Imaging

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Biochemistry and Molecular Biology June 2021

Age-Related Retinal Changes in Wild-Type C57BL/6J Mice Between 2 and 32 Months

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Salma Ferdous; Kristie L. Liao; Isabelle D. Gefke; Vivian R. Summers; Wenfei Wu; Kevin J. Donaldson; Yong-Kyu Kim; Jana T. Sellers; Jendayi A. Dixon; Debresha A. Shelton; Shanu Markand; Somin M. Kim; Nan Zhang; Jeffrey H. Boatright; John M. Nickerson
TAGS: eye, mice, mice, inbred c57bl, body weight, photoreceptors, aging, retina
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):9. doi: https://doi.org/10.1167/iovs.62.7.9

Includes: Supplemental Content

Visual Neuroscience June 2021

Elavl2 Regulates Retinal Function Via Modulating the Differentiation of Amacrine Cells Subtype

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Mengjuan Wu; Qinqin Deng; Xinlan Lei; Yuxin Du; Yin Shen
TAGS: abdominal compartment syndrome, acute coronary syndromes, amacrine cells, american cancer society, american college of surgeons, electroretinography, mice, retina, ablation, rna
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):1. doi: https://doi.org/10.1167/iovs.62.7.1

Includes: Supplemental Content

Visual Neuroscience May 2021

Correcting QUEST Magnetic Resonance Imaging–Sensitive Free Radical Production in the Outer Retina In Vivo Does Not Correct Reduced Visual Performance in 24-Month-Old C57BL/6J Mice

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Bruce A. Berkowitz; Robert H. Podolsky; Karen Lins Childers; Robin Roberts; Michael Schneider; Emma Graffice; Kenan Sinan; Ali Berri; Lamis Harp
TAGS: free radicals, magnetic resonance imaging, mice, mice, inbred c57bl, retina, vision, antioxidants
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):24. doi: https://doi.org/10.1167/iovs.62.6.24

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology May 2021

Cerebral Visual Impairment Characterized by Abnormal Visual Orienting Behavior With Preserved Visual Cortical Activation

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John P. Kelly; James O. Phillips; Russell P. Saneto; Hedieh Khalatbari; Andrew Poliakov; Kristina Tarczy-Hornoch; Avery H. Weiss
TAGS: brain, cortical blindness, evoked potentials, visual, magnetic resonance imaging, pathophysiology, visual impairment, white matter, child, eye movement, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):15. doi: https://doi.org/10.1167/iovs.62.6.15

Includes: Supplemental Content

Clinical and Epidemiologic Research May 2021

Swept-Source OCT Angiographic Characteristics of Treatment-Naïve Nonexudative Macular Neovascularization in AMD Prior to Exudation

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Mengxi Shen; Qinqin Zhang; Jin Yang; Hao Zhou; Zhongdi Chu; Xiao Zhou; William Feuer; Xiaoshuang Jiang; Yingying Shi; Luis de Sisternes; Mary K. Durbin; Ruikang K. Wang; Giovanni Gregori; Philip J. Rosenfeld
TAGS: angiogram, chief complaint, eye, fluid flow, neovascularization, pathologic, ventricular septal defect, volume, cortical blindness, face, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):14. doi: https://doi.org/10.1167/iovs.62.6.14

Biochemistry and Molecular Biology May 2021

In Vivo Molecular Changes in the Retina of Patients With Multiple Sclerosis

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Salut Alba-Arbalat; Magi Andorra; Bernardo Sanchez-Dalmau; Anna Camos-Carreras; Marina Dotti-Boada; Irene Pulido-Valdeolivas; Sara Llufriu; Yolanda Blanco; Maria Sepulveda; Albert Saiz; Oscar Batet; Iker Bilbao; Iratxe Torre; Ivan Amat-Roldan; Elena H. Martinez-Lapiscina; Pablo Villoslada
TAGS: molecule, multiple sclerosis, retina, spectrum analysis, raman
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):11. doi: https://doi.org/10.1167/iovs.62.6.11

Includes: Supplemental Content

Cornea May 2021

Bilateral Limbal Stem Cell Alterations in Patients With Unilateral Herpes Simplex Keratitis and Herpes Zoster Ophthalmicus as Shown by In Vivo Confocal Microscopy

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Xintian Liu; Shuo Xu; Yingbin Wang; Xin Jin; Yan Shi; Hong Zhang
TAGS: atypical, cornea, epithelial cells, eye, herpes zoster ophthalmicus, keratitis, herpetic, microscopy, confocal, neurons, stem cells, nose
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):12. doi: https://doi.org/10.1167/iovs.62.6.12

Retina May 2021

Relationship Between Optical Coherence Tomography Parameter and Visual Function in Eyes With Epiretinal Membrane

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Ayaka Murase; Ryo Asaoka; Tatsuya Inoue; Koichi Nagura; Rei Arasaki; Kentaro Nakamura; Kazuyoshi Okawa; Shin Tanaka; Yasuo Yanagi; Maiko Maruyama-Inoue; Kazuaki Kadonosono
TAGS: epiretinal membrane, eye, metamorphopsias, optical coherence tomography, vision, linear regression
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):6. doi: https://doi.org/10.1167/iovs.62.6.6

Clinical and Epidemiologic Research May 2021

Small Nerve Fiber Damage and Langerhans Cells in Type 1 and Type 2 Diabetes and LADA Measured by Corneal Confocal Microscopy

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Luca D'Onofrio; Alise Kalteniece; Maryam Ferdousi; Shazli Azmi; Ioannis N. Petropoulos; Georgios Ponirakis; Uazman Alam; Omar Asghar; Andrew Marshall; Andrew J.M. Boulton; Nathan Efron; Raffaella Buzzetti; Handrean Soran; Rayaz A. Malik
TAGS: anterior descending branch of left coronary artery, cornea, diabetes mellitus, type 2, langerhans cell, microscopy, confocal, nerve fibers, neurons, nervousness
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):5. doi: https://doi.org/10.1167/iovs.62.6.5

Visual Neuroscience April 2021

Correlations Between Dark-Adapted Rod Threshold Elevations and ERG Response Deficits in Duchenne Muscular Dystrophy

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Mirella Telles Salgueiro Barboni; Sarah Leonardo Dias; Leonardo Aparecido Silva; Francisco Max Damico; Kallene Summer Vidal; Marcelo Fernandes Costa; Balázs Vince Nagy; Jan Kremers; Dora Fix Ventura
TAGS: duchenne's muscular dystrophy, electroretinography, rod photoreceptors, dark adaptation, retinal cone
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):29. doi: https://doi.org/10.1167/iovs.62.4.29

Includes: Supplemental Content

Glaucoma April 2021

Posture-Dependent Collapse of the Optic Nerve Subarachnoid Space: A Combined MRI and Modeling Study

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Petter Holmlund; Karen-Helene Støverud; Anders Wåhlin; Urban Wiklund; Jan Malm; Gauti Jóhannesson; Anders Eklund
TAGS: magnetic resonance imaging, optic nerve, posture, subarachnoid space
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):26. doi: https://doi.org/10.1167/iovs.62.4.26

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging April 2021

Early Identification of Retinal Neuropathy in Subclinical Diabetic Eyes by Reduced Birefringence of the Peripapillary Retinal Nerve Fiber Layer

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Andreas Pollreisz; Sylvia Desissaire; Aleksandra Sedova; Dorottya Hajdu; Felix Datlinger; Florian Schwarzhans; Stefan Steiner; Irene Steiner; Clemens Vass; Christoph K. Hitzenberger; Michael Pircher; Ursula Schmidt-Erfurth
TAGS: birefringence, diabetes mellitus, early diagnosis, eye, neuropathy, retinal nerve fiber layer, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):24. doi: https://doi.org/10.1167/iovs.62.4.24

Retinal Cell Biology April 2021

Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors

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Yi Chen; Binxin Wu; Jian Feng He; Jingyao Chen; Zi Wei Kang; Dandan Liu; Junjie Luo; Kexin Fang; Xiaoxu Leng; Haibin Tian; Jingying Xu; Caixia Jin; Jieping Zhang; Juan Wang; Jingfa Zhang; Qingjian Ou; Lixia Lu; Furong Gao; Guo-Tong Xu
TAGS: epithelial to mesenchymal transition, retinal pigment cell, signal transduction inhibitor, primary eosinophilic endomyocardial cardiomyopathy
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):21. doi: https://doi.org/10.1167/iovs.62.4.21

Includes: Supplemental Content

Letters to the Editor April 2021

Author Response: Surface Area of the Exposed Eye

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Ben J. Glasgow
TAGS: eye
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):19. doi: https://doi.org/10.1167/iovs.62.4.19

Retina April 2021

Subretinal Rather Than Intravitreal Adeno-Associated Virus–Mediated Delivery of a Complement Alternative Pathway Inhibitor Is Effective in a Mouse Model of RPE Damage

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Balasubramaniam Annamalai; Nathaniel Parsons; Crystal Nicholson; Elisabeth Obert; Bryan Jones; Bärbel Rohrer
TAGS: complement system proteins, familial hypercholesterolemia, family history, mice, adeno-associated virus
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):11. doi: https://doi.org/10.1167/iovs.62.4.11

Glaucoma April 2021

Longitudinal Observation of Border Tissue Configuration During Axial Elongation in Childhood

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Yong Woo Kim; Jin Ju Choi; Michael J. A. Girard; Jean Martial Mari; Dong Gyu Choi; Ki Ho Park
TAGS: body tissue, child, eye, nose
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):10. doi: https://doi.org/10.1167/iovs.62.4.10

Includes: Multimedia, Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology March 2021

Macular Microvasculature and Associated Retinal Layer Thickness in Pediatric Amblyopia: Magnification-Corrected Analyses

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Noriko Nishikawa; Jacqueline Chua; Yuriya Kawaguchi; Tomoko Ro-Mase; Leopold Schmetterer; Yasuo Yanagi; Akitoshi Yoshida
TAGS: amblyopia, amblyopia, pediatric, macular vasculature, magnification, eye
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):39. doi: https://doi.org/10.1167/iovs.62.3.39

Includes: Supplemental Content

Retina March 2021

Association of Near-Infrared and Short-Wavelength Autofluorescence With the Retinal Sensitivity in Eyes With Resolved Central Serous Chorioretinopathy

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Hirotsugu Soga; Ryo Asaoka; Kazuaki Kadonosono; Maiko Maruyama-Inoue; Nozomi Igarashi; Marie Kitano; Kohdai Kitamoto; Keiko Azuma; Ryo Obata; Tatsuya Inoue
TAGS: autofluorescence, central serous chorioretinopathy, eye, perimetry, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):36. doi: https://doi.org/10.1167/iovs.62.3.36

Retina March 2021

Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime

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Eric Seifert; Svenja Rebecca Sonntag; Philipp Kleingarn; Dirk Theisen-Kunde; Salvatore Grisanti; Reginald Birngruber; Yoko Miura; Ralf Brinkmann
TAGS: lasers, pigment, epithelium, cell injury
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):32. doi: https://doi.org/10.1167/iovs.62.3.32

Visual Neuroscience March 2021

Altered Visual Function in a Larval Zebrafish Knockout of Neurodevelopmental Risk Gene pdzk1

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Jiaheng Xie; Patricia R. Jusuf; Bang V. Bui; Stefanie Dudczig; Tamar E. Sztal; Patrick T. Goodbourn
TAGS: electroretinography, genes, genetics, larva, spatial frequency, vision, zebrafish, serotonin, depression, post-stroke, persistent speech disorders
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):29. doi: https://doi.org/10.1167/iovs.62.3.29

Includes: Supplemental Content

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Age-Related Retinal Changes in Wild-Type C57BL/6J Mice Between 2 and 32 Months

Elavl2 Regulates Retinal Function Via Modulating the Differentiation of Amacrine Cells Subtype

Correcting QUEST Magnetic Resonance Imaging–Sensitive Free Radical Production in the Outer Retina In Vivo Does Not Correct Reduced Visual Performance in 24-Month-Old C57BL/6J Mice

Cerebral Visual Impairment Characterized by Abnormal Visual Orienting Behavior With Preserved Visual Cortical Activation

Swept-Source OCT Angiographic Characteristics of Treatment-Naïve Nonexudative Macular Neovascularization in AMD Prior to Exudation

In Vivo Molecular Changes in the Retina of Patients With Multiple Sclerosis

Bilateral Limbal Stem Cell Alterations in Patients With Unilateral Herpes Simplex Keratitis and Herpes Zoster Ophthalmicus as Shown by In Vivo Confocal Microscopy

Relationship Between Optical Coherence Tomography Parameter and Visual Function in Eyes With Epiretinal Membrane

Small Nerve Fiber Damage and Langerhans Cells in Type 1 and Type 2 Diabetes and LADA Measured by Corneal Confocal Microscopy

Correlations Between Dark-Adapted Rod Threshold Elevations and ERG Response Deficits in Duchenne Muscular Dystrophy

Posture-Dependent Collapse of the Optic Nerve Subarachnoid Space: A Combined MRI and Modeling Study

Early Identification of Retinal Neuropathy in Subclinical Diabetic Eyes by Reduced Birefringence of the Peripapillary Retinal Nerve Fiber Layer

Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors

Author Response: Surface Area of the Exposed Eye

Subretinal Rather Than Intravitreal Adeno-Associated Virus–Mediated Delivery of a Complement Alternative Pathway Inhibitor Is Effective in a Mouse Model of RPE Damage

Longitudinal Observation of Border Tissue Configuration During Axial Elongation in Childhood

Macular Microvasculature and Associated Retinal Layer Thickness in Pediatric Amblyopia: Magnification-Corrected Analyses

Association of Near-Infrared and Short-Wavelength Autofluorescence With the Retinal Sensitivity in Eyes With Resolved Central Serous Chorioretinopathy

Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime

Altered Visual Function in a Larval Zebrafish Knockout of Neurodevelopmental Risk Gene pdzk1

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