External Eye Disease

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Physiology and Pharmacology July 2018

TRPV1 and TRPM8 Channels and Nocifensive Behavior in a Rat Model for Dry Eye

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David A. Bereiter; Mostafeezur Rahman; Randall Thompson; Pannaporn Stephenson; Hiroto Saito
TAGS: capsaicin, dry eye syndromes, menthol, eye, rats, trpv1 receptor
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3739-3746. doi: 10.1167/iovs.18-24304

Cornea July 2018

Tear Film Proteomics Reveal Important Differences Between Patients With and Without Ocular GvHD After Allogeneic Hematopoietic Cell Transplantation

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Nadine Gerber-Hollbach; Kim Plattner; Olivia E. O'Leary; Paul Jenoe; Suzette Moes; Beatrice Drexler; Andreas Schoetzau; Jörg P. Halter; David Goldblum
TAGS: hematopoietic stem cell transplantation, graft-versus-host disease, dry eye syndromes, proteins, proteomics, tear film finding
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3521-3530. doi: 10.1167/iovs.18-24433

Includes: Supplemental Content

Cornea July 2018

Psychometric Analysis of the SPEED Questionnaire and CLDEQ-8

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Andrew D. Pucker; Bradley E. Dougherty; Lisa A. Jones-Jordan; Justin T. Kwan; Carolina M. E. Kunnen; Sruthi Srinivasan
TAGS: psychometrics, questionnaires, self-report, dry eye syndromes
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3307-3313. doi: 10.1167/iovs.18-24016

Includes: Supplemental Content

Cornea June 2018

Effects of Topical Mucolytic Agents on the Tears and Ocular Surface: A Plausible Animal Model of Mucin-Deficient Dry Eye

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Xiangzhe Li; Boram Kang; In Ho Woo; Youngsub Eom; Hyung Keun Lee; Hyo Myung Kim; Jong Suk Song
TAGS: administration, topical, dry eye syndromes, animal model, mucins, conjunctiva, eye, mass or substance concentration per volume, tear film finding, mucolytic agents
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):3104-3114. doi: 10.1167/iovs.18-23860

Immunology and Microbiology June 2018

MyD88 Deficiency Protects Against Dry Eye–Induced Damage

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Rose Y. Reins; Carolina Lema; Justin Courson; Carolina M. E. Kunnen; Rachel L. Redfern
TAGS: cytokine, signal transduction, dry eye syndromes, mice, myd88 gene
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2967-2976. doi: 10.1167/iovs.17-23397

Includes: Supplemental Content

Immunology and Microbiology May 2018

Antibodies to Conserved Surface Polysaccharides Protect Mice Against Bacterial Conjunctivitis

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Tanweer S. Zaidi; Tauqeer Zaidi; Gerald B. Pier
TAGS: conjunctivitis, alginates, monoclonal antibodies, bacterial conjunctivitis, polysaccharides, infection, antibodies, conjunctiva, mice, pathology
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2512-2519. doi: 10.1167/iovs.18-23795

Cornea May 2018

Labial Salivary Gland Transplantation for Severe Dry Eye in a Rhesus Monkey Model

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Yi Qin; Yingnan Zhang; Qingfeng Liang; Xiaolin Xu; Qian Li; Zhiqiang Pan; Antoine Labbé
TAGS: cytology, dry eye syndromes, macaca mulatta, surgical procedures, operative, tissue transplants, conjunctiva, eye, lip, salivary glands, transplantation
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2478-2486. doi: 10.1167/iovs.18-23966

Includes: Supplemental Content

Immunology and Microbiology May 2018

Non-Chlamydial Bacterial Infection and Progression of Conjunctival Scarring in Trachoma

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Victor H. Hu; David Macleod; Patrick Massae; Isaac Afwamba; Helen A. Weiss; David C. W. Mabey; Robin L. Bailey; Matthew J. Burton
TAGS: bacterial infections, cicatrix, trachoma, chlamydia, conjunctiva
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2339-2344. doi: 10.1167/iovs.17-23381

Clinical and Epidemiologic Research May 2018

Clinical Outcomes of Fixed Versus As-Needed Use of Artificial Tears in Dry Eye Disease: A 6-Week, Observer-Masked Phase 4 Clinical Trial

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Penny Asbell; Algis J. Vingrys; Jacqueline Tan; Abayomi Ogundele; Laura E. Downie; Gary Jerkins; Lee Shettle
TAGS: phase iv trial, dry eye syndromes, treatment outcome, ocular lubricants
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2275-2280. doi: 10.1167/iovs.17-23733

Includes: Supplemental Content

Cornea April 2018

Alterations of Murine Subbasal Corneal Nerves After Environmental Dry Eye Stress

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Cem Simsek; Takashi Kojima; Murat Dogru; Kazuo Tsubota
TAGS: bodily secretions, dry eye syndromes, neurons, cornea, mice, stress
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1986-1995. doi: 10.1167/iovs.17-23743

Cornea April 2018

The Relationship of Lid Wiper Epitheliopathy to Ocular Surface Signs and Symptoms

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Wing Li; Thao N. Yeh; Tiana Leung; Tiffany Yuen; Mariel Lerma; Meng C. Lin
TAGS: contact lenses, questionnaires, signs and symptoms, ocular signs and symptoms
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1878-1887. doi: 10.1167/iovs.17-23639

Includes: Supplemental Content

Anatomy and Pathology/Oncology April 2018

The Imbalance of Lymphocyte Subsets and Cytokines: Potential Immunologic Insights Into the Pathogenesis of Chronic Dacryocystitis

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Xiaoxuan Yang; Lizhen Wang; Lunhao Li; Zhang Yu; Caiwen Xiao
TAGS: cytokine, dacryocystitis, lymphocyte subset, imbalance, pathogenesis, immunology
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1802-1809. doi: 10.1167/iovs.17-23660

Letters to the Editor March 2018

Tear Levels of 8-hydroxy-2′-deoxyguanosine

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Louis Tong
TAGS: deoxyguanosine
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1587-1587. doi: 10.1167/iovs.17-23604

Letters to the Editor March 2018

Author Response: Tear Levels of 8-hydroxy-2′-deoxyguanosine

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Kristina Haworth; Heather Chandler
TAGS: deoxyguanosine
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1588-1588. doi: 10.1167/iovs.17-23682

Physiology and Pharmacology March 2018

Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders

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Suzanne Hagan; Matthew C. T. Fyfe; Boatemaa Ofori-Frimpong; Katherine Oliver; Martyn R. Foster; Sameer Sirohi; Yemisi Solanke; Michael Doughty; Adele Rowley; Mike Taylor; Steve Webber; Claire A. Walshe
TAGS: cytokine, endotoxins, gene expression, dry eye syndromes, gelatinase b, interleukin-8, lipopolysaccharides, mitogen-activated protein kinases, monocyte chemoattractant protein-1, phosphotransferases, uveitis, conjunctiva, hyperosmolality, mass or substance concentration per volume, rna, kinase inhibitor, inflammatory disorder, hyperglycemia hyperosmolar, peripheral blood mononuclear cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1443-1453. doi: 10.1167/iovs.17-23479

Includes: Supplemental Content

Clinical and Epidemiologic Research February 2018

Clinical Age-Specific Seasonal Conjunctivitis Patterns and Their Online Detection in Twitter, Blog, Forum, and Comment Social Media Posts

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Michael S. Deiner; Stephen D. McLeod; James Chodosh; Catherine E. Oldenburg; Cherie A. Fathy; Thomas M. Lietman; Travis C. Porco
TAGS: conjunctivitis, allergic conjunctivitis, electronic medical records, social media
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):910-920. doi: 10.1167/iovs.17-22818

Includes: Supplemental Content

Anatomy and Pathology/Oncology February 2018

HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status

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Jinfeng Cao; Niels J. Brouwer; Ekaterina S. Jordanova; Marina Marinkovic; Sjoerd G. van Duinen; Nadine E. de Waard; Bruce R. Ksander; Arend Mulder; Frans H. J. Claas; Mirjam H. M. Heemskerk; Martine J. Jager
TAGS: human leukocyte antigens, cell lines, malignant melanoma of conjunctiva, human leukocyte antigen class i, programmed cell death 1 ligand 1
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):1005-1015. doi: 10.1167/iovs.17-23209

Includes: Supplemental Content

Physiology and Pharmacology February 2018

A Biodegradable, Sustained-Released, Tacrolimus Microfilm Drug Delivery System for the Management of Allergic Conjunctivitis in a Mouse Model

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Yu-Chi Liu; Xu Wen Ng; Ericia Pei Wen Teo; Heng-Pei Ang; Nyein Chan Lwin; Nicole Shu Wen Chan; Subbu S. Venkatraman; Tina T. Wong; Jodhbir S. Mehta
TAGS: immunohistochemistry, allergic conjunctivitis, drug delivery systems, mice, tacrolimus, drug release
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):675-684. doi: 10.1167/iovs.17-23066

Anatomy and Pathology/Oncology January 2018

BRAF , NRAS , and GNAQ Mutations in Conjunctival Melanocytic Nevi

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Jasmine H. Francis; Hans E. Grossniklaus; Larissa A. Habib; Brian Marr; David H. Abramson; Klaus J. Busam
TAGS: mutation, nevus, melanocytic nevus, conjunctiva, nevus of conjunctiva, braf gene
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):117-121. doi: 10.1167/iovs.17-22517

Cornea January 2018

Pain Sensitivity Associated With the Length of the Maximum Interblink Period

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Wing Li; Meng C. Lin
TAGS: dry eye syndromes, dysmenorrhea, pain threshold
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):238-245. doi: 10.1167/iovs.17-22950

Includes: Multimedia, Supplemental Content

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TRPV1 and TRPM8 Channels and Nocifensive Behavior in a Rat Model for Dry Eye

Tear Film Proteomics Reveal Important Differences Between Patients With and Without Ocular GvHD After Allogeneic Hematopoietic Cell Transplantation

Psychometric Analysis of the SPEED Questionnaire and CLDEQ-8

Effects of Topical Mucolytic Agents on the Tears and Ocular Surface: A Plausible Animal Model of Mucin-Deficient Dry Eye

MyD88 Deficiency Protects Against Dry Eye–Induced Damage

Antibodies to Conserved Surface Polysaccharides Protect Mice Against Bacterial Conjunctivitis

Labial Salivary Gland Transplantation for Severe Dry Eye in a Rhesus Monkey Model

Non-Chlamydial Bacterial Infection and Progression of Conjunctival Scarring in Trachoma

Clinical Outcomes of Fixed Versus As-Needed Use of Artificial Tears in Dry Eye Disease: A 6-Week, Observer-Masked Phase 4 Clinical Trial

Alterations of Murine Subbasal Corneal Nerves After Environmental Dry Eye Stress

The Relationship of Lid Wiper Epitheliopathy to Ocular Surface Signs and Symptoms

The Imbalance of Lymphocyte Subsets and Cytokines: Potential Immunologic Insights Into the Pathogenesis of Chronic Dacryocystitis

Tear Levels of 8-hydroxy-2′-deoxyguanosine

Author Response: Tear Levels of 8-hydroxy-2′-deoxyguanosine

Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders

Clinical Age-Specific Seasonal Conjunctivitis Patterns and Their Online Detection in Twitter, Blog, Forum, and Comment Social Media Posts

HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status

A Biodegradable, Sustained-Released, Tacrolimus Microfilm Drug Delivery System for the Management of Allergic Conjunctivitis in a Mouse Model

BRAF , NRAS , and GNAQ Mutations in Conjunctival Melanocytic Nevi

Pain Sensitivity Associated With the Length of the Maximum Interblink Period

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