Biochemistry and Molecular Biology

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Glaucoma September 2021

Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma

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Naga Pradeep Rayana; Chenna Kesavulu Sugali; Jiannong Dai; Michael Peng; Shaohui Liu; Yucheng Zhang; Jun Wan; Weiming Mao
TAGS: crispr, eye, glaucoma, mice, ocular hypertension, cytomegalovirus, lentiviral vector, adenoviruses, genes
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):7. doi: https://doi.org/10.1167/iovs.62.12.7

Includes: Supplemental Content

Retina August 2021

Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium

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Dongfeng Cao; Belinda Leong; Jeffrey D. Messinger; Deepayan Kar; Thomas Ach; Lawrence A. Yannuzzi; K. Bailey Freund; Christine A. Curcio
TAGS: age-related macular degeneration, atrophic condition of skin, atrophy, cell transdifferentiation, diagnostic imaging, donors, eye, immunohistochemistry, optical coherence tomography, phenotype
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):34. doi: https://doi.org/10.1167/iovs.62.10.34

Includes: Supplemental Content

Immunology and Microbiology August 2021

Dysbiosis in the Gut Microbiome in Streptozotocin-Induced Diabetes Rats and Follow-Up During Retinal Changes

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Shalem Raj Padakandla; Taraprasad Das; Gumpili Sai Prashanthi; Kiran Kumar Angadi; S. Sreenivasa Reddy; G. Bhanuprakash Reddy; Sisinthy Shivaji
TAGS: diabetes mellitus, intestinal bacteria, microbiome, rats, streptozocin, dysbiosis
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):31. doi: https://doi.org/10.1167/iovs.62.10.31

Includes: Supplemental Content

Cornea August 2021

Tear Proteomics in Keratoconus: A Quantitative SWATH-MS Analysis

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Maite López-López; Uxía Regueiro; Susana B. Bravo; María del Pilar Chantada-Vázquez; Rubén Varela-Fernández; Paulo Ávila-Gómez; Pablo Hervella; Isabel Lema
TAGS: keratoconus, proteins, proteomics
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):30. doi: https://doi.org/10.1167/iovs.62.10.30

Includes: Supplemental Content

Glaucoma August 2021

Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10

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Hang-Jing Wu; Douglas P. Mortlock; Rachel W. Kuchtey; John Kuchtey
TAGS: fibrillin-2, fibrillins, glaucoma, mice, microfibrils, mutation, fibrillin-1, fluorescent antibody technique
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):26. doi: https://doi.org/10.1167/iovs.62.10.26

Cornea August 2021

Exploring the Mechanism of the miRNA-145/Paxillin Axis in Cell Metabolism During VEGF-A–Induced Corneal Angiogenesis

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Wanju Yang; Yanning Yang; Shanshan Wan; Ya Xu; Jing Li; Lu Zhang; Wanruo Guo; Yijun Zheng; Yi Xiang; Yiqiao Xing
TAGS: corneal neovascularization, metabolism, vascular endothelial growth factor a, micrornas, angiogenesis, lactic acid, 1-phosphatidylinositol 3-kinase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):25. doi: https://doi.org/10.1167/iovs.62.10.25

Retina August 2021

Analysis of the Aqueous Humor Proteome in Patients With Age-Related Macular Degeneration

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Batya Rinsky; Gala Beykin; Michelle Grunin; Radgonde Amer; Samer Khateb; Liran Tiosano; Diego Almeida; Shira Hagbi-Levi; Sarah Elbaz-Hayoun; Itay Chowers
TAGS: age-related macular degeneration, aqueous humor, hypertension, proteins, proteome, enzyme-linked immunosorbent assay
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):18. doi: https://doi.org/10.1167/iovs.62.10.18

Includes: Supplemental Content

Glaucoma August 2021

Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression

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Heather M. Schmitt; Rachel L. Fehrman; Margaret E. Maes; Huan Yang; Lian-Wang Guo; Cassandra L. Schlamp; Heather R. Pelzel; Robert W. Nickells
TAGS: apoptosis, disease susceptibility, immunohistochemistry, mice, neurons, plasmids, signal transduction, proteins, caspase-3, histone deacetylase
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):14. doi: https://doi.org/10.1167/iovs.62.10.14

Includes: Supplemental Content

Retina August 2021

Metabolomics Analyses of Mouse Retinas in Oxygen-Induced Retinopathy

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Yedi Zhou; Wei Tan; Jingling Zou; Jian Cao; Qian Huang; Bing Jiang; Shigeo Yoshida; Yun Li
TAGS: metabolites, metabolomics, mice, oxygen, retina, retinal diseases, amino acids
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):9. doi: https://doi.org/10.1167/iovs.62.10.9

Biochemistry and Molecular Biology August 2021

Conjunctival Expression of Toll-Like Receptor 3 Plays a Pathogenic Role in the Formation of Ultraviolet Light–Induced Pterygium

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Chun-Chieh Lai; Sung-Huei Tseng; Sheng-Min Hsu; Yin-Ting Huang; Chi-Chang Shieh
TAGS: conjunctiva, pterygium, toll-like receptor 3, ultraviolet b radiation, pectoral compartment nerve block type 1, picture exchange communication system, epithelial cells, ultraviolet rays
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):6. doi: https://doi.org/10.1167/iovs.62.10.6

Includes: Supplemental Content

Review August 2021

Metabolomics in Diabetic Retinopathy: A Systematic Review

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Xiao-Wen Hou; Ying Wang; Chen-Wei Pan
TAGS: biological markers, diabetic retinopathy, metabolites, metabolomics, systematic reviews
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):4. doi: https://doi.org/10.1167/iovs.62.10.4

Includes: Supplemental Content

Retinal Cell Biology July 2021

Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction

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Cristina Escrevente; Ana S. Falcão; Michael J. Hall; Mafalda Lopes-da-Silva; Pedro Antas; Miguel M. Mesquita; Inês S. Ferreira; M. Helena Cardoso; Daniela Oliveira; Ana C. Fradinho; Thomas Ciossek; Paul Nicklin; Clare E. Futter; Sandra Tenreiro; Miguel C. Seabra
TAGS: granules, lipofuscin, lysosomes, pathophysiology, retinal pigment epithelium, cathepsin d, flow cytometry, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):39. doi: https://doi.org/10.1167/iovs.62.9.39

Includes: Supplemental Content

Biochemistry and Molecular Biology July 2021

Assocation Between Leber's Hereditary Optic Neuropathy and MT-ND1 3460G>A Mutation-Induced Alterations in Mitochondrial Function, Apoptosis, and Mitophagy

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Juanjuan Zhang; Yanchun Ji; Jie Chen; Man Xu; Guoping Wang; Xiaorui Ci; Bing Lin; Jun Q. Mo; Xiangtian Zhou; Min-Xin Guan
TAGS: apoptosis, cell lines, mitochondria, mutation, optic atrophy, hereditary, leber, mitochondrial membranes
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):38. doi: https://doi.org/10.1167/iovs.62.9.38

Includes: Supplemental Content

Retina July 2021

CD146/Soluble CD146 Pathway Is a Novel Biomarker of Angiogenesis and Inflammation in Proliferative Diabetic Retinopathy

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Ahmed M. Abu El-Asrar; Mohd Imtiaz Nawaz; Ajmal Ahmad; Mohammad Mairaj Siddiquei; Eef Allegaert; Priscilla W. Gikandi; Gert De Hertogh; Ghislain Opdenakker
TAGS: angiogenesis, biological markers, diabetes mellitus, endothelial cells, enzyme-linked immunosorbent assay, inflammation, proliferative diabetic retinopathy, rats, retina, tissue membrane
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):32. doi: https://doi.org/10.1167/iovs.62.9.32

Retina July 2021

Activated Blood Coagulation Factor X (FXa) Contributes to the Development of Traumatic PVR Through Promoting RPE Epithelial-Mesenchymal Transition

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Han Han; Xiao Zhao; Mengyu Liao; Yinting Song; Caiyun You; Xue Dong; Xueli Yang; Xiaohong Wang; Bo Huang; Mei Du; Hua Yan
TAGS: epithelial to mesenchymal transition, eye, factor x, fibrosis, mice, ocular trauma, oryctolagus cuniculus, receptor, par-1, retinal pigment cell, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):29. doi: https://doi.org/10.1167/iovs.62.9.29

Includes: Supplemental Content

Retinal Cell Biology July 2021

Salidroside Prevents Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Damage Via miR-138/ROBO4 Axis

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Xiaoling Shi; Nuo Dong; Qi Qiu; Shanhua Li; Jiaxing Zhang
TAGS: hypoxia, wounds and injuries, endothelial cells
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):25. doi: https://doi.org/10.1167/iovs.62.9.25

Physiology and Pharmacology July 2021

Canonical Wnt Signaling Drives Myopia Development and Can Be Pharmacologically Modulated

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Zhen Liu; Yanghui Xiu; Fangfang Qiu; Zhenzhen Zhu; Rongrong Zong; Xiangtian Zhou; Jianhong An; Qiongsi Wang; Peter S Reinach; Wei Li; Wensheng Chen; Zuguo Liu
TAGS: myopia, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):21. doi: https://doi.org/10.1167/iovs.62.9.21

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology July 2021

Protective Role of Limitrin in Experimental Autoimmune Optic Neuritis

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Bo Young Chun; Jong-Heon Kim; Youn-Kwan Jung; Yoon Seok Choi; Gunwoo Kim; Tomoko Yonezawa; Kyoungho Suk
TAGS: astrocytes, autoimmunity, mice, optic nerve, optic neuritis, plasma
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):8. doi: https://doi.org/10.1167/iovs.62.9.8

Includes: Supplemental Content

Cornea July 2021

Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway

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Runpu Li; Yingxin Qu; Xiaoqi Li; Ye Tao; Qinghua Yang; Junyi Wang; Yumei Diao; Qian Li; Yifan Fang; Yifei Huang; Liqiang Wang
TAGS: chronic exertional compartment syndrome, cornea, oryctolagus cuniculus, hepatorenal syndrome, wounds and injuries, hrs trial, hydrogen, endothelium
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):2. doi: https://doi.org/10.1167/iovs.62.9.2

Glaucoma June 2021

Small RNA Sequencing of Aqueous Humor and Plasma in Patients With Primary Open-Angle Glaucoma

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Wouter H. G. Hubens; Julian Krauskopf; Henny J. M. Beckers; Jos C. S. Kleinjans; Carroll A. B. Webers; Theo G. M. F. Gorgels
TAGS: glaucoma, hypertension, micrornas, open-angle glaucoma, plasma, rna, small, aqueous humor, rna-seq, biological markers
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):24. doi: https://doi.org/10.1167/iovs.62.7.24

Includes: Supplemental Content

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Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma

Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium

Dysbiosis in the Gut Microbiome in Streptozotocin-Induced Diabetes Rats and Follow-Up During Retinal Changes

Tear Proteomics in Keratoconus: A Quantitative SWATH-MS Analysis

Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10

Exploring the Mechanism of the miRNA-145/Paxillin Axis in Cell Metabolism During VEGF-A–Induced Corneal Angiogenesis

Analysis of the Aqueous Humor Proteome in Patients With Age-Related Macular Degeneration

Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression

Metabolomics Analyses of Mouse Retinas in Oxygen-Induced Retinopathy

Conjunctival Expression of Toll-Like Receptor 3 Plays a Pathogenic Role in the Formation of Ultraviolet Light–Induced Pterygium

Metabolomics in Diabetic Retinopathy: A Systematic Review

Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction

Assocation Between Leber's Hereditary Optic Neuropathy and MT-ND1 3460G>A Mutation-Induced Alterations in Mitochondrial Function, Apoptosis, and Mitophagy

CD146/Soluble CD146 Pathway Is a Novel Biomarker of Angiogenesis and Inflammation in Proliferative Diabetic Retinopathy

Activated Blood Coagulation Factor X (FXa) Contributes to the Development of Traumatic PVR Through Promoting RPE Epithelial-Mesenchymal Transition

Salidroside Prevents Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Damage Via miR-138/ROBO4 Axis

Canonical Wnt Signaling Drives Myopia Development and Can Be Pharmacologically Modulated

Protective Role of Limitrin in Experimental Autoimmune Optic Neuritis

Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway

Small RNA Sequencing of Aqueous Humor and Plasma in Patients With Primary Open-Angle Glaucoma

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