External Eye Disease

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Cornea January 2020

HIF1α-mediated TRAIL Expression Regulates Lacrimal Gland Inflammation in Dry Eye Disease

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Yong Woo Ji; Joon H. Lee; Eun Young Choi; Hyun Goo Kang; Kyoung Yul Seo; Jong Suk Song; Hyeon Chang Kim; Hyung Keun Lee
TAGS: acinar cells, apoptosis, dacryoadenitis, dry eye syndromes, immunoblotting, inflammation, langer-giedion syndrome, mice, cd45 antigens, leukocytes
Invest. Ophthalmol. Vis. Sci.. 2020; 61(1):3. doi: https://doi.org/10.1167/iovs.61.1.3

Includes: Supplemental Content

Articles December 2019

A Deep Learning Approach for Meibomian Gland Atrophy Evaluation in Meibography Images

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Jiayun Wang; Thao N. Yeh; Rudrasis Chakraborty; Stella X. Yu; Meng C. Lin
TAGS: atrophy, deep learning, meibomian gland
Trans. Vis. Sci. Tech.. 2019; 8(6):37. doi: https://doi.org/10.1167/tvst.8.6.37

Articles December 2019

Assessment of Corneal Fluorescein Staining in Different Dry Eye Subtypes Using Digital Image Analysis

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Marco Pellegrini; Federico Bernabei; Fabiana Moscardelli; Aldo Vagge; Riccardo Scotto; Cristina Bovone; Vincenzo Scorcia; Giuseppe Giannaccare
TAGS: cornea, digital image analysis, dry eye syndromes, fluorescein stain method, reliability
Trans. Vis. Sci. Tech.. 2019; 8(6):34. doi: https://doi.org/10.1167/tvst.8.6.34

Biochemistry and Molecular Biology December 2019

Changes in Human Tear Proteome Following Topical Treatment of Dry Eye Disease: Cyclosporine A Versus Diquafosol Tetrasodium

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Yong Woo Ji; Hye Min Kim; Sun Young Ryu; Jae Won Oh; Areum Yeo; Chul Young Choi; Myoung Joon Kim; Jong Suk Song; Hyun Seung Kim; Kyoung Yul Seo; Kwang Pyo Kim; Hyung Keun Lee
TAGS: cyclosporine, dry eye syndromes, proteins, proteome, proteomics
Invest. Ophthalmol. Vis. Sci.. 2019; 60(15):5035-5044. doi: https://doi.org/10.1167/iovs.19-27872

Includes: Supplemental Content

Cornea November 2019

Comparison of MicroRNA Expression in Tears of Normal Subjects and Sjögren Syndrome Patients

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Yu Jeong Kim; Yeji Yeon; Won June Lee; Yong Un Shin; Heeyoon Cho; Yoon-Kyoung Sung; Du Roo Kim; Han Woong Lim; Min Ho Kang
TAGS: micrornas, sjogren's syndrome
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4889-4895. doi: https://doi.org/10.1167/iovs.19-27062

Biochemistry and Molecular Biology November 2019

Antifibrotic Effects of Sakuraso-Saponin in Primary Cultured Pterygium Fibroblasts in Comparison With Mitomycin C

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Hun Lee; Hana Jeong; Chang Mok Lee; Jin-A Shin; Sung-Wuk Jang; Jae Hyuck Lee; So Young Park; Jae Yong Kim; Hungwon Tchah
TAGS: fibroblasts, hpfs trial, mitomycin, pterygium, cell motility, recurrence
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4784-4791. doi: https://doi.org/10.1167/iovs.19-27153

Lecture November 2019

Introducing Sheila K. West, the Recipient of the 2019 Weisenfeld Award

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Alfred Sommer
TAGS: awards and prizes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4803-4804. doi: https://doi.org/10.1167/iovs.19-28630

Articles November 2019

The Role of Meibography in the Diagnosis of Meibomian Gland Dysfunction in Ocular Surface Diseases

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Mathieu Robin; Hong Liang; Ghislaine Rabut; Edouard Augstburger; Christophe Baudouin; Antoine Labbé
TAGS: meibomian gland, pathophysiology, hypersensitivity, schirmer tear test procedure, signs and symptoms
Trans. Vis. Sci. Tech.. 2019; 8(6):6. doi: https://doi.org/10.1167/tvst.8.6.6

Articles November 2019

Efficacy of Strip Meniscometry for Detecting Lacrimal Obstructive Diseases Among Patients With Epiphora

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Sho Ishikawa; Takuhei Shoji; Norihiro Yamada; Kei Shinoda
TAGS: excessive tearing, trimethylamine, tissue microarray, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2019; 8(6):8. doi: https://doi.org/10.1167/tvst.8.6.8

Biochemistry and Molecular Biology November 2019

P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts

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Minhong Xiang; Lijuan Mo; Yueping Zhan; Hang Wen; Huanming Zhou; Wanhong Miao
TAGS: cell aging, conjunctivochalasis, fibroblasts, signal transduction, mitogen-activated protein kinases, conjunctiva, body tissue
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4643-4651. doi: https://doi.org/10.1167/iovs.19-27617

Includes: Supplemental Content

Cornea November 2019

Graft Versus Host Disease-Associated Dry Eye: Role of Ocular Surface Mucins and the Effect of Rebamipide, a Mucin Secretagogue

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Kiumars Shamloo; Ashley Barbarino; Saleh Alfuraih; Ajay Sharma
TAGS: cornea, dry eye syndromes, graft-versus-host disease, mucins, rebamipide, secretagogues, mice, tissue transplants, tear film finding, transplantation, homologous
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4511-4519. doi: https://doi.org/10.1167/iovs.19-27843

Immunology and Microbiology November 2019

Composition and Diversity of Bacterial Community on the Ocular Surface of Patients With Meibomian Gland Dysfunction

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Xiaojin Dong; Yuqian Wang; Weina Wang; Ping Lin; Yusen Huang
TAGS: meibomian gland dysfunction, microbiome, community, conjunctival sac
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4774-4783. doi: https://doi.org/10.1167/iovs.19-27719

Includes: Supplemental Content

Articles October 2019

Spatial Distribution of Noninvasive Break Up Times and Clinical Relevance in Healthy Participants and Mild Dry Eye

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Louis Tong; Calesta Hui Yi Teo; Ryan Khee Jin Lee
TAGS: dry eye syndromes, lipids, signs and symptoms, eye
Trans. Vis. Sci. Tech.. 2019; 8(5):30. doi: https://doi.org/10.1167/tvst.8.5.30

Cornea September 2019

Therapeutic Effects of STAT3 Inhibition on Experimental Murine Dry Eye

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Mingli Qu; Xia Qi; Qian Wang; Lei Wan; Jing Li; Wei Li; Yingli Li; Qingjun Zhou
TAGS: dry eye syndromes, mice, stat3 protein
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3776-3785. doi: https://doi.org/10.1167/iovs.19-26928

Cornea September 2019

The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model

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Hyun Jung Lee; Soojung Shin; Seul-Gi Yoon; Eun Jeong Cheon; So-Hyang Chung
TAGS: animal model, chloroquine, dry eye syndromes, mice, sjogren's syndrome, syndrome, autophagy, sjogren's syndrome a antibody, phenotype, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3708-3716. doi: https://doi.org/10.1167/iovs.19-27469

Includes: Supplemental Content

Articles August 2019

Potential Effect of Epilation on the Outcome of Surgery for Trachomatous Trichiasis

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Sandra Liliana Talero; Beatriz Muñoz; Sheila K. West
TAGS: eyelid trichiasis, general hair removal - epilation, surgical outcome, surgical procedures, operative, entropion
Trans. Vis. Sci. Tech.. 2019; 8(4):30. doi: https://doi.org/10.1167/tvst.8.4.30

Cornea July 2019

Induction of DDIT4 Impairs Autophagy Through Oxidative Stress in Dry Eye

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Bowen Wang; Lulu Peng; Hong Ouyang; Li Wang; Dalian He; Jing Zhong; Yichen Xiao; Yuqing Deng; Meng Li; Saiqun Li; Jin Yuan
TAGS: autophagy, dry eye syndromes, oxidative stress, western blotting, stress, mice, cell survival
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):2836-2847. doi: https://doi.org/10.1167/iovs.19-27072

Includes: Supplemental Content

Anatomy and Pathology/Oncology June 2019

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

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Ikram El Zaoui; Maya Bucher; Donata Rimoldi; Michael Nicolas; Gurkan Kaya; Rosanna Pescini Gobert; Nicola Bedoni; Ann Schalenbourg; Ezziat Sakina; Leonidas Zografos; Serge Leyvraz; Nicolo Riggi; Carlo Rivolta; Alexandre P. Moulin
TAGS: 1-phosphatidylinositol 3-kinase, malignant melanoma of conjunctiva, mitogen-activated protein kinases, molecular targeted therapy, mtor serine-threonine kinases, phosphoinositide 3-kinase, braf gene, proto-oncogene proteins c-akt, melanoma, mutation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2764-2772. doi: https://doi.org/10.1167/iovs.18-26508

Includes: Supplemental Content

Cornea June 2019

Expression and Role of Nucleotide-Binding Oligomerization Domain 2 (NOD2) in the Ocular Surface of Murine Dry Eye

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Ying Li; Rujun Jin; Lan Li; Hyeon Jeong Yoon; Joo-Hee Choi; Jong-Hwan Park; Zuguo Liu; Wei Li; Zhengri Li; Kyung Chul Yoon
TAGS: body tissue, conjunctiva, cornea, dry eye syndromes, mice, nucleotides, cytokine, in situ nick-end labeling, ripk2 gene, interleukin-6
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2641-2649. doi: https://doi.org/10.1167/iovs.19-27144

Articles June 2019

Human Lacrimal Production Rate and Wetted Length of Modified Schirmer's Tear Test Strips

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Young Hyun Kim; Andrew D. Graham; Wing Li; Clayton J. Radke; Meng C. Lin
TAGS: evaporation, eye, heterogeneity of variance, loa, sample size, tear production, dry eye syndromes, humidity, reading (activity), anesthetics
Trans. Vis. Sci. Tech.. 2019; 8(3):40. doi: https://doi.org/10.1167/tvst.8.3.40

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HIF1α-mediated TRAIL Expression Regulates Lacrimal Gland Inflammation in Dry Eye Disease

A Deep Learning Approach for Meibomian Gland Atrophy Evaluation in Meibography Images

Assessment of Corneal Fluorescein Staining in Different Dry Eye Subtypes Using Digital Image Analysis

Changes in Human Tear Proteome Following Topical Treatment of Dry Eye Disease: Cyclosporine A Versus Diquafosol Tetrasodium

Comparison of MicroRNA Expression in Tears of Normal Subjects and Sjögren Syndrome Patients

Antifibrotic Effects of Sakuraso-Saponin in Primary Cultured Pterygium Fibroblasts in Comparison With Mitomycin C

Introducing Sheila K. West, the Recipient of the 2019 Weisenfeld Award

The Role of Meibography in the Diagnosis of Meibomian Gland Dysfunction in Ocular Surface Diseases

Efficacy of Strip Meniscometry for Detecting Lacrimal Obstructive Diseases Among Patients With Epiphora

P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts

Graft Versus Host Disease-Associated Dry Eye: Role of Ocular Surface Mucins and the Effect of Rebamipide, a Mucin Secretagogue

Composition and Diversity of Bacterial Community on the Ocular Surface of Patients With Meibomian Gland Dysfunction

Spatial Distribution of Noninvasive Break Up Times and Clinical Relevance in Healthy Participants and Mild Dry Eye

Therapeutic Effects of STAT3 Inhibition on Experimental Murine Dry Eye

The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model

Potential Effect of Epilation on the Outcome of Surgery for Trachomatous Trichiasis

Induction of DDIT4 Impairs Autophagy Through Oxidative Stress in Dry Eye

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

Expression and Role of Nucleotide-Binding Oligomerization Domain 2 (NOD2) in the Ocular Surface of Murine Dry Eye

Human Lacrimal Production Rate and Wetted Length of Modified Schirmer's Tear Test Strips

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