Clinical and Epidemiologic Research

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Clinical and Epidemiologic Research June 2025

Changes in Retinal Vasculature Phenotype and Choroidal Blood Flow at High Altitude in Healthy Lowlanders

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Jérémy De Abreu; Aymeric Paillisser; Florence Berquet; Stephen Hogg; Emanuele Trucco; Martial H. Geiser; Aurélien Pichon; Michael Furian; Emeric Stauffer; Benoit Champigneulle; Julien Vincent Brugniaux; Thomas J. Macgillivray; Samuel Vergès; Christophe Chiquet
TAGS: high altitude, hypoxia, phenotype, retinal vasculature, vascular flow, vasculature, laser-doppler flowmetry, altitude, ophthalmic examination and evaluation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):50. https://doi.org/10.1167/iovs.66.6.50

Includes: Supplemental Content

Clinical and Epidemiologic Research June 2025

Myopia Development During Transition From Kindergarten to Early Grades in Elementary School: Population-Based Evidence From an Epidemic Area in Taiwan

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Yu-Chieh Yang; Der-Chong Tsai; Shao-You Fang; Hsin-Yu Yang; Chiao-Yu Wang; Chia-Wei Lee; Pei-Wei Huang; Mong-Ping Shyong; Yen-Lin Chen; Nai-Wei Hsu
TAGS: child, elementary schools, kindergartens, myopia, taiwan, epidemics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):48. https://doi.org/10.1167/iovs.66.6.48

Includes: Supplemental Content

Clinical and Epidemiologic Research June 2025

Prevalence of Myopia and Axial Length Distribution in China: The Wuhu Children and Adolescents Eye Study

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Li Dong; Wen-Da Zhou; Ya-Bin Hu; Li Wei; Wei Cao; Ning-Hong Chen; Di Liu; Cheng Zhen; Yu-Chun Zheng; Jost B. Jonas; Wen-Bin Wei
TAGS: adolescent, child, china, eye, myopia, prevalence, refractive errors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):33. https://doi.org/10.1167/iovs.66.6.33

Includes: Supplemental Content

Retina June 2025

Relationship of Choroidal Thickness With Age-Related Macular Degeneration in Asians: An Asian Eye Epidemiology Consortium Meta-Analysis

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Mariko Sasaki; Kai Xiong Cheong; Crystal Chun Yuen Chong; Marco Yu; Akiko Hanyuda; Kenya Yuki; Kazuno Negishi; Sawako Hashimoto; Kohta Fujiwara; Kohei Sonoda; Ya Xing Wang; Fei Gao; Anyarak Amornpetchsathaporn; Methaphon Chainakul; Ramyaa Srinivasan; Rehana Khan; Rajiv Raman; Paisan Ruamviboonsuk; Sung Ho Kim; Su Jeong Song; Mohammad Hassan Emamian; Hassan Hashemi; Akbar Fotouhi; Juping Liu; Xiaorong Li; Jost B. Jonas; Chui Ming Gemmy Cheung; Tien Yin Wong; Ching-Yu Cheng; Yih Chung Tham; Yasuo Yanagi; Anna Cheng Sim Tan
TAGS: age-related macular degeneration, asian, epidemiology, eye, meta-analysis, choroid, smoking
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):36. https://doi.org/10.1167/iovs.66.6.36

Includes: Supplemental Content

Clinical and Epidemiologic Research June 2025

Prevalence and Patient-Centered, Health-Related, and Economic Impact of Under-Corrected Refractive Error in Community-Based Older Singaporean Adults: A Population-Based Study

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Preeti Gupta; Ryan E. K. Man; Chiew Meng Johnny Wong; Sahil Thakur; Eva K. Fenwick; Tai Anh Vu; Amudha Aravindhan; Alex A. Black; Joanne M. Wood; Ecosse L. Lamoureux
TAGS: adult, community, economics, health, patient-centered care, prevalence, refractive errors, risk factors, ophthalmic examination and evaluation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):3. https://doi.org/10.1167/iovs.66.6.3

Includes: Supplemental Content

Anatomy and Pathology/Oncology May 2025

Validation of Four Prognostic Models for Metastatic Posterior Uveal Melanoma in a Danish Cohort

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Tine Gadegaard Hindso; Camilla Wium Bjerrum; Kristoffer Nissen; Mette Bagger Sjøl; Carsten Faber; Steffen Heegaard; Karine Madsen; Susanne Rosthøj; Jens Folke Kiilgaard
TAGS: cohort studies, danish, nomogram, patient prognosis, uveal melanoma, calibration
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):38. https://doi.org/10.1167/iovs.66.5.38

Includes: Supplemental Content

Retina May 2025

Area Under the Curve Analysis in a Real-World Cohort of Finnish Patients Treated for Neovascular Age-Related Macular Degeneration

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Terhi Ollila; Ashwini Joshi; Sangita Kulathinal; Ilkka Immonen
TAGS: area under curve, cohort studies, exudative age-related macular degeneration, finnish, visual acuity
Trans. Vis. Sci. Tech.. 2025; 14(5):23. https://doi.org/10.1167/tvst.14.5.23

Clinical and Epidemiologic Research May 2025

Spatial and Temporal Changes in Choroid Morphology Associated With Long-Duration Spaceflight

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Charles Bélanger Nzakimuena; Marissé Masís Solano; Rémy Marcotte-Collard; Mark Richard Lesk; Santiago Costantino
TAGS: choroid, space flight, language morphology, morphology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):17. https://doi.org/10.1167/iovs.66.5.17

Includes: Supplemental Content

Clinical and Epidemiologic Research May 2025

Three-Year Change in Subfoveal Choroidal Thickness and Area With Multifocal Contact Lens Wear in the Bifocal Lenses in Nearsighted Kids (BLINK) Study

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Maria K. Walker; David A. Berntsen; Matt L. Robich; Rachel L. Fenton; Anita Ticak; Justina R. Assaad; Hope M. Queener; Stephanie J. Chiu; Sina Farsiu; Donald O. Mutti; Lisa A. Jones-Jordan; Jeffrey J. Walline; for the BLINK Study Group
TAGS: child, choroid, contact lenses, lens (device), lens, crystalline, myopia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):5. https://doi.org/10.1167/iovs.66.5.5

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Absolute Risks and Decision Tools for Communicating the Risks of Visual Impairment From Myopia-Related Diseases

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Emma Dow; Stephanie Kearney; Mhairi Day
TAGS: myopia, open-angle glaucoma, rhegmatogenous retinal detachment, visual impairment, decision support systems
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):82. https://doi.org/10.1167/iovs.66.4.82

Clinical and Epidemiologic Research April 2025

Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study

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Zi Xuan Lin; Xiu Juan Zhang; Fang Yao Tang; Yuzhou Zhang; Ka Wai Kam; Alvin L. Young; Patrick Ip; Carol Y. Cheung; Chi Pui Pang; Clement C. Tham; Li Jia Chen; Kyoko Ohno-Matsui; Jason C. Yam
TAGS: child, eye, myopia, retinal vasculature, hong kong
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):64. https://doi.org/10.1167/iovs.66.4.64

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Associations of Cardiovascular Health and New-Onset Age-Related Macular Diseases From UK Biobank

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Yu Peng; Yuzhou Zhang; Ka Wai Kam; Gavin Wong; Mary Ho; Simon Sezto; Sunny Au; Xiujuan Zhang; Mandy P. H. Ng; Patrick Ip; Alvin Young; Chi Pui Pang; Clement C. Tham; Li Jia Chen; Jason C. Yam
TAGS: health, macular disorders, uk biobank, follow-up
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):63. https://doi.org/10.1167/iovs.66.4.63

Includes: Supplemental Content

Retina April 2025

Assessment of Ocular Magnification in Relation to Biometric Parameters and Measurement Techniques: A Prospective Study

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Serhat Ermiş; Ece Özal; Emrullah Şimşek; Özlem Taştan; Murat Karapapak
TAGS: biometry, magnification, prospective studies, fovea centralis, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):57. https://doi.org/10.1167/iovs.66.4.57

Clinical and Epidemiologic Research April 2025

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

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Wenxu Wang; Rui Ren; Yue Liu; Xingyue Ye; Ru Zhang; Linze Xi; Liying Wang; Yao Zhang; Yi Zhang; Difei Wang
TAGS: age-related macular degeneration, genetic predisposition to disease, genetics, health, polygenic risk score, prospective studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):54. https://doi.org/10.1167/iovs.66.4.54

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

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Wei-Qi Song; Wen-Fang Zhong; Zhi-Hao Li; Dan Liu; Jiao-Jiao Ren; Dong Shen; Jian Gao; Pei-Liang Chen; Jin Yang; Xiao-Meng Wang; Fang-Fei You; Chuan Li; Huan Chen; Jia-Hao Xie; Chen Mao
TAGS: glaucoma, genetic predisposition to disease
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):47. https://doi.org/10.1167/iovs.66.4.47

Includes: Supplemental Content

Optica Fall Vision Meeting Abstract April 2025

Contributed Talks III: The Berkeley Widefield Model Eye

Austin Roorda; Pavan Tiruveedhula; Gareth Dudley Hastings
TAGS: eye
Journal of Vision. 2025; 25(5):56. https://doi.org/10.1167/jov.25.5.56

Retina March 2025

Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy

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Rajya L. Gurung; Charvi Nangia; Tengda Cai; Liesel M. FitzGerald; Bennet J. McComish; Ebony Liu; Georgia Kaidonis; Bronwyn Ridge; Alex W. Hewitt; Brendan Vote; Nitin Verma; Jamie E. Craig; Colin N. A. Palmer; Kathryn P. Burdon; Weihua Meng
TAGS: cohort studies, diabetes mellitus, genetics, genome-wide association study, macular disorders, meta-analysis, single nucleotide polymorphism, genotype determination, diabetes mellitus, type 2
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):55. https://doi.org/10.1167/iovs.66.3.55

Includes: Supplemental Content

Clinical and Epidemiologic Research March 2025

Orbital Clinicopathological Differences in Thyroid Eye Disease: An Analysis of Cytokines With Histopathological and Clinical Correlation

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Yue Li; Jiaqi Tang; Gaojing Jing; Yueyue Li; Rui Ma; Xin Kang; Liyuan Rong; Wenlu Liu; Lan Yao; Xiaohui Lv; Aijun Deng; Wei Wu; Xinji Yang
TAGS: connective tissue, cytokine, histopathology tests, graves' ophthalmopathy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):33. https://doi.org/10.1167/iovs.66.3.33

Includes: Supplemental Content

Clinical and Epidemiologic Research March 2025

NLRP3 Activation With Bisphosphonate Use and the Risk of Incident Age-Related Macular Degeneration

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Joseph Magagnoli; Tammy Cummings; James W. Hardin; S. Scott Sutton; Jayakrishna Ambati
TAGS: age-related macular degeneration, bisphosphonates, nlr family, pyrin domain-containing 3 protein
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):32. https://doi.org/10.1167/iovs.66.3.32

Includes: Supplemental Content

Clinical and Epidemiologic Research March 2025

The Epidemiology of Eye Cancer, Eyelid Cancer, and Ophthalmic Lymphoma in a Chinese Population in Hong Kong: A Population-Based Registry Study 2005–2018

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Allie Lee; Dennis T. W. Law; Alex H. S. Kan; Flores F. P. Cruz; Vishal Jhanji; Hunter K. L. Yuen; Michael Y. Ni
TAGS: chinese (other dialects), eye, eye cancer, eyelid neoplasms, hong kong, lymphoma, chinese people, epidemiology, incidence
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):15. https://doi.org/10.1167/iovs.66.3.15

Includes: Supplemental Content

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Changes in Retinal Vasculature Phenotype and Choroidal Blood Flow at High Altitude in Healthy Lowlanders

Myopia Development During Transition From Kindergarten to Early Grades in Elementary School: Population-Based Evidence From an Epidemic Area in Taiwan

Prevalence of Myopia and Axial Length Distribution in China: The Wuhu Children and Adolescents Eye Study

Relationship of Choroidal Thickness With Age-Related Macular Degeneration in Asians: An Asian Eye Epidemiology Consortium Meta-Analysis

Prevalence and Patient-Centered, Health-Related, and Economic Impact of Under-Corrected Refractive Error in Community-Based Older Singaporean Adults: A Population-Based Study

Validation of Four Prognostic Models for Metastatic Posterior Uveal Melanoma in a Danish Cohort

Area Under the Curve Analysis in a Real-World Cohort of Finnish Patients Treated for Neovascular Age-Related Macular Degeneration

Spatial and Temporal Changes in Choroid Morphology Associated With Long-Duration Spaceflight

Three-Year Change in Subfoveal Choroidal Thickness and Area With Multifocal Contact Lens Wear in the Bifocal Lenses in Nearsighted Kids (BLINK) Study

Absolute Risks and Decision Tools for Communicating the Risks of Visual Impairment From Myopia-Related Diseases

Association of Retinal Microvasculature With Myopia Progression in Children: The Hong Kong Children Eye Study

Associations of Cardiovascular Health and New-Onset Age-Related Macular Diseases From UK Biobank

Assessment of Ocular Magnification in Relation to Biometric Parameters and Measurement Techniques: A Prospective Study

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

Contributed Talks III: The Berkeley Widefield Model Eye

Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy

Orbital Clinicopathological Differences in Thyroid Eye Disease: An Analysis of Cytokines With Histopathological and Clinical Correlation

NLRP3 Activation With Bisphosphonate Use and the Risk of Incident Age-Related Macular Degeneration

The Epidemiology of Eye Cancer, Eyelid Cancer, and Ophthalmic Lymphoma in a Chinese Population in Hong Kong: A Population-Based Registry Study 2005–2018

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