Eye Anatomy and Disorders

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Retina December 2018

In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode–Based Retinal Prosthesis

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Brandon Bosse; Samir Damle; Abraham Akinin; Yi Jing; Dirk-Uwe Bartsch; Lingyun Cheng; Nicholas Oesch; Yu-Hwa Lo; Gert Cauwenberghs; William R. Freeman
TAGS: evoked potentials, visual, oryctolagus cuniculus, silicon, surgical procedures, operative, retina, implantation procedure, nanowires, implants, prostheses, visual prosthesis
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5885-5892. doi: 10.1167/iovs.18-24554

Retina December 2018

Diabetic Nonperfused Areas in Macular and Extramacular Regions on Wide-Field Optical Coherence Tomography Angiography

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Shota Yasukura; Tomoaki Murakami; Kiyoshi Suzuma; Tatsuya Yoshitake; Hideo Nakanishi; Masahiro Fujimoto; Maho Oishi; Akitaka Tsujikawa
TAGS: angiogram, diabetes mellitus, arteriole, optic disk, perfusion, blood capillaries, eye, nonproliferative diabetic retinopathy, optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5893-5903. doi: 10.1167/iovs.18-25108

Includes: Supplemental Content

Glaucoma December 2018

Δ 9 -Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure

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Sally Miller; Laura Daily; Emma Leishman; Heather Bradshaw; Alex Straiker
TAGS: cannabinoids, cannabidiol, tetrahydrocannabinol, eye, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5904-5911. doi: 10.1167/iovs.18-24838

Retinal Cell Biology December 2018

Inhibition of Diabetes-Induced Lysyl Oxidase Overexpression Prevents Retinal Vascular Lesions Associated With Diabetic Retinopathy

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Brian Song; Dongjoon Kim; Ngan-Ha Nguyen; Sayon Roy
TAGS: diabetes mellitus, diabetic retinopathy, protein-lysine 6-oxidase, rats, retina, vascular lesions, rna, small interfering, protein overexpression
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5965-5972. doi: 10.1167/iovs.18-25543

Retina December 2018

Supernormal Flicker ERGs in Eyes With Central Retinal Vein Occlusion: Clinical Characteristics, Prognosis, and Effects of Anti-VEGF Agent

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Ryohei Miyata; Mineo Kondo; Kumiko Kato; Masahiko Sugimoto; Hisashi Matsubara; Kengo Ikesugi; Shinji Ueno; Shunsuke Yasuda; Hiroko Terasaki
TAGS: electroretinography, eye, central retinal vein occlusion, photopsia, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5854-5861. doi: 10.1167/iovs.18-25087

Includes: Supplemental Content

Glaucoma December 2018

The Relationship Between Peripapillary Vascular Density and Visual Field Sensitivity in Primary Open-Angle and Angle-Closure Glaucoma

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Youn Hye Jo; Kyung Rim Sung; Sung-Cheol Yun
TAGS: angle closure glaucoma, open-angle glaucoma, visual fields, eye, intraocular pressure, retinal nerve fiber layer
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5862-5867. doi: 10.1167/iovs.18-25423

Cornea December 2018

Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes

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Kiyokazu Ozaki; Yui Terayama; Tetsuro Matsuura
TAGS: hyperglycemia, diabetes mellitus, type 1, body weight, alloxan, neurons, streptozocin, sural nerve, cornea, mice, nerve lesions
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5868-5875. doi: 10.1167/iovs.18-25693

Glaucoma December 2018

Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma

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Emily Mathieu; Neeru Gupta; Luz A. Paczka-Giorgi; Xun Zhou; Amir Ahari; Rafael Lani; Joseph Hanna; Yeni H. Yücel
TAGS: glaucoma, cerebrospinal fluid, optic nerve
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5876-5884. doi: 10.1167/iovs.18-24521

Biochemistry and Molecular Biology December 2018

Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease

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Anastasia Marie Litke; Sarah Samuelson; Kerry R. Delaney; Yves Sauvé; Robert L. Chow
TAGS: mutation, corneal diseases, electroretinography, keratoconus, luciferases, missense mutation, cornea, diagnostic imaging, mice, pathogenicity
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5824-5835. doi: 10.1167/iovs.18-25490

Includes: Supplemental Content

Retina December 2018

Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability

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Gerard A. Rodrigues; Matthew Mason; Lori-Ann Christie; Candice Hansen; Lisa M. Hernandez; James Burke; Keith A. Luhrs; Thomas C. Hohman
TAGS: angiogenesis, vascular endothelial growth factor a, oryctolagus cuniculus, bevacizumab, ranibizumab, affinity, aflibercept, anti-vascular endothelial growth factor therapy, vascular permeability
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5836-5846. doi: 10.1167/iovs.18-25307

Retina December 2018

Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit

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Yuki Muraoka; Akihito Uji; Masaharu Ishikura; Yuto Iida; Sotaro Ooto; Akitaka Tsujikawa
TAGS: angiogram, microcirculation, retinal vessels, blood capillaries, optical coherence tomography, retinal vasculature
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5847-5853. doi: 10.1167/iovs.18-25301

Includes: Multimedia, Supplemental Content

Lens December 2018

Epithelial-Mesenchymal Transdifferentiation in Pediatric Lens Epithelial Cells

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Laura Wernecke; Susanne Keckeis; Nadine Reichhart; Olaf Strauß; Daniel J. Salchow
TAGS: epithelium, cataract, child, pediatrics, patient characteristics, lens epithelial cell, cell transdifferentiation, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5785-5794. doi: 10.1167/iovs.18-23789

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology December 2018

Binocular Summation for Reflexive Eye Movements: A Potential Diagnostic Tool for Stereodeficiencies

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Christian Quaia; Edmond J. FitzGibbon; Lance M. Optican; Bruce G. Cumming
TAGS: depth perception, vision, eye, noise, emmetropia, clinical diagnostic instrument, summation, eye movement
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5816-5822. doi: 10.1167/iovs.18-24520

Visual Psychophysics and Physiological Optics December 2018

Estimation of Contrast Sensitivity From Fixational Eye Movements

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Jonathan Denniss; Chris Scholes; Paul V. McGraw; Se-Ho Nam; Neil W. Roach
TAGS: contrast sensitivity, eye movement
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5408-5416. doi: 10.1167/iovs.18-24674

Retina December 2018

Cross-Sectional Imaging Analysis of Epiretinal Membrane Involvement in Unilateral Open-Angle Glaucoma Severity

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Susumu Sakimoto; Tomoyuki Okazaki; Shinichi Usui; Tomoyuki Ishibashi; Yoshihito Oura; Kentaro Nishida; Atsuya Miki; Ryo Kawasaki; Kenji Matsushita; Hirokazu Sakaguchi; Kohji Nishida
TAGS: glaucoma, open-angle glaucoma, diagnostic imaging, epiretinal membrane
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5745-5751. doi: 10.1167/iovs.18-25292

Includes: Supplemental Content

Clinical and Epidemiologic Research December 2018

Potential Role of Ocular Microbiome, Host Genotype, Tear Cytokines, and Environmental Factors in Corneal Infiltrative Events in Contact Lens Wearers

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Cecilia Chao; Lakshmi Akileswaran; Jessica N. Cooke Bailey; Mark Willcox; Russell Van Gelder; Carol Lakkis; Fiona Stapleton; Kathryn Richdale
TAGS: cytokine, environmental factors, contact lenses, genotype, cornea, interleukin-6, microbiome, whole exome sequencing
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5752-5761. doi: 10.1167/iovs.18-24845

Includes: Supplemental Content

Retina December 2018

Blue Cone Monochromacy Caused by the C203R Missense Mutation or Large Deletion Mutations

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Alexander Sumaroka; Alexandra V. Garafalo; Artur V. Cideciyan; Jason Charng; Alejandro J. Roman; Windy Choi; Supna Saxena; Valeryia Aksianiuk; Susanne Kohl; Bernd Wissinger; Samuel G. Jacobson
TAGS: mutation, cohort studies, retinal cone, genotype, missense mutation
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5762-5772. doi: 10.1167/iovs.18-25280

Multidisciplinary Ophthalmic Imaging December 2018

Human Retinal Pigment Epithelium: In Vivo Cell Morphometry, Multispectral Autofluorescence, and Relationship to Cone Mosaic

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Charles E. Granger; Qiang Yang; Hongxin Song; Kenichi Saito; Koji Nozato; Lisa R. Latchney; Bianca T. Leonard; Mina M. Chung; David R. Williams; Ethan A. Rossi
TAGS: retinal cone, photoreceptors, diagnostic imaging, mosaicism, autofluorescence, retinal pigment epithelium, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5705-5716. doi: 10.1167/iovs.18-24677

Includes: Supplemental Content

Glaucoma December 2018

Rates of Visual Field Loss in Primary Open-Angle Glaucoma and Primary Angle-Closure Glaucoma: Asymmetric Patterns

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Siamak Yousefi; Hiroshi Sakai; Hiroshi Murata; Yuri Fujino; Masato Matsuura; David Garway-Heath; Robert Weinreb; Ryo Asaoka
TAGS: blindness, open-angle glaucoma, visual fields, eye, angle closure glaucoma
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5717-5725. doi: 10.1167/iovs.18-25140

Retina December 2018

Optical Coherence Tomography Angiography in Familial Exudative Vitreoretinopathy: Clinical Features and Phenotype-Genotype Correlation

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Chonglin Chen; Chengxi Liu; Zhirong Wang; Limei Sun; Xiujuan Zhao; Songshan Li; Xiaoling Luo; Aiyuan Zhang; Victor Chong; Lin Lu; Xiaoyan Ding
TAGS: angiogram, phenotype, genotype, signs and symptoms, optical coherence tomography, familial exudative vitreoretinopathy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5726-5734. doi: 10.1167/iovs.18-25377

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In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode–Based Retinal Prosthesis

Diabetic Nonperfused Areas in Macular and Extramacular Regions on Wide-Field Optical Coherence Tomography Angiography

Δ 9 -Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure

Inhibition of Diabetes-Induced Lysyl Oxidase Overexpression Prevents Retinal Vascular Lesions Associated With Diabetic Retinopathy

Supernormal Flicker ERGs in Eyes With Central Retinal Vein Occlusion: Clinical Characteristics, Prognosis, and Effects of Anti-VEGF Agent

The Relationship Between Peripapillary Vascular Density and Visual Field Sensitivity in Primary Open-Angle and Angle-Closure Glaucoma

Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes

Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma

Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease

Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability

Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit

Epithelial-Mesenchymal Transdifferentiation in Pediatric Lens Epithelial Cells

Binocular Summation for Reflexive Eye Movements: A Potential Diagnostic Tool for Stereodeficiencies

Estimation of Contrast Sensitivity From Fixational Eye Movements

Cross-Sectional Imaging Analysis of Epiretinal Membrane Involvement in Unilateral Open-Angle Glaucoma Severity

Potential Role of Ocular Microbiome, Host Genotype, Tear Cytokines, and Environmental Factors in Corneal Infiltrative Events in Contact Lens Wearers

Blue Cone Monochromacy Caused by the C203R Missense Mutation or Large Deletion Mutations

Human Retinal Pigment Epithelium: In Vivo Cell Morphometry, Multispectral Autofluorescence, and Relationship to Cone Mosaic

Rates of Visual Field Loss in Primary Open-Angle Glaucoma and Primary Angle-Closure Glaucoma: Asymmetric Patterns

Optical Coherence Tomography Angiography in Familial Exudative Vitreoretinopathy: Clinical Features and Phenotype-Genotype Correlation

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