Genetics

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Retina November 2018

Clinically Relevant Outcome Measures for the I307N Rhodopsin Mouse: A Model of Inducible Autosomal Dominant Retinitis Pigmentosa

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Michael T. Massengill; Brianna Young; Deep Patel; Farwa Jafri; Ernesto Sabogal; Neil Ash; Hong Li; Cristhian J. Ildefonso; Alfred S. Lewin
TAGS: photoreceptors, retinal degeneration, retinitis pigmentosa, mice, retina, outcome measures, spectral-domain optical coherence tomography, rhodopsin
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5417-5430. doi: 10.1167/iovs.18-25345

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2018

SIRT1 Deletion Impairs Retinal Endothelial Cell Migration Through Downregulation of VEGF-A/VEGFR-2 and MMP14

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Yong Lin; Li Li; Junjie Liu; Xiaoting Zhao; Juxiu Ye; Peter S. Reinach; Jia Qu; Dongsheng Yan
TAGS: angiogenesis, vascular endothelial growth factor a, western blotting, endothelial cells, vascular endothelial growth factor receptor-2, down-regulation, mice, rna, small interfering
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5431-5440. doi: 10.1167/iovs.17-23558

Includes: Supplemental Content

Genetics November 2018

Spectrum of Variants in 389 Chinese Probands With Familial Exudative Vitreoretinopathy

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Jia-Kai Li; Yian Li; Xiang Zhang; Chun-Li Chen; Yu-Qing Rao; Ping Fei; Qi Zhang; Peiquan Zhao; Jing Li
TAGS: cohort studies, genes, proband, chinese people, chinese (other dialects), familial exudative vitreoretinopathy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5368-5381. doi: 10.1167/iovs.17-23541

Includes: Supplemental Content

Articles November 2018

Intravitreal Trimethoprim and Sulfamethoxazole Toxicity to the Retina of Albino Rabbits

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Orit Mazza; Zohar Habot-Wilner; Jonathan Shahar; Irit Mann; Anat Loewenstein; Ido Perlman
TAGS: albinism, electroretinography, evoked potentials, visual, follow-up, oryctolagus cuniculus, sulfamethoxazole, trimethoprim, trimethoprim-sulfamethoxazole combination, eye, retina, toxic effect, intravitreal injections
Trans. Vis. Sci. Tech.. 2018; 7(6):2. doi: 10.1167/tvst.7.6.2

Retina November 2018

The Henle Fiber Layer in Albinism: Comparison to Normal and Relationship to Outer Nuclear Layer Thickness and Foveal Cone Density

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Daniel J. Lee; Erica N. Woertz; Alexis Visotcky; Melissa A. Wilk; Heather Heitkotter; Rachel E. Linderman; Sergey Tarima; C. Gail Summers; Brian P. Brooks; Murray H. Brilliant; Bhavna J. Antony; Brandon J. Lujan; Joseph Carroll
TAGS: albinism, retinal cone
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5336-5348. doi: 10.1167/iovs.18-24145

Includes: Multimedia, Supplemental Content

Clinical and Epidemiologic Research November 2018

Possible Causes of Discordance in Refraction in Monozygotic Twins: Nearwork, Time Outdoors and Stochastic Variation

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Xiaohu Ding; Yin Hu; Xinxing Guo; Xiaobo Guo; Ian Morgan; Mingguang He
TAGS: environmental factors, questionnaires, twins, monozygotic twins, eye, refraction
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5349-5354. doi: 10.1167/iovs.18-24526

Includes: Supplemental Content

Articles October 2018

Matrix Metalloproteinase 9 Point-of-Care Immunoassay Result Predicts Response to Topical Cyclosporine Treatment in Dry Eye Disease

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Jae Yong Park; Bum Gi Kim; Jae Suk Kim; Je Hyung Hwang
TAGS: dry eye syndromes, gelatinase b, immunoassay, cyclosporine
Trans. Vis. Sci. Tech.. 2018; 7(5):31. doi: 10.1167/tvst.7.5.31

Genetics October 2018

Spontaneous Posterior Segment Vascular Disease Phenotype of a Mouse Model, rnv3 , Is Dependent on the Crb1 rd8 Allele

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Bo Chang; Bernard FitzMaurice; Jieping Wang; Benjamin E. Low; Michael V. Wiles; Patsy M. Nishina
TAGS: alleles, angiogenesis, phenotype, mutation, vascular diseases, mice
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5127-5139. doi: 10.1167/iovs.18-25046

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology October 2018

Retinal and Cerebral Microvasculopathy: Relationships and Their Genetic Contributions

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Jacoba A. van de Kreeke; H. Ton Nguyen; Elles Konijnenberg; Jori Tomassen; Anouk den Braber; Mara ten Kate; Carole H. Sudre; Frederik Barkhof; Dorret I. Boomsma; H. Stevie Tan; Frank D. Verbraak; Pieter Jelle Visser
TAGS: magnetic resonance imaging, cardiovascular disease risk factors, twins, brain, eye, genetics, small-vessel vasculitis, volume, white matter
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5025-5031. doi: 10.1167/iovs.18-25341

Includes: Supplemental Content

Lens October 2018

Lens Epithelial Cells Initiate an Inflammatory Response Following Cataract Surgery

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Jian Jiang; Mahbubul H. Shihan; Yan Wang; Melinda K. Duncan
TAGS: cytokine, inflammation, cataract surgery, genes, lens, crystalline, lens (device), surgical procedures, operative, inflammatory response, lens epithelial cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4986-4997. doi: 10.1167/iovs.18-25067

Includes: Supplemental Content

Genetics October 2018

Minimal Efficacy of Nitisinone Treatment in a Novel Mouse Model of Oculocutaneous Albinism, Type 3

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Ighovie F. Onojafe; Lucyanne H. Megan; Madeline G. Melch; Joseph O. Aderemi; Ramakrishna P. Alur; Mones S. Abu-Asab; Chi-Chao Chan; Isa M. Bernardini; Jessica S. Albert; Tiziana Cogliati; David R. Adams; Brian P. Brooks
TAGS: albinism, oculocutaneous, mice, inbred c57bl, mice, tyrosine, albinism, oculocutaneous, type iii, nitisinone
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4945-4952. doi: 10.1167/iovs.16-20293

Includes: Supplemental Content

Retina October 2018

A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye – Implications for Ocular Gene Therapy

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Shyamtanu Datta; Marian Renwick; Viet Q. Chau; Fang Zhang; Emily R. Nettesheim; Daniel M. Lipinski; John D. Hulleman
TAGS: gene therapy, dihydrofolate reductase, visual acuity, eye, mice, retina, potable water, regulation, proteins
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4909-4920. doi: 10.1167/iovs.18-24987

Includes: Supplemental Content

Genetics October 2018

Clinical Features of a Retinopathy Associated With a Dominant Allele of the RGR Gene

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Rola Ba-Abbad; Monique Leys; Xinjing Wang; Christina Chakarova; Naushin Waseem; Keren J. Carss; F. Lucy Raymond; Kinga M. Bujakowska; Eric A. Pierce; Omar A. Mahroo; Moin D. Mohamed; Graham E. Holder; Marybeth Hummel; Gavin Arno; Andrew R. Webster
TAGS: alleles, genes, genetic pedigree, retinal diseases, signs and symptoms
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4812-4820. doi: 10.1167/iovs.18-25061

Includes: Supplemental Content

Cornea October 2018

Rose Bengal and Green Light Versus Riboflavin–UVA Cross-Linking: Corneal Wound Repair Response

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Elvira Lorenzo-Martín; Patricia Gallego-Muñoz; Lucía Ibares-Frías; Susana Marcos; Pablo Pérez-Merino; Itziar Fernández; Irene E. Kochevar; M. Carmen Martínez-García
TAGS: rose bengal, wound healing, cornea, riboflavin, ultraviolet a radiation, cross-linking, green light
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4821-4830. doi: 10.1167/iovs.18-24881

Retinal Cell Biology October 2018

Epigenetics and Regulation of Oxidative Stress in Diabetic Retinopathy

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Arul J. Duraisamy; Manish Mishra; Anjaneyulu Kowluru; Renu A. Kowluru
TAGS: oxidative stress, diabetes mellitus, glucose, diabetic retinopathy, dna, dna methylation, dna modification methylases, genes, enzymes, mice, transcription factor, rna, small interfering, epigenetics, regulation, kiaa1546 gene, dna (cytosine-5-)-methyltransferase 1
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4831-4840. doi: 10.1167/iovs.18-24548

Articles October 2018

Development and Validation of the Singapore Thyroid Eye Disease Quality of Life Questionnaire

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Melissa H. Y. Wong; Eva Fenwick; Ai Tee Aw; Ecosse L. Lamoureux; Lay Leng Seah
TAGS: graves' ophthalmopathy, psychometrics, questionnaires, singapore, quality of life
Trans. Vis. Sci. Tech.. 2018; 7(5):14. doi: 10.1167/tvst.7.5.14

Includes: Supplemental Content

Perspective October 2018

Accessibility to and Quality of Human Eye Tissue for Research: A Cross-Sectional Survey of ARVO Members

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W. Daniel Stamer; Andrew M. Williams; Stephen Pflugfelder; Sarah E. Coupland
TAGS: research personnel, body tissue, eye, surveys, quality
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4783-4792. doi: 10.1167/iovs.18-25319

Retina October 2018

RDH12 Mutations Cause a Severe Retinal Degeneration With Relatively Spared Rod Function

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Tomas S. Aleman; Katherine E. Uyhazi; Leona W. Serrano; Vidyullatha Vasireddy; Scott J. Bowman; Michael J. Ammar; Denise J. Pearson; Albert M. Maguire; Jean Bennett
TAGS: mutation, retinal degeneration, rod photoreceptors, retina, pathophysiology, spectral-domain optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5225-5236. doi: 10.1167/iovs.18-24708

Includes: Supplemental Content

Cornea September 2018

CTG18.1 Expansion is the Best Classifier of Late-Onset Fuchs' Corneal Dystrophy Among 10 Biomarkers in a Cohort From the European Part of Russia

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Liubov O. Skorodumova; Alexandra V. Belodedova; Olga P. Antonova; Elena I. Sharova; Tatiana A. Akopian; Oksana V. Selezneva; Elena S. Kostryukova; Boris E. Malyugin
TAGS: alleles, biological markers, cohort studies, hereditary corneal dystrophy, dna, genes, russia, genotype determination
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4748-4754. doi: 10.1167/iovs.18-24590

Clinical and Epidemiologic Research September 2018

Aldose Reductase Polymorphisms, Fasting Blood Glucose, and Age-Related Cortical Cataract

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Ava Grace Tan; Annette Kifley; Elizabeth G. Holliday; Barbara E. K. Klein; Sudha K. Iyengar; Kristine E. Lee; Gyungah R. Jun; Robert G. Cumming; Wanting Zhao; Tien Yin Wong; Ching-Yu Cheng; Paul Mitchell; Jie Jin Wang
TAGS: polymorphism, aldehyde reductase, single nucleotide polymorphism, fasting blood glucose measurement, blood glucose, cortical cataract
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4755-4762. doi: 10.1167/iovs.18-24353

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Clinically Relevant Outcome Measures for the I307N Rhodopsin Mouse: A Model of Inducible Autosomal Dominant Retinitis Pigmentosa

SIRT1 Deletion Impairs Retinal Endothelial Cell Migration Through Downregulation of VEGF-A/VEGFR-2 and MMP14

Spectrum of Variants in 389 Chinese Probands With Familial Exudative Vitreoretinopathy

Intravitreal Trimethoprim and Sulfamethoxazole Toxicity to the Retina of Albino Rabbits

The Henle Fiber Layer in Albinism: Comparison to Normal and Relationship to Outer Nuclear Layer Thickness and Foveal Cone Density

Possible Causes of Discordance in Refraction in Monozygotic Twins: Nearwork, Time Outdoors and Stochastic Variation

Matrix Metalloproteinase 9 Point-of-Care Immunoassay Result Predicts Response to Topical Cyclosporine Treatment in Dry Eye Disease

Spontaneous Posterior Segment Vascular Disease Phenotype of a Mouse Model, rnv3 , Is Dependent on the Crb1 rd8 Allele

Retinal and Cerebral Microvasculopathy: Relationships and Their Genetic Contributions

Lens Epithelial Cells Initiate an Inflammatory Response Following Cataract Surgery

Minimal Efficacy of Nitisinone Treatment in a Novel Mouse Model of Oculocutaneous Albinism, Type 3

A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye – Implications for Ocular Gene Therapy

Clinical Features of a Retinopathy Associated With a Dominant Allele of the RGR Gene

Rose Bengal and Green Light Versus Riboflavin–UVA Cross-Linking: Corneal Wound Repair Response

Epigenetics and Regulation of Oxidative Stress in Diabetic Retinopathy

Development and Validation of the Singapore Thyroid Eye Disease Quality of Life Questionnaire

Accessibility to and Quality of Human Eye Tissue for Research: A Cross-Sectional Survey of ARVO Members

RDH12 Mutations Cause a Severe Retinal Degeneration With Relatively Spared Rod Function

CTG18.1 Expansion is the Best Classifier of Late-Onset Fuchs' Corneal Dystrophy Among 10 Biomarkers in a Cohort From the European Part of Russia

Aldose Reductase Polymorphisms, Fasting Blood Glucose, and Age-Related Cortical Cataract

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