Genetics

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Cornea March 2025

Corneal Keratocytes, Fibroblasts, and Myofibroblasts Exhibit Distinct Transcriptional Profiles In Vitro

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Kara Poole; Krithika S. Iyer; David W. Schmidtke; W. Matthew Petroll; Victor D. Varner
TAGS: cornea, fibroblasts, genes, keratocytes, myofibroblasts, transcription, genetic, stromal cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):28. https://doi.org/10.1167/iovs.66.3.28

Includes: Supplemental Content

Glaucoma March 2025

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

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Jing Wang; Yang Zhang; Huimin Zhong; Yumeng Zhang; Ruiqi Han; Yanzhi Guo; Shouyue Huang; Huan Yu; Yisheng Zhong
TAGS: ferroptosis, fibrosis, nadph oxidase 4, silicone oils, smad3 gene, trabecular meshwork, glaucoma, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):25. https://doi.org/10.1167/iovs.66.3.25

Genetics March 2025

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

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Qiu-Yi Huo; Rui-Zheng Zhang; Wan-Nan Jia; Ya-Lei Wang; Xin Shen; Xin-Yao Chen; Tian-Hui Chen; Yan Liu; Ling-Hao Song; Xinyue Wang; Yong Lv; Ze-Xu Chen; Yong-Xiang Jiang
TAGS: biomechanics, cornea, ectopia lentis, fibrillin-1, marfan syndrome, mutation, genotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):23. https://doi.org/10.1167/iovs.66.3.23

Includes: Supplemental Content

Glaucoma March 2025

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

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Jiayong Li; Yuncheng Ma; Lingling Xie; Kaichen Zhuo; Yuxian He; Xin Ma; Shufen Zheng; Shicheng Guo; Yizhen Tang; Guzainuer Muhetaer; Mireayi Aizezi; Dan Zhang; Aizezi Wumaier; Xu Zhang; Chao Tang; Wei Wang; Wenyong Huang; Xinbo Gao
TAGS: biological markers, exfoliation syndrome, mass spectrometry, mendelian randomization analysis, plasma, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):19. https://doi.org/10.1167/iovs.66.3.19

Includes: Supplemental Content

Cornea March 2025

The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy

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Tatsuya Nakagawa; Tetsuro Honda; Taichi Yuasa; Go Nishiuchi; Masakazu Sato; Ayumi Tokunaga; Makiko Nakahara; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Prema Padmanabhan; Amit Chatterjee; Gajanan Sathe; Vivek Ghose; Narayanan Janakiraman; Derek J. Blake; Noriko Koizumi; Sailaja Elchuri; Naoki Okumura
TAGS: apoptosis, cornea, endothelial cells, endothelium, genes, hereditary corneal dystrophy, pathogenesis, proteins, western blotting, liquid chromatography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):16. https://doi.org/10.1167/iovs.66.3.16

Includes: Supplemental Content

Cornea March 2025

Single-Cell Multiomics Analysis of Early Wound Response Programs in the Mouse Corneal Epithelium

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Zhao-Jing Lu; Jin-Guo Ye; Jing-Ni Li; Jiang-Bo Liang; Ming Zhou; Qiu-Ling Hu; Qi-Kai Zhang; Yu-Heng Lin; Ying-Feng Zheng
TAGS: corneal epithelium, genes, mice, wounds and injuries, chromatin, cornea, wound healing, multiomics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):9. https://doi.org/10.1167/iovs.66.3.9

Includes: Supplemental Content

Immunology and Microbiology March 2025

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis

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Zhuang Li; Xiuxing Liu; Zuoyi Li; Zhiqiang Xiao; Guanyu Chen; Yangyang Li; Jun Huang; Yunwei Hu; Haixiang Huang; Wenjie Zhu; Yuxun Shi; Minzhen Wang; Yanyan Xie; Wenru Su; Xiaoqing Chen; Dan Liang
TAGS: autoimmunity, flow cytometry, interleukin-17, mice, rna, small cytoplasmic, t follicular helper cells, uveitis, genes, t-lymphocytes, phenotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):8. https://doi.org/10.1167/iovs.66.3.8

Includes: Supplemental Content

Genetics March 2025

An Ocular Gene-Set Expression Library for Heritability Partition and Cell Line Enrichment Analyses

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Pirro G. Hysi; Christopher J. Hammond
TAGS: cell lines, genes, genome-wide association study, libraries
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):11. https://doi.org/10.1167/iovs.66.3.11

Includes: Supplemental Content

Retina March 2025

Fibronectin Mediates Endothelial-to-Mesenchymal Transition in Retina Angiogenesis

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Dan Liu; Zhishang Meng; Chen Jin; Fang Chen; Li Pu; Ze Wu; Qi Zeng; Jing Luo; Wenyi Wu
TAGS: angiogenesis, fibronectins, retina, genes, endothelium, vascular endothelial growth factor a, epithelial to mesenchymal transition, rna, small interfering, rna-seq
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):10. https://doi.org/10.1167/iovs.66.3.10

Includes: Supplemental Content

Retinal Cell Biology March 2025

Dicer Loss in Müller Glia Leads to a Defined Sequence of Pathological Events Beginning With Cone Dysfunction

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Daniel Larbi; Alexander M. Rief; Seoyoung Kang; Shaoheng Chen; Khulan Batsuuri; Sabine Fuhrmann; Suresh Viswanathan; Stefanie G. Wohl
TAGS: embryonic lethal mutation, health, mice, micrornas, neuroglia, pathophysiology, retina, retinal cone, rod photoreceptors, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):7. https://doi.org/10.1167/iovs.66.3.7

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2025

Butyrate Ameliorates Graves’ Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota

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Pingbo Ouyang; Jia Qi; Boding Tong; Yunping Li; Jiamin Cao; Lujue Wang; Tongxin Niu; Xin Qi
TAGS: butyrates, fibroblasts, gastrointestinal microbiome, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):5. https://doi.org/10.1167/iovs.66.3.5

Includes: Supplemental Content

Letters to the Editor March 2025

Author Response: Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

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Patricia Barreto; Claudia Farinha; Rita Coimbra; Rufino Silva
TAGS: age-related macular degeneration, genetics, statins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):3. https://doi.org/10.1167/iovs.66.3.3

Cornea February 2025

Identification of Wnt-5a Receptors Important in Diabetic and Non-Diabetic Corneal Epithelial Wound Healing

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Ruchi Shah; Cynthia Amador; Adam J. Poe; Tanya M. Spektor; Priyanka Bhandary; Yizhou Wang; Zhiping Paul Wang; Daniel J. Weisenberger; Vanessa F. Borges; Onkar B. Sawant; Ezra Maguen; Pedram Hamrah; Andrei A. Kramerov; Mehrnoosh Saghizadeh; Alexander V. Ljubimov
TAGS: cornea, diabetes mellitus, receptors, wnt, wnt-5a protein, wound healing, epithelium, receptor tyrosine kinase-like orphan receptor 2
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):64. https://doi.org/10.1167/iovs.66.2.64

Includes: Supplemental Content

Cornea February 2025

Untargeted Tear Proteomics in a Large South-Asian Cohort Reveals Inflammatory Signaling, ECM Remodeling, and Altered Metabolism in Keratoconus

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Ramaraj Kannan; Rohit Shetty; Trailokyanath Panigrahi; Siew Kwan Koh; Pooja Khamar; Vrushali Deshpande; Rudy M. M. A. Nuijts; Marlies Gijs; Krishnatej Nishtala; Lei Zhou; Arkasubhra Ghosh
TAGS: proteins, cohort studies, keratoconus, proteomics, signal transduction, metabolism
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):60. https://doi.org/10.1167/iovs.66.2.60

Includes: Supplemental Content

Genetics February 2025

Does Age Modify the Relation Between Genetic Predisposition to Glaucoma and Various Glaucoma Traits in the UK Biobank?

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Jihye Kim; Jae H. Kang; Janey L. Wiggs; Hetince Zhao; Keva Li; Nazlee Zebardast; Ayellet Segrè; David S. Friedman; Ron Do; Anthony P. Khawaja; Hugues Aschard; Louis R. Pasquale
TAGS: glaucoma, uk biobank, genetic predisposition to disease
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):57. https://doi.org/10.1167/iovs.66.2.57

Includes: Supplemental Content

Immunology and Microbiology February 2025

Elevated Plasma Complement Factors in CRB1 -Associated Inherited Retinal Dystrophies

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Lude Moekotte; Joke H. de Boer; Sanne Hiddingh; Aafke de Ligt; Xuan-Thanh-An Nguyen; Carel B. Hoyng; Chris F. Inglehearn; Martin McKibbin; Tina M. Lamey; Jennifer A. Thompson; Fred K. Chen; Terri L. McLaren; Alaa AlTalbishi; Daan M. Panneman; Erica G. M. Boonen; Sandro Banfi; Béatrice Bocquet; Isabelle Meunier; Elfride De Baere; Robert Koenekoop; Monika Ołdak; Carlo Rivolta; Lisa Roberts; Raj Ramesar; Rasa Strupaitė-Šileikienė; Susanne Kohl; G. Jane Farrar; Marion van Vugt; Jessica van Setten; Susanne Roosing; L. Ingeborgh van den Born; Camiel J. F. Boon; Maria M. van Genderen; Jonas J. W. Kuiper
TAGS: complement system proteins, hereditary retinal dystrophy, plasma, proteins, genotype, proteome, genes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):55. https://doi.org/10.1167/iovs.66.2.55

Includes: Supplemental Content

Cornea February 2025

Melatonin Alleviates Age-Related Lacrimal Gland Dysfunction Via SIRT-1/NLRP3 Pathway

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Chao Wang; Yu-Zhi Li; Huan Guo; Shi-Rui Zhou; Xi Peng; Jia-Song Wang; Hua-Tao Xie; Ming-Chang Zhang
TAGS: lacrimal gland, nlr family, pyrin domain-containing 3 protein, sirt1 gene, melatonin, pathophysiology, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):51. https://doi.org/10.1167/iovs.66.2.51

Includes: Supplemental Content

Retina February 2025

Clinical, Genetic, Imaging and Electrophysiological Findings in a Cohort of Patients With GUCA1A -Associated Retinopathy

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Gilad Allon; Siying Lin; Anthony G. Robson; Gavin Arno; Magella M. Neveu; Pirro G. Hysi; Michel Michaelides; Andrew R. Webster; Omar A. Mahroo
TAGS: cohort studies, diagnostic imaging, genetics, retinal diseases, visual acuity, electrophysiology, family, eye, vision
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):50. https://doi.org/10.1167/iovs.66.2.50

Retina February 2025

Accessible LED Lightbox for Light-induced Retinal Damage in Pigmented Mice

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Hunter L. Aliff; Alexis B. Crockett; Micah A. Chrenek; John M. Nickerson; Jeffrey H. Boatright; Oxana Tseytlin; Matthew Johnson; Hayley G. Bockius; Sierra G. Kuzak; Visvanathan Ramamurthy
TAGS: mice, mice, inbred c57bl, erg protein, human, electroretinography, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):49. https://doi.org/10.1167/iovs.66.2.49

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology February 2025

Chiasmal Decussation in Oculo-Cutaneous Albinism Type 8

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Maxence Rateaux; Smaïl Hadj-Rabia; Rémi Barrois; Olivia Zambrowski; Vincent Michaud; Ester Moreno-Artero; Dominique Bremond-Gignac; Sophie Javerzat; Matthieu P. Robert
TAGS: albinism
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):44. https://doi.org/10.1167/iovs.66.2.44

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Corneal Keratocytes, Fibroblasts, and Myofibroblasts Exhibit Distinct Transcriptional Profiles In Vitro

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy

Single-Cell Multiomics Analysis of Early Wound Response Programs in the Mouse Corneal Epithelium

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis

An Ocular Gene-Set Expression Library for Heritability Partition and Cell Line Enrichment Analyses

Fibronectin Mediates Endothelial-to-Mesenchymal Transition in Retina Angiogenesis

Dicer Loss in Müller Glia Leads to a Defined Sequence of Pathological Events Beginning With Cone Dysfunction

Butyrate Ameliorates Graves’ Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota

Author Response: Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

Identification of Wnt-5a Receptors Important in Diabetic and Non-Diabetic Corneal Epithelial Wound Healing

Untargeted Tear Proteomics in a Large South-Asian Cohort Reveals Inflammatory Signaling, ECM Remodeling, and Altered Metabolism in Keratoconus

Does Age Modify the Relation Between Genetic Predisposition to Glaucoma and Various Glaucoma Traits in the UK Biobank?

Elevated Plasma Complement Factors in CRB1 -Associated Inherited Retinal Dystrophies

Melatonin Alleviates Age-Related Lacrimal Gland Dysfunction Via SIRT-1/NLRP3 Pathway

Clinical, Genetic, Imaging and Electrophysiological Findings in a Cohort of Patients With GUCA1A -Associated Retinopathy

Accessible LED Lightbox for Light-induced Retinal Damage in Pigmented Mice

Chiasmal Decussation in Oculo-Cutaneous Albinism Type 8

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