Biochemistry and Molecular Biology

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Genetics August 2018

Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect

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Sherin Shaaban; Sarah MacKinnon; Caroline Andrews; Sandra E. Staffieri; Gail D. E. Maconachie; Wai-Man Chan; Mary C. Whitman; Sarah U. Morton; Seyhan Yazar; Stuart MacGregor; James E. Elder; Elias I. Traboulsi; Irene Gottlob; Alex W. Hewitt; Strabismus Genetics Research Consortium; David G. Hunter; David A. Mackey; Elizabeth C. Engle
TAGS: meta-analysis, esotropia, cohort studies, disease susceptibility, genome, parent, single nucleotide polymorphism, strabismus, genetics, genome-wide association study
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4054-4064. doi: 10.1167/iovs.18-24082

Includes: Supplemental Content

Cornea August 2018

Instability of TCF4 Triplet Repeat Expansion With Parent–Child Transmission in Fuchs' Endothelial Corneal Dystrophy

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Joanna S. Saade; Chao Xing; Xin Gong; Zhengyang Zhou; V. Vinod Mootha
TAGS: alleles, child, hereditary corneal dystrophy, endothelium, parent, trinucleotide repeats
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4065-4070. doi: 10.1167/iovs.18-24119

Includes: Supplemental Content

Cornea August 2018

Differential Distribution of Laminin N-Terminus α31 Across the Ocular Surface: Implications for Corneal Wound Repair

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Valentina Barrera; Lee D. Troughton; Valentina Iorio; Siyin Liu; Olutobi Oyewole; Carl M. Sheridan; Kevin J. Hamill
TAGS: immunohistochemistry, epithelium, homeostasis, laminin, wound healing, antibodies, cornea, mice, proteins
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4082-4093. doi: 10.1167/iovs.18-24037

Includes: Supplemental Content

Retinal Cell Biology August 2018

MicroRNA-124 Dysregulation is Associated With Retinal Inflammation and Photoreceptor Death in the Degenerating Retina

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Joshua A. Chu-Tan; Matt Rutar; Kartik Saxena; Riemke Aggio-Bruce; Rohan W. Essex; Krisztina Valter; Haihan Jiao; Nilisha Fernando; Yvette Wooff; Michele C. Madigan; Jan Provis; Riccardo Natoli
TAGS: monocyte chemoattractant protein-1, photoreceptors, retinal degeneration, retinitis, retina, micrornas
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4094-4105. doi: 10.1167/iovs.18-24623

Includes: Supplemental Content

Letters to the Editor August 2018

Comments on Assays Used to Measure VEGF in the Presence of Anti-VEGF Therapeutics

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Eric Wakshull; Robert Avery; Mauricio Maia
TAGS: vascular endothelial growth factor a, therapeutics, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4106-4106. doi: 10.1167/iovs.18-24792

Letters to the Editor August 2018

Author Response: Comments on Assays Used to Measure VEGF in the Presence of Anti-VEGF Therapeutics

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Hidenori Takahashi; Yasuo Yanagi
TAGS: vascular endothelial growth factor a, therapeutics, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4107-4107. doi: 10.1167/iovs.18-25216

Biochemistry and Molecular Biology August 2018

Murine Retinal Citrullination Declines With Age and is Mainly Dependent on Peptidyl Arginine Deiminase 4 (PAD4)

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T. J. Hollingsworth; Marko Z. Radic; Sarka Beranova-Giorgianni; Francesco Giorgianni; Yanming Wang; Alessandro Iannaccone
TAGS: western blotting, arginine, peptides, antibodies, mice, retina, citrullination
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3808-3815. doi: 10.1167/iovs.18-24118

Includes: Supplemental Content

Retinal Cell Biology August 2018

Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina

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Kota Sato; Yukihiro Shiga; Yurika Nakagawa; Kosuke Fujita; Koji M. Nishiguchi; Hiroshi Tawarayama; Namie Murayama; Shigeto Maekawa; Takeshi Yabana; Kazuko Omodaka; Shota Katayama; Qiwei Feng; Satoru Tsuda; Toru Nakazawa
TAGS: optic nerve injuries, mice, optic nerve, retina, crispr
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3943-3951. doi: 10.1167/iovs.18-23784

Includes: Supplemental Content

Glaucoma August 2018

Resveratrol Delays Retinal Ganglion Cell Loss and Attenuates Gliosis-Related Inflammation From Ischemia-Reperfusion Injury

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Hongdou Luo; Jiejie Zhuang; Piaopiao Hu; Wei Ye; Shanshan Chen; Yulian Pang; Ningfeng Li; Cong Deng; Xu Zhang
TAGS: apoptosis, inflammation, gliosis, reperfusion injury, wounds and injuries, retina, resveratrol, attenuation, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3879-3888. doi: 10.1167/iovs.18-23806

Glaucoma August 2018

Matricellular Protein Levels in Aqueous Humor and Surgical Outcomes of Trabeculectomy

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Zhihua Zhang; Yuyu Miao; Jing Wang; Minwen Zhou; Mingshui Fu; Ying Wang
TAGS: surgical procedures, operative, aqueous humor, blister, proteins, surgical outcome, sparc study, trabeculectomy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3906-3910. doi: 10.1167/iovs.18-24534

Special Issue July 2018

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

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Sayan Ghosh; Peng Shang; Hiroto Terasaki; Nadezda Stepicheva; Stacey Hose; Meysam Yazdankhah; Joseph Weiss; Taiji Sakamoto; Imran A. Bhutto; Shuli Xia; J. Samuel Zigler, Jr; Ram Kannan; Jiang Qian; James T. Handa; Debasish Sinha
TAGS: crystallins, age-related macular degeneration, epithelial to mesenchymal transition, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD104-AMD113. doi: 10.1167/iovs.18-24132

Includes: Supplemental Content

Biochemistry and Molecular Biology July 2018

The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation

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Ying Yuan; Min Li; Chi Ho To; Thomas Chuen Lam; Peng Wang; Yunjie Yu; Qingzhong Chen; Xiaojun Hu; Bilian Ke
TAGS: signal transduction pathways, fibroblasts, sclera, signal pathway, rhoa gtp-binding protein, myofibroblast
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3619-3629. doi: 10.1167/iovs.17-23580

Retinal Cell Biology July 2018

Capn5 Expression in the Healthy and Regenerating Zebrafish Retina

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Cagney E. Coomer; Ann C. Morris
TAGS: zebrafish, rod photoreceptors, retina, photoreceptors, retinal cone, tissue degeneration, adult
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3643-3654. doi: 10.1167/iovs.18-24278

Includes: Supplemental Content

Review July 2018

Ocular Biomarkers of Alzheimer's Disease: The Role of Anterior Eye and Potential Future Directions

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Cirous Dehghani; Shaun Frost; Rajiv Jayasena; Colin L. Masters; Yogesan Kanagasingam
TAGS: amyloid, alzheimer's disease, biological markers, lens, crystalline, lens (device), neurons, body tissue, aqueous humor, brain, cornea, eye
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3554-3563. doi: 10.1167/iovs.18-24694

Biochemistry and Molecular Biology July 2018

Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells

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David W. Sant; Vladimir Camarena; Sushmita Mustafi; Yiwen Li; Zachary Wilkes; Derek Van Booven; Rong Wen; Gaofeng Wang
TAGS: vascular endothelial growth factor a, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3608-3618. doi: 10.1167/iovs.18-24101

Includes: Supplemental Content

Cornea July 2018

Tear Film Proteomics Reveal Important Differences Between Patients With and Without Ocular GvHD After Allogeneic Hematopoietic Cell Transplantation

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Nadine Gerber-Hollbach; Kim Plattner; Olivia E. O'Leary; Paul Jenoe; Suzette Moes; Beatrice Drexler; Andreas Schoetzau; Jörg P. Halter; David Goldblum
TAGS: hematopoietic stem cell transplantation, graft-versus-host disease, dry eye syndromes, proteins, proteomics, tear film finding
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3521-3530. doi: 10.1167/iovs.18-24433

Includes: Supplemental Content

Retinal Cell Biology July 2018

Defined Conditions for Differentiation of Functional Retinal Ganglion Cells From Human Pluripotent Stem Cells

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Junwon Lee; Sang-Hwi Choi; Young-Beom Kim; Ikhyun Jun; Jin Jea Sung; Dongjin R. Lee; Yang In Kim; Myung Soo Cho; Suk Ho Byeon; Dae-Sung Kim; Dong-Wook Kim
TAGS: mitochondria, fibroblast growth factor 2, patient isolation, prescriptions, drug, eye, stem cells, pluripotent, pax6 transcription factor, enhanced s-cone syndrome, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3531-3542. doi: 10.1167/iovs.17-23439

Includes: Multimedia, Supplemental Content

Retina July 2018

Irreversible Photoreceptors and RPE Cells Damage by Intravenous Sodium Iodate in Mice Is Related to Macrophage Accumulation

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Mayu Moriguchi; Shinsuke Nakamura; Yuki Inoue; Anri Nishinaka; Maho Nakamura; Masamitsu Shimazawa; Hideaki Hara
TAGS: immunohistochemistry, injection of therapeutic agent, iodates, macrophage, photoreceptors, mice, retina, sodium, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3476-3487. doi: 10.1167/iovs.17-23532

Glaucoma July 2018

Anatomic Evidence for Information Exchange between Primary Afferent Sensory Neurons Innervating the Anterior Eye Chamber and the Dura Mater in Rat

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Haixia Liu; Xutao Zhu; Yun Ling; Xiaobin He; Lei Pei; Zhidan Zhang; Fang Yang; Fuqiang Xu
TAGS: dura mater, neurons, neurons, afferent, synapses, eye, rats
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3424-3430. doi: 10.1167/iovs.18-24308

Immunology and Microbiology June 2018

MyD88 Deficiency Protects Against Dry Eye–Induced Damage

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Rose Y. Reins; Carolina Lema; Justin Courson; Carolina M. E. Kunnen; Rachel L. Redfern
TAGS: cytokine, signal transduction, dry eye syndromes, mice, myd88 gene
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2967-2976. doi: 10.1167/iovs.17-23397

Includes: Supplemental Content

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Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect

Instability of TCF4 Triplet Repeat Expansion With Parent–Child Transmission in Fuchs' Endothelial Corneal Dystrophy

Differential Distribution of Laminin N-Terminus α31 Across the Ocular Surface: Implications for Corneal Wound Repair

MicroRNA-124 Dysregulation is Associated With Retinal Inflammation and Photoreceptor Death in the Degenerating Retina

Comments on Assays Used to Measure VEGF in the Presence of Anti-VEGF Therapeutics

Author Response: Comments on Assays Used to Measure VEGF in the Presence of Anti-VEGF Therapeutics

Murine Retinal Citrullination Declines With Age and is Mainly Dependent on Peptidyl Arginine Deiminase 4 (PAD4)

Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina

Resveratrol Delays Retinal Ganglion Cell Loss and Attenuates Gliosis-Related Inflammation From Ischemia-Reperfusion Injury

Matricellular Protein Levels in Aqueous Humor and Surgical Outcomes of Trabeculectomy

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation

Capn5 Expression in the Healthy and Regenerating Zebrafish Retina

Ocular Biomarkers of Alzheimer's Disease: The Role of Anterior Eye and Potential Future Directions

Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells

Tear Film Proteomics Reveal Important Differences Between Patients With and Without Ocular GvHD After Allogeneic Hematopoietic Cell Transplantation

Defined Conditions for Differentiation of Functional Retinal Ganglion Cells From Human Pluripotent Stem Cells

Irreversible Photoreceptors and RPE Cells Damage by Intravenous Sodium Iodate in Mice Is Related to Macrophage Accumulation

Anatomic Evidence for Information Exchange between Primary Afferent Sensory Neurons Innervating the Anterior Eye Chamber and the Dura Mater in Rat

MyD88 Deficiency Protects Against Dry Eye–Induced Damage

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