Biochemistry and Molecular Biology

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Physiology and Pharmacology June 2025

Modeling the Ocular Pharmacokinetics and Pharmacodynamics of Ranibizumab for Improved Understanding and Data Collection Strategies in Ocular Diseases

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Jessica R. Crawshaw; Eamonn A. Gaffney; Michael Gertz; Philip K. Maini; Antonello Caruso
TAGS: aqueous humor, ranibizumab, vascular endothelial growth factor a, pharmacodynamics, eye diseases, pharmacokinetics, mathematical model
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):20. https://doi.org/10.1167/iovs.66.6.20

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology June 2025

Biallelic NSUN3 Variants Cause Diverse Phenotypic Spectrum Disease: From Isolated Optic Atrophy to Severe Early-Onset Mitochondrial Disorder

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Neringa Jurkute; Heiko Brennenstuhl; Monika Kustermann; Lindsey Van Haute; Christian D. Mutti; Enrico Bugiardini; Takayuki Handa; Masaru Shimura; Axel Petzold; James Acheson; Anthony G. Robson; William L. Macken; Michael G. Hanna; Robert D. S. Pitceathly; Ashirwad Merve; Urania Kotzaeridou; Stefan Kölker; Michael Freilinger; Marcus Erdler; Reginald E. Bittner; Johannes A. Mayr; Yasushi Okazaki; Kei Murayama; Holger Prokisch; Andrew R. Webster; Michal Minczuk; Gavin Arno; Berthold Pemp; Georg F. Hoffmann; Wolfgang M. Schmidt; Patrick Yu-Wai-Man
TAGS: family, mitochondrial diseases, optic atrophy, phenotype, mitochondria, optic nerve disorders, respiratory chain
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):17. https://doi.org/10.1167/iovs.66.6.17

Includes: Supplemental Content

Physiology and Pharmacology June 2025

Impact of Second-Generation PDE 5 Inhibitor, Avanafil, on Retinal Function: Studies From Ex Vivo ERG

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Sama Saeid; Frans Vinberg; Ari Koskelainen
TAGS: avanafil, electroretinography, phosphodiesterase 5 inhibitors, rod photoreceptors, phototransduction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):14. https://doi.org/10.1167/iovs.66.6.14

Cornea June 2025

Activation of Sympathetic Nervous System Drives Dry Eye Onset Via Norepinephrine-β2-Adrenergic Receptor Signaling in Mice

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Mingli Qu; Xiaofei Bai; Mengyao Zhang; Jingyi Wu; Lei Wan; Xiaoyu Li; Qun Wang; Lin Cong; Benxiang Qi; Qingjun Zhou
TAGS: cornea, dry eye syndromes, mice, norepinephrine, sympathetic nervous system, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):13. https://doi.org/10.1167/iovs.66.6.13

Includes: Supplemental Content

Immunology and Microbiology June 2025

Disruption of Epidermal Growth Factor Receptor Signaling in RPE Cells Increases Resistance to Ocular Toxoplasmosis

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Amelia Pfaff; Alyssa Hubal; Sarah Vos; Vera Bonilha; Carlos S. Subauste
TAGS: epidermal growth factor receptors, ocular toxoplasmosis, retinal pigment cell, signal transduction, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):11. https://doi.org/10.1167/iovs.66.6.11

Includes: Supplemental Content

Glaucoma June 2025

PRMT5 Regulates Senescence in Retinal Ganglion Cells by Targeting the Wnt/β-Catenin Signaling Cascade

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Yumeng Zhang; Hanwen Huang; Huimin Zhong; Yang Zhang; Siqi He; Yanzhi Guo; Yiwei Wang; Ping Huang; Shouyue Huang; Yisheng Zhong
TAGS: aging, mice, older adult, signal transduction, retinal ganglion cells, western blotting, hypoxia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):8. https://doi.org/10.1167/iovs.66.6.8

Includes: Supplemental Content

Cornea June 2025

Fatty Acid Desaturase 1 Knockdown Promotes Wound Healing and Functional Recovery of the Corneal Epithelium in Diabetes

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Yangqi Zhao; Yi Dong; Qingqing Zheng; Yue Zhao; Yingjie Ni; Peijin Qiu; Chuannan Chen; Mengyue Xu; Chaoyang Hong; Ting Shen
TAGS: cornea, diabetes mellitus, rna, small interfering, wound healing, fatty acid desaturases, stearoyl-coa desaturase, epithelium, recovery of function, corneal epithelium, corneal epithelial cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):6. https://doi.org/10.1167/iovs.66.6.6

Includes: Supplemental Content

Retina May 2025

Clic6 Deficiency Triggers Aberrant Apical Microvilli in RPE

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Sangwan Park; Naran Suvarnpradip; Niusha Kasiri; Glenn Yiu; Sara M. Thomasy; Denise M. Imai; K. C. Kent Lloyd; Brian C. Leonard; Ala Moshiri
TAGS: mice, microvilli, precipitating factors, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):44. https://doi.org/10.1167/iovs.66.5.44

Includes: Supplemental Content

Immunology and Microbiology May 2025

Adrb2 Expression in Ocular-Infiltrating Macrophages Is Necessary for Interleukin-6 Expression and Choroidal Neovascularization

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Joyce Gong; Kyle S. Chan; Amrita Rajesh; Steve Droho; Jeremy A. Lavine
TAGS: adrb2 gene, beta-2 adrenergic receptors, choroidal neovascularization, interleukin-6, lasers, macrophages, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):43. https://doi.org/10.1167/iovs.66.5.43

Includes: Supplemental Content

Cornea May 2025

Tear Proteomic Analysis From Offspring of Keratoconus Patients: New Insights Into Corneal Biomechanical Weakness and Disease Risk Stages

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Maite López-López; Uxía Regueiro; Susana Bravo; Carmen Pena; Yaiza Pastoriza; Mercedes Conde-Amboage; Pablo Hervella; Isabel Lema
TAGS: asthenia, cornea, keratoconus, offspring, proteins, proteomics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):41. https://doi.org/10.1167/iovs.66.5.41

Includes: Supplemental Content

Cornea May 2025

Metabolomic Profiling of Ocular Fluid Identifies Host Response Factors for Risk Stratification in Bacterial Endophthalmitis

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Naren Shetty; Padmamalini Mahendradas; Ramaraj Kannan; Samayitree Das; Priyanka Sathe; Rohit Shetty; Arkasubhra Ghosh; Vrushali Deshpande
TAGS: bacterial endophthalmitis, metabolites, metabolomics, immune response, stratification
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):27. https://doi.org/10.1167/iovs.66.5.27

Includes: Supplemental Content

Biochemistry and Molecular Biology May 2025

Distinct Transcriptomic Profiles of Cultured Anterior and Posterior Populations of Human Infant Scleral Fibroblasts: Including Dopamine Receptors

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Jiali Guan; Guangliang Hong; Zhong Liu; Yingfeng Zheng; Jiangping He; Dajiang Qin; He Li
TAGS: fibroblasts, sclera, infant, single-cell rna-seq, dopamine receptors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):29. https://doi.org/10.1167/iovs.66.5.29

Includes: Supplemental Content

Glaucoma May 2025

Metabolomic Profiling of Aqueous Humor From Glaucoma Patients Identifies Metabolites With Anti-Inflammatory and Neuroprotective Potential in Mice

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Monu Monu; Bhoj Kumar; Rahmat Asfiya; Nariman Nassiri; Vaama Patel; Shibandri Das; Sarah Syeda; Mamta Kanwar; Vivian Rajeswaren; Bret A. Hughes; Mark S. Juzych; Akhil Srivastava; Ashok Kumar; Pawan Kumar Singh
TAGS: agmatine, anti-inflammatory agents, aqueous humor, glaucoma, hypertension, metabolites, metabolomics, mice, open-angle glaucoma, thiamine
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):28. https://doi.org/10.1167/iovs.66.5.28

Biochemistry and Molecular Biology May 2025

Canonical and Truncated Transglutaminase-2 Drive TGF-β1 Autocrine Loop to Induce Fibrosis in Graves’ Orbitopathy

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Xiaoli Bao; Zhihui Xu; Xi Wang; Te Zhang; Xiaotong Sha; Anqi Sun; Huijing Ye; Huasheng Yang
TAGS: fibrosis, protein glutamine gamma glutamyltransferase 2, autocrine, genes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):22. https://doi.org/10.1167/iovs.66.5.22

Includes: Supplemental Content

Retina May 2025

Muscone Attenuates Uveitis Through the PI3K/AKT Signaling Pathway

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Xianyang Liu; Hangjia Zuo; Chao Wu; Na Li; Qian Zhou; Fan Cao; Baorui Chu; Shuhao Zeng; Hui Feng; Yakun Wang; Fengyang Lei; Ke Hu; Shengping Hou
TAGS: akt signaling pathway, mice, phosphoinositide 3-kinase, proteins, uveitis, inflammation, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):21. https://doi.org/10.1167/iovs.66.5.21

Includes: Supplemental Content

Lens May 2025

LncRNA HOTAIR Interaction With WTAP Promotes m 6 A Methyltransferase Complex Assembly and Posterior Capsule Opacification Formation by Increasing THBS1

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Xi Chen; Chenshuang Li; Jiankui Li; Zaoxia Guo; Siqi Zhang; Chenjun Guo; Hong Yan
TAGS: after-cataract, epithelial to mesenchymal transition, methyltransferase, proteins, rna, thrombospondin 1, western blotting, protein overexpression, polymerase chain reaction, cataract surgery
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):20. https://doi.org/10.1167/iovs.66.5.20

Includes: Supplemental Content

Biochemistry and Molecular Biology May 2025

Regulatory Effects of the Wnt7b/β-Catenin/MMP-2 Signaling Pathway on Scleral Stiffness in Guinea Pigs With Form-Deprivation Myopia

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Binyu Wen; Hangyu Li; Hui Tao; Hong Ren; Bosheng Ma; Mengdi Shi; Shen Chen; Jiaqi Du; Ziyi Cai; Jing Zhang; Dongshi Guan; Zhihong Deng
TAGS: caviidae, collagen, gelatinase a, myopia, sclera, signal pathway, signal transduction pathways
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):19. https://doi.org/10.1167/iovs.66.5.19

Includes: Supplemental Content

Retina May 2025

Endoplasmic Reticulum Stress Drives Neuroinflammation Through Lipocalin 2 Upregulation in Retinal Microglia After Optic Nerve Injury

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Weifeng Huang; Yaoming Liu; Jinmiao Li; Yang Gao; Junjie Tang; Siuhang Yip; Xinyue Wang; Hongwei Zhang; Yujun Ma; Shicai Su; Jiahe Nie; Rong Lu
TAGS: endoplasmic reticulum stress, lipocalin-2 protein, microglia, neuroinflammatory diseases, optic nerve injuries, up-regulation (physiology), inflammation, lcn2 gene, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):12. https://doi.org/10.1167/iovs.66.5.12

Includes: Supplemental Content

Retina May 2025

Aqueous Humor Levels of Vascular Endothelial Growth Factor in Patients With Dry Age-Related Macular Degeneration and Subretinal Drusenoid Deposits

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Eun Gyu Yoon; Ki Tae Nam; Mihyun Choi; Kwang-Eon Choi; Cheolmin Yun
TAGS: age-related macular degeneration, aqueous humor, vascular endothelial growth factor a, drusen
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):10. https://doi.org/10.1167/iovs.66.5.10

Includes: Supplemental Content

Cornea May 2025

Retinoic Acid Receptor Alpha- and Beta-Mediated Signaling Regulates Conjunctival Epithelial Cell Keratinization

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Hokoru Yoshioka; Mayumi Ueta; Seiichi Yokoo; Norihiko Yokoi; Katsura Mizushima; Yuji Naito; Shigeru Kinoshita; Chie Sotozono
TAGS: conjunctival epithelial cells, keratinization, retinoic acid receptor, retinoic acid receptor alpha, signal transduction, tretinoin, vitamin a, polymerase chain reaction, rna, small interfering
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):6. https://doi.org/10.1167/iovs.66.5.6

Includes: Supplemental Content

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Modeling the Ocular Pharmacokinetics and Pharmacodynamics of Ranibizumab for Improved Understanding and Data Collection Strategies in Ocular Diseases

Biallelic NSUN3 Variants Cause Diverse Phenotypic Spectrum Disease: From Isolated Optic Atrophy to Severe Early-Onset Mitochondrial Disorder

Impact of Second-Generation PDE 5 Inhibitor, Avanafil, on Retinal Function: Studies From Ex Vivo ERG

Activation of Sympathetic Nervous System Drives Dry Eye Onset Via Norepinephrine-β2-Adrenergic Receptor Signaling in Mice

Disruption of Epidermal Growth Factor Receptor Signaling in RPE Cells Increases Resistance to Ocular Toxoplasmosis

PRMT5 Regulates Senescence in Retinal Ganglion Cells by Targeting the Wnt/β-Catenin Signaling Cascade

Fatty Acid Desaturase 1 Knockdown Promotes Wound Healing and Functional Recovery of the Corneal Epithelium in Diabetes

Clic6 Deficiency Triggers Aberrant Apical Microvilli in RPE

Adrb2 Expression in Ocular-Infiltrating Macrophages Is Necessary for Interleukin-6 Expression and Choroidal Neovascularization

Tear Proteomic Analysis From Offspring of Keratoconus Patients: New Insights Into Corneal Biomechanical Weakness and Disease Risk Stages

Metabolomic Profiling of Ocular Fluid Identifies Host Response Factors for Risk Stratification in Bacterial Endophthalmitis

Distinct Transcriptomic Profiles of Cultured Anterior and Posterior Populations of Human Infant Scleral Fibroblasts: Including Dopamine Receptors

Metabolomic Profiling of Aqueous Humor From Glaucoma Patients Identifies Metabolites With Anti-Inflammatory and Neuroprotective Potential in Mice

Canonical and Truncated Transglutaminase-2 Drive TGF-β1 Autocrine Loop to Induce Fibrosis in Graves’ Orbitopathy

Muscone Attenuates Uveitis Through the PI3K/AKT Signaling Pathway

LncRNA HOTAIR Interaction With WTAP Promotes m 6 A Methyltransferase Complex Assembly and Posterior Capsule Opacification Formation by Increasing THBS1

Regulatory Effects of the Wnt7b/β-Catenin/MMP-2 Signaling Pathway on Scleral Stiffness in Guinea Pigs With Form-Deprivation Myopia

Endoplasmic Reticulum Stress Drives Neuroinflammation Through Lipocalin 2 Upregulation in Retinal Microglia After Optic Nerve Injury

Aqueous Humor Levels of Vascular Endothelial Growth Factor in Patients With Dry Age-Related Macular Degeneration and Subretinal Drusenoid Deposits

Retinoic Acid Receptor Alpha- and Beta-Mediated Signaling Regulates Conjunctival Epithelial Cell Keratinization

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