Eye Anatomy and Disorders

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Glaucoma April 2019

The Role of Schlemm's Canal Endothelium Cellular Connectivity in Giant Vacuole Formation: A 3D Electron Microscopy Study

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Julia Lai; Yanfeng Su; David L. Swain; Davy Huang; Dimitr Getchevski; Haiyan Gong
TAGS: endothelium, perfusion, reconstructive surgical procedures, body tissue, vacuole, eye, immersion, schlemm's canal, volume, shape
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1630-1643. doi: 10.1167/iovs.18-26011

Includes: Multimedia, Supplemental Content

Visual Neuroscience April 2019

ON-Type Retinal Ganglion Cells are Preferentially Affected in STZ-Induced Diabetic Mice

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Run-Ze Cui; Lu Wang; Sheng-Nan Qiao; Yong-Chen Wang; Xin Wang; Fei Yuan; Shi-Jun Weng; Xiong-Li Yang; Yong-Mei Zhong
TAGS: diabetes mellitus, streptozocin, mice, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1644-1656. doi: 10.1167/iovs.18-26359

Glaucoma April 2019

Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation

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Yan Hu; Arturo O. Barron; Sofya Gindina; Sandeep Kumar; Shravan Chintala; Ashima Nayyar; John Danias
TAGS: alteplase, urokinase, gelatinase b, platelet count measurement, mice, regulation, fibrinolysis pathway
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1571-1580. doi: 10.1167/iovs.18-25698

Clinical and Epidemiologic Research April 2019

Retinal Layer Thicknesses in Early Age-Related Macular Degeneration: Results From the German AugUR Study

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Caroline Brandl; Christiane Brücklmayer; Felix Günther; Martina E. Zimmermann; Helmut Küchenhoff; Horst Helbig; Bernhard H. F. Weber; Iris M. Heid; Klaus J. Stark
TAGS: sample size, biological response modifiers, color, photoreceptors, reference values, software, diagnostic imaging, eye, age-related macular degeneration, reliability, german, spectral-domain optical coherence tomography, surveys
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1581-1594. doi: 10.1167/iovs.18-25332

Includes: Supplemental Content

Retinal Cell Biology April 2019

Enhancing Retinal Endothelial Glycolysis by Inhibiting UCP2 Promotes Physiologic Retinal Vascular Development in a Model of Retinopathy of Prematurity

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Xiaokun Han; Jun Kong; M. Elizabeth Hartnett; Haibo Wang
TAGS: oxygen, vascular endothelial growth factor a, cell proliferation, endothelial cells, vascular endothelial growth factor receptor-2, glucose, electroretinography, endothelium, glycolysis, intraperitoneal injections, retinopathy of prematurity, retina, glucose uptake
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1604-1613. doi: 10.1167/iovs.19-26553

Includes: Supplemental Content

Retina April 2019

Cone-Mediated Function Correlates to Altered Foveal Morphology in Preterm-Born Children at School Age

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Wadim Bowl; Sinan Raoof; Birgit Lorenz; Kerstin Holve; Silke Schweinfurth; Knut Stieger; Monika Andrassi-Darida
TAGS: child, retinal cone, perimetry, school (environment), morphology, language morphology, pupillometry, pupil reaction
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1614-1620. doi: 10.1167/iovs.18-24892

Lens April 2019

Calcium-Activated Chloride Channels in Newly Differentiating Mouse Lens Fiber Cells and Their Role in Volume Regulation

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Jun-Jie Tong; Pooja Acharya; Lisa Ebihara
TAGS: calcium, chloride channels, chlorides, lens, crystalline, lens (device), mice, volume, regulation, anoctamin-1
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1621-1629. doi: 10.1167/iovs.19-26626

Retina April 2019

CHM/REP1 Transcript Expression and Loss of Visual Function in Patients Affected by Choroideremia

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Valentina Di Iorio; Gabriella Esposito; Francesca De Falco; Rosa Boccia; Tiziana Fioretti; Raffaella Colucci; Giuseppe De Rosa; Paolo Melillo; Francesco Salvatore; Francesca Simonelli; Francesco Testa
TAGS: choroideremia, vision, phenotype, genotype
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1547-1555. doi: 10.1167/iovs.18-25501

Retina April 2019

Optical Coherence Tomography Angiography in Mice: Quantitative Analysis After Experimental Models of Retinal Damage

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Corey A. Smith; Michele L. Hooper; Balwantray C. Chauhan
TAGS: fluorescence, perfusion, wounds and injuries, diagnostic imaging, optical coherence tomography, optic nerve, mice, angiogram, injections, respiratory arrest
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1556-1565. doi: 10.1167/iovs.18-26441

Includes: Supplemental Content

Genetics April 2019

Multiple Differentially Methylated Regions Specific to Keratoconus Explain Known Keratoconus Linkage Loci

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Michal Kabza; Justyna A. Karolak; Malgorzata Rydzanicz; Monika Udziela; Piotr Gasperowicz; Rafal Ploski; Jacek P. Szaflik; Marzena Gajecka
TAGS: disease susceptibility, dna, dna methylation, genes, keratoconus, methylation, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1501-1509. doi: 10.1167/iovs.18-25916

Includes: Supplemental Content

Retina April 2019

Longitudinal Assessment of Rod Function in Intermediate Age-Related Macular Degeneration With and Without Reticular Pseudodrusen

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Rose S. Tan; Robyn H. Guymer; Khin-Zaw Aung; Emily Caruso; Chi D. Luu
TAGS: follow-up, rod photoreceptors, age-related macular degeneration
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1511-1518. doi: 10.1167/iovs.18-26385

Retina April 2019

Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy

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Haitao Liu; Jie Tang; Yunpeng Du; Aicha Saadane; Ivy Samuels; Alex Veenstra; Jianying Z. Kiser; Krzysztof Palczewski; Timothy S. Kern
TAGS: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, photoreceptors, phototransduction, rod photoreceptors, vision, mice, retina, tissue degeneration
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1538-1546. doi: 10.1167/iovs.18-26433

Clinical and Epidemiologic Research April 2019

The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration

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Emily E. Brown; Jacob D. Ball; Zhaoyi Chen; Gibran S. Khurshid; Mattia Prosperi; John D. Ash
TAGS: metformin, age-related macular degeneration, antidiabetics
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1470-1477. doi: 10.1167/iovs.18-26422

Physiology and Pharmacology April 2019

PARP Inhibitor Protects Against Chronic Hypoxia/Reoxygenation-Induced Retinal Injury by Regulation of MAPKs, HIF1α, Nrf2, and NFκB

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Krisztina Kovacs; Alexandra Vaczy; Katalin Fekete; Petra Kovari; Tamas Atlasz; Dora Reglodi; Robert Gabriel; Ferenc Gallyas; Balazs Sumegi
TAGS: hypoxia, retina, retinal injuries, poly(adp-ribose) polymerase inhibitors, olaparib, hypoxia chronic
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1478-1490. doi: 10.1167/iovs.18-25936

Retina April 2019

The Retina in Alzheimer's Disease: Histomorphometric Analysis of an Ophthalmologic Biomarker

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Samuel Asanad; Fred N. Ross-Cisneros; Marco Nassisi; Ernesto Barron; Rustum Karanjia; Alfredo A. Sadun
TAGS: alzheimer's disease, body tissue, optic nerve, retina, retinal nerve fiber layer, autopsy, biological markers
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1491-1500. doi: 10.1167/iovs.18-25966

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology April 2019

Quantification of Visual Fixation in Multiple Sclerosis

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Jenny A. Nij Bijvank; Axel Petzold; Danko Coric; H. Stevie Tan; Bernard M. J. Uitdehaag; Lisanne J. Balk; Laurentius J. van Rijn
TAGS: eye movement, ocular fixation, multiple sclerosis, vision, prevalence, quality of life, disability, gaze, illness length
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1372-1383. doi: 10.1167/iovs.18-26096

Includes: Supplemental Content

Physiology and Pharmacology April 2019

The Effect of Molecular Weight on Passage of Proteins Through the Blood-Aqueous Barrier

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Susanne Ragg; Melissa Key; Fernanda Rankin; Darrell WuDunn
TAGS: hypertension, plasma, proteins
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1461-1469. doi: 10.1167/iovs.19-26542

Biochemistry and Molecular Biology April 2019

PH20 Inhibits TGFβ1-Induced Differentiation of Perimysial Orbital Fibroblasts via Hyaluronan-CD44 Pathway in Thyroid-Associated Ophthalmopathy

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Ruiqi Ma; Hui Ren; Binbin Xu; Yun Cheng; Lu Gan; Rui Zhang; Jihong Wu; Jiang Qian
TAGS: fibroblasts, graves' ophthalmopathy, cd44 antigens, ovarian failure, premature, hyaluronan, homing-associated cell adhesion molecule
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1431-1441. doi: 10.1167/iovs.18-26268

Includes: Supplemental Content

Physiology and Pharmacology April 2019

A Mixture of U.S. Food and Drug Administration–Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness

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Henri Leinonen; Elliot H. Choi; Anthony Gardella; Vladimir J. Kefalov; Krzysztof Palczewski
TAGS: retinal cone, disease susceptibility, night blindness, rod photoreceptors, transducin, united states food and drug administration, diagnostic imaging, eye, mice, retina, disease models
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1442-1453. doi: 10.1167/iovs.19-26560

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2019

Small Hard Macular Drusen and Associations in 11- to 12-Year-Old Children in the Copenhagen Child Cohort 2000 Eye Study

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Inger Christine Munch; Xiao Qiang Li; Shaista Sumbal Mulk Ahmad; Else Marie Olsen; Anne Mette Skovgaard; Michael Larsen
TAGS: drusen, child, cohort studies, retinal drusen, eye
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1454-1460. doi: 10.1167/iovs.18-25877

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The Role of Schlemm's Canal Endothelium Cellular Connectivity in Giant Vacuole Formation: A 3D Electron Microscopy Study

ON-Type Retinal Ganglion Cells are Preferentially Affected in STZ-Induced Diabetic Mice

Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation

Retinal Layer Thicknesses in Early Age-Related Macular Degeneration: Results From the German AugUR Study

Enhancing Retinal Endothelial Glycolysis by Inhibiting UCP2 Promotes Physiologic Retinal Vascular Development in a Model of Retinopathy of Prematurity

Cone-Mediated Function Correlates to Altered Foveal Morphology in Preterm-Born Children at School Age

Calcium-Activated Chloride Channels in Newly Differentiating Mouse Lens Fiber Cells and Their Role in Volume Regulation

CHM/REP1 Transcript Expression and Loss of Visual Function in Patients Affected by Choroideremia

Optical Coherence Tomography Angiography in Mice: Quantitative Analysis After Experimental Models of Retinal Damage

Multiple Differentially Methylated Regions Specific to Keratoconus Explain Known Keratoconus Linkage Loci

Longitudinal Assessment of Rod Function in Intermediate Age-Related Macular Degeneration With and Without Reticular Pseudodrusen

Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy

The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration

PARP Inhibitor Protects Against Chronic Hypoxia/Reoxygenation-Induced Retinal Injury by Regulation of MAPKs, HIF1α, Nrf2, and NFκB

The Retina in Alzheimer's Disease: Histomorphometric Analysis of an Ophthalmologic Biomarker

Quantification of Visual Fixation in Multiple Sclerosis

The Effect of Molecular Weight on Passage of Proteins Through the Blood-Aqueous Barrier

PH20 Inhibits TGFβ1-Induced Differentiation of Perimysial Orbital Fibroblasts via Hyaluronan-CD44 Pathway in Thyroid-Associated Ophthalmopathy

A Mixture of U.S. Food and Drug Administration–Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness

Small Hard Macular Drusen and Associations in 11- to 12-Year-Old Children in the Copenhagen Child Cohort 2000 Eye Study

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