Biochemistry and Molecular Biology

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Biochemistry and Molecular Biology October 2019

Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma

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Chandrani Chattopadhyay; Junna Oba; Jason Roszik; Joseph R. Marszalek; Ken Chen; Yuan Qi; Karina Eterovic; A. Gordon Robertson; Jared K. Burks; Tara A. McCannel; Elizabeth A. Grimm; Scott E. Woodman
TAGS: genes, intraocular melanoma, metabolism, neoplasms, sdha gene, cancer, cell lines, monosomy, mitomycin, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4187-4195. doi: 10.1167/iovs.19-28082

Includes: Supplemental Content

Physiology and Pharmacology October 2019

Rapid Development of Glaucoma Via ITV Nonselective ANGPT 1/2 Antibody: A Potential Role for ANGPT/TIE2 Signaling in Primate Aqueous Humor Outflow

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Evan A. Thackaberry; Yi Zhou; Christina L. Zuch de Zafra; Germaine Fuh; Chingwei V. Lee; Sarah Sanowar; John B. Ridgway; Aija M. Kusi; Cindy Farman; Helen Booler; Daniel Sheinson; Carol A. Rasmussen; Paul E. Miller; Eric Wakshull; Minhong Yan; Vladimir Bantseev
TAGS: antibodies, anti-vascular endothelial growth factor therapy, aqueous humor, eye, glaucoma, intraocular pressure, macaca fascicularis, primates, signal transduction, mice
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4097-4108. doi: 10.1167/iovs.18-26349

Biochemistry and Molecular Biology October 2019

Therapeutic Effect of Curcumin, a Plant Polyphenol Extracted From Curcuma longae , in Fibroblasts From Patients With Graves' Orbitopathy

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Jihei Sara Lee; Jinjoo Kim; Eun Jig Lee; Jin Sook Yoon
TAGS: curcumin, fibroblasts, polyphenols, plants
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4129-4140. doi: 10.1167/iovs.19-27376

Visual Neuroscience September 2019

Reductions in Calcium Signaling Limit Inhibition to Diabetic Retinal Rod Bipolar Cells

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Johnnie M. Moore-Dotson; Erika D. Eggers
TAGS: amacrine cells, diabetes mellitus, gamma-aminobutyric acid, retinal bipolar cells, rod photoreceptors, diabetes mellitus, type 2
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):4063-4073. doi: 10.1167/iovs.19-27137

Genetics September 2019

Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration

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Andrea R. Waksmunski; Michelle Grunin; Tyler G. Kinzy; Robert P. Igo, Jr; Jonathan L. Haines; Jessica N. Cooke Bailey; for the International Age-Related Macular Degeneration Genomics Consortium
TAGS: age-related macular degeneration, candidate disease gene, genes, genome, genome-wide association study, ophthalmology, universities, schools, medical, proteins, genetics
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):4041-4051. doi: 10.1167/iovs.19-27827

Includes: Supplemental Content

Glaucoma September 2019

Activation of αvβ3 Integrin Alters Fibronectin Fibril Formation in Human Trabecular Meshwork Cells in a ROCK-Independent Manner

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Mark S. Filla; Jennifer A. Faralli; Harini Desikan; Jennifer L. Peotter; Abigail C. Wannow; Donna M. Peters
TAGS: fibril, fibronectins, integrins
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3897-3913. doi: 10.1167/iovs.19-27171

Includes: Supplemental Content

Lens September 2019

Lens Connexin Channels Have Differential Permeability to the Second Messenger cAMP

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Virginijus Valiunas; Peter R. Brink; Thomas W. White
TAGS: cyclic amp, gap junction protein, lens (device), permeability, lens, crystalline, connexin 43, second messenger systems
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3821-3829. doi: 10.1167/iovs.19-27302

Retina September 2019

Immune and Inflammatory Proteins in Cord Blood as Predictive Biomarkers of Retinopathy of Prematurity in Preterm Infants

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Young Joo Park; Se Joon Woo; Yu Mi Kim; Subeen Hong; Young Eun Lee; Kyo Hoon Park
TAGS: biological markers, infant, premature, plasma, proteins, retinopathy of prematurity, umbilical cord blood, laser therapy, interleukin-6
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3813-3820. doi: 10.1167/iovs.19-27258

Includes: Supplemental Content

Retinal Cell Biology September 2019

Survival of Alpha and Intrinsically Photosensitive Retinal Ganglion Cells in NMDA-Induced Neurotoxicity and a Mouse Model of Normal Tension Glaucoma

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Sari Honda; Kazuhiko Namekata; Atsuko Kimura; Xiaoli Guo; Chikako Harada; Akira Murakami; Akira Matsuda; Takayuki Harada
TAGS: glaucoma, glaucoma, normal-tension, melanopsin, mice, neurotoxicity syndromes, n-methylaspartate, retina, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3696-3707. doi: 10.1167/iovs.19-27145

Includes: Supplemental Content

Glaucoma August 2019

Physiologic Electrical Fields Direct Retinal Ganglion Cell Axon Growth In Vitro

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Kimberly K. Gokoffski; Xingyuan Jia; Daniel Shvarts; Guohua Xia; Min Zhao
TAGS: axon, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3659-3668. doi: 10.1167/iovs.18-25118

Includes: Multimedia, Supplemental Content

Glaucoma August 2019

Mitochondrial-Targeted Antioxidants Attenuate TGF-β2 Signaling in Human Trabecular Meshwork Cells

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Vidhya R. Rao; Jonathan D. Lautz; Simon Kaja; Eileen M. Foecking; Emőke Lukács; Evan B. Stubbs, Jr
TAGS: antioxidants, attenuation, mitochondria, signal transduction, trabecular meshwork
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3613-3624. doi: 10.1167/iovs.19-27542

Editorial August 2019

Reviewers

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TAGS: acoustic evoked brain stem potentials, arthritis, juvenile rheumatoid, aves, betula, burns, chewing, christianity, cluster headache, enzyme-linked immunosorbent assay, esters
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3414-3420. doi: 10.1167/iovs.19-28020

Cornea August 2019

Small Molecule Modulation of the Integrated Stress Response Governs the Keratoconic Phenotype In Vitro

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Uri Simcha Soiberman; Ahmed Elsayed Mahmoud Shehata; Michelle Xiaoyi Lu; Tempest Young; Yassine J. Daoud; Shukti Chakravarti; Albert S. Jun; James William Foster
TAGS: keratoconus, phenotype, regulation, small molecule, stress response, fibroblasts, proteins, cell count, collagen synthesis, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3422-3431. doi: 10.1167/iovs.19-27151

Includes: Supplemental Content

Physiology and Pharmacology August 2019

Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis

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Caitriona O'Leary; Mary K. McGahon; Sadaf Ashraf; Jennifer McNaughten; Thomas Friedel; Patrizia Cincolà; Peter Barabas; Jose A. Fernandez; Alan W. Stitt; J. Graham McGeown; Tim M. Curtis
TAGS: angiogenesis, trpv1 receptor
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3297-3309. doi: 10.1167/iovs.18-26344

Includes: Multimedia, Supplemental Content

Retina July 2019

Arginine and Carnitine Metabolites Are Altered in Diabetic Retinopathy

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Katherine Sumarriva; Karan Uppal; Chunyu Ma; David J. Herren; Yating Wang; Isaac M. Chocron; Cassandra Warden; Sabrina L. Mitchell; L. Goodwin Burgess; Megan P. Goodale; Melissa P. Osborn; Allison J. Ferreira; Janice C. Law; Edward F. Cherney; Dean P. Jones; Milam A. Brantley, Jr
TAGS: arginine, carnitine, diabetic retinopathy, metabolites, nonproliferative diabetic retinopathy, diabetes mellitus
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3119-3126. doi: 10.1167/iovs.19-27321

Includes: Supplemental Content

Retinal Cell Biology July 2019

Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All- trans Retinal

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Yi Liao; Houjian Zhang; Danxue He; Yan Wang; Binxiang Cai; Jingmeng Chen; Jianxing Ma; Zuguo Liu; Yalin Wu
TAGS: caspase-1, inflammasomes, nlr family, pyrin domain-containing 3 protein, retinal pigment epithelium, cell death, interleukin-18
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3034-3045. doi: 10.1167/iovs.18-26360

Includes: Supplemental Content

Cornea July 2019

Differentiation Capacity of Human Mesenchymal Stem Cells into Keratocyte Lineage

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Aurelie Dos Santos; Alis Balayan; Martha L. Funderburgh; John Ngo; James L. Funderburgh; Sophie X. Deng
TAGS: keratocytes, stem cell, mesenchymal, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3013-3023. doi: 10.1167/iovs.19-27008

Includes: Supplemental Content

Biochemistry and Molecular Biology July 2019

Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells

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Feng He; Ralph M. Nichols; Lavanya Kailasam; Theodore G. Wensel; Melina A. Agosto
TAGS: biopharmaceutics classification system, phosphatidylinositols, phosphotransferases, retinal bipolar cells, tissue degeneration, mice, tissue membrane, rod photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):2861-2874. doi: 10.1167/iovs.19-26586

Includes: Supplemental Content

Anatomy and Pathology/Oncology June 2019

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

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Ikram El Zaoui; Maya Bucher; Donata Rimoldi; Michael Nicolas; Gurkan Kaya; Rosanna Pescini Gobert; Nicola Bedoni; Ann Schalenbourg; Ezziat Sakina; Leonidas Zografos; Serge Leyvraz; Nicolo Riggi; Carlo Rivolta; Alexandre P. Moulin
TAGS: 1-phosphatidylinositol 3-kinase, malignant melanoma of conjunctiva, mitogen-activated protein kinases, molecular targeted therapy, mtor serine-threonine kinases, phosphoinositide 3-kinase, braf gene, proto-oncogene proteins c-akt, melanoma, mutation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2764-2772. doi: 10.1167/iovs.18-26508

Includes: Supplemental Content

Retina June 2019

Blast-Mediated Traumatic Brain Injury Exacerbates Retinal Damage and Amyloidosis in the APPswePSENd19e Mouse Model of Alzheimer's Disease

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Matthew M. Harper; Adam Hedberg-Buenz; Judith Herlein; Eric E. Abrahamson; Michael G. Anderson; Markus H. Kuehn; Randy H. Kardon; Pieter Poolman; Milos D. Ikonomovic
TAGS: alzheimer's disease, amyloidosis, basic local alignment search tool, mice, nerve degeneration, traumatic brain injuries, optic nerve, brain, retina, blast injuries
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2716-2725. doi: 10.1167/iovs.18-26353

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Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma

Rapid Development of Glaucoma Via ITV Nonselective ANGPT 1/2 Antibody: A Potential Role for ANGPT/TIE2 Signaling in Primate Aqueous Humor Outflow

Therapeutic Effect of Curcumin, a Plant Polyphenol Extracted From Curcuma longae , in Fibroblasts From Patients With Graves' Orbitopathy

Reductions in Calcium Signaling Limit Inhibition to Diabetic Retinal Rod Bipolar Cells

Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration

Activation of αvβ3 Integrin Alters Fibronectin Fibril Formation in Human Trabecular Meshwork Cells in a ROCK-Independent Manner

Lens Connexin Channels Have Differential Permeability to the Second Messenger cAMP

Immune and Inflammatory Proteins in Cord Blood as Predictive Biomarkers of Retinopathy of Prematurity in Preterm Infants

Survival of Alpha and Intrinsically Photosensitive Retinal Ganglion Cells in NMDA-Induced Neurotoxicity and a Mouse Model of Normal Tension Glaucoma

Physiologic Electrical Fields Direct Retinal Ganglion Cell Axon Growth In Vitro

Mitochondrial-Targeted Antioxidants Attenuate TGF-β2 Signaling in Human Trabecular Meshwork Cells

Reviewers

Small Molecule Modulation of the Integrated Stress Response Governs the Keratoconic Phenotype In Vitro

Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis

Arginine and Carnitine Metabolites Are Altered in Diabetic Retinopathy

Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All- trans Retinal

Differentiation Capacity of Human Mesenchymal Stem Cells into Keratocyte Lineage

Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

Blast-Mediated Traumatic Brain Injury Exacerbates Retinal Damage and Amyloidosis in the APPswePSENd19e Mouse Model of Alzheimer's Disease

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