Biochemistry and Molecular Biology

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Visual Neuroscience April 2019

ON-Type Retinal Ganglion Cells are Preferentially Affected in STZ-Induced Diabetic Mice

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Run-Ze Cui; Lu Wang; Sheng-Nan Qiao; Yong-Chen Wang; Xin Wang; Fei Yuan; Shi-Jun Weng; Xiong-Li Yang; Yong-Mei Zhong
TAGS: diabetes mellitus, streptozocin, mice, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1644-1656. doi: 10.1167/iovs.18-26359

Retina April 2019

Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy

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Haitao Liu; Jie Tang; Yunpeng Du; Aicha Saadane; Ivy Samuels; Alex Veenstra; Jianying Z. Kiser; Krzysztof Palczewski; Timothy S. Kern
TAGS: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, photoreceptors, phototransduction, rod photoreceptors, vision, mice, retina, tissue degeneration
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1538-1546. doi: 10.1167/iovs.18-26433

Physiology and Pharmacology April 2019

The Effect of Molecular Weight on Passage of Proteins Through the Blood-Aqueous Barrier

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Susanne Ragg; Melissa Key; Fernanda Rankin; Darrell WuDunn
TAGS: hypertension, plasma, proteins
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1461-1469. doi: 10.1167/iovs.19-26542

Biochemistry and Molecular Biology April 2019

PH20 Inhibits TGFβ1-Induced Differentiation of Perimysial Orbital Fibroblasts via Hyaluronan-CD44 Pathway in Thyroid-Associated Ophthalmopathy

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Ruiqi Ma; Hui Ren; Binbin Xu; Yun Cheng; Lu Gan; Rui Zhang; Jihong Wu; Jiang Qian
TAGS: fibroblasts, graves' ophthalmopathy, cd44 antigens, ovarian failure, premature, hyaluronan, homing-associated cell adhesion molecule
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1431-1441. doi: 10.1167/iovs.18-26268

Includes: Supplemental Content

Retina April 2019

Anatomic Response to Intravitreal Dexamethasone Implant and Baseline Aqueous Humor Cytokine Levels in Diabetic Macular Edema

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Marc Figueras-Roca; Anna Sala-Puigdollers; Javier Zarranz-Ventura; Carmen Alba-Linero; Socorro Alforja; Cristina Esquinas; Blanca Molins; Alfredo Adán
TAGS: cytokine, hypertension, dexamethasone, monocyte chemoattractant protein-1, aqueous humor, macular edema, diabetic, implants
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1336-1343. doi: 10.1167/iovs.18-26215

Lecture April 2019

Discovering Mechanisms in the Changing and Diverse Pathology of Retinopathy of Prematurity: The Weisenfeld Award Lecture

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M. Elizabeth Hartnett
TAGS: vascular endothelial growth factor a, signal transduction, awards and prizes, neovascularization, pathologic, retinopathy of prematurity, pathology, retina, vitreous neovascularization
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1286-1297. doi: 10.1167/iovs.18-25525

Biochemistry and Molecular Biology March 2019

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

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Kailin Chen; Kairan Lai; Xiaobo Zhang; Zhenwei Qin; Qiuli Fu; Chenqi Luo; Xiuming Jin; Jianghua Hu; Siyu Liu; Ke Yao
TAGS: fibroblasts, conjunctiva, pterygium, proto-oncogene proteins c-akt, bromfenac, hpfs trial
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1156-1164. doi: 10.1167/iovs.18-24743

Includes: Supplemental Content

Retinal Cell Biology March 2019

Dual Properties of Lactate in Müller Cells: The Effect of GPR81 Activation

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Rupali Vohra; Blanca I. Aldana; Helle Waagepetersen; Linda H. Bergersen; Miriam Kolko
TAGS: lactates, glutamate, glucose
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):999-1008. doi: 10.1167/iovs.18-25458

Retinal Cell Biology March 2019

Neuroprotective Effects of HSF1 in Retinal Ischemia-Reperfusion Injury

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Wei Liu; Fan Xia; Yonju Ha; Shuang Zhu; Yi Li; Oluwarotimi Folorunso; Aryan Pashaei-Marandi; Pei-Yi Lin; Ronald G. Tilton; Anson P. Pierce; Hua Liu; Wenbo Zhang
TAGS: ischemia, wounds and injuries, eye, mice, proteins, stress, neuroprotective effect, protein overexpression, retina, reperfusion injury, heat-shock proteins 70, reperfusion therapy, retinal ischemia, immunohistochemistry
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):965-977. doi: 10.1167/iovs.18-26216

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2019

Electrophysiological Changes During Early Steps of Retinitis Pigmentosa

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Ulisse Bocchero; Beatrice M. Tam; Colette N. Chiu; Vincent Torre; Orson L. Moritz
TAGS: animals, transgenic, darkness, electroretinography, photons, phototransduction, retinitis pigmentosa, rhodopsin, rod photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):933-943. doi: 10.1167/iovs.18-25347

Includes: Supplemental Content

Cornea March 2019

Mediators of Corneal Haze Following Implantation of Presbyopic Corneal Inlays

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Beau J. Fenner; Yu-Chi Liu; Siew Kwan Koh; Yan Gao; Lu Deng; Roger W. Beuerman; Lei Zhou; Julian T. S. Theng; Jodhbir S. Mehta
TAGS: corneal opacity, cornea, eye, proteins, proteomics, implantation procedure
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):868-876. doi: 10.1167/iovs.18-25761

Includes: Supplemental Content

Special Issue February 2019

IMI – Myopia Genetics Report

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Milly S. Tedja; Annechien E. G. Haarman; Magda A. Meester-Smoor; Jaakko Kaprio; David A. Mackey; Jeremy A. Guggenheim; Christopher J. Hammond; Virginie J. M. Verhoeven; Caroline C. W. Klaver; for the CREAM Consortium
TAGS: genes, myopia, refractive errors, genetics, genome-wide association study, universities
Invest. Ophthalmol. Vis. Sci.. 2019; 60(3):M89-M105. doi: 10.1167/iovs.18-25965

Glaucoma February 2019

Myosin-X Silencing in the Trabecular Meshwork Suggests a Role for Tunneling Nanotubes in Outflow Regulation

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Ying Ying Sun; Yong-Feng Yang; Kate E. Keller
TAGS: actins, western blotting, myosin, dimethyl sulfoxide, lentivirus, matrix metalloproteinases, microscopy, confocal, perfusion, phagocytosis, trabecular meshwork, proteins, regulation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):843-851. doi: 10.1167/iovs.18-26055

Includes: Supplemental Content

Retina February 2019

The Neuroprotective Peptide PACAP1-38 Contributes to Horizontal Cell Development in Postnatal Rat Retina

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Viktoria Denes; Orsolya Hideg; Zsolt Nyisztor; Monika Lakk; Zoltan Godri; Gergely Berta; Peter Geck; Robert Gabriel
TAGS: immunohistochemistry, peptides, proliferating cell nuclear antigen, retina, horizontal cells
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):770-778. doi: 10.1167/iovs.18-25719

Physiology and Pharmacology February 2019

1 H NMR Spectroscopy Characterization of Porcine Vitreous Humor in Physiological and Photoreceptor Degeneration Conditions

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Alberto Elmi; Domenico Ventrella; Luca Laghi; Giacomo Carnevali; Chenglin Zhu; Grazia Pertile; Francesca Barone; Fabio Benfenati; Maria Laura Bacci
TAGS: photoreceptors, spectrum analysis, suidae, vitreous body, tissue degeneration, molecule
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):741-747. doi: 10.1167/iovs.18-25675

Includes: Supplemental Content

Cornea February 2019

KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27

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Anil Tiwari; Sudha Swamynathan; Nicholas Alexander; John Gnalian; Shenghe Tian; Paul R. Kinchington; Shivalingappa K. Swamynathan
TAGS: signal transduction, corneal epithelium, cornea, rna, ablation, corneal epithelial cells, cyclin-dependent kinase inhibitors
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):731-740. doi: 10.1167/iovs.18-26423

Includes: Supplemental Content

Biochemistry and Molecular Biology February 2019

DNA Methylation Regulates Corneal Epithelial Wound Healing by Targeting miR-200a and CDKN2B

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Guangying Luo; Xia Jing; Shuai Yang; Dewei Peng; Jing Dong; Li Li; Peter S. Reinach; Dongsheng Yan
TAGS: epithelium, dna, dna methylation, wound healing, wounds and injuries, cornea, hypermethylation, dna (cytosine-5-)-methyltransferase 1, cdkn2b gene, rna, small interfering, methylation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):650-660. doi: 10.1167/iovs.18-25443

Includes: Supplemental Content

Retina February 2019

MMP Inhibition Preserves Integrin Ligation and FAK Activation to Induce Survival and Regeneration in RGCs Following Optic Nerve Damage

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Philippe M. D'Onofrio; Alireza P. Shabanzadeh; Brian K. Choi; Mathias Bähr; Paulo D. Koeberle
TAGS: immunohistochemistry, integrins, axon, axotomy, injections, ligation, matrix metalloproteinases, stromelysin 1, wounds and injuries, optic nerve, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):634-649. doi: 10.1167/iovs.18-25257

Glaucoma February 2019

Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon's Capsule + Conjunctival Model

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Rachel Gater; Tugce Ipek; Salman Sadiq; Dan Nguyen; Lynval Jones; Alicia El Haj; Ying Yang
TAGS: actins, tumor necrosis factors, vascular endothelial growth factor a, enzyme-linked immunosorbent assay, fibroblasts, fibrosis, glaucoma, growth factor, suidae, aqueous humor, conjunctiva, tenon's capsule, shear stress
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):605-614. doi: 10.1167/iovs.18-25335

Anatomy and Pathology/Oncology February 2019

A Genome-Wide Association Study for Susceptibility to Visual Experience-Induced Myopia

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Yu Huang; Chea-su Kee; Paul M. Hocking; Cathy Williams; Shea Ping Yip; Jeremy A. Guggenheim; for The UK Biobank Eye and Vision Consortium and The CREAM Consortium
TAGS: child, genetics, myopia, refractive errors, genome-wide association study, disease susceptibility
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):559-569. doi: 10.1167/iovs.18-25597

Includes: Supplemental Content

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ON-Type Retinal Ganglion Cells are Preferentially Affected in STZ-Induced Diabetic Mice

Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy

The Effect of Molecular Weight on Passage of Proteins Through the Blood-Aqueous Barrier

PH20 Inhibits TGFβ1-Induced Differentiation of Perimysial Orbital Fibroblasts via Hyaluronan-CD44 Pathway in Thyroid-Associated Ophthalmopathy

Anatomic Response to Intravitreal Dexamethasone Implant and Baseline Aqueous Humor Cytokine Levels in Diabetic Macular Edema

Discovering Mechanisms in the Changing and Diverse Pathology of Retinopathy of Prematurity: The Weisenfeld Award Lecture

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

Dual Properties of Lactate in Müller Cells: The Effect of GPR81 Activation

Neuroprotective Effects of HSF1 in Retinal Ischemia-Reperfusion Injury

Electrophysiological Changes During Early Steps of Retinitis Pigmentosa

Mediators of Corneal Haze Following Implantation of Presbyopic Corneal Inlays

IMI – Myopia Genetics Report

Myosin-X Silencing in the Trabecular Meshwork Suggests a Role for Tunneling Nanotubes in Outflow Regulation

The Neuroprotective Peptide PACAP1-38 Contributes to Horizontal Cell Development in Postnatal Rat Retina

1 H NMR Spectroscopy Characterization of Porcine Vitreous Humor in Physiological and Photoreceptor Degeneration Conditions

KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27

DNA Methylation Regulates Corneal Epithelial Wound Healing by Targeting miR-200a and CDKN2B

MMP Inhibition Preserves Integrin Ligation and FAK Activation to Induce Survival and Regeneration in RGCs Following Optic Nerve Damage

Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon's Capsule + Conjunctival Model

A Genome-Wide Association Study for Susceptibility to Visual Experience-Induced Myopia

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