External Eye Disease

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Cornea September 2022

AKR1C1 Protects Corneal Epithelial Cells Against Oxidative Stress-Mediated Ferroptosis in Dry Eye

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Xin Zuo; Hao Zeng; Bowen Wang; Xue Yang; Dalian He; Li Wang; Hong Ouyang; Jin Yuan
TAGS: corneal epithelial cells, dry eye syndromes, ferroptosis, stress
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):3. doi: https://doi.org/10.1167/iovs.63.10.3

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2022

Early Dry Eye Disease Onset in a NOD.H-2 h4 Mouse Model of Sjögren's Syndrome

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Lili Li; Kimberly J. Jasmer; Jean M. Camden; Lucas T. Woods; Adam L. Martin; Yong Yang; Maria Layton; Michael J. Petris; Olga J. Baker; Gary A. Weisman; Carisa K. Petris
TAGS: mice, dry eye syndromes, sjogren's syndrome
Invest. Ophthalmol. Vis. Sci.. 2022; 63(6):18. doi: https://doi.org/10.1167/iovs.63.6.18

Includes: Supplemental Content

Immunology and Microbiology June 2022

PPAR-α Agonist Fenofibrate Ameliorates Sjögren Syndrome–Like Dacryoadenitis by Modulating Th1/Th17 and Treg Cell Responses in NOD Mice

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Xingyi Guo; Weiyu Dang; Na Li; Ying Wang; Deming Sun; Hong Nian; Ruihua Wei
TAGS: dacryoadenitis, dry eye syndromes, fenofibrate, peroxisome proliferator-activated receptors, regulatory t-lymphocytes, mice, inbred nod, sjogren's syndrome, agonists
Invest. Ophthalmol. Vis. Sci.. 2022; 63(6):12. doi: https://doi.org/10.1167/iovs.63.6.12

Includes: Supplemental Content

Cornea June 2022

Corneal Epithelium–Derived Netrin-1 Alleviates Dry Eye Disease via Regulating Dendritic Cell Activation

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Chaoqun Yu; Peng Chen; Jing Xu; Susu Wei; Qilong Cao; Chuanlong Guo; Xianggen Wu; Guohu Di
TAGS: cornea, corneal epithelium, dendritic cells, dry eye syndromes, mice, netrin-1, regulation, antibodies
Invest. Ophthalmol. Vis. Sci.. 2022; 63(6):1. doi: https://doi.org/10.1167/iovs.63.6.1

Cornea May 2022

Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway

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Ren Liu; Jing Li; Yue Xu; Ziyan Chen; Huijing Ye; Jinhui Tang; Lai Wei; Lingyi Liang
TAGS: cytokine, epithelial cells, lipogenesis, meibomian gland, melatonin, mitogen-activated protein kinases, proteins, toll-like receptor 4
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):6. doi: https://doi.org/10.1167/iovs.63.5.6

Includes: Supplemental Content

Biochemistry and Molecular Biology May 2022

The Protective Effects of KAT5 Inhibition on Ocular Inflammation by Mediating the PI3K/AKT Pathway in a Murine Model of Allergic Conjunctivitis

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Fei Luo; Yu Tao; Mengyu Wang; Liuqing Yang; Ruifeng Su; Zhiqiang Pan; Xiaobo Tan
TAGS: 1-phosphatidylinositol 3-kinase, mice, phosphoinositide 3-kinase, eye inflammation, protein overexpression, allergic conjunctivitis, inflammatory response, proto-oncogene proteins c-akt, phenotype, akt signaling pathway
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):4. doi: https://doi.org/10.1167/iovs.63.5.4

Biochemistry and Molecular Biology April 2022

Atypical U3 snoRNA Suppresses the Process of Pterygium Through Modulating 18S Ribosomal RNA Synthesis

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Xin Zhang; Yaping Jiang; Qian Wang; Weishu An; Xiaoyan Zhang; Ming Xu; Yihui Chen
TAGS: pterygium, rna, ribosomal, 18s, small nucleolar rna, atypical
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):17. doi: https://doi.org/10.1167/iovs.63.4.17

Includes: Supplemental Content

Cornea March 2022

Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway

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Peng Zhang; Lei Tian; Jiayu Bao; Shang Li; Ao Li; Ya Wen; Jingyi Wang; Ying Jie
TAGS: isotretinoin, meibomian gland, meibomian gland dysfunction
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):29. doi: https://doi.org/10.1167/iovs.63.3.29

Cornea March 2022

Obstructive Sleep Apnea Affects Lacrimal Gland Function

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Shaopan Wang; Xin He; Qingmin Li; Yuhan Zhang; Jiaoyue Hu; Rongrong Zong; Jingyi Zhuang; Andrew J. Quantock; Yingying Gao; Wei Li; Zuguo Liu
TAGS: lacrimal gland, mice, obstructive sleep apnea, tear production, lipids, hypoxia, fenofibrate, fluorescent antibody technique, immunohistochemistry, inflammation
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):3. doi: https://doi.org/10.1167/iovs.63.3.3

Includes: Supplemental Content

Cornea February 2022

Transmembrane Mucin 1 Blocks Fluorescein Ingress to Corneal Epithelium

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Yi-Chen Sun; Kai-Feng Hung; Tzu-Yun Li; Yu-An Chang; Po-Ting Yeh; Fung-Rong Hu
TAGS: fluorescein, mucins, corneal epithelium, dry eye syndromes
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):31. doi: https://doi.org/10.1167/iovs.63.2.31

Includes: Supplemental Content

Cornea January 2022

A Novel Rat Model of Dry Eye Induced by Aerosol Exposure of Particulate Matter

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Ning Mu; He Wang; Dongyan Chen; Fan Wang; Ling Ji; Can Zhang; Mingxin Li; Peirong Lu
TAGS: aerosols, cornea, dry eye syndromes, inflammation, ocular surfaces, particulate matter, tear film finding, epithelium, volume, eye
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):39. doi: https://doi.org/10.1167/iovs.63.1.39

Cornea January 2022

Hyperglycemia Induces Meibomian Gland Dysfunction

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Yuli Guo; Houjian Zhang; Zhongyang Zhao; Xin Luo; Minjie Zhang; Jinghua Bu; Minghui Liang; Han Wu; Jingwen Yu; Hui He; Rongrong Zong; Yongxiong Chen; Zuguo Liu; Wei Li
TAGS: diabetes mellitus, hyperglycemia, meibomian gland dysfunction, rats, western blotting
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):30. doi: https://doi.org/10.1167/iovs.63.1.30

Includes: Supplemental Content

Physiology and Pharmacology January 2022

Pathogenic Mechanism of Dry Eye–Induced Chronic Ocular Pain and a Mechanism-Based Therapeutic Approach

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Yuto Tei; Yoshinori Mikami; Masanori Ito; Taichiro Tomida; Daisuke Ohshima; Yuichi Hori; Satomi Adachi-Akahane
TAGS: dry eye syndromes, eye, trigeminal nuclei, hypersensitivity, hyperalgesia, linear gingival erythema, ocular pain, pregabalin, cornea
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):7. doi: https://doi.org/10.1167/iovs.63.1.7

Includes: Supplemental Content

Cornea November 2021

Optogenetic Inhibition of Na v 1.8 Expressing Corneal Afferents Reduces Persistent Dry Eye Pain

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Neal E. Mecum; Rachel Russell; Jun Lee; Cara Sullivan; Ian D. Meng
TAGS: cornea, dry eye syndromes, linear gingival erythema, mice, optogenetics, pain, persistence, conditioning (psychology)
Invest. Ophthalmol. Vis. Sci.. 2021; 62(14):15. doi: https://doi.org/10.1167/iovs.62.14.15

Cornea October 2021

Hyperkeratinization and Proinflammatory Cytokine Expression in Meibomian Glands Induced by Staphylococcus aureus

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Hua Chen; Hui Gao; Hua-Tao Xie; Shu-Ting Liu; Yu-Kan Huang; Ming-Chang Zhang
TAGS: cytokine, meibomian gland, mice, staphylococcus aureus, proteins
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):11. doi: https://doi.org/10.1167/iovs.62.13.11

Biochemistry and Molecular Biology September 2021

Effects of Aging on Human Meibum

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Igor A. Butovich; Tomo Suzuki
TAGS: aging, lipids, significance, meibomian gland dysfunction
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):23. doi: https://doi.org/10.1167/iovs.62.12.23

Includes: Supplemental Content

Immunology and Microbiology September 2021

Ocular Surface Microbiota in Diabetic Patients With Dry Eye Disease

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Zhang Zhang; Xinrong Zou; Wenwen Xue; Pei Zhang; Shanshan Wang; Haidong Zou
TAGS: diabetes mellitus, dry eye syndromes, microbiome
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):13. doi: https://doi.org/10.1167/iovs.62.12.13

Includes: Supplemental Content

Biochemistry and Molecular Biology August 2021

Conjunctival Expression of Toll-Like Receptor 3 Plays a Pathogenic Role in the Formation of Ultraviolet Light–Induced Pterygium

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Chun-Chieh Lai; Sung-Huei Tseng; Sheng-Min Hsu; Yin-Ting Huang; Chi-Chang Shieh
TAGS: conjunctiva, pterygium, toll-like receptor 3, ultraviolet b radiation, pectoral compartment nerve block type 1, picture exchange communication system, epithelial cells, ultraviolet rays
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):6. doi: https://doi.org/10.1167/iovs.62.10.6

Includes: Supplemental Content

Cornea July 2021

Human Meibum and Tear Film Derived (O-Acyl)-Omega-Hydroxy Fatty Acids as Biomarkers of Tear Film Dynamics in Meibomian Gland Dysfunction and Dry Eye Disease

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Safal Khanal; Yuqiang Bai; William Ngo; Kelly K. Nichols; Landon Wilson; Stephen Barnes; Jason J. Nichols
TAGS: biological markers, dry eye syndromes, fatty acids, meibomian gland dysfunction, tear film finding, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):13. doi: https://doi.org/10.1167/iovs.62.9.13

Cornea April 2021

The Dopaminergic Neuronal System Regulates the Inflammatory Status of Mouse Lacrimal Glands in Dry Eye Disease

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Yong Woo Ji; Hyun Goo Kang; Jong Suk Song; Ji Won Jun; Kyusun Han; Tae-im Kim; Kyoung Yul Seo; Hyung Keun Lee
TAGS: dopamine, dopamine receptors, dry eye syndromes, langer-giedion syndrome, mice, cornea
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):14. doi: https://doi.org/10.1167/iovs.62.4.14

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AKR1C1 Protects Corneal Epithelial Cells Against Oxidative Stress-Mediated Ferroptosis in Dry Eye

Early Dry Eye Disease Onset in a NOD.H-2 h4 Mouse Model of Sjögren's Syndrome

PPAR-α Agonist Fenofibrate Ameliorates Sjögren Syndrome–Like Dacryoadenitis by Modulating Th1/Th17 and Treg Cell Responses in NOD Mice

Corneal Epithelium–Derived Netrin-1 Alleviates Dry Eye Disease via Regulating Dendritic Cell Activation

Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway

The Protective Effects of KAT5 Inhibition on Ocular Inflammation by Mediating the PI3K/AKT Pathway in a Murine Model of Allergic Conjunctivitis

Atypical U3 snoRNA Suppresses the Process of Pterygium Through Modulating 18S Ribosomal RNA Synthesis

Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway

Obstructive Sleep Apnea Affects Lacrimal Gland Function

Transmembrane Mucin 1 Blocks Fluorescein Ingress to Corneal Epithelium

A Novel Rat Model of Dry Eye Induced by Aerosol Exposure of Particulate Matter

Hyperglycemia Induces Meibomian Gland Dysfunction

Pathogenic Mechanism of Dry Eye–Induced Chronic Ocular Pain and a Mechanism-Based Therapeutic Approach

Optogenetic Inhibition of Na v 1.8 Expressing Corneal Afferents Reduces Persistent Dry Eye Pain

Hyperkeratinization and Proinflammatory Cytokine Expression in Meibomian Glands Induced by Staphylococcus aureus

Effects of Aging on Human Meibum

Ocular Surface Microbiota in Diabetic Patients With Dry Eye Disease

Conjunctival Expression of Toll-Like Receptor 3 Plays a Pathogenic Role in the Formation of Ultraviolet Light–Induced Pterygium

Human Meibum and Tear Film Derived (O-Acyl)-Omega-Hydroxy Fatty Acids as Biomarkers of Tear Film Dynamics in Meibomian Gland Dysfunction and Dry Eye Disease

The Dopaminergic Neuronal System Regulates the Inflammatory Status of Mouse Lacrimal Glands in Dry Eye Disease

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