Patients With Neovascular Age-Related Macular Degeneration

Altered Decorin Biology in Proliferative Vitreoretinopathy: A Mechanistic and Cohort Study

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