Genetics

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Retina September 2022

Phenotyping of ABCA4 Retinopathy by Machine Learning Analysis of Full-Field Electroretinography

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Sophie L. Glinton; Antonio Calcagni; Watjana Lilaonitkul; Nikolas Pontikos; Sandra Vermeirsch; Gongyu Zhang; Gavin Arno; Siegfried K. Wagner; Michel Michaelides; Pearse A. Keane; Andrew R. Webster; Omar A. Mahroo; Anthony G. Robson
TAGS: electroretinography, machine learning, retinal diseases, abca4 gene, phenotype, phenotype determination
Trans. Vis. Sci. Tech.. 2022; 11(9):34. doi: https://doi.org/10.1167/tvst.11.9.34

Includes: Supplemental Content

Ocular Oncology September 2022

Germline RB1 Mutation in Retinoblastoma Patients: Detection Methods and Implication in Tumor Focality

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Duangnate Rojanaporn; Sermsiri Chitphuk; Nareenart Iemwimangsa; Takol Chareonsirisuthigul; Duangporn Saengwimol; Rangsima Aroonroch; Usanarat Anurathathapan; Suradej Hongeng; Rossukon Kaewkhaw
TAGS: massively-parallel genome sequencing, mutation, neoplasms, retinoblastoma, exons
Trans. Vis. Sci. Tech.. 2022; 11(9):30. doi: https://doi.org/10.1167/tvst.11.9.30

Includes: Supplemental Content

Cornea September 2022

SIRT1 Protects Against Particulate Matter-Induced Oxidative Stress in Human Corneal and Conjunctival Epithelial Cells

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Xiangzhe Li; Boram Kang; Youngsub Eom; Jingxiang Zhong; Hyung Keun Lee; Hyo Myung Kim; Jong Suk Song
TAGS: apoptosis, cellular senescence, conjunctival epithelial cells, cornea, cytotoxicity, oxidative stress, prevention, transcriptional activation, ocular surfaces, proteins
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):19. doi: https://doi.org/10.1167/iovs.63.10.19

Includes: Supplemental Content

Glaucoma September 2022

Biological Correlations and Confounders for Quantification of Retinal Ganglion Cells by Optical Coherence Tomography Based on Studies of Outbred Mice

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Adam Hedberg-Buenz; Kacie J. Meyer; Carly J. van der Heide; Wenxiang Deng; Kyungmoo Lee; Dana A. Soukup; Monica Kettelson; Danielle Pellack; Hannah Mercer; Kai Wang; Mona K. Garvin; Michael D. Abramoff; Michael G. Anderson
TAGS: axon, diagnostic imaging, mice, optic nerve, optical coherence tomography, retina, retinal ganglion cells, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2022; 11(9):17. doi: https://doi.org/10.1167/tvst.11.9.17

Includes: Supplemental Content

Retinal Cell Biology September 2022

Timed Notch Inhibition Drives Photoreceptor Fate Specification in Human Retinal Organoids

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Shereen H. Chew; Cassandra Martinez; Kathleen R. Chirco; Sangeetha Kandoi; Deepak A. Lamba
TAGS: organoids, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):12. doi: https://doi.org/10.1167/iovs.63.10.12

Includes: Supplemental Content

Genetics September 2022

Comprehensive Genetic Analysis Unraveled the Missing Heritability in a Chinese Cohort With Wolfram Syndrome 1: Clinical and Genetic Findings

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Xin Zhang; Yue Xie; Ke Xu; Haoyu Chang; Xiaohui Zhang; Yang Li
TAGS: chinese (other dialects), chinese people, cohort studies, genetic analysis, genetics, wolfram syndrome, genes, whole genome sequencing, eye, polymerase chain reaction
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):9. doi: https://doi.org/10.1167/iovs.63.10.9

Includes: Supplemental Content

Retina September 2022

UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair

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Ningda Xu; Yue Liu; Shanshan Nai; Yong Tao; Yuehe Ding; Lemei Jia; Qizhi Geng; Jie Li; Yujing Bai; Gong-Hong Wei; Meng-Qiu Dong; Linyi Luo; Mingwei Zhao; Xingzhi Xu; Xiao-Xin Li; Jing Li; Lvzhen Huang
TAGS: antibodies, blue light, chromatin, double strand break repair, immunoprecipitation, mice, proliferating cell nuclear antigen, proteins, electroretinography, plasmids
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):7. doi: https://doi.org/10.1167/iovs.63.10.7

Biochemistry and Molecular Biology September 2022

Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts

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Jiale Diao; Xinxin Chen; Pei Mou; Xiaoye Ma; Ruili Wei
TAGS: berberine, fibroblasts, fibrosis, graves' ophthalmopathy, tissue remodeling, inflammation, western blotting, proteins, enzyme-linked immunosorbent assay, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):6. doi: https://doi.org/10.1167/iovs.63.10.6

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology September 2022

Impaired Extraocular Muscle Innervation Is Present Before Eye Opening in a Mouse Model of Infantile Nystagmus Syndrome

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Sampath Kumar Vemula; Seoyoung A. Kim; Tapiwa Muvavarirwa; Jessica L. Bell; Mary C. Whitman
TAGS: albinism, eye, mice, muscle of orbit, nerve supply, pathologic nystagmus, syndrome, muscle
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):4. doi: https://doi.org/10.1167/iovs.63.10.4

Article September 2022

Directed forgetting of pictures of everyday objects

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Paul S. Scotti; Ashleigh M. Maxcey
TAGS: debriefing, long-term memory, memory, data analysis, confusion, cues, photic stimulation
Journal of Vision. 2022; 22(10):8. doi: https://doi.org/10.1167/jov.22.10.8

Methods September 2022

PseudoSloan: A perimetric-complexity and area-controlled font for vision and reading research

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Vladimir Y. Vildavski; Luca Lo Verde; Gail Blumberg; Joss Parsey; Anthony M. Norcia
TAGS: reading (activity), vision, symbols
Journal of Vision. 2022; 22(10):7. doi: https://doi.org/10.1167/jov.22.10.7

Cornea September 2022

AKR1C1 Protects Corneal Epithelial Cells Against Oxidative Stress-Mediated Ferroptosis in Dry Eye

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Xin Zuo; Hao Zeng; Bowen Wang; Xue Yang; Dalian He; Li Wang; Hong Ouyang; Jin Yuan
TAGS: corneal epithelial cells, dry eye syndromes, ferroptosis, stress
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):3. doi: https://doi.org/10.1167/iovs.63.10.3

Includes: Supplemental Content

Lens September 2022

Deficiency of Jamc Leads to Congenital Nuclear Cataract and Activates the Unfolded Protein Response in Mouse Lenses

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Jiani Li; Xuhua Tan; Qihang Sun; Xuri Li; Rongyuan Chen; Lixia Luo
TAGS: cataract, cataract, nuclear, lens (device), lens, crystalline, mice, unfolded protein response
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):1. doi: https://doi.org/10.1167/iovs.63.10.1

Includes: Supplemental Content

Genetics August 2022

Decreased Levels of DNA Methylation in the PCDHA Gene Cluster as a Risk Factor for Early-Onset High Myopia in Young Children

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Joanna Swierkowska; Justyna A. Karolak; Sangeetha Vishweswaraiah; Malgorzata Mrugacz; Uppala Radhakrishna; Marzena Gajecka
TAGS: child, dna methylation, genes, methylation, myopia, gene clusters, risk factors
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):31. doi: https://doi.org/10.1167/iovs.63.9.31

Includes: Supplemental Content

Retina August 2022

Dependence of Retinal Pigment Epithelium Integrity on the NRF2–Heme Oxygenase-1 Axis

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Yida Jiang; Li-Juan Duan; Jingbo Pi; Yun-Zheng Le; Guo-Hua Fong
TAGS: body tissue, heme, mice, oxidative stress, oxygenases, painful bladder syndrome, personal integrity, retinal pigment cell, retinal pigment epithelium, eye
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):30. doi: https://doi.org/10.1167/iovs.63.9.30

Includes: Supplemental Content

Retina August 2022

Identification of Novel Retinal Pericyte-Targeting rAAV Vectors Through Directed Evolution

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Dwani D. Patel; Damien Marsic; Ramesh Periasamy; Sergei Zolotukhin; Daniel M. Lipinski
TAGS: capsid, pericytes, spatial vectors, libraries
Trans. Vis. Sci. Tech.. 2022; 11(8):28. doi: https://doi.org/10.1167/tvst.11.8.28

Includes: Supplemental Content

Data Science August 2022

Transcriptomic Responses of Human Retinal Vascular Endothelial Cells to Inflammatory Cytokines

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Feargal J. Ryan; Yuefang Ma; Liam M. Ashander; Michael Kvopka; Binoy Appukuttan; David J. Lynn; Justine R. Smith
TAGS: cytokine, endothelial cells, sequence analysis, rna, rna, datasets
Trans. Vis. Sci. Tech.. 2022; 11(8):27. doi: https://doi.org/10.1167/tvst.11.8.27

Includes: Supplemental Content

Retinal Cell Biology August 2022

Sensitivity of the Dorsal-Central Retinal Pigment Epithelium to Sodium Iodate-Induced Damage Is Associated With Overlying M-Cone Photoreceptors in Mice

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Lili Lian; Yifan Zhai; Xuejiao Wan; Linxin Chen; Zuimeng Liu; Ruona Liu; Shijia Li; Jiajia Zhou; Yu Chen; Ling Hou; Huirong Li
TAGS: mice, photoreceptors, retina, retinal cone, sodium, tissue degeneration, wounds and injuries, iodates, albinism, mice, inbred c57bl
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):29. doi: https://doi.org/10.1167/iovs.63.9.29

Includes: Supplemental Content

Retina August 2022

Retinal Transcriptome and Cellular Landscape in Relation to the Progression of Diabetic Retinopathy

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Jiang-Hui Wang; Raymond C. B. Wong; Guei-Sheung Liu
TAGS: diabetic retinopathy, genes, gender, cyclin d1, gene expression, donors
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):26. doi: https://doi.org/10.1167/iovs.63.9.26

Includes: Supplemental Content

Biochemistry and Molecular Biology August 2022

Gene Expression Signatures of Contact Lens-Induced Myopia in Guinea Pig Retinal Pigment Epithelium

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So Goto; Sandra E. Muroy; Yan Zhang; Kaoru Saijo; Sree Rohit Raj Kolora; Qiurong Zhu; Christine F. Wildsoet
TAGS: eye, gene expression, guinea, lens (device), lens, crystalline, myopia, retinal pigment epithelium
Invest. Ophthalmol. Vis. Sci.. 2022; 63(9):25. doi: https://doi.org/10.1167/iovs.63.9.25

Includes: Supplemental Content

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Phenotyping of ABCA4 Retinopathy by Machine Learning Analysis of Full-Field Electroretinography

Germline RB1 Mutation in Retinoblastoma Patients: Detection Methods and Implication in Tumor Focality

SIRT1 Protects Against Particulate Matter-Induced Oxidative Stress in Human Corneal and Conjunctival Epithelial Cells

Biological Correlations and Confounders for Quantification of Retinal Ganglion Cells by Optical Coherence Tomography Based on Studies of Outbred Mice

Timed Notch Inhibition Drives Photoreceptor Fate Specification in Human Retinal Organoids

Comprehensive Genetic Analysis Unraveled the Missing Heritability in a Chinese Cohort With Wolfram Syndrome 1: Clinical and Genetic Findings

UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair

Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts

Impaired Extraocular Muscle Innervation Is Present Before Eye Opening in a Mouse Model of Infantile Nystagmus Syndrome

Directed forgetting of pictures of everyday objects

PseudoSloan: A perimetric-complexity and area-controlled font for vision and reading research

AKR1C1 Protects Corneal Epithelial Cells Against Oxidative Stress-Mediated Ferroptosis in Dry Eye

Deficiency of Jamc Leads to Congenital Nuclear Cataract and Activates the Unfolded Protein Response in Mouse Lenses

Decreased Levels of DNA Methylation in the PCDHA Gene Cluster as a Risk Factor for Early-Onset High Myopia in Young Children

Dependence of Retinal Pigment Epithelium Integrity on the NRF2–Heme Oxygenase-1 Axis

Identification of Novel Retinal Pericyte-Targeting rAAV Vectors Through Directed Evolution

Transcriptomic Responses of Human Retinal Vascular Endothelial Cells to Inflammatory Cytokines

Sensitivity of the Dorsal-Central Retinal Pigment Epithelium to Sodium Iodate-Induced Damage Is Associated With Overlying M-Cone Photoreceptors in Mice

Retinal Transcriptome and Cellular Landscape in Relation to the Progression of Diabetic Retinopathy

Gene Expression Signatures of Contact Lens-Induced Myopia in Guinea Pig Retinal Pigment Epithelium

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