Cornea

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Cornea July 2025

Efferocytosis by Macrophages Attenuates Inflammatory Responses Following Ultraviolet B-Induced Apoptosis in Corneal Stromal Cells

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Seung Hyeun Lee; Soo Jin Lee; Ahra Koh; Ki Hean Kim; Kyoung Woo Kim
TAGS: apoptotic cell clearance, cornea, macrophages, ultraviolet b radiation, apoptosis, keratitis, inflammatory response
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):49. https://doi.org/10.1167/iovs.66.9.49

Includes: Supplemental Content

Immunology and Microbiology July 2025

Hyperglycemia-Suppressed Acod1 Expression Contributes to Innate Immune Deficiency in Pseudomonas aeruginosa Keratitis

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Nan Gao; Rao Me; Sukhvinder Singh; Ashok Kumar; Fu-Shin X. Yu
TAGS: cornea, diabetes mellitus, hyperglycemia, infections, itaconate, keratitis, mice, osteogenesis imperfecta, oxygenation index measurement, deficiency, immune
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):51. https://doi.org/10.1167/iovs.66.9.51

Includes: Supplemental Content

Glaucoma July 2025

Decoding the Cornea-Glaucoma Association: Evidence From Mendelian Randomization

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Victor A. de Vries; Anita Szabo; Joëlle E. Vergroesen; Siyin Liu; Karin A. van Garderen; Kirithika Muthusamy; Petra Liskova; Lubica Dudakova; Anthony P. Khawaja; Stephen J. Tuft; Caroline C. W. Klaver; Alice E. Davidson; Wishal D. Ramdas
TAGS: cardiac ct, cohort studies, cornea, glaucoma, mendelian randomization analysis, genetic risk score, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):22. https://doi.org/10.1167/iovs.66.9.22

Includes: Supplemental Content

Cornea July 2025

DJ-1 Promotes Diabetic Corneal Epithelial Wound Healing by Attenuating Hyperglycemia-Induced Oxidative Stress Through Inhibiting PTEN

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Haoyu Li; Hanhan Peng; Benteng Ma; Xinyue Sun; Liwei Zhang; Baihua Chen
TAGS: cornea, diabetes mellitus, epithelium, hyperglycemia, oxidative stress, proteins, pten gene, wound healing, antioxidants, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):20. https://doi.org/10.1167/iovs.66.9.20

Includes: Supplemental Content

Cornea July 2025

Inhibitor of DNA-Binding 3 Is a Novel Regulator of Limbal Epithelial Cell Migration Via the EphA2/Akt Signaling Pathway

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Elwin D. Clutter; Wending Yang; Jacob Han; Nihal Kaplan; Han Peng
TAGS: akt signaling pathway, cell motility, dna, epithelial cells, proto-oncogene proteins c-akt, signal transduction, wound healing, wounds and injuries, cornea, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):2. https://doi.org/10.1167/iovs.66.9.2

Includes: Supplemental Content

Cornea June 2025

Human Platelet Lysate Treatment for Exposure Keratopathy: An In Vivo Confocal Microscopy and Anterior Segment OCT Study

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Chia-Ying Tsai; Wei-Lun Huang; Shang-Chih Yang; Bo-Da Huang; Vladlen Klochkov; Shu-Lang Liao; Albert Y. Wu; Wei-Li Chen
TAGS: adrenal corticosteroids, blood platelets, cornea, epithelium, exposure keratoconjunctivitis, glucocorticoids, lysate, microscopy, confocal, mineralocorticoids, anti-inflammatory agents
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):73. https://doi.org/10.1167/iovs.66.6.73

Cornea June 2025

FGF10 Protects the Corneal Epithelium From Dry Eye-Induced Oxidative and ER Stress Via Upregulation of SLC7A11

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Zhiwei Zha; Juan Li; Shuang Xie; Xunjie Shang; Zixin Xu; Haiyuan Chang; Kaisheng Wang; Yang Liu; Wei Chen
TAGS: dry eye syndromes, endoplasmic reticulum stress, fgf10 protein, human, mice, cornea, corneal epithelium, up-regulation (physiology), eye, body tissue, stress
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):72. https://doi.org/10.1167/iovs.66.6.72

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2025

Circadian Rhythms in Murine Ocular Tissues Including Sclera Are Affected by Neurobasal A Medium Preincubation and Mouse Strain, but Not Sex

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Nemanja Milićević; Cristina Sandu; Etienne Challet; Teemu O. Ihalainen; Soile Nymark; Marie-Paule Felder-Schmittbuhl
TAGS: bioluminescence, body tissue, circadian rhythms, mice, sclera, rhythm, pectoral compartment nerve block type 1, picture exchange communication system, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):62. https://doi.org/10.1167/iovs.66.6.62

Includes: Supplemental Content

Cornea June 2025

RIPK3-Mediated Necroptosis Drives Macrophage Infiltration and Corneal Neovascularization After Alkali Burn

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Yue Li; Boyu Yang; Qi Chen; Yuchen Zhou; Wen Hu; Xiaojia Huang; Guangyi Huang; Ningning Tang; Fen Tang; Hui Huang; Qianqian Lan; Wenjing He; Fan Xu; Yiming Ye; Li Jiang
TAGS: alkalies, burns, cornea, corneal neovascularization, macrophages, necroptosis, fluorescent antibody technique, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):54. https://doi.org/10.1167/iovs.66.6.54

Includes: Supplemental Content

Cornea June 2025

Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in Aspergillus fumigatus –Induced Fungal Keratitis

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Jingze Kan; Shiqi Song; Mengzhu Liu; Qiang Xu; Jieun Lee; Jintao Sun; Shasha Xue; Xiaoyan Sun; Chengye Che
TAGS: aspergillus fumigatus, caspase-3, cornea, fungal keratitis, infections, inflammation, keratitis, mice, pyroptosis, rna, small interfering
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):52. https://doi.org/10.1167/iovs.66.6.52

Cornea June 2025

HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway

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Hua Yang; Mengzhu Liu; Shiqi Song; Qiang Xu; Jieun Lee; Jintao Sun; Shasha Xue; Xiaoyan Sun; Chengye Che
TAGS: aspergillus fumigatus, caspase-8, cornea, inflammatory response, keratitis, macrophages, mice, pyroptosis, infections, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):32. https://doi.org/10.1167/iovs.66.6.32

Cornea June 2025

M2a Macrophage-Dominant Microenvironment in Inflammation Attenuation and Wound Healing of Human Corneal Endothelial Cells

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Seung Hyeun Lee; Ahra Koh; Soo Jin Lee; Hun Lee; Kyoung Woo Kim
TAGS: cornea, exosomes, inflammation, macrophages, endothelial cells, endothelium, wound healing, wounds and injuries, anti-inflammatory agents, corneal endothelium
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):35. https://doi.org/10.1167/iovs.66.6.35

Includes: Supplemental Content

Cornea June 2025

SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction

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Yizhou Li; Feijia Xie; Lingling Yang; Xiaolei Wang; Yangyang Zhang; Hongqi Ge; Min Wang; Rui Cao; Qingjun Zhou; Ya Li
TAGS: cornea, epithelium, mice, stem cells, taurine, wound healing, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):25. https://doi.org/10.1167/iovs.66.6.25

Includes: Supplemental Content

Cornea June 2025

Cornea Nerves Can Identify Different Types of Parkinson's Disease

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Dongyu Li; Xinyu Zhang; Fan Yang; Xin Jin; Shumin Li; Haonan Yuan; Lifen Yao; Hong Zhang
TAGS: cornea, nervousness, neurons, parkinson disease
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):21. https://doi.org/10.1167/iovs.66.6.21

Cornea June 2025

Generation of a Mouse Model of Fuchs Endothelial Corneal Dystrophy by Knock-in of CTG Trinucleotide Repeat Expansion in the TCF4 Gene

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Yuki Oyama; Suguru Ito; Taichi Yuasa; Mizuki Ueda; Satoshi Chiba; Tatsuya Nakagawa; Ayaka Izumi; Masahito Ikawa; Noriko Koizumi; Naoki Okumura
TAGS: endothelium, genes, hereditary corneal dystrophy, mice, trinucleotide repeat expansion, cornea, sequence analysis, rna
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):18. https://doi.org/10.1167/iovs.66.6.18

Includes: Supplemental Content

Cornea June 2025

Activation of Sympathetic Nervous System Drives Dry Eye Onset Via Norepinephrine-β2-Adrenergic Receptor Signaling in Mice

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Mingli Qu; Xiaofei Bai; Mengyao Zhang; Jingyi Wu; Lei Wan; Xiaoyu Li; Qun Wang; Lin Cong; Benxiang Qi; Qingjun Zhou
TAGS: cornea, dry eye syndromes, mice, norepinephrine, sympathetic nervous system, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):13. https://doi.org/10.1167/iovs.66.6.13

Includes: Supplemental Content

Cornea June 2025

Fatty Acid Desaturase 1 Knockdown Promotes Wound Healing and Functional Recovery of the Corneal Epithelium in Diabetes

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Yangqi Zhao; Yi Dong; Qingqing Zheng; Yue Zhao; Yingjie Ni; Peijin Qiu; Chuannan Chen; Mengyue Xu; Chaoyang Hong; Ting Shen
TAGS: cornea, diabetes mellitus, rna, small interfering, wound healing, fatty acid desaturases, stearoyl-coa desaturase, epithelium, recovery of function, corneal epithelium, corneal epithelial cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):6. https://doi.org/10.1167/iovs.66.6.6

Includes: Supplemental Content

Review May 2025

Recent Advances in Stem Cells of Corneal Epithelia

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Yijian Li; Yong Liu
TAGS: cornea, corneal epithelium, epithelium, heterogeneity, stem cells, mice, adult stem cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):45. https://doi.org/10.1167/iovs.66.5.45

Cornea May 2025

Tear Proteomic Analysis From Offspring of Keratoconus Patients: New Insights Into Corneal Biomechanical Weakness and Disease Risk Stages

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Maite López-López; Uxía Regueiro; Susana Bravo; Carmen Pena; Yaiza Pastoriza; Mercedes Conde-Amboage; Pablo Hervella; Isabel Lema
TAGS: asthenia, cornea, keratoconus, offspring, proteins, proteomics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):41. https://doi.org/10.1167/iovs.66.5.41

Includes: Supplemental Content

Cornea May 2025

Assessment of Corneal Endothelial Barrier Function Based on “Y-Junctions”: A Finite Element Analysis

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Dongfang Li; Haoyun Duan; Xinhang Wang; Zhan Lin; Kun Dai; Xiangyue Hu; Xintian Zhao; Qingjun Zhou; Zongyi Li; Lixin Xie
TAGS: chronic exertional compartment syndrome, cornea, endothelium, finite element analysis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):33. https://doi.org/10.1167/iovs.66.5.33

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Efferocytosis by Macrophages Attenuates Inflammatory Responses Following Ultraviolet B-Induced Apoptosis in Corneal Stromal Cells

Hyperglycemia-Suppressed Acod1 Expression Contributes to Innate Immune Deficiency in Pseudomonas aeruginosa Keratitis

Decoding the Cornea-Glaucoma Association: Evidence From Mendelian Randomization

DJ-1 Promotes Diabetic Corneal Epithelial Wound Healing by Attenuating Hyperglycemia-Induced Oxidative Stress Through Inhibiting PTEN

Inhibitor of DNA-Binding 3 Is a Novel Regulator of Limbal Epithelial Cell Migration Via the EphA2/Akt Signaling Pathway

Human Platelet Lysate Treatment for Exposure Keratopathy: An In Vivo Confocal Microscopy and Anterior Segment OCT Study

FGF10 Protects the Corneal Epithelium From Dry Eye-Induced Oxidative and ER Stress Via Upregulation of SLC7A11

Circadian Rhythms in Murine Ocular Tissues Including Sclera Are Affected by Neurobasal A Medium Preincubation and Mouse Strain, but Not Sex

RIPK3-Mediated Necroptosis Drives Macrophage Infiltration and Corneal Neovascularization After Alkali Burn

Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in Aspergillus fumigatus –Induced Fungal Keratitis

HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway

M2a Macrophage-Dominant Microenvironment in Inflammation Attenuation and Wound Healing of Human Corneal Endothelial Cells

SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction

Cornea Nerves Can Identify Different Types of Parkinson's Disease

Generation of a Mouse Model of Fuchs Endothelial Corneal Dystrophy by Knock-in of CTG Trinucleotide Repeat Expansion in the TCF4 Gene

Activation of Sympathetic Nervous System Drives Dry Eye Onset Via Norepinephrine-β2-Adrenergic Receptor Signaling in Mice

Fatty Acid Desaturase 1 Knockdown Promotes Wound Healing and Functional Recovery of the Corneal Epithelium in Diabetes

Recent Advances in Stem Cells of Corneal Epithelia

Tear Proteomic Analysis From Offspring of Keratoconus Patients: New Insights Into Corneal Biomechanical Weakness and Disease Risk Stages

Assessment of Corneal Endothelial Barrier Function Based on “Y-Junctions”: A Finite Element Analysis

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