Eye Injuries / Ocular Trauma

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Cornea March 2025

Isolated Mitochondrial Transplantation as a Novel Treatment for Corneal Chemical Burns

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Dan Jiang; Jinjie Yu; Xiaoqing Wu; Xintong Yu; Pinyan Jin; Huikang Zheng; Huiru Liu; Wei Xu; Qizhou Lian; Wei Chen
TAGS: mitochondria, cornea, transplantation, mice, chemical burns
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):14. https://doi.org/10.1167/iovs.66.3.14

Includes: Multimedia, Supplemental Content

Cornea January 2025

Mustard Gas Induced Corneal Injury Involves Ferroptosis and p38 MAPK Signaling

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Nishant R. Sinha; Alexandria C. Hofmann; Laila A. Suleiman; Maxwell T. Jeffrey; William C. Jeffrey; Rajnish Kumar; Ratnakar Tripathi; Rajiv R. Mohan
TAGS: corneal injuries, ferroptosis, mitogen-activated protein kinase p38, mustard gas, signal transduction, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):23. https://doi.org/10.1167/iovs.66.1.23

Includes: Supplemental Content

Cornea January 2025

Recombinant Thrombomodulin Domain 1 Modulates Macrophage Polarization and Enhances Healing in Corneal Alkali Burns

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Chun-Hsiang Chang; I-Chen Peng; Yi-Hsun Huang
TAGS: alkalies, burns, cornea, macrophage activation, thrombomodulin, wound healing
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):21. https://doi.org/10.1167/iovs.66.1.21

Cornea November 2024

Silencing METTL3 Increases HSP70 Expression and Alleviates Fibrosis in Keratocytes

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Yapeng Jing; Jun Li; Peng Hao; Shulei Xing; Xuan Li
TAGS: acute erythroblastic leukemia, cornea, fibrosis, heat-shock proteins 70, keratocytes, alkalies, burns
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):9. https://doi.org/10.1167/iovs.65.13.9

Includes: Supplemental Content

Cornea October 2024

ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A Demethylation

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Wei Wang; Hua Li; Yiyong Qian; Min Li; Manli Deng; Dexi Bi; Jun Zou
TAGS: acute erythroblastic leukemia, alkalies, burns, choroidal neovascularization, cornea, corneal neovascularization, demethylation, forkhead box protein m1, neovascularization, pathologic, mice
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):34. https://doi.org/10.1167/iovs.65.12.34

Includes: Supplemental Content

Visual Neuroscience August 2024

Macrophages Modulate Optic Nerve Crush Injury Scar Formation and Retinal Ganglion Cell Function

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Yuan Liu; Xiangxiang Liu; Christopher A. Dorizas; Zixuan Hao; Richard K. Lee
TAGS: cicatrix, macrophages, mice, optic nerve, crushing injuries, optic nerve injuries, retinal ganglion cells, wounds and injuries
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):22. https://doi.org/10.1167/iovs.65.10.22

Includes: Supplemental Content

Cornea June 2024

Mesenchymal Stem Cell-Derived Exosomes as Drug Carriers for Delivering miRNA-29b to Ameliorate Inflammation in Corneal Injury Via Activating Autophagy

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Jinghua Liu; Juan Gao; Ping Lu; Yuchuan Wang; Shulei Xing; Yarong Yan; Ruifang Han; Peng Hao; Xuan Li
TAGS: 1-phosphatidylinositol 3-kinase, autophagy, cornea, corneal injuries, drug carriers, exosomes, fibrosis, inflammation, mice, micrornas
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):16. https://doi.org/10.1167/iovs.65.6.16

Glaucoma May 2024

Noninvasive Light Flicker Stimulation Promotes Optic Nerve Regeneration by Activating Microglia and Enhancing Neural Plasticity in Zebrafish

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Haijian Hu; Yulian Pang; Hongdou Luo; Bin Tong; Feifei Wang; Yuning Song; Qian Ying; Ke Xu; Chan Xiong; Zhida Peng; Hong Xu; Xu Zhang
TAGS: microglia, neuronal plasticity, optic nerve injuries, optic nerve regeneration, photopsia, zebrafish, retina, vision
Invest. Ophthalmol. Vis. Sci.. 2024; 65(5):3. https://doi.org/10.1167/iovs.65.5.3

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology February 2024

In Vivo Imaging of Secondary Neurodegeneration Associated With Phosphatidylserine Externalization Along Axotomized Axons

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Fan Yang; Mohammadali Almasieh; Leonard A. Levin
TAGS: axon, axotomy, diagnostic imaging, nerve degeneration, phosphatidylserines, wounds and injuries, lasers, retrograde degeneration
Invest. Ophthalmol. Vis. Sci.. 2024; 65(2):24. https://doi.org/10.1167/iovs.65.2.24

Includes: Supplemental Content

Cornea January 2024

Dopamine Receptor 1 Treatment Promotes Epithelial Repair of Corneal Injury by Inhibiting NOD-Like Receptor Protein 3–Associated Inflammation

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Licheng Li; Yang Yu; Zihao Zhuang; Qi Wu; Shu Lin; Jianmin Hu
TAGS: agonists, corneal injuries, dopamine receptors, epithelium, inflammation, nlr family, pyrin domain-containing 3 protein, nlr proteins, proteins, cornea, mice
Invest. Ophthalmol. Vis. Sci.. 2024; 65(1):49. https://doi.org/10.1167/iovs.65.1.49

Biochemistry and Molecular Biology January 2024

Exploring Corneal Neovascularization: An Integrated Approach Using Transcriptomics and Proteomics in an Alkali Burn Mouse Model

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Wei Wang; Manli Deng; Min Li; Lin Liu; Jun Zou; Yiyong Qian
TAGS: alkalies, burns, cornea, mice, proteins, proteomics, corneal neovascularization, genes, choroidal neovascularization
Invest. Ophthalmol. Vis. Sci.. 2024; 65(1):21. https://doi.org/10.1167/iovs.65.1.21

Includes: Supplemental Content

Retinal Cell Biology November 2023

Nestin Regulates Müller Glia Proliferation After Retinal Injury

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Aya Motoyoshi; Fuminori Saitoh; Tomohiro Iida; Hiroki Fujieda
TAGS: nestin protein, neuroglia, retinal injuries, wounds and injuries, rats, photoreceptors, retina, mice
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):8. https://doi.org/10.1167/iovs.64.14.8

Includes: Supplemental Content

Cornea November 2023

Interleukin-11 Suppresses Ocular Surface Inflammation and Accelerates Wound Healing

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Aastha Singh; WonKyung J. Cho; Vinay K. Pulimamidi; Sharad K. Mittal; Sunil K. Chauhan
TAGS: inflammation, interleukin-11, cornea, wound healing, wounds and injuries, ocular surfaces
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):1. https://doi.org/10.1167/iovs.64.14.1

Physiology and Pharmacology August 2023

Discovery of CTSK + Periosteal Stem Cells Mediating Bone Repair in Orbital Reconstruction

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Zeyang Liu; Jin Liu; Jipeng Li; Yinwei Li; Jing Sun; Yuan Deng; Huifang Zhou
TAGS: orbital reconstruction, osteoplasty, periosteum, stem cells, zygomatic bones, sequence analysis, rna
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):30. https://doi.org/10.1167/iovs.64.11.30

Visual Neuroscience April 2023

Modifications in Macular Perfusion and Neuronal Loss After Acute Traumatic Brain Injury

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Jenny L. Hepschke; Elinor Laws; Noor H. Bin Saliman; Stefana Juncu; Ella Courtie; Antonio Belli; Richard J. Blanch
TAGS: perfusion, traumatic brain injuries
Invest. Ophthalmol. Vis. Sci.. 2023; 64(4):35. https://doi.org/10.1167/iovs.64.4.35

Includes: Supplemental Content

Cornea April 2023

The CXCR4/miR-1910-5p/MMRN2 Axis Is Involved in Corneal Neovascularization by Affecting Vascular Permeability

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Xiao Wang; Zedu Cui; Xi Chen; Qian Luo; Zihua Jiang; Xuan Liu; Yuke Huang; Jingyi Jiang; Shuilian Chen; Jin Qiu; Yan Li; Keming Yu; Jing Zhuang
TAGS: choroidal neovascularization, cxcr4 receptors, corneal neovascularization, hypoxia, cornea
Invest. Ophthalmol. Vis. Sci.. 2023; 64(4):10. https://doi.org/10.1167/iovs.64.4.10

Includes: Supplemental Content

Retinal Cell Biology March 2023

Lithium Chloride Exerts Anti-Inflammatory and Neuroprotective Effects by Inhibiting Microglial Activation in LPS-Induced Retinal Injury

PDF

Nandan Wu; Qian Luo; Yuke Huang; Linxi Wan; Xiangtao Hou; Zihua Jiang; Yan Li; Jin Qiu; Pei Chen; Keming Yu; Jing Zhuang; Ying Yang
TAGS: anti-inflammatory agents, lithium chloride, mice, microglia, neuroinflammatory diseases, neuroprotective effect, proteins, retinal injuries, fluorescent antibody technique, 1-phosphatidylinositol 3-kinase
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):35. https://doi.org/10.1167/iovs.64.3.35

Includes: Supplemental Content

Retina September 2022

Short-Term Hyperuricemia Leads to Structural Retinal Changes That Can be Reversed by Serum Uric Acid Lowering Agents in Mice

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Hung-Liang Pai; Sophie Meng-Tien Hsieh; Yu-Shan Su; Xin-Yuan Sue; Han-Hsin Chang; David Pei-Cheng Lin
TAGS: allopurinol, angiotensin ii, apoptosis, benzbromarone, gelatinase a, hyperuricemia, mice, pik3ca-related overgrowth spectrum, retinal injuries, urate measurement, serum
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):8. https://doi.org/10.1167/iovs.63.10.8

Includes: Supplemental Content

Cornea April 2022

Forkhead Domain Inhibitor-6 Suppresses Corneal Neovascularization and Subsequent Fibrosis After Alkali Burn in Rats

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Chunlin Lan; Guo Liu; Longxiang Huang; Xizhen Wang; Junkai Tan; Yun Wang; Ning Fan; Yihua Zhu; Man Yu; Xuyang Liu
TAGS: alkalies, burns, cornea, corneal neovascularization, fibrosis, inflammation, rats
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):14. https://doi.org/10.1167/iovs.63.4.14

Biochemistry and Molecular Biology March 2022

Intravitreal Injection of PACAP Attenuates Acute Ocular Hypertension–Induced Retinal Injury Via Anti-Apoptosis and Anti-Inflammation in Mice

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Peng Lu; Yuxun Shi; Dan Ye; Xi Lu; Xiaoyu Tang; Lu Cheng; Yue Xu; Jingjing Huang
TAGS: pituitary adenylate cyclase activating polypeptide, retina, wounds and injuries, inflammation, mice
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):18. https://doi.org/10.1167/iovs.63.3.18

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Isolated Mitochondrial Transplantation as a Novel Treatment for Corneal Chemical Burns

Mustard Gas Induced Corneal Injury Involves Ferroptosis and p38 MAPK Signaling

Recombinant Thrombomodulin Domain 1 Modulates Macrophage Polarization and Enhances Healing in Corneal Alkali Burns

Silencing METTL3 Increases HSP70 Expression and Alleviates Fibrosis in Keratocytes

ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A Demethylation

Macrophages Modulate Optic Nerve Crush Injury Scar Formation and Retinal Ganglion Cell Function

Mesenchymal Stem Cell-Derived Exosomes as Drug Carriers for Delivering miRNA-29b to Ameliorate Inflammation in Corneal Injury Via Activating Autophagy

Noninvasive Light Flicker Stimulation Promotes Optic Nerve Regeneration by Activating Microglia and Enhancing Neural Plasticity in Zebrafish

In Vivo Imaging of Secondary Neurodegeneration Associated With Phosphatidylserine Externalization Along Axotomized Axons

Dopamine Receptor 1 Treatment Promotes Epithelial Repair of Corneal Injury by Inhibiting NOD-Like Receptor Protein 3–Associated Inflammation

Exploring Corneal Neovascularization: An Integrated Approach Using Transcriptomics and Proteomics in an Alkali Burn Mouse Model

Nestin Regulates Müller Glia Proliferation After Retinal Injury

Interleukin-11 Suppresses Ocular Surface Inflammation and Accelerates Wound Healing

Discovery of CTSK + Periosteal Stem Cells Mediating Bone Repair in Orbital Reconstruction

Modifications in Macular Perfusion and Neuronal Loss After Acute Traumatic Brain Injury

The CXCR4/miR-1910-5p/MMRN2 Axis Is Involved in Corneal Neovascularization by Affecting Vascular Permeability

Lithium Chloride Exerts Anti-Inflammatory and Neuroprotective Effects by Inhibiting Microglial Activation in LPS-Induced Retinal Injury

Short-Term Hyperuricemia Leads to Structural Retinal Changes That Can be Reversed by Serum Uric Acid Lowering Agents in Mice

Forkhead Domain Inhibitor-6 Suppresses Corneal Neovascularization and Subsequent Fibrosis After Alkali Burn in Rats

Intravitreal Injection of PACAP Attenuates Acute Ocular Hypertension–Induced Retinal Injury Via Anti-Apoptosis and Anti-Inflammation in Mice

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