External Eye Disease

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Immunology and Microbiology July 2020

Metagenomic Profiling of Ocular Surface Microbiome Changes in Meibomian Gland Dysfunction

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Fuxin Zhao; Dake Zhang; Chaoxiang Ge; Lei Zhang; Peter S. Reinach; Xiangjun Tian; Chengcheng Tao; Zhelin Zhao; Chenchen Zhao; Wenjie Fu; Changqing Zeng; Wei Chen
TAGS: meibomian gland dysfunction, microbiome, eyelid, skin, metagenomics, pathogenic organism
Invest. Ophthalmol. Vis. Sci.. 2020; 61(8):22. doi: https://doi.org/10.1167/iovs.61.8.22

Includes: Supplemental Content

Anatomy and Pathology/Oncology July 2020

Exploring the Molecular Mechanisms of Pterygium by Constructing lncRNA–miRNA–mRNA Regulatory Network

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Nuo Xu; Yi Cui; Jiaxing Dong; Li Huang
TAGS: micrornas, pterygium, rna, messenger, genes, proton pump inhibitors
Invest. Ophthalmol. Vis. Sci.. 2020; 61(8):12. doi: https://doi.org/10.1167/iovs.61.8.12

Includes: Supplemental Content

Letters to the Editor May 2020

Mouse Meibomian Gland Dysfunction Model

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Jingyi Wang; Yang Liu; Wendy R. Kam; David A. Sullivan
TAGS: meibomian gland dysfunction, mice
Invest. Ophthalmol. Vis. Sci.. 2020; 61(5):18. doi: https://doi.org/10.1167/iovs.61.5.18

Cornea April 2020

Organotypic Culture of Mouse Meibomian Gland: A Novel Model to Study Meibomian Gland Dysfunction In Vitro

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Kang-Kang Xu; Yu-Kan Huang; Xin Liu; Ming-Chang Zhang; Hua-Tao Xie
TAGS: meibomian gland, meibomian gland dysfunction, mice, lipids
Invest. Ophthalmol. Vis. Sci.. 2020; 61(4):30. doi: https://doi.org/10.1167/iovs.61.4.30

Immunology and Microbiology March 2020

IRT5 Probiotics Changes Immune Modulatory Protein Expression in the Extraorbital Lacrimal Glands of an Autoimmune Dry Eye Mouse Model

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Se Hyun Choi; Jae Won Oh; Jin Suk Ryu; Hye Min Kim; Sin-Hyeog Im; Kwang Pyo Kim; Mee Kum Kim
TAGS: antibiotics, autoimmunity, dry eye syndromes, lacrimal gland, mice, painful bladder syndrome, probiotics, proteins, intestinal bacteria
Invest. Ophthalmol. Vis. Sci.. 2020; 61(3):42. doi: https://doi.org/10.1167/iovs.61.3.42

Includes: Supplemental Content

Cornea March 2020

The Potential Inhibitory Effects of miR-19b on Ocular Inflammation are Mediated Upstream of the JAK/STAT Pathway in a Murine Model of Allergic Conjunctivitis

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Chen Guo; Jinghua Liu; Peng Hao; Yuchuan Wang; Shuangshuang Sui; Linghan Li; Ming Ying; Ruifang Han; Liming Wang; Xuan Li
TAGS: allergic conjunctivitis, eye inflammation, jak-stat signaling pathway, mice, protein overexpression, stat3 protein, thymic stromal lymphopoietin, conjunctiva, body tissue, painful bladder syndrome
Invest. Ophthalmol. Vis. Sci.. 2020; 61(3):8. doi: https://doi.org/10.1167/iovs.61.3.8

Includes: Supplemental Content

Cornea February 2020

Optical Analysis and Reappraisal of the Peripheral Light Focusing Theory of Nasal Pterygia Formation

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P. Ewen King-Smith; Thomas F. Mauger; Carolyn G. Begley; Patrice Tankam
TAGS: nose, optics, pterygium, ultraviolet rays, cornea
Invest. Ophthalmol. Vis. Sci.. 2020; 61(2):42. doi: https://doi.org/10.1167/iovs.61.2.42

Cornea January 2020

HIF1α-mediated TRAIL Expression Regulates Lacrimal Gland Inflammation in Dry Eye Disease

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Yong Woo Ji; Joon H. Lee; Eun Young Choi; Hyun Goo Kang; Kyoung Yul Seo; Jong Suk Song; Hyeon Chang Kim; Hyung Keun Lee
TAGS: acinar cells, apoptosis, dacryoadenitis, dry eye syndromes, immunoblotting, inflammation, langer-giedion syndrome, mice, cd45 antigens, leukocytes
Invest. Ophthalmol. Vis. Sci.. 2020; 61(1):3. doi: https://doi.org/10.1167/iovs.61.1.3

Includes: Supplemental Content

Biochemistry and Molecular Biology December 2019

Changes in Human Tear Proteome Following Topical Treatment of Dry Eye Disease: Cyclosporine A Versus Diquafosol Tetrasodium

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Yong Woo Ji; Hye Min Kim; Sun Young Ryu; Jae Won Oh; Areum Yeo; Chul Young Choi; Myoung Joon Kim; Jong Suk Song; Hyun Seung Kim; Kyoung Yul Seo; Kwang Pyo Kim; Hyung Keun Lee
TAGS: cyclosporine, dry eye syndromes, proteins, proteome, proteomics
Invest. Ophthalmol. Vis. Sci.. 2019; 60(15):5035-5044. doi: https://doi.org/10.1167/iovs.19-27872

Includes: Supplemental Content

Cornea November 2019

Comparison of MicroRNA Expression in Tears of Normal Subjects and Sjögren Syndrome Patients

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Yu Jeong Kim; Yeji Yeon; Won June Lee; Yong Un Shin; Heeyoon Cho; Yoon-Kyoung Sung; Du Roo Kim; Han Woong Lim; Min Ho Kang
TAGS: micrornas, sjogren's syndrome
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4889-4895. doi: https://doi.org/10.1167/iovs.19-27062

Biochemistry and Molecular Biology November 2019

Antifibrotic Effects of Sakuraso-Saponin in Primary Cultured Pterygium Fibroblasts in Comparison With Mitomycin C

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Hun Lee; Hana Jeong; Chang Mok Lee; Jin-A Shin; Sung-Wuk Jang; Jae Hyuck Lee; So Young Park; Jae Yong Kim; Hungwon Tchah
TAGS: fibroblasts, hpfs trial, mitomycin, pterygium, cell motility, recurrence
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4784-4791. doi: https://doi.org/10.1167/iovs.19-27153

Lecture November 2019

Introducing Sheila K. West, the Recipient of the 2019 Weisenfeld Award

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Alfred Sommer
TAGS: awards and prizes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4803-4804. doi: https://doi.org/10.1167/iovs.19-28630

Biochemistry and Molecular Biology November 2019

P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts

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Minhong Xiang; Lijuan Mo; Yueping Zhan; Hang Wen; Huanming Zhou; Wanhong Miao
TAGS: cell aging, conjunctivochalasis, fibroblasts, signal transduction, mitogen-activated protein kinases, conjunctiva, body tissue
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4643-4651. doi: https://doi.org/10.1167/iovs.19-27617

Includes: Supplemental Content

Cornea November 2019

Graft Versus Host Disease-Associated Dry Eye: Role of Ocular Surface Mucins and the Effect of Rebamipide, a Mucin Secretagogue

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Kiumars Shamloo; Ashley Barbarino; Saleh Alfuraih; Ajay Sharma
TAGS: cornea, dry eye syndromes, graft-versus-host disease, mucins, rebamipide, secretagogues, mice, tissue transplants, tear film finding, transplantation, homologous
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4511-4519. doi: https://doi.org/10.1167/iovs.19-27843

Immunology and Microbiology November 2019

Composition and Diversity of Bacterial Community on the Ocular Surface of Patients With Meibomian Gland Dysfunction

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Xiaojin Dong; Yuqian Wang; Weina Wang; Ping Lin; Yusen Huang
TAGS: meibomian gland dysfunction, microbiome, community, conjunctival sac
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4774-4783. doi: https://doi.org/10.1167/iovs.19-27719

Includes: Supplemental Content

Cornea September 2019

Therapeutic Effects of STAT3 Inhibition on Experimental Murine Dry Eye

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Mingli Qu; Xia Qi; Qian Wang; Lei Wan; Jing Li; Wei Li; Yingli Li; Qingjun Zhou
TAGS: dry eye syndromes, mice, stat3 protein
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3776-3785. doi: https://doi.org/10.1167/iovs.19-26928

Cornea September 2019

The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model

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Hyun Jung Lee; Soojung Shin; Seul-Gi Yoon; Eun Jeong Cheon; So-Hyang Chung
TAGS: animal model, chloroquine, dry eye syndromes, mice, sjogren's syndrome, syndrome, autophagy, sjogren's syndrome a antibody, phenotype, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3708-3716. doi: https://doi.org/10.1167/iovs.19-27469

Includes: Supplemental Content

Cornea July 2019

Induction of DDIT4 Impairs Autophagy Through Oxidative Stress in Dry Eye

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Bowen Wang; Lulu Peng; Hong Ouyang; Li Wang; Dalian He; Jing Zhong; Yichen Xiao; Yuqing Deng; Meng Li; Saiqun Li; Jin Yuan
TAGS: autophagy, dry eye syndromes, oxidative stress, western blotting, stress, mice, cell survival
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):2836-2847. doi: https://doi.org/10.1167/iovs.19-27072

Includes: Supplemental Content

Anatomy and Pathology/Oncology June 2019

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

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Ikram El Zaoui; Maya Bucher; Donata Rimoldi; Michael Nicolas; Gurkan Kaya; Rosanna Pescini Gobert; Nicola Bedoni; Ann Schalenbourg; Ezziat Sakina; Leonidas Zografos; Serge Leyvraz; Nicolo Riggi; Carlo Rivolta; Alexandre P. Moulin
TAGS: 1-phosphatidylinositol 3-kinase, malignant melanoma of conjunctiva, mitogen-activated protein kinases, molecular targeted therapy, mtor serine-threonine kinases, phosphoinositide 3-kinase, braf gene, proto-oncogene proteins c-akt, melanoma, mutation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2764-2772. doi: https://doi.org/10.1167/iovs.18-26508

Includes: Supplemental Content

Cornea June 2019

Expression and Role of Nucleotide-Binding Oligomerization Domain 2 (NOD2) in the Ocular Surface of Murine Dry Eye

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Ying Li; Rujun Jin; Lan Li; Hyeon Jeong Yoon; Joo-Hee Choi; Jong-Hwan Park; Zuguo Liu; Wei Li; Zhengri Li; Kyung Chul Yoon
TAGS: body tissue, conjunctiva, cornea, dry eye syndromes, mice, nucleotides, cytokine, in situ nick-end labeling, ripk2 gene, interleukin-6
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2641-2649. doi: https://doi.org/10.1167/iovs.19-27144

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Metagenomic Profiling of Ocular Surface Microbiome Changes in Meibomian Gland Dysfunction

Exploring the Molecular Mechanisms of Pterygium by Constructing lncRNA–miRNA–mRNA Regulatory Network

Mouse Meibomian Gland Dysfunction Model

Organotypic Culture of Mouse Meibomian Gland: A Novel Model to Study Meibomian Gland Dysfunction In Vitro

IRT5 Probiotics Changes Immune Modulatory Protein Expression in the Extraorbital Lacrimal Glands of an Autoimmune Dry Eye Mouse Model

The Potential Inhibitory Effects of miR-19b on Ocular Inflammation are Mediated Upstream of the JAK/STAT Pathway in a Murine Model of Allergic Conjunctivitis

Optical Analysis and Reappraisal of the Peripheral Light Focusing Theory of Nasal Pterygia Formation

HIF1α-mediated TRAIL Expression Regulates Lacrimal Gland Inflammation in Dry Eye Disease

Changes in Human Tear Proteome Following Topical Treatment of Dry Eye Disease: Cyclosporine A Versus Diquafosol Tetrasodium

Comparison of MicroRNA Expression in Tears of Normal Subjects and Sjögren Syndrome Patients

Antifibrotic Effects of Sakuraso-Saponin in Primary Cultured Pterygium Fibroblasts in Comparison With Mitomycin C

Introducing Sheila K. West, the Recipient of the 2019 Weisenfeld Award

P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts

Graft Versus Host Disease-Associated Dry Eye: Role of Ocular Surface Mucins and the Effect of Rebamipide, a Mucin Secretagogue

Composition and Diversity of Bacterial Community on the Ocular Surface of Patients With Meibomian Gland Dysfunction

Therapeutic Effects of STAT3 Inhibition on Experimental Murine Dry Eye

The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model

Induction of DDIT4 Impairs Autophagy Through Oxidative Stress in Dry Eye

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

Expression and Role of Nucleotide-Binding Oligomerization Domain 2 (NOD2) in the Ocular Surface of Murine Dry Eye

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