External Eye Disease

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Cornea March 2019

Rapamycin Rescues Endoplasmic Reticulum Stress–Induced Dry Eye Syndrome in Mice

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Bum-Joo Cho; Jin Sun Hwang; Young Joo Shin; Jeong Won Kim; Tae-Young Chung; Joon Young Hyon
TAGS: inflammation, rapamycin, dry eye syndromes, endoplasmic reticulum, mice, stress
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1254-1264. doi: 10.1167/iovs.18-25583

Biochemistry and Molecular Biology March 2019

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

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Kailin Chen; Kairan Lai; Xiaobo Zhang; Zhenwei Qin; Qiuli Fu; Chenqi Luo; Xiuming Jin; Jianghua Hu; Siyu Liu; Ke Yao
TAGS: fibroblasts, conjunctiva, pterygium, proto-oncogene proteins c-akt, bromfenac, hpfs trial
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1156-1164. doi: 10.1167/iovs.18-24743

Includes: Supplemental Content

Cornea March 2019

A New Ophthalmic Pharmaceutical Formulation, Topical Sulglycotide, Enhances the Ocular Mucin Secretion in Desiccation Stress-Mediated Dry Eye Disease

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Hyesook Lee; Sangwon Jeon; Chae Eun Kim; Young-Joon Park; Jaewook Yang
TAGS: dry eye syndromes, cornea, eye, stress, mucins, dosage forms, desiccation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1076-1087. doi: 10.1167/iovs.18-24935

Glaucoma February 2019

A Highly Selective Rho-Kinase Inhibitor (ITRI-E-212) Potentially Treats Glaucoma Upon Topical Administration With Low Incidence of Ocular Hyperemia

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Cherng-Ru Hsu; Yi-Hsun Chen; Chih-Peng Liu; Chih-Hung Chen; Kuo-Kuei Huang; Jui-Wen Huang; Meng-Nan Lin; Chih-Lung Lin; Wan-Ru Chen; Yi-Ling Hsu; Tze-chung Lee; Shuen-Hsiang Chou; Chia-Mu Tu; Chrong-Shiong Hwang; Yu Chuan Huang; Da-Wen Lu
TAGS: hypertension, glaucoma, incidence, intraocular pressure, conjunctival injection, oryctolagus cuniculus, phosphotransferases, administration, topical, erythema
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):624-633. doi: 10.1167/iovs.18-25252

Cornea February 2019

Changes in Murine Subbasal Corneal Nerves After Scopolamine-Induced Dry Eye Stress Exposure

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Cem Simsek; Takashi Kojima; Taeko Nagata; Murat Dogru; Kazuo Tsubota
TAGS: dry eye syndromes, neurons, cornea, mice, stress, scopolamine
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):615-623. doi: 10.1167/iovs.18-26318

Biochemistry and Molecular Biology January 2019

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

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Sun Woong Kim; Hye-In Kim; Bikash Thapa; Selikem Nuwromegbe; Keunwook Lee
TAGS: signal transduction, fibroblasts, pterygium, myofibroblasts, proto-oncogene proteins c-akt, hpfs trial, mechanistic target of rapamycin complex 2, mtor serine-threonine kinases
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):82-92. doi: 10.1167/iovs.18-25376

Clinical and Epidemiologic Research January 2019

Randomized, Controlled, Double-Masked, Multicenter, Pilot Study Evaluating Safety and Efficacy of Intranasal Neurostimulation for Dry Eye Disease

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Geoffrey S. Cohn; Dean Corbett; Abi Tenen; Minas Coroneo; James McAlister; Jennifer P. Craig; Trevor Gray; David Kent; Neil Murray; Con Petsoglou; Stephanie N. Baba; Edward J. Holland
TAGS: dry eye syndromes, tear production, safety, pilot projects
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):147-153. doi: 10.1167/iovs.18-23984

Includes: Supplemental Content

Clinical and Epidemiologic Research December 2018

Clinically Relevant Immune-Cellular Metrics of Inflammation in Meibomian Gland Dysfunction

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Yureeda Qazi; Ahmad Kheirkhah; Caroline Blackie; Monique Trinidad; Candice Williams; Andrea Cruzat; Donald R. Korb; Pedram Hamrah
TAGS: conjunctiva, inflammation, pathophysiology, epithelium, signs and symptoms, eyelid, meibomian gland
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6111-6123. doi: 10.1167/iovs.18-25571

Includes: Supplemental Content

Special Issue November 2018

Dry Eye Research Update in Japan in Celebration of the 25th Anniversary of the Dry Eye Society and the 10th Anniversary of Hakone Dry Eye Club

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Kazuo Tsubota
TAGS: dry eye syndromes, societies
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DESi-DESii. doi: 10.1167/iovs.18-24625

Special Issue November 2018

What We Know About the Epidemiology of Dry Eye Disease in Japan

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Miki Uchino
TAGS: epidemiology, dry eye syndromes, risk factors, signs and symptoms, prevalence
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES1-DES6. doi: 10.1167/iovs.17-23491

Special Issue November 2018

Definition and Diagnostic Criteria of Dry Eye Disease: Historical Overview and Future Directions

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Jun Shimazaki
TAGS: dry eye syndromes, signs and symptoms
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES7-DES12. doi: 10.1167/iovs.17-23475

Special Issue November 2018

Assessment of Dry Eye Symptoms: Current Trends and Issues of Dry Eye Questionnaires in Japan

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Atsushi Shiraishi; Yuri Sakane
TAGS: dry eye syndromes, questionnaires, signs and symptoms, trend
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES23-DES28. doi: 10.1167/iovs.18-24570

Special Issue November 2018

Functional Visual Acuity

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Minako Kaido
TAGS: glaucoma, cataract, vision, visual acuity, quality, system of measurement
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES29-DES35. doi: 10.1167/iovs.17-23721

Special Issue November 2018

Irregular Astigmatism and Higher-Order Aberrations in Eyes With Dry Eye Disease

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Shizuka Koh
TAGS: astigmatism, dry eye syndromes, optics, cornea, eye, tear film finding, quality
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES36-DES40. doi: 10.1167/iovs.17-23500

Special Issue November 2018

Application of In Vivo Confocal Microscopy in Dry Eye Disease

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Yukihiro Matsumoto; Osama M. A. Ibrahim
TAGS: inflammatory cells, dry eye syndromes, meibomian gland, microscopy, confocal, neurons, cornea
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES41-DES47. doi: 10.1167/iovs.17-23602

Special Issue November 2018

Meibography: A Japanese Perspective

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Reiko Arita
TAGS: eyelid, meibomian gland, lipids, pathophysiology, japanese
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES48-DES55. doi: 10.1167/iovs.17-23631

Special Issue November 2018

Relationship Between Eyelid Pressure and Ocular Surface Disorders in Patients With Healthy and Dry Eyes

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Masahiko Yamaguchi; Atsushi Shiraishi
TAGS: dry eye syndromes, eyelid, eye
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES56-DES63. doi: 10.1167/iovs.17-23586

Special Issue November 2018

Short Tear Film Breakup Time–Type Dry Eye

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Kazuo Tsubota
TAGS: dry eye syndromes, tear film finding
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES64-DES70. doi: 10.1167/iovs.17-23746

Special Issue November 2018

Sjögren's Syndrome, Non-Sjögren's Syndrome, and Graft-Versus-Host Disease Related Dry Eye

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Yoko Ogawa
TAGS: graft-versus-host disease, dry eye syndromes, sjogren's syndrome, syndrome
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES71-DES79. doi: 10.1167/iovs.17-23750

Special Issue November 2018

Severe Dry Eye With Combined Mechanisms is Involved in the Ocular Sequelae of SJS/TEN at the Chronic Stage

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Chie Sotozono; Mayumi Ueta; Norihiko Yokoi
TAGS: dry eye syndromes, signs and symptoms, stevens-johnson syndrome
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES80-DES86. doi: 10.1167/iovs.18-24019

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Rapamycin Rescues Endoplasmic Reticulum Stress–Induced Dry Eye Syndrome in Mice

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

A New Ophthalmic Pharmaceutical Formulation, Topical Sulglycotide, Enhances the Ocular Mucin Secretion in Desiccation Stress-Mediated Dry Eye Disease

A Highly Selective Rho-Kinase Inhibitor (ITRI-E-212) Potentially Treats Glaucoma Upon Topical Administration With Low Incidence of Ocular Hyperemia

Changes in Murine Subbasal Corneal Nerves After Scopolamine-Induced Dry Eye Stress Exposure

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

Randomized, Controlled, Double-Masked, Multicenter, Pilot Study Evaluating Safety and Efficacy of Intranasal Neurostimulation for Dry Eye Disease

Clinically Relevant Immune-Cellular Metrics of Inflammation in Meibomian Gland Dysfunction

Dry Eye Research Update in Japan in Celebration of the 25th Anniversary of the Dry Eye Society and the 10th Anniversary of Hakone Dry Eye Club

What We Know About the Epidemiology of Dry Eye Disease in Japan

Definition and Diagnostic Criteria of Dry Eye Disease: Historical Overview and Future Directions

Assessment of Dry Eye Symptoms: Current Trends and Issues of Dry Eye Questionnaires in Japan

Functional Visual Acuity

Irregular Astigmatism and Higher-Order Aberrations in Eyes With Dry Eye Disease

Application of In Vivo Confocal Microscopy in Dry Eye Disease

Meibography: A Japanese Perspective

Relationship Between Eyelid Pressure and Ocular Surface Disorders in Patients With Healthy and Dry Eyes

Short Tear Film Breakup Time–Type Dry Eye

Sjögren's Syndrome, Non-Sjögren's Syndrome, and Graft-Versus-Host Disease Related Dry Eye

Severe Dry Eye With Combined Mechanisms is Involved in the Ocular Sequelae of SJS/TEN at the Chronic Stage

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