Cornea

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Cornea June 2021

PEDF Gene Deletion Disrupts Corneal Innervation and Ocular Surface Function

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Zhenying Shang; Chenxi Li; Xuemei Liu; Manhong Xu; Xiaomin Zhang; Xiaorong Li; Colin J. Barnstable; Shaozhen Zhao; Joyce Tombran-Tink
TAGS: cornea, mice, gene deletion, nerve supply
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):18. doi: https://doi.org/10.1167/iovs.62.7.18

Cornea June 2021

IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium

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Evan D. Bogdan; Whitney L. Stuard; Rossella Titone; Danielle M. Robertson
TAGS: corneal epithelium, homeostasis, hyperosmolality, insulin-like growth factor binding protein 3, sodium chloride, stress, mosmol, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):11. doi: https://doi.org/10.1167/iovs.62.7.11

Includes: Supplemental Content

Cornea June 2021

Ex Vivo–Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice

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Jun Zhu; Takenori Inomata; Keiichi Fujimoto; Koichiro Uchida; Kenta Fujio; Ken Nagino; Maria Miura; Naoko Negishi; Yuichi Okumura; Yasutsugu Akasaki; Kunihiko Hirosawa; Mizu Kuwahara; Atsuko Eguchi; Hurramhon Shokirova; Ai Yanagawa; Akie Midorikawa-Inomata; Akira Murakami
TAGS: cornea, keratoplasty, myeloid-derived suppressor cells, mice, rejection (psychology), transplant rejection
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):3. doi: https://doi.org/10.1167/iovs.62.7.3

Includes: Supplemental Content

Cornea May 2021

CLEC-1 Acts as a Negative Regulator of Dectin-1 Induced Host Inflammatory Response Signature in Aspergillus fumigatus Keratitis

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Guoqiang Zhu; Leyu Lyu; Hua Yang; Jieun Lee; Jintao Sun; Jie Zhang; Shasha Xue; Haijing Yan; Limei Wang; Xiaomeng Chen; Chengye Che
TAGS: clec7a gene, keratitis, mice, polymerase chain reaction, aspergillus fumigatus, inflammatory response, cornea, western blotting, infections, protein overexpression
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):28. doi: https://doi.org/10.1167/iovs.62.6.28

Cornea May 2021

Baicalein Protects Against Aspergillus fumigatus Keratitis by Reducing Fungal Load and Inhibiting TSLP-Induced Inflammatory Response

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Yunan Zhu; Xudong Peng; Yingxue Zhang; Jing Lin; Guiqiu Zhao
TAGS: fungal keratitis, inflammatory response, keratitis, mice, thymic stromal lymphopoietin, dimethyl sulfoxide, aspergillus fumigatus
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):26. doi: https://doi.org/10.1167/iovs.62.6.26

Cornea May 2021

Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer

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James W. Foster; Rupin N. Parikh; Jiangxia Wang; Kraig S. Bower; Mario Matthaei; Shukti Chakravarti; Albert S. Jun; Charles G. Eberhart; Uri S. Soiberman
TAGS: epithelium, keratoconus, wnt10a gene, bowman's layer
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):16. doi: https://doi.org/10.1167/iovs.62.6.16

Includes: Supplemental Content

Cornea May 2021

Bilateral Limbal Stem Cell Alterations in Patients With Unilateral Herpes Simplex Keratitis and Herpes Zoster Ophthalmicus as Shown by In Vivo Confocal Microscopy

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Xintian Liu; Shuo Xu; Yingbin Wang; Xin Jin; Yan Shi; Hong Zhang
TAGS: atypical, cornea, epithelial cells, eye, herpes zoster ophthalmicus, keratitis, herpetic, microscopy, confocal, neurons, stem cells, nose
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):12. doi: https://doi.org/10.1167/iovs.62.6.12

Cornea May 2021

Role of IL-36γ/IL-36R Signaling in Corneal Innate Defense Against Candida albicans Keratitis

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Chenyang Dai; Rao Me; Nan Gao; Guanyu Su; Xinyi Wu; Fu-Shin X. Yu
TAGS: cornea, keratitis, mice, signal transduction, fungal keratitis, cytokine, infections, candida albicans, interleukin-33
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):10. doi: https://doi.org/10.1167/iovs.62.6.10

Clinical and Epidemiologic Research May 2021

Small Nerve Fiber Damage and Langerhans Cells in Type 1 and Type 2 Diabetes and LADA Measured by Corneal Confocal Microscopy

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Luca D'Onofrio; Alise Kalteniece; Maryam Ferdousi; Shazli Azmi; Ioannis N. Petropoulos; Georgios Ponirakis; Uazman Alam; Omar Asghar; Andrew Marshall; Andrew J.M. Boulton; Nathan Efron; Raffaella Buzzetti; Handrean Soran; Rayaz A. Malik
TAGS: anterior descending branch of left coronary artery, cornea, diabetes mellitus, type 2, langerhans cell, microscopy, confocal, nerve fibers, neurons, nervousness
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):5. doi: https://doi.org/10.1167/iovs.62.6.5

Cornea April 2021

Epigenetic Landscape Analysis of the Long Non-Coding RNA and Messenger RNA in a Mouse Model of Corneal Alkali Burns

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Li Jiang; Wenjing He; Fen Tang; Ningning Tang; Guangyi Huang; Wei Huang; Xiaonian Wu; Jianpei Guan; Siming Zeng; Min Li; Qi Chen; Mingyuan Zhang; Haibin Zhong; Qianqian Lan; Ling Cui; Lili Li; Fan Xu
TAGS: alkalies, burns, cornea, mice, rna, rna, messenger, epigenetics
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):28. doi: https://doi.org/10.1167/iovs.62.4.28

Includes: Supplemental Content

Cornea April 2021

Tear Film Cytokine Profile of Patients With the Boston Keratoprosthesis Type 1: Comparing Patients With and Without Glaucoma

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Dominique Geoffrion; Marie-Claude Robert; Adriana Di Polo; Robert K. Koenekoop; Younes Agoumi; Mona Harissi-Dagher
TAGS: cytokine, glaucoma, tear film finding, eye
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):20. doi: https://doi.org/10.1167/iovs.62.4.20

Includes: Supplemental Content

Review April 2021

Interleukin-1 and Transforming Growth Factor Beta: Commonly Opposing, but Sometimes Supporting, Master Regulators of the Corneal Wound Healing Response to Injury

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Steven E. Wilson
TAGS: cornea, fibroblasts, interleukin-1, wounds and injuries, myofibroblasts, wound healing, keratocytes, transforming growth factor beta, epithelium
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):8. doi: https://doi.org/10.1167/iovs.62.4.8

Cornea April 2021

IL-36α Exerts Proinflammatory Effects in A spergillus fumigatus Keratitis of Mice Through the Pathway of IL-36α/IL-36R/NF-κB

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Yawen Niu; Changjie Ren; Xudong Peng; Cui Li; Qiang Xu; Liting Hu; Ziyue Zhang; Guiqiu Zhao; Jing Lin
TAGS: aspergillus fumigatus, cornea, cytokine, keratitis, macrophages, mice, proteins, interleukin-6, rna, messenger, infections
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):16. doi: https://doi.org/10.1167/iovs.62.4.16

Cornea April 2021

The Dopaminergic Neuronal System Regulates the Inflammatory Status of Mouse Lacrimal Glands in Dry Eye Disease

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Yong Woo Ji; Hyun Goo Kang; Jong Suk Song; Ji Won Jun; Kyusun Han; Tae-im Kim; Kyoung Yul Seo; Hyung Keun Lee
TAGS: dopamine, dopamine receptors, dry eye syndromes, langer-giedion syndrome, mice, cornea
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):14. doi: https://doi.org/10.1167/iovs.62.4.14

Cornea March 2021

Isorhamnetin Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load, Inhibiting Pattern-Recognition Receptors and Inflammatory Cytokines

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Xue Tian; Xudong Peng; Jing Lin; Yingxue Zhang; Lu Zhan; Jiao Yin; Ranran Zhang; Guiqiu Zhao
TAGS: antifungal agents, anti-inflammatory agents, cytokine, keratitis, mice, pattern recognition receptors, aspergillus fumigatus, dimethyl sulfoxide, cornea
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):38. doi: https://doi.org/10.1167/iovs.62.3.38

Cornea March 2021

Innate and Adaptive Gene Single Nucleotide Polymorphisms Associated With Susceptibility of Severe Inflammatory Complications in Acanthamoeba Keratitis

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Nicole A. Carnt; Ignatius Pang; Kathryn P. Burdon; Virginia Calder; John K. Dart; Dinesh Subedi; Alison J. Hardcastle
TAGS: acanthamoeba keratitis, disease susceptibility, genes, genetics, inflammation, single nucleotide polymorphism, interleukin-8
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):33. doi: https://doi.org/10.1167/iovs.62.3.33

Includes: Supplemental Content

Retina March 2021

Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime

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Eric Seifert; Svenja Rebecca Sonntag; Philipp Kleingarn; Dirk Theisen-Kunde; Salvatore Grisanti; Reginald Birngruber; Yoko Miura; Ralf Brinkmann
TAGS: lasers, pigment, epithelium, cell injury
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):32. doi: https://doi.org/10.1167/iovs.62.3.32

Cornea March 2021

Modulating Ocular Surface Pain Through Neurokinin-1 Receptor Blockade

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Romina Mayra Lasagni Vitar; Marco Barbariga; Philippe Fonteyne; Fabio Bignami; Paolo Rama; Giulio Ferrari
TAGS: aprepitant, cornea, pain, substance p receptor, neurons
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):26. doi: https://doi.org/10.1167/iovs.62.3.26

Includes: Supplemental Content

Review March 2021

Mitophagy: An Emerging Target in Ocular Pathology

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Jessica M. Skeie; Darryl Y. Nishimura; Cheryl L. Wang; Gregory A. Schmidt; Benjamin T. Aldrich; Mark A. Greiner
TAGS: dna, mitochondrial, mitochondria, pathophysiology, proteins, pathology, park2 gene, mutation
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):22. doi: https://doi.org/10.1167/iovs.62.3.22

Cornea March 2021

Cigarette Smoke Triggers Loss of Corneal Endothelial Cells and Disruption of Descemet's Membrane Proteins in Mice

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Muhammad Ali; Shahid Y. Khan; Yura Jang; Chan Hyun Na; C. Conover Talbot, Jr; John D. Gottsch; James T. Handa; S. Amer Riazuddin
TAGS: cigarette smoke, cornea, endothelial cells, mice, proteins, proteome, descemet's membrane, precipitating factors
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):3. doi: https://doi.org/10.1167/iovs.62.3.3

Includes: Supplemental Content

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PEDF Gene Deletion Disrupts Corneal Innervation and Ocular Surface Function

IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium

Ex Vivo–Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice

CLEC-1 Acts as a Negative Regulator of Dectin-1 Induced Host Inflammatory Response Signature in Aspergillus fumigatus Keratitis

Baicalein Protects Against Aspergillus fumigatus Keratitis by Reducing Fungal Load and Inhibiting TSLP-Induced Inflammatory Response

Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer

Bilateral Limbal Stem Cell Alterations in Patients With Unilateral Herpes Simplex Keratitis and Herpes Zoster Ophthalmicus as Shown by In Vivo Confocal Microscopy

Role of IL-36γ/IL-36R Signaling in Corneal Innate Defense Against Candida albicans Keratitis

Small Nerve Fiber Damage and Langerhans Cells in Type 1 and Type 2 Diabetes and LADA Measured by Corneal Confocal Microscopy

Epigenetic Landscape Analysis of the Long Non-Coding RNA and Messenger RNA in a Mouse Model of Corneal Alkali Burns

Tear Film Cytokine Profile of Patients With the Boston Keratoprosthesis Type 1: Comparing Patients With and Without Glaucoma

Interleukin-1 and Transforming Growth Factor Beta: Commonly Opposing, but Sometimes Supporting, Master Regulators of the Corneal Wound Healing Response to Injury

IL-36α Exerts Proinflammatory Effects in A spergillus fumigatus Keratitis of Mice Through the Pathway of IL-36α/IL-36R/NF-κB

The Dopaminergic Neuronal System Regulates the Inflammatory Status of Mouse Lacrimal Glands in Dry Eye Disease

Isorhamnetin Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load, Inhibiting Pattern-Recognition Receptors and Inflammatory Cytokines

Innate and Adaptive Gene Single Nucleotide Polymorphisms Associated With Susceptibility of Severe Inflammatory Complications in Acanthamoeba Keratitis

Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime

Modulating Ocular Surface Pain Through Neurokinin-1 Receptor Blockade

Mitophagy: An Emerging Target in Ocular Pathology

Cigarette Smoke Triggers Loss of Corneal Endothelial Cells and Disruption of Descemet's Membrane Proteins in Mice

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