Genetics

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Articles October 2019

Fully Automated Estimation of Spacing and Density for Retinal Mosaics

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Robert F. Cooper; Geoffrey K. Aguirre; Jessica I. W. Morgan
TAGS: mosaicism, retinal cone, photoreceptors
Trans. Vis. Sci. Tech.. 2019; 8(5):26. doi: 10.1167/tvst.8.5.26

Retina October 2019

Effect of Choroidal Vessel Density on the Ellipsoid Zone and Visual Function in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography

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Ruyuan Liu; Jing Lu; Qiuhui Liu; Yishen Wang; Di Cao; Jing Wang; Xiao Wang; Jianying Pan; Li Ma; Chenjin Jin; SriniVas Sadda; Yan Luo; Lin Lu
TAGS: angiogram, optical coherence tomography, retinitis pigmentosa, vision, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4328-4335. doi: 10.1167/iovs.18-24921

Biochemistry and Molecular Biology October 2019

TSHR Signaling Stimulates Proliferation Through PI3K/Akt and Induction of miR-146a and miR-155 in Thyroid Eye Disease Orbital Fibroblasts

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Collynn F. Woeller; Elisa Roztocil; Christine Hammond; Steven E. Feldon
TAGS: micrornas, phosphoinositide 3-kinase, proto-oncogene proteins c-akt, signal transduction, thyrotropin, thyrotropin receptor, fibroblasts, graves' ophthalmopathy
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4336-4345. doi: 10.1167/iovs.19-27865

Genetics October 2019

Exome Sequencing Reveals a Heterozygous OAS3 Mutation in a Chinese Family With Juvenile-Onset Open-Angle Glaucoma

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Xiaoqiang Xiao; Chukai Huang; Yingjie Cao; Shaowan Chen; Yanxuan Xu; Haoyu Chen; Chipui Pang; Mingzhi Zhang
TAGS: child, chinese (other dialects), chinese people, family, heterozygote, mutation, open-angle glaucoma, whole exome sequencing
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4277-4284. doi: 10.1167/iovs.19-27545

Includes: Supplemental Content

Retina October 2019

Late-Onset Stargardt Disease Due to Mild, Deep-Intronic ABCA4 Alleles

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Esmee H. Runhart; Dyon Valkenburg; Stéphanie S. Cornelis; Mubeen Khan; Riccardo Sangermano; Silvia Albert; Nathalie M. Bax; Galuh D. N. Astuti; Christian Gilissen; Jan-Willem R. Pott; Joke B. G. M. Verheij; Ellen A. W. Blokland; Frans P. M. Cremers; L. Ingeborgh van den Born; Carel B. Hoyng
TAGS: alleles, introns, penetrance, genetic, stargardt's disease, cohort studies, photoreceptors, age of onset, stem cells
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4249-4256. doi: 10.1167/iovs.19-27524

Includes: Supplemental Content

Retina October 2019

miR-590-3p Inhibits Pyroptosis in Diabetic Retinopathy by Targeting NLRP1 and Inactivating the NOX4 Signaling Pathway

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Chufeng Gu; Deji Draga; Chuandi Zhou; Tong Su; Chen Zou; Qing Gu; Tashi Lahm; Zhi Zheng; Qinghua Qiu
TAGS: diabetic retinopathy, nadph oxidase 4, pyroptosis, caspase-1, signal pathway, signal transduction pathways
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4215-4223. doi: 10.1167/iovs.19-27825

Includes: Supplemental Content

Cornea October 2019

Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide

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Changjun Wang; Laura Schaefer; Fang Bian; Zhiyuan Yu; Stephen C. Pflugfelder; Robert A. Britton; Cintia S. de Paiva
TAGS: antibiotics, dysbiosis, inflammatory response, mice, microbiome, conjunctiva, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4224-4233. doi: 10.1167/iovs.19-27939

Article October 2019

Luminance-contrast properties of texture-shape and texture-surround suppression of contour shape

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Elena Gheorghiu; Frederick A. A. Kingdom
TAGS: luminance, perceptual aftereffect, polarity, shape
Journal of Vision. 2019; 19(12):4. doi: 10.1167/19.12.4

Includes: Multimedia, Supplemental Content

Retina October 2019

Blast Preconditioning Protects Retinal Ganglion Cells and Reveals Targets for Prevention of Neurodegeneration Following Blast-Mediated Traumatic Brian Injury

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Matthew M. Harper; Addison W. Woll; Lucy P. Evans; Michael Delcau; Abhigna Akurathi; Adam Hedberg-Buenz; Dana A. Soukup; Nickolas Boehme; Marco M. Hefti; Laura M. Dutca; Michael G. Anderson; Alexander G. Bassuk
TAGS: basic local alignment search tool, blast injuries, mice, wounds and injuries, nerve degeneration, retinal ganglion cells, prevention, rna
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4159-4170. doi: 10.1167/iovs.19-27565

Includes: Supplemental Content

Biochemistry and Molecular Biology October 2019

Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma

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Chandrani Chattopadhyay; Junna Oba; Jason Roszik; Joseph R. Marszalek; Ken Chen; Yuan Qi; Karina Eterovic; A. Gordon Robertson; Jared K. Burks; Tara A. McCannel; Elizabeth A. Grimm; Scott E. Woodman
TAGS: genes, intraocular melanoma, metabolism, neoplasms, sdha gene, cancer, cell lines, monosomy, mitomycin, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4187-4195. doi: 10.1167/iovs.19-28082

Includes: Supplemental Content

Retina October 2019

Induced Expression of VEGFC , ANGPT , and EFNB2 and Their Receptors Characterizes Neovascularization in Proliferative Diabetic Retinopathy

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Yaping Li; Dong Chen; Luguo Sun; Yannan Wu; Ying Zou; Chen Liang; Yongli Bao; Jingwen Yi; Yu Zhang; Jing Hou; Zhen Li; Fengyun Yu; Yanxin Huang; Chunlei Yu; Lei Liu; Zaoxia Liu; Yi Zhang; Yuxin Li
TAGS: diabetes mellitus, type 2, genes, neovascularization, pathologic, proliferative diabetic retinopathy, retina, vascular endothelial growth factor c, gene expression, vascular endothelial growth factor a, rna, growth factor
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4084-4096. doi: 10.1167/iovs.19-26767

Includes: Supplemental Content

Retina October 2019

Characteristics and Utility of Fundus Autofluorescence in Congenital Aniridia Using Scanning Laser Ophthalmoscopy

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Erlend C. S. Landsend; Hilde R. Pedersen; Øygunn A. Utheim; Corina S. Rueegg; Rigmor C. Baraas; Neil Lagali; Ragnheidur Bragadóttir; Morten C. Moe; Tor P. Utheim
TAGS: aniridia, foveal hypoplasia, fundus autofluorescence imaging, scanning laser ophthalmoscopy
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4120-4128. doi: 10.1167/iovs.19-26994

Includes: Supplemental Content

Biochemistry and Molecular Biology October 2019

Therapeutic Effect of Curcumin, a Plant Polyphenol Extracted From Curcuma longae , in Fibroblasts From Patients With Graves' Orbitopathy

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Jihei Sara Lee; Jinjoo Kim; Eun Jig Lee; Jin Sook Yoon
TAGS: curcumin, fibroblasts, polyphenols, plants
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4129-4140. doi: 10.1167/iovs.19-27376

Genetics September 2019

Expanding the Phenotypic and Genotypic Landscape of Nonsyndromic High Myopia: A Cross-Sectional Study in 731 Chinese Patients

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Xue-Bi Cai; Yi-Han Zheng; De-Fu Chen; Fang-Yue Zhou; Lu-Qi Xia; Xin-Ran Wen; Yi-Min Yuan; Fang Han; Shun-Yu Piao; Wenjuan Zhuang; Fan Lu; Jia Qu; A-Yong Yu; Zi-Bing Jin
TAGS: chinese (other dialects), chinese people, genotype, myopia, phenotype, refractive errors, retinal diseases, mutation, visual impairment, genes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):4052-4062. doi: 10.1167/iovs.19-27921

Includes: Supplemental Content

Visual Neuroscience September 2019

The Detection Of Misrouting In Albinism: Evaluation of Different VEP Procedures in a Heterogeneous Cohort

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Charlotte C. Kruijt; Gerard C. de Wit; Herman E. Talsma; Nicoline E. Schalij-Delfos; Maria M. van Genderen
TAGS: albinism, cohort studies, evoked potentials, visual, heterogeneity
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3963-3969. doi: 10.1167/iovs.19-27364

Includes: Supplemental Content

Cornea September 2019

Quantitative Studies of Muscleblind Proteins and Their Interaction With TCF4 RNA Foci Support Involvement in the Mechanism of Fuchs' Dystrophy

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Ziye Rong; Jiaxin Hu; David R. Corey; V. Vinod Mootha
TAGS: proteins, rna, cornea, body tissue
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3980-3991. doi: 10.1167/iovs.19-27641

Includes: Supplemental Content

Glaucoma September 2019

NOS3 Deletion in Cav1 Deficient Mice Decreases Drug Sensitivity to a Nitric Oxide Donor and Two Nitric Oxide Synthase Inhibitors

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Maomao Song; Liping Li; Yuan Lei; Xinghuai Sun
TAGS: donors, intraocular pressure, mice, nitric oxide, nitric oxide synthase, nitric oxide synthase inhibitors, cyclic gmp, ng-nitroarginine methyl ester, single nucleotide polymorphism
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):4002-4007. doi: 10.1167/iovs.19-27582

Includes: Supplemental Content

Genetics September 2019

Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration

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Andrea R. Waksmunski; Michelle Grunin; Tyler G. Kinzy; Robert P. Igo, Jr; Jonathan L. Haines; Jessica N. Cooke Bailey; for the International Age-Related Macular Degeneration Genomics Consortium
TAGS: age-related macular degeneration, candidate disease gene, genes, genome, genome-wide association study, ophthalmology, universities, schools, medical, proteins, genetics
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):4041-4051. doi: 10.1167/iovs.19-27827

Includes: Supplemental Content

Articles September 2019

In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability

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Wayne Heaselgrave; Anas Hamad; Steven Coles; Scott Hau
TAGS: acanthamoeba, cysts, ophthalmic agents, trophozoite, bronchioloalveolar carcinoma, toxic effect
Trans. Vis. Sci. Tech.. 2019; 8(5):17. doi: 10.1167/tvst.8.5.17

Genetics September 2019

MicroRNA-Related Genetic Variants Are Associated With Diabetic Retinopathy in Type 1 Diabetes Mellitus

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Ebony Liu; Georgia Kaidonis; Bennet J. McComish; Mark C. Gillies; Sotoodeh Abhary; Rohan W. Essex; John H. Chang; Bishwanath Pal; Mark Daniell; Stewart Lake; Nikolai Petrovsky; Alex W. Hewitt; Alicia Jenkins; Ecosse L. Lamoureux; Jonathan M. Gleadle; Jamie E. Craig; Kathryn P. Burdon
TAGS: diabetes mellitus, type 1, diabetic retinopathy, genes, genetics, micrornas, single nucleotide polymorphism
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3937-3942. doi: 10.1167/iovs.18-25570

Includes: Supplemental Content

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Fully Automated Estimation of Spacing and Density for Retinal Mosaics

Effect of Choroidal Vessel Density on the Ellipsoid Zone and Visual Function in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography

TSHR Signaling Stimulates Proliferation Through PI3K/Akt and Induction of miR-146a and miR-155 in Thyroid Eye Disease Orbital Fibroblasts

Exome Sequencing Reveals a Heterozygous OAS3 Mutation in a Chinese Family With Juvenile-Onset Open-Angle Glaucoma

Late-Onset Stargardt Disease Due to Mild, Deep-Intronic ABCA4 Alleles

miR-590-3p Inhibits Pyroptosis in Diabetic Retinopathy by Targeting NLRP1 and Inactivating the NOX4 Signaling Pathway

Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide

Luminance-contrast properties of texture-shape and texture-surround suppression of contour shape

Blast Preconditioning Protects Retinal Ganglion Cells and Reveals Targets for Prevention of Neurodegeneration Following Blast-Mediated Traumatic Brian Injury

Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma

Induced Expression of VEGFC , ANGPT , and EFNB2 and Their Receptors Characterizes Neovascularization in Proliferative Diabetic Retinopathy

Characteristics and Utility of Fundus Autofluorescence in Congenital Aniridia Using Scanning Laser Ophthalmoscopy

Therapeutic Effect of Curcumin, a Plant Polyphenol Extracted From Curcuma longae , in Fibroblasts From Patients With Graves' Orbitopathy

Expanding the Phenotypic and Genotypic Landscape of Nonsyndromic High Myopia: A Cross-Sectional Study in 731 Chinese Patients

The Detection Of Misrouting In Albinism: Evaluation of Different VEP Procedures in a Heterogeneous Cohort

Quantitative Studies of Muscleblind Proteins and Their Interaction With TCF4 RNA Foci Support Involvement in the Mechanism of Fuchs' Dystrophy

NOS3 Deletion in Cav1 Deficient Mice Decreases Drug Sensitivity to a Nitric Oxide Donor and Two Nitric Oxide Synthase Inhibitors

Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration

In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability

MicroRNA-Related Genetic Variants Are Associated With Diabetic Retinopathy in Type 1 Diabetes Mellitus

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