Biochemistry and Molecular Biology

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Cornea September 2022

METTL3 Attenuates Inflammation in Fusarium solani –Induced Keratitis via the PI3K/AKT Signaling Pathway

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Liwei Huang; Hanfeng Tang; Jianzhang Hu
TAGS: 1-phosphatidylinositol 3-kinase, akt signaling pathway, cornea, inflammation, keratitis, mice, signal pathway, signal transduction pathways, fusarium solani, infections
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):20. doi: https://doi.org/10.1167/iovs.63.10.20

Biochemistry and Molecular Biology September 2022

RO4929097, a Selective γ-Secretase Inhibitor, Inhibits Subretinal Fibrosis Via Suppressing Notch and ERK1/2 Signaling in Laser-Induced Mouse Model

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Chaoyang Zhang; Shiyue Qin; Hai Xie; Qinghua Qiu; Haiyan Wang; Jingting Zhang; Dawei Luo; Jingfa Zhang
TAGS: choroidal neovascularization, epithelial to mesenchymal transition, fibrosis, lasers, mice, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):14. doi: https://doi.org/10.1167/iovs.63.10.14

Includes: Supplemental Content

Retinal Cell Biology September 2022

Timed Notch Inhibition Drives Photoreceptor Fate Specification in Human Retinal Organoids

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Shereen H. Chew; Cassandra Martinez; Kathleen R. Chirco; Sangeetha Kandoi; Deepak A. Lamba
TAGS: organoids, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):12. doi: https://doi.org/10.1167/iovs.63.10.12

Includes: Supplemental Content

Retina September 2022

Short-Term Hyperuricemia Leads to Structural Retinal Changes That Can be Reversed by Serum Uric Acid Lowering Agents in Mice

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Hung-Liang Pai; Sophie Meng-Tien Hsieh; Yu-Shan Su; Xin-Yuan Sue; Han-Hsin Chang; David Pei-Cheng Lin
TAGS: allopurinol, angiotensin ii, apoptosis, benzbromarone, gelatinase a, hyperuricemia, mice, pik3ca-related overgrowth spectrum, retinal injuries, urate measurement, serum
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):8. doi: https://doi.org/10.1167/iovs.63.10.8

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2022

Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts

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Jiale Diao; Xinxin Chen; Pei Mou; Xiaoye Ma; Ruili Wei
TAGS: berberine, fibroblasts, fibrosis, graves' ophthalmopathy, tissue remodeling, inflammation, western blotting, proteins, enzyme-linked immunosorbent assay, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):6. doi: https://doi.org/10.1167/iovs.63.10.6

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology September 2022

Impaired Extraocular Muscle Innervation Is Present Before Eye Opening in a Mouse Model of Infantile Nystagmus Syndrome

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Sampath Kumar Vemula; Seoyoung A. Kim; Tapiwa Muvavarirwa; Jessica L. Bell; Mary C. Whitman
TAGS: albinism, eye, mice, muscle of orbit, nerve supply, pathologic nystagmus, syndrome, muscle
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):4. doi: https://doi.org/10.1167/iovs.63.10.4

Genetics August 2022

Decreased Levels of DNA Methylation in the PCDHA Gene Cluster as a Risk Factor for Early-Onset High Myopia in Young Children

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Joanna Swierkowska; Justyna A. Karolak; Sangeetha Vishweswaraiah; Malgorzata Mrugacz; Uppala Radhakrishna; Marzena Gajecka
TAGS: child, dna methylation, genes, methylation, myopia, gene clusters, risk factors
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):31. doi: https://doi.org/10.1167/iovs.63.9.31

Includes: Supplemental Content

Retina August 2022

Dependence of Retinal Pigment Epithelium Integrity on the NRF2–Heme Oxygenase-1 Axis

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Yida Jiang; Li-Juan Duan; Jingbo Pi; Yun-Zheng Le; Guo-Hua Fong
TAGS: body tissue, heme, mice, oxidative stress, oxygenases, painful bladder syndrome, personal integrity, retinal pigment cell, retinal pigment epithelium, eye
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):30. doi: https://doi.org/10.1167/iovs.63.9.30

Includes: Supplemental Content

Biochemistry and Molecular Biology August 2022

Gene Expression Signatures of Contact Lens-Induced Myopia in Guinea Pig Retinal Pigment Epithelium

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So Goto; Sandra E. Muroy; Yan Zhang; Kaoru Saijo; Sree Rohit Raj Kolora; Qiurong Zhu; Christine F. Wildsoet
TAGS: eye, gene expression, guinea, lens (device), lens, crystalline, myopia, retinal pigment epithelium
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):25. doi: https://doi.org/10.1167/iovs.63.9.25

Includes: Supplemental Content

Glaucoma August 2022

Prediagnostic Plasma Metabolomics and the Risk of Exfoliation Glaucoma

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Jae H. Kang; Oana Zeleznik; Lisa Frueh; Jessica Lasky-Su; A. Heather Eliassen; Clary Clish; Bernard A. Rosner; Louis R. Pasquale; Janey L. Wiggs
TAGS: exfoliation syndrome, metabolites, plasma, metabolomics
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):15. doi: https://doi.org/10.1167/iovs.63.9.15

Includes: Supplemental Content

Genetics August 2022

Consequences of a Rare Complement Factor H Variant for Age-Related Macular Degeneration in the Amish

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Andrea R. Waksmunski; Kristy Miskimen; Yeunjoo E. Song; Michelle Grunin; Renee Laux; Denise Fuzzell; Sarada Fuzzell; Larry D. Adams; Laura Caywood; Michael Prough; Dwight Stambolian; William K. Scott; Margaret A. Pericak-Vance; Jonathan L. Haines
TAGS: age-related macular degeneration, alleles, complement factor h, proteins, c-reactive protein, rna
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):8. doi: https://doi.org/10.1167/iovs.63.9.8

Includes: Supplemental Content

Retinal Cell Biology August 2022

Ciliary Neurotrophic Factor Derived From Astrocytes Protects Retinal Ganglion Cells Through PI3K/AKT, JAK/STAT, and MAPK/ERK Pathways

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Kwanghyun Lee; Jin-Ok Choi; Ahreum Hwang; Hyoung Won Bae; Chan Yun Kim
TAGS: 1-phosphatidylinositol 3-kinase, astrocytes, ciliary neurotrophic factor, mitogen-activated protein kinases, proto-oncogene proteins c-akt, phosphoinositide 3-kinase, stat family gene, statim, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):4. doi: https://doi.org/10.1167/iovs.63.9.4

Includes: Supplemental Content

Glaucoma August 2022

A Mathematical Model of Aqueous Humor Production and Composition

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Mariia Dvoriashyna; Alexander J. E. Foss; Eamonn A. Gaffney; Rodolfo Repetto
TAGS: aqueous humor, hypertension, ion channels, mass or substance concentration per volume, mathematical model, solutes, water, membrane transport proteins, adenosine triphosphatases, tissue membrane
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):1. doi: https://doi.org/10.1167/iovs.63.9.1

Retina July 2022

EGF Receptor Signaling Modulates YAP Activation and Promotes Experimental Proliferative Vitreoretinopathy

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Wei Zhang; Jing Li
TAGS: epidermal growth factor receptors, signal transduction, vitreoretinopathy, proliferative
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):24. doi: https://doi.org/10.1167/iovs.63.8.24

Retina July 2022

LGALS3BP in Microglia Promotes Retinal Angiogenesis Through PI3K/AKT Pathway During Hypoxia

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Chenyang Zhao; Yusen Liu; Jiayu Meng; Xiaotang Wang; Xianyang Liu; Wanqian Li; Qian Zhou; Junjie Xiang; Na Li; Shengping Hou
TAGS: 1-phosphatidylinositol 3-kinase, akt signaling pathway, angiogenesis, hypoxia, microglia
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):25. doi: https://doi.org/10.1167/iovs.63.8.25

Biochemistry and Molecular Biology July 2022

High Glucose Aggravates Retinal Endothelial Cell Dysfunction by Activating the RhoA/ROCK1/pMLC/Connexin43 Signaling Pathway

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Hongran Zhao; Hui Kong; Wenjuan Wang; Tianran Chen; Yuting Zhang; Jing Zhu; Dandan Feng; Yan Cui
TAGS: connexin 43, endothelial cells, glucose, pathophysiology, rhoa gtp-binding protein, symptom aggravating factors, signal pathway, signal transduction pathways
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):22. doi: https://doi.org/10.1167/iovs.63.8.22

Includes: Supplemental Content

Genetics July 2022

Genomewide Association Study of Retinal Traits in the Amish Reveals Loci Influencing Drusen Development and Link to Age-Related Macular Degeneration

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Michael D. Osterman; Yeunjoo E. Song; Muneeswar Nittala; SriniVas R. Sadda; William K. Scott; Dwight Stambolian; Margaret A. Pericak-Vance; Jonathan L. Haines
TAGS: age-related macular degeneration, drusen, genetics, genome-wide association study, genetic risk
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):17. doi: https://doi.org/10.1167/iovs.63.8.17

Includes: Supplemental Content

Biochemistry and Molecular Biology July 2022

Hypoxia-Induced Scleral HIF-2α Upregulation Contributes to Rises in MMP-2 Expression and Myopia Development in Mice

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Wenjing Wu; Yongchao Su; Changxi Hu; Huixin Tao; Ying Jiang; Guandong Zhu; Jiadi Zhu; Ying Zhai; Jia Qu; Xiangtian Zhou; Fei Zhao
TAGS: gelatinase a, hypoxia, mice, myopia, sclera, up-regulation (physiology)
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):2. doi: https://doi.org/10.1167/iovs.63.8.2

Physiology and Pharmacology June 2022

Sleep Loss Causes Dysfunction in Murine Extraorbital Lacrimal Glands

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Shenzhen Huang; Hongli Si; Jiangman Liu; Di Qi; Xiaoting Pei; Dingli Lu; Sen Zou; Zhijie Li
TAGS: genes, mice, pathophysiology, rhythm, sleep deprivation, bodily secretions
Invest. Ophthalmol. Vis. Sci.. 2022; 63(6):19. doi: https://doi.org/10.1167/iovs.63.6.19

Includes: Supplemental Content

Glaucoma June 2022

High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study

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Denis Plotnikov; Yu Huang; Anthony P. Khawaja; Paul J. Foster; Zhuoting Zhu; Jeremy A. Guggenheim; Mingguang He
TAGS: blood pressure, glaucoma, hypertension, intraocular pressure, mendelian randomization analysis, open-angle glaucoma
Invest. Ophthalmol. Vis. Sci.. 2022; 63(6):29. doi: https://doi.org/10.1167/iovs.63.6.29

Includes: Supplemental Content

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METTL3 Attenuates Inflammation in Fusarium solani –Induced Keratitis via the PI3K/AKT Signaling Pathway

RO4929097, a Selective γ-Secretase Inhibitor, Inhibits Subretinal Fibrosis Via Suppressing Notch and ERK1/2 Signaling in Laser-Induced Mouse Model

Timed Notch Inhibition Drives Photoreceptor Fate Specification in Human Retinal Organoids

Short-Term Hyperuricemia Leads to Structural Retinal Changes That Can be Reversed by Serum Uric Acid Lowering Agents in Mice

Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts

Impaired Extraocular Muscle Innervation Is Present Before Eye Opening in a Mouse Model of Infantile Nystagmus Syndrome

Decreased Levels of DNA Methylation in the PCDHA Gene Cluster as a Risk Factor for Early-Onset High Myopia in Young Children

Dependence of Retinal Pigment Epithelium Integrity on the NRF2–Heme Oxygenase-1 Axis

Gene Expression Signatures of Contact Lens-Induced Myopia in Guinea Pig Retinal Pigment Epithelium

Prediagnostic Plasma Metabolomics and the Risk of Exfoliation Glaucoma

Consequences of a Rare Complement Factor H Variant for Age-Related Macular Degeneration in the Amish

Ciliary Neurotrophic Factor Derived From Astrocytes Protects Retinal Ganglion Cells Through PI3K/AKT, JAK/STAT, and MAPK/ERK Pathways

A Mathematical Model of Aqueous Humor Production and Composition

EGF Receptor Signaling Modulates YAP Activation and Promotes Experimental Proliferative Vitreoretinopathy

LGALS3BP in Microglia Promotes Retinal Angiogenesis Through PI3K/AKT Pathway During Hypoxia

High Glucose Aggravates Retinal Endothelial Cell Dysfunction by Activating the RhoA/ROCK1/pMLC/Connexin43 Signaling Pathway

Genomewide Association Study of Retinal Traits in the Amish Reveals Loci Influencing Drusen Development and Link to Age-Related Macular Degeneration

Hypoxia-Induced Scleral HIF-2α Upregulation Contributes to Rises in MMP-2 Expression and Myopia Development in Mice

Sleep Loss Causes Dysfunction in Murine Extraorbital Lacrimal Glands

High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study

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