Eye Anatomy and Disorders

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Retina January 2019

Do Müller Cells Act as Optical Fibers in the Primate Retina?

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Kuno Kirschfeld
TAGS: optics, photoreceptors, primates, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):345-348. doi: 10.1167/iovs.18-25831

Glaucoma January 2019

Optic Nerve Head Astrocytes Display Axon-Dependent and -Independent Reactivity in Response to Acutely Elevated Intraocular Pressure

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Shandiz Tehrani; Lauren Davis; William O. Cepurna; R. Katherine Delf; Diana C. Lozano; Tiffany E. Choe; Elaine C. Johnson; John C. Morrison
TAGS: astrocytes, axon, optic disk, wounds and injuries, intraocular pressure, optic nerve, raised intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):312-321. doi: 10.1167/iovs.18-25447

Retinal Cell Biology January 2019

Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration

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Tina Storm; Thomas Burgoyne; Joshua L. Dunaief; Erik I. Christensen; Clare Futter; Rikke Nielsen
TAGS: ldl-receptor related protein 2, retinal degeneration, mice, ablation, retinal pigment epithelium
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):322-330. doi: 10.1167/iovs.18-25667

Includes: Multimedia, Supplemental Content

Retinal Cell Biology January 2019

Distribution and Activity of Mitochondrial Proteins in Vascular and Avascular Retinas: Implications for Retinal Metabolism

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Glyn Chidlow; John P. M. Wood; Paul I. Sia; Robert J. Casson
TAGS: mitochondria, guinea, mitochondrial proteins, oryctolagus cuniculus, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):331-344. doi: 10.1167/iovs.18-25536

Includes: Supplemental Content

Retina January 2019

Exosomes Derived From Mesenchymal Stem Cells Modulate miR-126 to Ameliorate Hyperglycemia-Induced Retinal Inflammation Via Targeting HMGB1

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Wei Zhang; Yang Wang; Yichun Kong
TAGS: diabetes mellitus, hyperglycemia, inflammation, glucose, retinitis, rats, stem cell, mesenchymal, exosomes, hmgb1 protein
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):294-303. doi: 10.1167/iovs.18-25617

Retina January 2019

Identification and Quantification of the Angiofibrotic Switch in Neovascular AMD

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Philipp K. Roberts; Stefan Zotter; Alessio Montuoro; Michael Pircher; Bernhard Baumann; Markus Ritter; Christoph K. Hitzenberger; Ursula Schmidt-Erfurth
TAGS: choroidal neovascularization, injections, eye, exudative age-related macular degeneration, volume, anti-vascular endothelial growth factor therapy, fibrosis, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):304-311. doi: 10.1167/iovs.18-25189

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging January 2019

Spectrally Resolved Fundus Autofluorescence in ABCA4 -Related Retinopathy

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Chantal Dysli; Philipp L. Müller; Johannes Birtel; Frank G. Holz; Philipp Herrmann
TAGS: color, retinal diseases, diagnostic imaging, fundus autofluorescence imaging
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):274-281. doi: 10.1167/iovs.18-25755

Retina January 2019

VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site

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Peter H. Tang; Gabriel Velez; Stephen H. Tsang; Alexander G. Bassuk; Vinit B. Mahajan
TAGS: mutation, exons, gelatinase a, surgical procedures, operative, vitreous body, eye, retina, cytokinesis, tissue degeneration, histopathology tests, proteolysis, proteins, splice-site mutation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):282-293. doi: 10.1167/iovs.18-25624

Includes: Supplemental Content

Articles January 2019

The Utility of Frame Averaging for Automated Algorithms in Analyzing Retinal Vascular Biomarkers in AngioVue OCTA

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Taly Gilat Schmidt; Rachel E. Linderman; Margaret R. Strampe; Toco Y. P. Chui; Richard B. Rosen; Joseph Carroll
TAGS: biological markers, pica disease, surrogate endpoints, image quality, parafoveal region
Trans. Vis. Sci. Tech.. 2019; 8(1):10. doi: 10.1167/tvst.8.1.10

Retinal Cell Biology January 2019

Chemokine Expression in Murine RPE/Choroid in Response to Systemic Viral Infection and Elevated Levels of Circulating Interferon-γ

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Carsten Faber; Helene Bæk Juel; Benjamin Anderschou Holbech Jensen; Jan Pravsgaard Christensen; Jan Ulrik Prause; Allan Randrup Thomsen; Mogens Holst Nissen
TAGS: chemokines, genes, interferons, lymphocytic choriomeningitis virus, virus diseases, infection, choroid, mice
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):192-201. doi: 10.1167/iovs.18-25721

Includes: Supplemental Content

Glaucoma January 2019

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway

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Yiwen Wang; Deborah Osakue; Enzhi Yang; Yi Zhou; Haiyan Gong; Xiaobo Xia; Yiqin Du
TAGS: stress response, stem cells, endoplasmic reticulum, trabecular meshwork, stress
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):265-273. doi: 10.1167/iovs.18-25477

Includes: Supplemental Content

Article January 2019

Temporal attention improves perception similarly at foveal and parafoveal locations

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Antonio Fernández; Rachel N. Denison; Marisa Carrasco
TAGS: attention, perception, visual fields, parafoveal region
Journal of Vision. 2019; 19(1):12. doi: 10.1167/19.1.12

Article January 2019

A top-down saliency model with goal relevance

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James Tanner; Laurent Itti
TAGS: attention, masks, eye, comprehension, machine learning, gaze, video games, eye movement, jumping, questionnaires
Journal of Vision. 2019; 19(1):11. doi: 10.1167/19.1.11

Cornea January 2019

The Protective Effect of a Topical Mucin Secretagogue on Ocular Surface Damage Induced by Airborne Carbon Black Exposure

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Xiangzhe Li; Boram Kang; Youngsub Eom; Hyung Keun Lee; Hyo Myung Kim; Jong Suk Song
TAGS: western blotting, secretagogues, immunoglobulin e, eye, immunoglobulin g, cytokine, cornea, carbon, prevention, mass or substance concentration per volume, normal saline, mucins, cervical lymph node group
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):255-264. doi: 10.1167/iovs.18-25964

Cornea January 2019

Identification of Leukocytes Associated With Midday Fogging in the Post-Lens Tear Film of Scleral Contact Lens Wearers

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Cameron K. Postnikoff; Andrew D. Pucker; John Laurent; Carrie Huisingh; Gerald McGwin; Jason J. Nichols
TAGS: small cell carcinoma of lung, contact lenses, lens, crystalline, lens (device), leukocytes, eye, sclera, tear film finding
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):226-233. doi: 10.1167/iovs.18-24664

Biochemistry and Molecular Biology January 2019

Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers

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Saima Limi; Yilin Zhao; Peng Guo; Melissa Lopez-Jones; Deyou Zheng; Robert H. Singer; Arthur I. Skoultchi; Ales Cvekl
TAGS: crystallins, lens, crystalline, lens (device), rna, messenger, mice, rna, genes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):234-244. doi: 10.1167/iovs.18-25921

Includes: Supplemental Content

Cornea January 2019

Epithelial Membrane Protein-2 (EMP2) Antibody Blockade Reduces Corneal Neovascularization in an In Vivo Model

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Michel M. Sun; Ann M. Chan; Samuel M. Law; Sergio Duarte; Daniel Diaz-Aguilar; Madhuri Wadehra; Lynn K. Gordon
TAGS: vascular endothelial growth factor a, epithelium, burns, corneal neovascularization, tissue membrane, antibodies, proteins
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):245-254. doi: 10.1167/iovs.18-24345

Includes: Supplemental Content

Biochemistry and Molecular Biology January 2019

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

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Sun Woong Kim; Hye-In Kim; Bikash Thapa; Selikem Nuwromegbe; Keunwook Lee
TAGS: signal transduction, fibroblasts, pterygium, myofibroblasts, proto-oncogene proteins c-akt, hpfs trial, mechanistic target of rapamycin complex 2, mtor serine-threonine kinases
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):82-92. doi: 10.1167/iovs.18-25376

Retina January 2019

Systemic Levels of Interleukin-6 Correlate With Progression Rate of Geographic Atrophy Secondary to Age-Related Macular Degeneration

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Marie Krogh Nielsen; Yousif Subhi; Christopher Rue Molbech; Mads Krüger Falk; Mogens Holst Nissen; Torben Lykke Sørensen
TAGS: inflammation, atrophy, plasma, c-reactive protein, interleukin-6, age-related macular degeneration, atrophic condition of skin, exudative age-related macular degeneration
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):202-208. doi: 10.1167/iovs.18-25878

Includes: Supplemental Content

Cornea January 2019

The Effects of Diabetes and High-Fat Diet on Polymodal Nociceptor and Cold Thermoreceptor Nerve Terminal Endings in the Corneal Epithelium

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Abdulhakeem S. Alamri; James A. Brock; Chandana B. Herath; Indu G. Rajapaksha; Peter W. Angus; Jason J. Ivanusic
TAGS: diabetes mellitus, diabetes mellitus, type 2, common cold, cold temperature, nerve supply, cold sensation, cornea, nerve endings, nerve fibers, corneal epithelium, thermoreceptors, nociceptors, diet, high-fat
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):209-217. doi: 10.1167/iovs.18-25788

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Do Müller Cells Act as Optical Fibers in the Primate Retina?

Optic Nerve Head Astrocytes Display Axon-Dependent and -Independent Reactivity in Response to Acutely Elevated Intraocular Pressure

Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration

Distribution and Activity of Mitochondrial Proteins in Vascular and Avascular Retinas: Implications for Retinal Metabolism

Exosomes Derived From Mesenchymal Stem Cells Modulate miR-126 to Ameliorate Hyperglycemia-Induced Retinal Inflammation Via Targeting HMGB1

Identification and Quantification of the Angiofibrotic Switch in Neovascular AMD

Spectrally Resolved Fundus Autofluorescence in ABCA4 -Related Retinopathy

VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site

The Utility of Frame Averaging for Automated Algorithms in Analyzing Retinal Vascular Biomarkers in AngioVue OCTA

Chemokine Expression in Murine RPE/Choroid in Response to Systemic Viral Infection and Elevated Levels of Circulating Interferon-γ

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway

Temporal attention improves perception similarly at foveal and parafoveal locations

A top-down saliency model with goal relevance

The Protective Effect of a Topical Mucin Secretagogue on Ocular Surface Damage Induced by Airborne Carbon Black Exposure

Identification of Leukocytes Associated With Midday Fogging in the Post-Lens Tear Film of Scleral Contact Lens Wearers

Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers

Epithelial Membrane Protein-2 (EMP2) Antibody Blockade Reduces Corneal Neovascularization in an In Vivo Model

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

Systemic Levels of Interleukin-6 Correlate With Progression Rate of Geographic Atrophy Secondary to Age-Related Macular Degeneration

The Effects of Diabetes and High-Fat Diet on Polymodal Nociceptor and Cold Thermoreceptor Nerve Terminal Endings in the Corneal Epithelium

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