Glaucoma

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Glaucoma April 2025

Targeted Neuroprotection of Retinal Ganglion Cells Via AAV2-hSyn-NGF Gene Therapy in Glaucoma Models

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Xinlei Zhu; Benxiang Qi; Zhongmei Ren; Lin Cong; Xiaojing Pan; Qingjun Zhou; Bi Ning Zhang; Lixin Xie
TAGS: glaucoma, injections, gene therapy, neuroprotection, retinal ganglion cells, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):48. https://doi.org/10.1167/iovs.66.4.48

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

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Wei-Qi Song; Wen-Fang Zhong; Zhi-Hao Li; Dan Liu; Jiao-Jiao Ren; Dong Shen; Jian Gao; Pei-Liang Chen; Jin Yang; Xiao-Meng Wang; Fang-Fei You; Chuan Li; Huan Chen; Jia-Hao Xie; Chen Mao
TAGS: glaucoma, genetic predisposition to disease
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):47. https://doi.org/10.1167/iovs.66.4.47

Includes: Supplemental Content

Glaucoma April 2025

Vitamin K1 Alleviates Retinal Inflammation Following Acute Ocular Hypertension by Modulating Microglial Ferroptosis

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Xi Chen; Yan Rong; Yuxian Jiang; Qiuxiang Zhang; Sifei Xiang; Zhiqi Chen; Wei Chen; Hong Zhang; Chaohua Deng; Junming Wang
TAGS: retinitis, vitamin k 1, wounds and injuries, ocular hypertension, ferroptosis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):46. https://doi.org/10.1167/iovs.66.4.46

Glaucoma April 2025

Association Between Cup-to-Disc Ratio and Structural and Functional Damage Parameters in Glaucoma: Insights From Multiparametric Modeling

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Aliah McCalla; Mengyu Wang; Mohammad Eslami; Saber Kazeminasab; Yan Luo; Hannah Rana; Sajib Saha; Min Shi; Yu Tian; Nazlee Zebardast; Tobias Elze
TAGS: glaucoma, clinicians, optic disk
Trans. Vis. Sci. Tech.. 2025; 14(4):17. https://doi.org/10.1167/tvst.14.4.17

Includes: Supplemental Content

Visual Neuroscience April 2025

Fetal Growth Restriction Is Associated With Altered Optic Nerve Head Morphology in Term-Born Children and Adolescents

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Achim Fieß; Sandra Gißler; Stephanie Grabitz; Esther M. Hoffmann; Eva Mildenberger; Timo Uphaus; Marianne Hahn; Norbert Pfeiffer; Alica Hartmann; Alexander K. Schuster
TAGS: adolescent, child, fetal growth retardation, language morphology, morphology, optic disk, birth weight
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):35. https://doi.org/10.1167/iovs.66.4.35

Includes: Supplemental Content

Visual Neuroscience April 2025

Enlarged Blind Spot Linked to Gamma Zone and Peripapillary Hyperreflective Ovoid Mass-Like Structures in Non-Pathological Highly Myopic Eyes

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Qiuyan Wu; Ruihan Hu; Qihong Liu; Fang Li; Yuanyuan Wang; Zuohuizi Yi; Jiajia Yuan; Yilei Shao; Meixiao Shen; Hongmei Zheng; Changzheng Chen
TAGS: eye, retinal blind spot, glaucoma, myopia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):5. https://doi.org/10.1167/iovs.66.4.5

Includes: Supplemental Content

Glaucoma April 2025

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

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Jinpeng Yang; Yangjiani Li; Qi Zhang; Simei Zeng; Haishun Huang; Caiqing Wu; Zhe Liu; Jiahui Tang; Siting Wu; Yuze Chen; Yehong Zhuo; Yangfan Yang; Yiqing Li
TAGS: glaucoma, language morphology, morphology, myopia, optic disk, optic nerve, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):18. https://doi.org/10.1167/iovs.66.4.18

Includes: Supplemental Content

Glaucoma April 2025

Effects of Verteporfin on Interstitial Fluid Flow-Induced Fibrotic Transdifferentiation of Human Tenon Fibroblasts

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Janne Frömmichen; Emma Bungert; Jeanne Ströble; Moritz Gläser; Charlotte Gottwald; Kosovare Zeqiri; Thomas Reinhard; Jan Lübke; Günther Schlunck; Cornelius Jakob Wiedenmann
TAGS: fibroblasts, fibrosis, fluid flow, interstitial fluid, verteporfin, actins, cell transdifferentiation, connective tissue growth factor
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):17. https://doi.org/10.1167/iovs.66.4.17

Glaucoma April 2025

Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition

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Nana Takahashi; Yukihiro Shiga; Naoki Kiyota; Masayuki Yasuda; Naoki Takahashi; Kota Sato; Ryutaro Arita; Akiko Kikuchi; Shin Takayama; Tadashi Ishii; Toru Nakazawa
TAGS: common cold, open-angle glaucoma, optic disk, vascular flow, cold sensation, cold temperature, eye, glaucoma
Trans. Vis. Sci. Tech.. 2025; 14(4):9. https://doi.org/10.1167/tvst.14.4.9

Includes: Supplemental Content

Glaucoma April 2025

Comparison of the Humphrey Field Analyzer and MP-3 Microperimeter in Patients With Glaucoma, Classified by Severity and Misalignment of Test Points

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Taiga Inooka; Ryo Tomita; Taro Kominami; Marie Mochizuki; Koji M. Nishiguchi; Kenya Yuki
TAGS: glaucoma, open-angle glaucoma, eye, reliability
Trans. Vis. Sci. Tech.. 2025; 14(4):6. https://doi.org/10.1167/tvst.14.4.6

Glaucoma April 2025

Longitudinal Change in Retinal Nerve Fiber Layer Thickness and Intraocular Pressure in Young Adults

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Samantha Sze-Yee Lee; Gareth Lingham; Alex W. Hewitt; David A. Mackey
TAGS: intraocular pressure, retinal nerve fiber layer, young adult, eye, ophthalmic examination and evaluation
Trans. Vis. Sci. Tech.. 2025; 14(4):3. https://doi.org/10.1167/tvst.14.4.3

Includes: Supplemental Content

Uveitis April 2025

Identification of Subtypes of Herpetic Anterior Uveitis and Characterization of Their Clinical Features and Visual Outcome in a Chinese Population

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Hui Liu; Suo Guo; Yaning Liu; Guannan Su; Peizeng Yang
TAGS: chinese (other dialects), signs and symptoms, uveitis, anterior, chinese people, cytomegalovirus, intraocular pressure
Trans. Vis. Sci. Tech.. 2025; 14(4):2. https://doi.org/10.1167/tvst.14.4.2

Includes: Supplemental Content

Optica Fall Vision Meeting Abstract April 2025

Invited Session III: Machine Learning and AI Approaches to Retinal Diagnostics: Optimizing clinician-AI teaming to enhance glaucoma care

Jithin Yohannan
TAGS: clinicians, glaucoma, machine learning
Journal of Vision. 2025; 25(5):32. https://doi.org/10.1167/jov.25.5.32

Artificial Intelligence March 2025

Multimodal Artificial Intelligence Models Predicting Glaucoma Progression Using Electronic Health Records and Retinal Nerve Fiber Layer Scans

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Abigail Koornwinder; Youchen Zhang; Rohith Ravindranath; Robert T. Chang; Isaac A. Bernstein; Sophia Y. Wang
TAGS: artificial intelligence, electronic medical records, glaucoma, retinal nerve fiber layer, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(3):27. https://doi.org/10.1167/tvst.14.3.27

Includes: Supplemental Content

Glaucoma March 2025

Fibrosis-Related Gene and Protein Expression in Normal and Glaucomatous Trabecular Meshwork Cells

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Yong-Feng Yang; Paul Holden; Ying Ying Sun; Jennifer A. Faralli; Donna M. Peters; Kate E. Keller
TAGS: fibrosis, genes, glaucoma, proteins, trabecular meshwork
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):48. https://doi.org/10.1167/iovs.66.3.48

Includes: Supplemental Content

Glaucoma March 2025

The Association of Social Determinants of Health on Monitoring for Disease Progression Among Patients With Primary Open-Angle Glaucoma

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Kunal Kanwar; Rithambara Ramachandran; Joshua D. Stein; Chris A. Andrews; Azraa S. Chaudhury; Maryam Ige; Xueqing Zhou; Shikha Marwah; Yang Li; Charlesnika T. Evans; Abel N. Kho; Paul J. Bryar; Dustin D. French; on behalf of the Sight Outcomes Research Collaborative (SOURCE) Consortium
TAGS: open-angle glaucoma, optic nerve, disease progression
Trans. Vis. Sci. Tech.. 2025; 14(3):15. https://doi.org/10.1167/tvst.14.3.15

Includes: Supplemental Content

Glaucoma March 2025

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

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Jing Wang; Yang Zhang; Huimin Zhong; Yumeng Zhang; Ruiqi Han; Yanzhi Guo; Shouyue Huang; Huan Yu; Yisheng Zhong
TAGS: ferroptosis, fibrosis, nadph oxidase 4, silicone oils, smad3 gene, trabecular meshwork, glaucoma, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):25. https://doi.org/10.1167/iovs.66.3.25

Glaucoma March 2025

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

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Jiayong Li; Yuncheng Ma; Lingling Xie; Kaichen Zhuo; Yuxian He; Xin Ma; Shufen Zheng; Shicheng Guo; Yizhen Tang; Guzainuer Muhetaer; Mireayi Aizezi; Dan Zhang; Aizezi Wumaier; Xu Zhang; Chao Tang; Wei Wang; Wenyong Huang; Xinbo Gao
TAGS: biological markers, exfoliation syndrome, mass spectrometry, mendelian randomization analysis, plasma, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):19. https://doi.org/10.1167/iovs.66.3.19

Includes: Supplemental Content

Glaucoma March 2025

Morphological Comparison of Astrocytes in the Lamina Cribrosa and Glial Lamina

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Susannah Waxman; Hannah Schilpp; Ashley Linton; Tatjana C. Jakobs; Ian A. Sigal
TAGS: astrocytes, language morphology, morphology, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):1. https://doi.org/10.1167/iovs.66.3.1

Includes: Supplemental Content

Glaucoma February 2025

Characterization, Enrichment, and Computational Modeling of Cross-Linked Actin Networks in Transformed Trabecular Meshwork Cells

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Haiyan Li; Devon H. Harvey; Jiannong Dai; Steven P. Swingle; Anthony M. Compton; Chenna Kesavulu Sugali; Kamesh Dhamodaran; Jing Yao; Tsai-Yu Lin; Todd Sulchek; Taeyoon Kim; C. Ross Ethier; Weiming Mao
TAGS: actins, adhesions, computer simulation, trabecular meshwork, cell nucleus, green fluorescent proteins, diagnostic imaging, incidence
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):65. https://doi.org/10.1167/iovs.66.2.65

Includes: Multimedia, Supplemental Content

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Targeted Neuroprotection of Retinal Ganglion Cells Via AAV2-hSyn-NGF Gene Therapy in Glaucoma Models

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

Vitamin K1 Alleviates Retinal Inflammation Following Acute Ocular Hypertension by Modulating Microglial Ferroptosis

Association Between Cup-to-Disc Ratio and Structural and Functional Damage Parameters in Glaucoma: Insights From Multiparametric Modeling

Fetal Growth Restriction Is Associated With Altered Optic Nerve Head Morphology in Term-Born Children and Adolescents

Enlarged Blind Spot Linked to Gamma Zone and Peripapillary Hyperreflective Ovoid Mass-Like Structures in Non-Pathological Highly Myopic Eyes

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

Effects of Verteporfin on Interstitial Fluid Flow-Induced Fibrotic Transdifferentiation of Human Tenon Fibroblasts

Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition

Comparison of the Humphrey Field Analyzer and MP-3 Microperimeter in Patients With Glaucoma, Classified by Severity and Misalignment of Test Points

Longitudinal Change in Retinal Nerve Fiber Layer Thickness and Intraocular Pressure in Young Adults

Identification of Subtypes of Herpetic Anterior Uveitis and Characterization of Their Clinical Features and Visual Outcome in a Chinese Population

Invited Session III: Machine Learning and AI Approaches to Retinal Diagnostics: Optimizing clinician-AI teaming to enhance glaucoma care

Multimodal Artificial Intelligence Models Predicting Glaucoma Progression Using Electronic Health Records and Retinal Nerve Fiber Layer Scans

Fibrosis-Related Gene and Protein Expression in Normal and Glaucomatous Trabecular Meshwork Cells

The Association of Social Determinants of Health on Monitoring for Disease Progression Among Patients With Primary Open-Angle Glaucoma

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

Morphological Comparison of Astrocytes in the Lamina Cribrosa and Glial Lamina

Characterization, Enrichment, and Computational Modeling of Cross-Linked Actin Networks in Transformed Trabecular Meshwork Cells

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