Cornea

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Cornea December 2018

Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes

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Kiyokazu Ozaki; Yui Terayama; Tetsuro Matsuura
TAGS: hyperglycemia, diabetes mellitus, type 1, body weight, alloxan, neurons, streptozocin, sural nerve, cornea, mice, nerve lesions
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5868-5875. doi: 10.1167/iovs.18-25693

Biochemistry and Molecular Biology December 2018

Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease

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Anastasia Marie Litke; Sarah Samuelson; Kerry R. Delaney; Yves Sauvé; Robert L. Chow
TAGS: mutation, corneal diseases, electroretinography, keratoconus, luciferases, missense mutation, cornea, diagnostic imaging, mice, pathogenicity
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5824-5835. doi: 10.1167/iovs.18-25490

Includes: Supplemental Content

Retina December 2018

Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability

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Gerard A. Rodrigues; Matthew Mason; Lori-Ann Christie; Candice Hansen; Lisa M. Hernandez; James Burke; Keith A. Luhrs; Thomas C. Hohman
TAGS: angiogenesis, vascular endothelial growth factor a, oryctolagus cuniculus, bevacizumab, ranibizumab, affinity, aflibercept, anti-vascular endothelial growth factor therapy, vascular permeability
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5836-5846. doi: 10.1167/iovs.18-25307

Clinical and Epidemiologic Research December 2018

Potential Role of Ocular Microbiome, Host Genotype, Tear Cytokines, and Environmental Factors in Corneal Infiltrative Events in Contact Lens Wearers

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Cecilia Chao; Lakshmi Akileswaran; Jessica N. Cooke Bailey; Mark Willcox; Russell Van Gelder; Carol Lakkis; Fiona Stapleton; Kathryn Richdale
TAGS: cytokine, environmental factors, contact lenses, genotype, cornea, interleukin-6, microbiome, whole exome sequencing
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5752-5761. doi: 10.1167/iovs.18-24845

Includes: Supplemental Content

Cornea November 2018

The Chemokine Receptor CXCR4 Mediates Recruitment of CD11c + Conventional Dendritic Cells Into the Inflamed Murine Cornea

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Maria J. Lopez; Yashar Seyed-Razavi; Arsia Jamali; Deshea L. Harris; Pedram Hamrah
TAGS: centers for disease control and prevention (u.s.), dendritic cells, cornea, mice, stromal cell-derived factor 1, cxcr4 receptors, chemokine receptors
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5671-5681. doi: 10.1167/iovs.18-25084

Includes: Supplemental Content

Cornea November 2018

Downregulation of IL-7 and IL-7R Reduces Membrane-Type Matrix Metalloproteinase 14 in Granular Corneal Dystrophy Type 2 Keratocyte

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So Young Kim; Areum Yeo; Hyemi Noh; Yong Woo Ji; Jong Suk Song; Hyeon Chang Kim; Lark Kyun Kim; Hyung Keun Lee
TAGS: matrix metalloproteinases, keratocytes, interleukin-7, hereditary corneal dystrophy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5693-5703. doi: 10.1167/iovs.18-25161

Includes: Supplemental Content

Special Issue November 2018

Tear Film–Oriented Diagnosis and Tear Film–Oriented Therapy for Dry Eye Based on Tear Film Dynamics

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Norihiko Yokoi; Georgi As Georgiev
TAGS: epithelium, dry eye syndromes, fluorescein, mucins, signs and symptoms, eye, eyedrops, tear film finding
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES13-DES22. doi: 10.1167/iovs.17-23700

Special Issue November 2018

Irregular Astigmatism and Higher-Order Aberrations in Eyes With Dry Eye Disease

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Shizuka Koh
TAGS: astigmatism, dry eye syndromes, optics, cornea, eye, tear film finding, quality
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES36-DES40. doi: 10.1167/iovs.17-23500

Special Issue November 2018

Application of In Vivo Confocal Microscopy in Dry Eye Disease

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Yukihiro Matsumoto; Osama M. A. Ibrahim
TAGS: inflammatory cells, dry eye syndromes, meibomian gland, microscopy, confocal, neurons, cornea
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES41-DES47. doi: 10.1167/iovs.17-23602

Special Issue November 2018

Inflamed Obstructive Meibomian Gland Dysfunction Causes Ocular Surface Inflammation

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Tomo Suzuki
TAGS: inflammation, meibomian gland, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES94-DES101. doi: 10.1167/iovs.17-23345

Special Issue November 2018

Dry Eye After LASIK

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Ikuko Toda
TAGS: dry eye syndromes, keratomileusis, laser in situ, signs and symptoms
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES109-DES115. doi: 10.1167/iovs.17-23538

Cornea November 2018

Sex Effects on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome

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Sara Tellefsen; Mathias Kaurstad Morthen; Stephen M. Richards; Scott M. Lieberman; Raheleh Rahimi Darabad; Wendy R. Kam; David A. Sullivan
TAGS: gene expression, autoimmune diseases, autoimmunity, genes, sjogren's syndrome, body tissue, mice, mice, inbred nod, mice, inbred mrl lpr
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5599-5614. doi: 10.1167/iovs.18-25772

Cornea November 2018

Mapping of Corneal Layer Thicknesses With Polarization-Sensitive Optical Coherence Tomography Using a Conical Scan Pattern

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Florian Beer; Andreas Wartak; Niklas Pircher; Stephan Holzer; Jan Lammer; Gerald Schmidinger; Bernhard Baumann; Michael Pircher; Christoph K. Hitzenberger
TAGS: cornea, eye, optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5579-5588. doi: 10.1167/iovs.18-25311

Cornea November 2018

Scanning Acoustic Microscopy Comparison of Descemet's Membrane Normal Tissue and Tissue With Fuchs' Endothelial Dystrophy

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Esam T. Ahmed Mohamed; Jean-Marc Perone; Sebastian Brand; Michael Koegel; Nico F. Declercq
TAGS: descemet's membrane, fuchs' endothelial dystrophy, glass, body tissue, acoustics
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5627-5632. doi: 10.1167/iovs.18-25516

Cornea November 2018

IL-1 and TGF-β Modulation of Epithelial Basement Membrane Components Perlecan and Nidogen Production by Corneal Stromal Cells

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Paramananda Saikia; Shanmugapriya Thangavadivel; Carla S. Medeiros; Luciana Lassance; Rodrigo Carlos de Oliveira; Steven E. Wilson
TAGS: cytokine, western blotting, interleukin-1, epithelium, evidence-based medicine, basement membrane, oryctolagus cuniculus, stromal cells, cornea, proteins, keratocytes, myofibroblasts, nidogen, regulation, growth factor
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5589-5598. doi: 10.1167/iovs.18-25202

Cornea November 2018

No Relation Between the Severity of Corneal Nerve, Epithelial, and Keratocyte Cell Morphology With Measures of Dry Eye Disease in Type 1 Diabetes

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Maryam Ferdousi; Ioannis N. Petropoulos; Alise Kalteniece; Shazli Azmi; Georgios Ponirakis; Nathan Efron; Handrean Soran; Rayaz Ahmed Malik
TAGS: diabetes mellitus, type 1, epithelium, dry eye syndromes, neurons, cornea, keratocytes, morphology, cellular morphology, language morphology
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5525-5530. doi: 10.1167/iovs.18-25321

Includes: Supplemental Content

Cornea November 2018

Altered Signaling Pathways in Aniridia-Related Keratopathy

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André Vicente; Berit Byström; Fátima Pedrosa Domellöf
TAGS: epithelium, antibodies, cornea, signal pathway, signal transduction pathways, notch1 gene, beta catenin, pax6 transcription factor, pannus, aniridia
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5531-5541. doi: 10.1167/iovs.18-25175

Cornea November 2018

Sleep Deprivation Induces Dry Eye Through Inhibition of PPARα Expression in Corneal Epithelium

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Liying Tang; Xue Wang; Jieli Wu; San Ming Li; Zhaoqiang Zhang; Sangang Wu; Ting Su; Zhirong Lin; Xueting Chen; Xulin Liao; Ting Bai; Yan Qiu; Peter Sol Reinach; Wei Li; Yongxiong Chen; Zuguo Liu
TAGS: dry eye syndromes, corneal epithelium, microvilli, sleep deprivation, cornea, lipids, mice, sleep, morphology, ppar alpha, language morphology
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5494-5508. doi: 10.1167/iovs.18-24504

Cornea November 2018

Assessment of Topical Therapies for Improving the Optical Clarity Following Stromal Wounding in a Novel Ex Vivo Canine Cornea Model

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William M. Berkowski; Daniel J. Gibson; SooJung Seo; Laura R. Proietto; R. David Whitley; Gregory S. Schultz; Caryn E. Plummer
TAGS: fibrosis, optics, placebos, sepharose, wounds and injuries, cornea, epithelialization, vorinostat, pirfenidone, dog, domestic, corneal opacity
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5509-5521. doi: 10.1167/iovs.17-23085

Cornea November 2018

In Vivo Prediction of Air-Puff Induced Corneal Deformation Using LASIK, SMILE, and PRK Finite Element Simulations

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Mathew Francis; Pooja Khamar; Rohit Shetty; Kanchan Sainani; Rudy M. M. A. Nuijts; Bart Haex; Abhijit Sinha Roy
TAGS: keratomileusis, laser in situ, postoperative care, preoperative care, surgical procedures, operative, cornea, eye, surgical ocular refractive procedure
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5320-5328. doi: 10.1167/iovs.18-2470

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Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes

Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease

Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability

Potential Role of Ocular Microbiome, Host Genotype, Tear Cytokines, and Environmental Factors in Corneal Infiltrative Events in Contact Lens Wearers

The Chemokine Receptor CXCR4 Mediates Recruitment of CD11c + Conventional Dendritic Cells Into the Inflamed Murine Cornea

Downregulation of IL-7 and IL-7R Reduces Membrane-Type Matrix Metalloproteinase 14 in Granular Corneal Dystrophy Type 2 Keratocyte

Tear Film–Oriented Diagnosis and Tear Film–Oriented Therapy for Dry Eye Based on Tear Film Dynamics

Irregular Astigmatism and Higher-Order Aberrations in Eyes With Dry Eye Disease

Application of In Vivo Confocal Microscopy in Dry Eye Disease

Inflamed Obstructive Meibomian Gland Dysfunction Causes Ocular Surface Inflammation

Dry Eye After LASIK

Sex Effects on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome

Mapping of Corneal Layer Thicknesses With Polarization-Sensitive Optical Coherence Tomography Using a Conical Scan Pattern

Scanning Acoustic Microscopy Comparison of Descemet's Membrane Normal Tissue and Tissue With Fuchs' Endothelial Dystrophy

IL-1 and TGF-β Modulation of Epithelial Basement Membrane Components Perlecan and Nidogen Production by Corneal Stromal Cells

No Relation Between the Severity of Corneal Nerve, Epithelial, and Keratocyte Cell Morphology With Measures of Dry Eye Disease in Type 1 Diabetes

Altered Signaling Pathways in Aniridia-Related Keratopathy

Sleep Deprivation Induces Dry Eye Through Inhibition of PPARα Expression in Corneal Epithelium

Assessment of Topical Therapies for Improving the Optical Clarity Following Stromal Wounding in a Novel Ex Vivo Canine Cornea Model

In Vivo Prediction of Air-Puff Induced Corneal Deformation Using LASIK, SMILE, and PRK Finite Element Simulations

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