Eye Anatomy and Disorders

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Anatomy and Pathology/Oncology September 2021

Dual Inhibition of Histone Deacetylases and the Mechanistic Target of Rapamycin Promotes Apoptosis in Cell Line Models of Uveal Melanoma

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Ruchi P. Patel; Joanna R. Thomas; Katherine M. Curt; Christina M. Fitzsimmons; Pedro J. Batista; Susan E. Bates; Michael M. Gottesman; Robert W. Robey
TAGS: apoptosis, cell lines, histone deacetylase, intraocular melanoma, mtor inhibitors, mtor serine-threonine kinases, rapamycin, romidepsin, proteins
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):16. doi: https://doi.org/10.1167/iovs.62.12.16

Includes: Supplemental Content

Cornea September 2021

Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy

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Rajalekshmy Shyam; Diego G. Ogando; Moonjung Choi; Paloma B. Liton; Joseph A. Bonanno
TAGS: animal model, autophagy, cornea, endothelial cells, endothelium, impairment, mitochondria, mitoq compound, pathophysiology, proteins
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):15. doi: https://doi.org/10.1167/iovs.62.12.15

Includes: Supplemental Content

Retina September 2021

Retinal Degeneration Caused by Ago2 Disruption

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Xue-Jiao Chen; Chang-Jun Zhang; Ya-Han Wang; Zi-Bing Jin
TAGS: mice, retina, retinal degeneration, micrornas
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):14. doi: https://doi.org/10.1167/iovs.62.12.14

Includes: Supplemental Content

Immunology and Microbiology September 2021

Ocular Surface Microbiota in Diabetic Patients With Dry Eye Disease

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Zhang Zhang; Xinrong Zou; Wenwen Xue; Pei Zhang; Shanshan Wang; Haidong Zou
TAGS: diabetes mellitus, dry eye syndromes, microbiome
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):13. doi: https://doi.org/10.1167/iovs.62.12.13

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology September 2021

Binocular Integration of Perceptually Suppressed Visual Information in Amblyopia

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Amy Chow; Andrew E. Silva; Katelyn Tsang; Gabriel Ng; Cindy Ho; Benjamin Thompson
TAGS: amblyopia, eye, motion
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):11. doi: https://doi.org/10.1167/iovs.62.12.11

Glaucoma September 2021

Binocular Interactions in Glaucoma Patients With Nonoverlapping Visual Field Defects: Contrast Summation, Rivalry, and Phase Combination

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Catarina A. R. João; Lorenzo Scanferla; Nomdo M. Jansonius
TAGS: eye, glaucoma, summation, vision, visual field defects
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):9. doi: https://doi.org/10.1167/iovs.62.12.9

Retina September 2021

Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy

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Bhubanananda Sahu; Laura Moreno Leon; Wei Zhang; Nikita Puranik; Ramesh Periasamy; Hemant Khanna; Michael Volkert
TAGS: gene therapy, injections, mice, nerve degeneration, oxidative stress, retinal degeneration, retinal diseases, photoreceptors, caspases, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):8. doi: https://doi.org/10.1167/iovs.62.12.8

Includes: Supplemental Content

Glaucoma September 2021

Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma

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Naga Pradeep Rayana; Chenna Kesavulu Sugali; Jiannong Dai; Michael Peng; Shaohui Liu; Yucheng Zhang; Jun Wan; Weiming Mao
TAGS: crispr, eye, glaucoma, mice, ocular hypertension, cytomegalovirus, lentiviral vector, adenoviruses, genes
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):7. doi: https://doi.org/10.1167/iovs.62.12.7

Includes: Supplemental Content

Glaucoma September 2021

U-Shaped Effect of Blood Pressure on Structural OCT Metrics and Retinal Perfusion in Ophthalmologically Healthy Subjects

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Konstantinos Pappelis; Nomdo M. Jansonius
TAGS: blood pressure, glaucoma, homeostasis, hypotension, perfusion, vascular flow, ventricular rate rapid, mediation analysis, hypertension, did not receive therapy or drug
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):5. doi: https://doi.org/10.1167/iovs.62.12.5

Includes: Supplemental Content

Cornea September 2021

Mitochondrial Targeting of the Ammonia-Sensitive Uncoupler SLC4A11 by the Chaperone-Mediated Carrier Pathway in Corneal Endothelium

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Moonjung Choi; Joseph A. Bonanno
TAGS: hsp90 heat-shock proteins, mitochondria, molecular chaperones, ammonia
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):4. doi: https://doi.org/10.1167/iovs.62.12.4

Includes: Supplemental Content

Glaucoma September 2021

The Relationship Between Optic Disc and Retinal Artery Position and Glaucomatous Visual Field Progression

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Yuri Fujino; Ryo Asaoka; Hiroshi Murata; Takehiro Yamashita
TAGS: central retinal artery, glaucoma, intraocular pressure, optic disk, retina, visual fields, maximum tolerated dose
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):6. doi: https://doi.org/10.1167/iovs.62.12.6

Lens September 2021

Genotype, Age, Genetic Background, and Sex Influence Epha2 -Related Cataract Development in Mice

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Alpana Dave; Jamie E. Craig; Mohammad Alamein; Karina Skrzypiec; Justin Beltz; Annalise Pfaff; Kathryn P. Burdon; Nuran Ercal; Robb U. de Iongh; Shiwani Sharma
TAGS: cataract, genetic background, genotype, mice, lens (device), lens, crystalline
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):3. doi: https://doi.org/10.1167/iovs.62.12.3

Includes: Supplemental Content

Retina September 2021

Progressive Dysmorphia of Retinal Pigment Epithelium in Age-Related Macular Degeneration Investigated by Fluorescence Lifetime Imaging

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Martin Hammer; Juliane Jakob-Girbig; Linda Schwanengel; Christine A. Curcio; Somar Hasan; Daniel Meller; Rowena Schultz
TAGS: age-related macular degeneration, diagnostic imaging, fluorescence, hyperpigmentation, retinal pigment epithelium, atrophy
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):2. doi: https://doi.org/10.1167/iovs.62.12.2

Cornea September 2021

Changes in Conjunctival Microbiota Associated With HIV Infection and Antiretroviral Therapy

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Qun Liu; Zhi-Yi Xu; Xiao-Li Wang; Xiao-Mei Huang; Wen-Lin Zheng; Mei-Jun Li; Fan Xiao; Pei-Wen Ouyang; Xiao-Hua Yang; Yu-Hong Cui; Hong-Wei Pan
TAGS: anti-retroviral agents, antiretroviral therapy, highly active, conjunctiva, hiv infections, microbiome, did not receive therapy or drug, hiv, hiv seropositivity
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):1. doi: https://doi.org/10.1167/iovs.62.12.1

Glaucoma August 2021

Implications of the Relationship Between Refractive Error and Biometry in the Pathogenesis of Primary Angle Closure

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Kilhwan Shon; Kyung Rim Sung; Joo Young Yoon
TAGS: biometry, eye, pathogenesis, refractive errors, cornea, correlation studies, regression analysis
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):38. doi: https://doi.org/10.1167/iovs.62.10.38

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology August 2021

Velocity Discrimination in Infantile Nystagmus Syndrome

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Bing Dai; Kwang Meng Cham; Larry Allen Abel
TAGS: pathologic nystagmus, syndrome, velocity, gaze
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):35. doi: https://doi.org/10.1167/iovs.62.10.35

Includes: Multimedia, Supplemental Content

Retina August 2021

Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium

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Dongfeng Cao; Belinda Leong; Jeffrey D. Messinger; Deepayan Kar; Thomas Ach; Lawrence A. Yannuzzi; K. Bailey Freund; Christine A. Curcio
TAGS: age-related macular degeneration, atrophic condition of skin, atrophy, cell transdifferentiation, diagnostic imaging, donors, eye, immunohistochemistry, optical coherence tomography, phenotype
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):34. doi: https://doi.org/10.1167/iovs.62.10.34

Includes: Supplemental Content

Cornea August 2021

Tear Proteomics in Keratoconus: A Quantitative SWATH-MS Analysis

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Maite López-López; Uxía Regueiro; Susana B. Bravo; María del Pilar Chantada-Vázquez; Rubén Varela-Fernández; Paulo Ávila-Gómez; Pablo Hervella; Isabel Lema
TAGS: keratoconus, proteins, proteomics
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):30. doi: https://doi.org/10.1167/iovs.62.10.30

Includes: Supplemental Content

Retina August 2021

Inner Macular Changes in Fellow Eye of Patients With Unilateral Idiopathic Epiretinal Membrane

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Andrea M. Coppe; Giuliana Lapucci; Guido Ripandelli; Francesca R. Pesci; Luca Buzzonetti; Giancarlo Iarossi
TAGS: epiretinal membrane, eye, significance, retina
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):29. doi: https://doi.org/10.1167/iovs.62.10.29

Glaucoma August 2021

iPSC-Derived Trabecular Meshwork Cells Stimulate Endogenous TM Cell Division Through Gap Junction in a Mouse Model of Glaucoma

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Shangru Sui; Hongxia Yu; Xiangji Wang; Wenyan Wang; Xuejiao Yang; Xiaojing Pan; Qingjun Zhou; Chen Xin; Rong Du; Shen Wu; Jingxue Zhang; Qilong Cao; Ningli Wang; Markus H. Kuehn; Wei Zhu
TAGS: cell growth, connexin 43, gap junction protein, glaucoma, medication therapy management, mice, trabecular meshwork, myoc gene, coculture techniques, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2021; 62(10):28. doi: https://doi.org/10.1167/iovs.62.10.28

Includes: Supplemental Content

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Dual Inhibition of Histone Deacetylases and the Mechanistic Target of Rapamycin Promotes Apoptosis in Cell Line Models of Uveal Melanoma

Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy

Retinal Degeneration Caused by Ago2 Disruption

Ocular Surface Microbiota in Diabetic Patients With Dry Eye Disease

Binocular Integration of Perceptually Suppressed Visual Information in Amblyopia

Binocular Interactions in Glaucoma Patients With Nonoverlapping Visual Field Defects: Contrast Summation, Rivalry, and Phase Combination

Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy

Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma

U-Shaped Effect of Blood Pressure on Structural OCT Metrics and Retinal Perfusion in Ophthalmologically Healthy Subjects

Mitochondrial Targeting of the Ammonia-Sensitive Uncoupler SLC4A11 by the Chaperone-Mediated Carrier Pathway in Corneal Endothelium

The Relationship Between Optic Disc and Retinal Artery Position and Glaucomatous Visual Field Progression

Genotype, Age, Genetic Background, and Sex Influence Epha2 -Related Cataract Development in Mice

Progressive Dysmorphia of Retinal Pigment Epithelium in Age-Related Macular Degeneration Investigated by Fluorescence Lifetime Imaging

Changes in Conjunctival Microbiota Associated With HIV Infection and Antiretroviral Therapy

Implications of the Relationship Between Refractive Error and Biometry in the Pathogenesis of Primary Angle Closure

Velocity Discrimination in Infantile Nystagmus Syndrome

Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium

Tear Proteomics in Keratoconus: A Quantitative SWATH-MS Analysis

Inner Macular Changes in Fellow Eye of Patients With Unilateral Idiopathic Epiretinal Membrane

iPSC-Derived Trabecular Meshwork Cells Stimulate Endogenous TM Cell Division Through Gap Junction in a Mouse Model of Glaucoma

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