Eye Anatomy and Disorders

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Immunology and Microbiology June 2021

Retinal Pigment Epithelial Cells Express Antimicrobial Peptide Lysozyme – A Novel Mechanism of Innate Immune Defense of the Blood-Retina Barrier

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Jian Liu; Caijiao Yi; Wei Ming; Miao Tang; Xiao Tang; Chang Luo; Bo Lei; Mei Chen; Heping Xu
TAGS: muramidase, retinal pigment cell, antimicrobials, peptides
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):21. doi: https://doi.org/10.1167/iovs.62.7.21

Visual Neuroscience June 2021

Synaptosomal Actin Dynamics in the Developmental Visual Cortex Regulate Behavioral Visual Acuity in Rats

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Ai-Ling Bi; Yue-Ying Zhang; Zhi-Yuan Lu; Hong-Ying Tang; Xiu-Yan Zhang; Zi-Han Zhang; Bo-Qin Li; Da-Dong Guo; Sheng Gong; Qian Li; Xing-Rong Wang; Xiu-Zhen Lu; Hong-Sheng Bi
TAGS: actins, rats, visual acuity, visual cortex, mitochondria, primary visual cortex
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):20. doi: https://doi.org/10.1167/iovs.62.7.20

Includes: Supplemental Content

Retina June 2021

Association Between Gut Microbial Abundance and Sight-Threatening Diabetic Retinopathy

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Rehana Khan; Abhishek Sharma; Raghul Ravikumar; Avani Parekh; Ramyaa Srinivasan; Ronnie Jacob George; Rajiv Raman
TAGS: diabetic retinopathy, dysbiosis, vision, diabetes mellitus, diabetes mellitus, type 2, massively-parallel genome sequencing, intestinal bacteria
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):19. doi: https://doi.org/10.1167/iovs.62.7.19

Cornea June 2021

PEDF Gene Deletion Disrupts Corneal Innervation and Ocular Surface Function

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Zhenying Shang; Chenxi Li; Xuemei Liu; Manhong Xu; Xiaomin Zhang; Xiaorong Li; Colin J. Barnstable; Shaozhen Zhao; Joyce Tombran-Tink
TAGS: cornea, mice, gene deletion, nerve supply
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):18. doi: https://doi.org/10.1167/iovs.62.7.18

Retina June 2021

North Carolina Macular Dystrophy: Phenotypic Variability and Computational Analysis of Disease-Associated Noncoding Variants

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David J. Green; Eva Lenassi; Cerys S. Manning; David McGaughey; Vinod Sharma; Graeme C. Black; Jamie M. Ellingford; Panagiotis I. Sergouniotis
TAGS: body tissue, datasets, macular dystrophy, phenotype, retina, gene expression, genetic screening, genes, enhancer elements, genetic
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):16. doi: https://doi.org/10.1167/iovs.62.7.16

Includes: Supplemental Content

Perspective June 2021

Shared Features in Retinal Disorders With Involvement of Retinal Pigment Epithelium

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Janet R. Sparrow; Rait Parmann; Stephen H. Tsang; Rando Allikmets; Stanley Chang; Ruben Jauregui
TAGS: retinal diseases, retinal pigment epithelium, spectral domain-optical coherence tomography, mutation, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):15. doi: https://doi.org/10.1167/iovs.62.7.15

Low Vision June 2021

Quality of Life and Participation of Children With Visual Impairment: Comparison With Population Reference Scores

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Ellen B. M. Elsman; Mitchel Koel; Ruth M. A. van Nispen; Ger H. M. B. van Rens
TAGS: child, quality of life, visual impairment, parent
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):14. doi: https://doi.org/10.1167/iovs.62.7.14

Retina June 2021

The Retinal Ganglion Cell Response to Blast-Mediated Traumatic Brain Injury Is Genetic Background Dependent

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Matthew M. Harper; Nickolas Boehme; Laura M. Dutca; Michael G. Anderson
TAGS: basic local alignment search tool, blast injuries, genetic background, genetics, mice, retinal ganglion cells, traumatic brain injuries, phenotype
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):13. doi: https://doi.org/10.1167/iovs.62.7.13

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics June 2021

Dichoptic Perceptual Training and Sensory Eye Dominance Plasticity in Normal Vision

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Ka Yee Kam; Dorita H. F. Chang
TAGS: emmetropia, learning, motion, noise, ocular dominance, training, visual training, eye, depth perception, balance, device
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):12. doi: https://doi.org/10.1167/iovs.62.7.12

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2021

Age-Related Retinal Changes in Wild-Type C57BL/6J Mice Between 2 and 32 Months

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Salma Ferdous; Kristie L. Liao; Isabelle D. Gefke; Vivian R. Summers; Wenfei Wu; Kevin J. Donaldson; Yong-Kyu Kim; Jana T. Sellers; Jendayi A. Dixon; Debresha A. Shelton; Shanu Markand; Somin M. Kim; Nan Zhang; Jeffrey H. Boatright; John M. Nickerson
TAGS: eye, mice, mice, inbred c57bl, body weight, photoreceptors, aging, retina
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):9. doi: https://doi.org/10.1167/iovs.62.7.9

Includes: Supplemental Content

Cornea June 2021

IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium

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Evan D. Bogdan; Whitney L. Stuard; Rossella Titone; Danielle M. Robertson
TAGS: corneal epithelium, homeostasis, hyperosmolality, insulin-like growth factor binding protein 3, sodium chloride, stress, mosmol, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):11. doi: https://doi.org/10.1167/iovs.62.7.11

Includes: Supplemental Content

Retina June 2021

Anatomic–Functional Correlates in Lesions of Retinal Vein Occlusion

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Meiaad Khayat; Jennifer Perais; David M. Wright; Michael Williams; Noemi Lois
TAGS: eye, retinal ischemia, retinal vein occlusion, ischemia, follow-up, retina
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):10. doi: https://doi.org/10.1167/iovs.62.7.10

Physiology and Pharmacology June 2021

Acute Inhibitory Effects of Antidepressants on Lacrimal Gland Secretion in the Anesthetized Rat

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Martin Dankis; Ozgu Aydogdu; Gunnar Tobin; Michael Winder
TAGS: antidepressive agents, bodily secretions, lacrimal gland, reflex, tear production, clomipramine, escitalopram, methacholine, cholinergic agents
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):8. doi: https://doi.org/10.1167/iovs.62.7.8

Retina June 2021

Association of Aberrant Posterior Vitreous Detachment and Pathologic Tractional Forces With Myopic Macular Degeneration

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Kai Yuan Tey; Qiu Ying Wong; Yee Shan Dan; Andrew S. H. Tsai; Daniel S. W. Ting; Marcus Ang; Gemmy Chiu Ming Cheung; Shu Yen Lee; Tien Yin Wong; Quan V. Hoang; Chee Wai Wong
TAGS: eye, myopic macular degeneration, staphyloma, vitreous detachment, traction, medication therapy management, macular disorders, prevalence
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):7. doi: https://doi.org/10.1167/iovs.62.7.7

Retina June 2021

Expression of the SARS-CoV-2 Receptor ACE2 in Human Retina and Diabetes—Implications for Retinopathy

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Lingli Zhou; Zhenhua Xu; James Guerra; Avi Z. Rosenberg; Paride Fenaroli; Charles G. Eberhart; Elia J. Duh
TAGS: diabetes mellitus, diabetes mellitus, type 2, retina, retinal diseases, sars-cov-2
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):6. doi: https://doi.org/10.1167/iovs.62.7.6

Retinal Cell Biology June 2021

Sigma 1 Receptor Modulates Optic Nerve Head Astrocyte Reactivity

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Jing Zhao; Graydon Gonsalvez; Manuela Bartoli; Barbara A. Mysona; Sylvia B. Smith; Kathryn E. Bollinger
TAGS: astrocytes, glial fibrillary acidic protein, optic disk, receptors, sigma, mice, stress, ischemia, cell culture techniques
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):5. doi: https://doi.org/10.1167/iovs.62.7.5

Glaucoma June 2021

Biomechanical Glaucoma Factor and Corneal Hysteresis in Treated Primary Open-Angle Glaucoma and Their Associations With Visual Field Progression

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Shuichiro Aoki; Atsuya Miki; Takashi Omoto; Yuri Fujino; Masato Matsuura; Hiroshi Murata; Ryo Asaoka
TAGS: corneal hysteresis, eye, glaucoma, open-angle glaucoma, visual fields, datasets
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):4. doi: https://doi.org/10.1167/iovs.62.7.4

Cornea June 2021

Ex Vivo–Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice

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Jun Zhu; Takenori Inomata; Keiichi Fujimoto; Koichiro Uchida; Kenta Fujio; Ken Nagino; Maria Miura; Naoko Negishi; Yuichi Okumura; Yasutsugu Akasaki; Kunihiko Hirosawa; Mizu Kuwahara; Atsuko Eguchi; Hurramhon Shokirova; Ai Yanagawa; Akie Midorikawa-Inomata; Akira Murakami
TAGS: cornea, keratoplasty, myeloid-derived suppressor cells, mice, rejection (psychology), transplant rejection
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):3. doi: https://doi.org/10.1167/iovs.62.7.3

Includes: Supplemental Content

Glaucoma June 2021

Progression of Primary Angle Closure Suspect to Primary Angle Closure and Associated Risk Factors: The Handan Eye Study

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Ye Zhang; Ravi Thomas; Qing Zhang; Si Zhen Li; Ning Li Wang
TAGS: eye, primary angle closure suspect, risk factors, follow-up
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):2. doi: https://doi.org/10.1167/iovs.62.7.2

Visual Neuroscience June 2021

Elavl2 Regulates Retinal Function Via Modulating the Differentiation of Amacrine Cells Subtype

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Mengjuan Wu; Qinqin Deng; Xinlan Lei; Yuxin Du; Yin Shen
TAGS: abdominal compartment syndrome, acute coronary syndromes, amacrine cells, american cancer society, american college of surgeons, electroretinography, mice, retina, ablation, rna
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):1. doi: https://doi.org/10.1167/iovs.62.7.1

Includes: Supplemental Content

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Retinal Pigment Epithelial Cells Express Antimicrobial Peptide Lysozyme – A Novel Mechanism of Innate Immune Defense of the Blood-Retina Barrier

Synaptosomal Actin Dynamics in the Developmental Visual Cortex Regulate Behavioral Visual Acuity in Rats

Association Between Gut Microbial Abundance and Sight-Threatening Diabetic Retinopathy

PEDF Gene Deletion Disrupts Corneal Innervation and Ocular Surface Function

North Carolina Macular Dystrophy: Phenotypic Variability and Computational Analysis of Disease-Associated Noncoding Variants

Shared Features in Retinal Disorders With Involvement of Retinal Pigment Epithelium

Quality of Life and Participation of Children With Visual Impairment: Comparison With Population Reference Scores

The Retinal Ganglion Cell Response to Blast-Mediated Traumatic Brain Injury Is Genetic Background Dependent

Dichoptic Perceptual Training and Sensory Eye Dominance Plasticity in Normal Vision

Age-Related Retinal Changes in Wild-Type C57BL/6J Mice Between 2 and 32 Months

IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium

Anatomic–Functional Correlates in Lesions of Retinal Vein Occlusion

Acute Inhibitory Effects of Antidepressants on Lacrimal Gland Secretion in the Anesthetized Rat

Association of Aberrant Posterior Vitreous Detachment and Pathologic Tractional Forces With Myopic Macular Degeneration

Expression of the SARS-CoV-2 Receptor ACE2 in Human Retina and Diabetes—Implications for Retinopathy

Sigma 1 Receptor Modulates Optic Nerve Head Astrocyte Reactivity

Biomechanical Glaucoma Factor and Corneal Hysteresis in Treated Primary Open-Angle Glaucoma and Their Associations With Visual Field Progression

Ex Vivo–Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice

Progression of Primary Angle Closure Suspect to Primary Angle Closure and Associated Risk Factors: The Handan Eye Study

Elavl2 Regulates Retinal Function Via Modulating the Differentiation of Amacrine Cells Subtype

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