Cornea

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Genetics April 2019

Multiple Differentially Methylated Regions Specific to Keratoconus Explain Known Keratoconus Linkage Loci

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Michal Kabza; Justyna A. Karolak; Malgorzata Rydzanicz; Monika Udziela; Piotr Gasperowicz; Rafal Ploski; Jacek P. Szaflik; Marzena Gajecka
TAGS: disease susceptibility, dna, dna methylation, genes, keratoconus, methylation, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1501-1509. doi: 10.1167/iovs.18-25916

Includes: Supplemental Content

Cornea March 2019

Rapamycin Rescues Endoplasmic Reticulum Stress–Induced Dry Eye Syndrome in Mice

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Bum-Joo Cho; Jin Sun Hwang; Young Joo Shin; Jeong Won Kim; Tae-Young Chung; Joon Young Hyon
TAGS: inflammation, rapamycin, dry eye syndromes, endoplasmic reticulum, mice, stress
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1254-1264. doi: 10.1167/iovs.18-25583

Cornea March 2019

A New Ophthalmic Pharmaceutical Formulation, Topical Sulglycotide, Enhances the Ocular Mucin Secretion in Desiccation Stress-Mediated Dry Eye Disease

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Hyesook Lee; Sangwon Jeon; Chae Eun Kim; Young-Joon Park; Jaewook Yang
TAGS: dry eye syndromes, cornea, eye, stress, mucins, dosage forms, desiccation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1076-1087. doi: 10.1167/iovs.18-24935

Cornea March 2019

Hyaluronan Derived From the Limbus is a Key Regulator of Corneal Lymphangiogenesis

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Mingxia Sun; Sudan Puri; Kazadi N. Mutoji; Yvette M. Coulson-Thomas; Vincent C. Hascall; David G. Jackson; Tarsis F. Gesteira; Vivien J. Coulson-Thomas
TAGS: burns, cornea, mice, lymphatic vessels, hyaluronan, alkalies, lymphangiogenesis
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1050-1062. doi: 10.1167/iovs.18-25920

Includes: Supplemental Content

Cornea March 2019

Descemet's Membrane Modulation of Posterior Corneal Fibrosis

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Carla S. Medeiros; Paramananda Saikia; Rodrigo Carlos de Oliveira; Luciana Lassance; Marcony R. Santhiago; Steven E. Wilson
TAGS: fibrosis, endothelium, in situ nick-end labeling, wounds and injuries, antibodies, cornea, descemet's membrane, cicatrix, myofibroblasts
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1010-1020. doi: 10.1167/iovs.18-26451

Includes: Supplemental Content

Cornea March 2019

Mediators of Corneal Haze Following Implantation of Presbyopic Corneal Inlays

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Beau J. Fenner; Yu-Chi Liu; Siew Kwan Koh; Yan Gao; Lu Deng; Roger W. Beuerman; Lei Zhou; Julian T. S. Theng; Jodhbir S. Mehta
TAGS: corneal opacity, cornea, eye, proteins, proteomics, implantation procedure
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):868-876. doi: 10.1167/iovs.18-25761

Includes: Supplemental Content

Cornea February 2019

Longitudinal Changes in Corneal Cell and Nerve Fiber Morphology in Young Patients with Type 1 Diabetes with and without Diabetic Retinopathy: A 2-Year Follow-up Study

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Eszter A. Deák; Eszter Szalai; Noémi Tóth; Rayaz A. Malik; András Berta; Adrienne Csutak
TAGS: diabetes mellitus, type 1, diabetic retinopathy, nerve fibers, cornea, morphology, follow-up studies, language morphology
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):830-837. doi: 10.1167/iovs.18-24516

Cornea February 2019

Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy

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Naoki Okumura; Ryosuke Hayashi; Masakazu Nakano; Kengo Yoshii; Kei Tashiro; Takahiko Sato; Derek J. Blake; Ross Aleff; Malinda Butz; Edward W. Highsmith; Eric D. Wieben; Michael P. Fautsch; Keith H. Baratz; Yuya Komori; Makiko Nakahara; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Noriko Koizumi
TAGS: polymerase chain reaction, hereditary corneal dystrophy, dna, endothelium, corneal endothelium, genome, rna, messenger, trinucleotide repeat expansion, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):779-786. doi: 10.1167/iovs.18-25760

Includes: Supplemental Content

Cornea February 2019

KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27

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Anil Tiwari; Sudha Swamynathan; Nicholas Alexander; John Gnalian; Shenghe Tian; Paul R. Kinchington; Shivalingappa K. Swamynathan
TAGS: signal transduction, corneal epithelium, cornea, rna, ablation, corneal epithelial cells, cyclin-dependent kinase inhibitors
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):731-740. doi: 10.1167/iovs.18-26423

Includes: Supplemental Content

Cornea February 2019

Transformation of the Transcriptomic Profile of Mouse Periocular Mesenchyme During Formation of the Embryonic Cornea

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Justin Ma; Peter Lwigale
TAGS: cornea, mice, junctional premature complex, mesenchyme, genes, embryo
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):661-676. doi: 10.1167/iovs.18-26018

Includes: Supplemental Content

Immunology and Microbiology February 2019

Varicella Zoster Virus Induces Differential Cell-Type Specific Responses in Human Corneal Epithelial Cells and Keratocytes

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Christina N. Como; Andrew N. Bubak; Anna M. Blackmon; Dallas Jones; Niklaus H. Mueller; Richard Davidson; Maria A. Nagel
TAGS: cytokine, human herpesvirus 3, viruses, varicella-zoster virus infections, corneal epithelial cells, keratocytes, cells
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):704-711. doi: 10.1167/iovs.18-25801

Biochemistry and Molecular Biology February 2019

DNA Methylation Regulates Corneal Epithelial Wound Healing by Targeting miR-200a and CDKN2B

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Guangying Luo; Xia Jing; Shuai Yang; Dewei Peng; Jing Dong; Li Li; Peter S. Reinach; Dongsheng Yan
TAGS: epithelium, dna, dna methylation, wound healing, wounds and injuries, cornea, hypermethylation, dna (cytosine-5-)-methyltransferase 1, cdkn2b gene, rna, small interfering, methylation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):650-660. doi: 10.1167/iovs.18-25443

Includes: Supplemental Content

Cornea February 2019

Changes in Murine Subbasal Corneal Nerves After Scopolamine-Induced Dry Eye Stress Exposure

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Cem Simsek; Takashi Kojima; Taeko Nagata; Murat Dogru; Kazuo Tsubota
TAGS: dry eye syndromes, neurons, cornea, mice, stress, scopolamine
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):615-623. doi: 10.1167/iovs.18-26318

Cornea February 2019

A Novel Tissue-Engineered Corneal Stromal Equivalent Based on Amniotic Membrane and Keratocytes

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Xin Che; Han Wu; Changkai Jia; Huimin Sun; Shangkun Ou; Junqi Wang; M. Vimalin Jeyalatha; Xin He; Jingwen Yu; Chengyou Zuo; Zuguo Liu; Wei Li
TAGS: amnion, corneal stroma, keratoplasty, body tissue, cornea, central serous chorioretinopathy, keratocytes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):517-527. doi: 10.1167/iovs.18-24869

Includes: Multimedia, Supplemental Content

Cornea January 2019

Bilateral Effect of the Unilateral Corneal Nerve Cut on Both Ocular Surface and Lacrimal Gland

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Hyo Kyung Lee; Kyoung Woo Kim; Jin Suk Ryu; Hyun Jeong Jeong; Sang-Mok Lee; Mee Kum Kim
TAGS: neurons, cornea, eye
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):430-441. doi: 10.1167/iovs.18-26051

Includes: Supplemental Content

Cornea January 2019

The Protective Effect of a Topical Mucin Secretagogue on Ocular Surface Damage Induced by Airborne Carbon Black Exposure

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Xiangzhe Li; Boram Kang; Youngsub Eom; Hyung Keun Lee; Hyo Myung Kim; Jong Suk Song
TAGS: western blotting, secretagogues, immunoglobulin e, eye, immunoglobulin g, cytokine, cornea, carbon, prevention, mass or substance concentration per volume, normal saline, mucins, cervical lymph node group
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):255-264. doi: 10.1167/iovs.18-25964

Cornea January 2019

Identification of Leukocytes Associated With Midday Fogging in the Post-Lens Tear Film of Scleral Contact Lens Wearers

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Cameron K. Postnikoff; Andrew D. Pucker; John Laurent; Carrie Huisingh; Gerald McGwin; Jason J. Nichols
TAGS: small cell carcinoma of lung, contact lenses, lens, crystalline, lens (device), leukocytes, eye, sclera, tear film finding
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):226-233. doi: 10.1167/iovs.18-24664

Cornea January 2019

Epithelial Membrane Protein-2 (EMP2) Antibody Blockade Reduces Corneal Neovascularization in an In Vivo Model

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Michel M. Sun; Ann M. Chan; Samuel M. Law; Sergio Duarte; Daniel Diaz-Aguilar; Madhuri Wadehra; Lynn K. Gordon
TAGS: vascular endothelial growth factor a, epithelium, burns, corneal neovascularization, tissue membrane, antibodies, proteins
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):245-254. doi: 10.1167/iovs.18-24345

Includes: Supplemental Content

Cornea January 2019

The Effects of Diabetes and High-Fat Diet on Polymodal Nociceptor and Cold Thermoreceptor Nerve Terminal Endings in the Corneal Epithelium

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Abdulhakeem S. Alamri; James A. Brock; Chandana B. Herath; Indu G. Rajapaksha; Peter W. Angus; Jason J. Ivanusic
TAGS: diabetes mellitus, diabetes mellitus, type 2, common cold, cold temperature, nerve supply, cold sensation, cornea, nerve endings, nerve fibers, corneal epithelium, thermoreceptors, nociceptors, diet, high-fat
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):209-217. doi: 10.1167/iovs.18-25788

Cornea January 2019

Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro

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Sheyla González; Denise Oh; Elfren R. Baclagon; Jie J. Zheng; Sophie X. Deng
TAGS: signal transduction, stem cells, molecule, small molecule, regulation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):107-112. doi: 10.1167/iovs.18-25740

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Multiple Differentially Methylated Regions Specific to Keratoconus Explain Known Keratoconus Linkage Loci

Rapamycin Rescues Endoplasmic Reticulum Stress–Induced Dry Eye Syndrome in Mice

A New Ophthalmic Pharmaceutical Formulation, Topical Sulglycotide, Enhances the Ocular Mucin Secretion in Desiccation Stress-Mediated Dry Eye Disease

Hyaluronan Derived From the Limbus is a Key Regulator of Corneal Lymphangiogenesis

Descemet's Membrane Modulation of Posterior Corneal Fibrosis

Mediators of Corneal Haze Following Implantation of Presbyopic Corneal Inlays

Longitudinal Changes in Corneal Cell and Nerve Fiber Morphology in Young Patients with Type 1 Diabetes with and without Diabetic Retinopathy: A 2-Year Follow-up Study

Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy

KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27

Transformation of the Transcriptomic Profile of Mouse Periocular Mesenchyme During Formation of the Embryonic Cornea

Varicella Zoster Virus Induces Differential Cell-Type Specific Responses in Human Corneal Epithelial Cells and Keratocytes

DNA Methylation Regulates Corneal Epithelial Wound Healing by Targeting miR-200a and CDKN2B

Changes in Murine Subbasal Corneal Nerves After Scopolamine-Induced Dry Eye Stress Exposure

A Novel Tissue-Engineered Corneal Stromal Equivalent Based on Amniotic Membrane and Keratocytes

Bilateral Effect of the Unilateral Corneal Nerve Cut on Both Ocular Surface and Lacrimal Gland

The Protective Effect of a Topical Mucin Secretagogue on Ocular Surface Damage Induced by Airborne Carbon Black Exposure

Identification of Leukocytes Associated With Midday Fogging in the Post-Lens Tear Film of Scleral Contact Lens Wearers

Epithelial Membrane Protein-2 (EMP2) Antibody Blockade Reduces Corneal Neovascularization in an In Vivo Model

The Effects of Diabetes and High-Fat Diet on Polymodal Nociceptor and Cold Thermoreceptor Nerve Terminal Endings in the Corneal Epithelium

Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro

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