Glaucoma

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Glaucoma January 2025

In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics

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Daniel Kim; Raymond Fang; Pengpeng Zhang; Zihang Yan; Cheng Sun; Guorong Li; Christa Montgomery; Simon W. M. John; W. Daniel Stamer; Hao F. Zhang; C. Ross Ethier
TAGS: anterior chamber of eye, aqueous humor, diagnostic imaging, eye, mice, vaccine information sheets, volume, x-ray microtomography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):18. https://doi.org/10.1167/iovs.66.1.18

Includes: Supplemental Content

Biochemistry and Molecular Biology December 2024

Integrated Profiling of Extracellular Vesicle microRNA Impact on Trabecular Meshwork mRNA Expression: Insights From Microarray Analysis

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Efrat Cohen-Davidi; Valeria Feinstein; Boris Knyazer; Elie Beit-Yannai; Isana Veksler-Lublinsky
TAGS: micrornas, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):38. https://doi.org/10.1167/iovs.65.14.38

Includes: Supplemental Content

Perspective December 2024

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

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Ted S. Acott; Michael P. Fautsch; Weiming Mao; C. Ross Ethier; Alex S. Huang; Mary J. Kelley; Mini Aga; Sanjoy K. Bhattacharya; Terete Borras; Diane Bovenkamp; Uttio Roy Chowdhury; Abbot F. Clark; Mohammed I. Dibas; Yiqin Du; Michael H. Elliott; Jennifer A. Faralli; Haiyan Gong; Samuel Herberg; Murray A. Johnstone; Paul L. Kaufman; Kate E. Keller; Ruth A. Kelly; David Krizaj; Markus H. Kuehn; Hoi Lam Li; Raquel Lieberman; Shan C. Lin; Yutao Liu; Fiona S. McDonnell; Colleen M. McDowell; Gillian J. McLellan; Philip Mzyk; Kayarat Saidas Nair; Darryl R. Overby; Donna M. Peters; VijayKrishna Raghunathan; Ponugoti Vasantha Rao; Gavin W. Roddy; Najam A. Sharif; Myoung Sup Shim; Yang Sun; Benjamin R. Thomson; Carol B. Toris; Colin E. Willoughby; Hao F. Zhang; Thomas F. Freddo; Rudolf Fuchshofer; Kamisha R. Hill; Alireza Karimi; Krishnakumar Kizhatil; Casey C. Kopcyznski; Paloma Liton; Gaurang Patel; Michael Peng; Padmanabhan P. Pattabiraman; Ganesh Prasanna; Ester Reina-Torres; E. Griffen Samples; John R. Samples; Cynthia L. Steel; Clemens A. Strohmaier; Preeti Subramanian; Chenna Kesavulu Sugali; Joseph van Batenburg-Sherwood; Cydney Wong; Hannah Youngblood; Gulab S. Zode; Elizabeth White; W. Daniel Stamer
TAGS: body tissue, eye, fluid flow, intraocular pressure, perfusion, regulation, organ culture techniques
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):32. https://doi.org/10.1167/iovs.65.14.32

Genetics December 2024

Linking Iris Cis -Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics

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Jiaying Li; Yun Chen; Wenbin Wang; Ye Zhang; Guangsong Su; Sean K. Wang; Yuanyuan Zhang; Yilong Yao; Shen Wu; Wange Lu; Kunlin Zhang; Chunyan Qiao; Shuning Li; Hengtong Li; Ching-Yu Cheng; Yuwen Liu; Ningli Wang
TAGS: angle closure glaucoma, iris, pathogenesis, enhancer of transcription, diagnostic imaging, chromatin, alleles, multiomics
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):18. https://doi.org/10.1167/iovs.65.14.18

Includes: Supplemental Content

Glaucoma December 2024

Sequence and Detectability of Changes in Macular Ganglion Cell Layer Thickness and Perfusion Density in Early Glaucoma

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Ryo Tomita; Corey A. Smith; Oksana M. Dyachok; Glen P. Sharpe; Paul E. Rafuse; Lesya M. Shuba; Marcelo T. Nicolela; Balwantray C. Chauhan
TAGS: glaucoma, perfusion, ganglia
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):8. https://doi.org/10.1167/iovs.65.14.8

Includes: Supplemental Content

Clinical and Epidemiologic Research December 2024

Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study

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Panagiotis Laspas; Alica Hartmann; Ida Scholz; Esther Maria Hoffmann; Anthony P. Khawaja; Karl Johannes Lackner; Thomas Münzel; Jasmin Ghaemi Kerahrodi; Irene Schmidtmann; Oliver Tüscher; Jörn Markus Schattenberg; Norbert Pfeiffer; Stavros Konstantinides; Philipp Sebastian Wild; Alexander Karl-Georg Schuster
TAGS: intraocular pressure, pharmaceutical preparations, health, beta-blockers
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):4. https://doi.org/10.1167/iovs.65.14.4

Includes: Supplemental Content

Retina November 2024

Comparing IOP-Induced Scleral Deformations in the Myopic and Myopic Glaucoma Spectrums

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Thanadet Chuangsuwanich; Tin A. Tun; Fabian A. Braeu; Rachel S. Chong; Xiaofei Wang; Ching-Lin Ho; Tin Aung; Michaël J. A. Girard; Quan V. Hoang
TAGS: glaucoma, intraocular pressure, macula lutea, sclera, nose, eye
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):54. https://doi.org/10.1167/iovs.65.13.54

Includes: Supplemental Content

Glaucoma November 2024

Metabolomic Profiling of Open-Angle Glaucoma Etiologic Endotypes: Tohoku Multi-Omics Glaucoma Study

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Akiko Hanyuda; Yoshihiko Raita; Takahiro Ninomiya; Kazuki Hashimoto; Naoko Takada; Kota Sato; Jin Inoue; Seizo Koshiba; Gen Tamiya; Akira Narita; Masato Akiyama; Kazuko Omodaka; Satoru Tsuda; Yu Yokoyama; Noriko Himori; Yasuko Yamamoto; Takazumi Taniguchi; Kazuno Negishi; Toru Nakazawa
TAGS: glaucoma, metabolomics, open-angle glaucoma, multiomics, metabolites
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):44. https://doi.org/10.1167/iovs.65.13.44

Includes: Supplemental Content

Glaucoma November 2024

The Mechanisms of Neuroprotection by Topical Rho Kinase Inhibition in Experimental Mouse Glaucoma and Optic Neuropathy

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Sarah E. Quillen; Elizabeth C. Kimball; Kelsey A. Ritter-Gordy; Liya Du; Zhuochen Yuan; Mary E. Pease; Salaheddine Madhoun; Thao D. Nguyen; Thomas V. Johnson; Harry A. Quigley; Ian F. Pitha
TAGS: astrocytes, did not receive therapy or drug, eye, glaucoma, mice, neuroprotection, optic nerve disorders, phosphotransferases, proteins, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):43. https://doi.org/10.1167/iovs.65.13.43

Includes: Supplemental Content

Retinal Cell Biology November 2024

Blind But Alive – Congenital Loss of atoh7 Disrupts the Visual System of Adult Zebrafish

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Juliane Hammer; Paul Röppenack; Sarah Yousuf; Anja Machate; Marika Fischer; Stefan Hans; Michael Brand
TAGS: adult, zebrafish, phenotype, visual system, retina
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):42. https://doi.org/10.1167/iovs.65.13.42

Includes: Supplemental Content

Cornea November 2024

Restoration of Corneal Stiffness in Rabbits Following Withdrawal of Travoprost

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XiaoBo Zheng; Chong Wang; YiWen Fan; YuXin Hong; Han Bao; ErChi Zhang; Yi Jin; Peng Yang; LingQiao Li; JunJie Wang; ShiHao Chen; Ahmed Elsheikh; FangJun Bao
TAGS: cornea, oryctolagus cuniculus, travoprost, cardiac ct, multiple wake test, eye
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):35. https://doi.org/10.1167/iovs.65.13.35

Glaucoma November 2024

Downregulation of SARM1 Protects Retinal Ganglion Cell Axonal and Somal Degeneration Via JNK Activation in a Glaucomatous Model of Ocular Hypertension

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Xuejin Zhang; Ting Li; Rong Zhang; Junfeng Li; Kaidi Wang; Jihong Wu
TAGS: axon, down-regulation, glaucoma, ocular hypertension, optic nerve, retina, retinal ganglion cells, tissue degeneration, wounds and injuries, injections
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):7. https://doi.org/10.1167/iovs.65.13.7

Includes: Supplemental Content

Glaucoma November 2024

Progressive Optic Neuropathy in Hydrocephalic Ccdc13 Mutant Mice Caused by Impaired Axoplasmic Transport at the Optic Nerve Head

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Mingjuan Wu; Xinyi Zhao; Shanzhen Peng; Xiaoyu Zhang; Jiali Ru; Lijing Xie; Tao Wen; Yingchun Su; Shujuan Xu; Dianlei Guo; Jianmin Hu; Haotian Lin; Tiansen Li; Chunqiao Liu
TAGS: axonal transport, mice, optic disk, optic nerve, optic nerve disorders, axon, retina, hydrocephalus
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):5. https://doi.org/10.1167/iovs.65.13.5

Includes: Supplemental Content

Glaucoma November 2024

Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult

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Manik Bansal; Bingrui Wang; Susannah Waxman; Fuqiang Zhong; Yi Hua; Yuankai Lu; Juan Reynaud; Brad Fortune; Ian A. Sigal
TAGS: axon, body tissue, intraocular pressure, optic disk, volume, reconstructive surgical procedures
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):1. https://doi.org/10.1167/iovs.65.13.1

Includes: Supplemental Content

Glaucoma October 2024

Trabecular Meshwork Abnormalities in a Model of Congenital Glaucoma Due to LTBP2 Mutation

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Odalys Torné; Kazuya Oikawa; Leandro B. C. Teixeira; Julie A. Kiland; Gillian J. McLellan
TAGS: cats, elastic fibers, glaucoma, congenital, mutation, trabecular meshwork, eye, shape, collagen
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):28. https://doi.org/10.1167/iovs.65.12.28

Includes: Supplemental Content

Clinical and Epidemiologic Research October 2024

Association of Ambient Air Pollution Exposure With Incident Glaucoma: 12-Year Evidence From the UK Biobank Cohort

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Zihan Sun; Kelsey V. Stuart; Robert N. Luben; Amy L. Auld; Nicholas G. Strouthidis; Peng T. Khaw; Hari Jayaram; Anthony P. Khawaja; Paul J. Foster; on behalf of the UK Biobank Eye and Vision Consortium
TAGS: air pollution, cohort studies, glaucoma, uk biobank
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):22. https://doi.org/10.1167/iovs.65.12.22

Includes: Supplemental Content

Glaucoma October 2024

Diagnostic Performance for Detection of Glaucomatous Structural Damage Using Pixelwise Analysis of Retinal Thickness Measurements

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Hongli Yang; Juan Reynaud; Glen P. Sharpe; Dawn Jennings; Cindy Albert; Trinity Holthausen; Xiue Jiang; Shaban Demirel; Steven L. Mansberger; Marcelo T. Nicolela; Stuart K. Gardiner; Balwantray C. Chauhan; Claude F. Burgoyne; Brad Fortune
TAGS: eye, glaucoma, pixel
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):17. https://doi.org/10.1167/iovs.65.12.17

Includes: Supplemental Content

Glaucoma October 2024

DAMPs Drive Fibroinflammatory Changes in the Glaucomatous ONH

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Emma K. Geiduschek; Emma K. Bricco; Colleen M. McDowell
TAGS: glaucoma, mice, optic disk, eye, retinal nerve fiber layer
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):13. https://doi.org/10.1167/iovs.65.12.13

Includes: Supplemental Content

Retina October 2024

Critical Impact of Working Distance on OCT Imaging: Correction of Optical Distortion and Its Effects on Measuring Retinal Curvature

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Yong Woo Kim; Glen P. Sharpe; Julia Siber; Ralf Keßler; Jörg Fischer; Tilman Otto; Balwantray C. Chauhan
TAGS: diagnostic imaging, eye, optics
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):10. https://doi.org/10.1167/iovs.65.12.10

Includes: Multimedia, Supplemental Content

Multidisciplinary Ophthalmic Imaging September 2024

Plexus-Specific Retinal Capillary Blood Flow Analysis Using Erythrocyte Mediated Angiography and Optical Coherence Tomography Angiography

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Victoria Y. Chen; Jessica A. Pottenburgh; Shih-En Chen; Sarah Kim; Lakyn Mayo; Aashka Damani; Marvin Cruz; Ashley Park; Lily Im; Laurence Magder; Osamah J. Saeedi
TAGS: angiogram, blood capillaries, erythrocytes, vascular flow, velocity, optical coherence tomography, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):33. https://doi.org/10.1167/iovs.65.11.33

Includes: Supplemental Content

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In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics

Integrated Profiling of Extracellular Vesicle microRNA Impact on Trabecular Meshwork mRNA Expression: Insights From Microarray Analysis

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

Linking Iris Cis -Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics

Sequence and Detectability of Changes in Macular Ganglion Cell Layer Thickness and Perfusion Density in Early Glaucoma

Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study

Comparing IOP-Induced Scleral Deformations in the Myopic and Myopic Glaucoma Spectrums

Metabolomic Profiling of Open-Angle Glaucoma Etiologic Endotypes: Tohoku Multi-Omics Glaucoma Study

The Mechanisms of Neuroprotection by Topical Rho Kinase Inhibition in Experimental Mouse Glaucoma and Optic Neuropathy

Blind But Alive – Congenital Loss of atoh7 Disrupts the Visual System of Adult Zebrafish

Restoration of Corneal Stiffness in Rabbits Following Withdrawal of Travoprost

Downregulation of SARM1 Protects Retinal Ganglion Cell Axonal and Somal Degeneration Via JNK Activation in a Glaucomatous Model of Ocular Hypertension

Progressive Optic Neuropathy in Hydrocephalic Ccdc13 Mutant Mice Caused by Impaired Axoplasmic Transport at the Optic Nerve Head

Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult

Trabecular Meshwork Abnormalities in a Model of Congenital Glaucoma Due to LTBP2 Mutation

Association of Ambient Air Pollution Exposure With Incident Glaucoma: 12-Year Evidence From the UK Biobank Cohort

Diagnostic Performance for Detection of Glaucomatous Structural Damage Using Pixelwise Analysis of Retinal Thickness Measurements

DAMPs Drive Fibroinflammatory Changes in the Glaucomatous ONH

Critical Impact of Working Distance on OCT Imaging: Correction of Optical Distortion and Its Effects on Measuring Retinal Curvature

Plexus-Specific Retinal Capillary Blood Flow Analysis Using Erythrocyte Mediated Angiography and Optical Coherence Tomography Angiography

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