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Lens May 2025

LncRNA HOTAIR Interaction With WTAP Promotes m 6 A Methyltransferase Complex Assembly and Posterior Capsule Opacification Formation by Increasing THBS1

PDF

Xi Chen; Chenshuang Li; Jiankui Li; Zaoxia Guo; Siqi Zhang; Chenjun Guo; Hong Yan
TAGS: after-cataract, epithelial to mesenchymal transition, methyltransferase, proteins, rna, thrombospondin 1, western blotting, protein overexpression, polymerase chain reaction, cataract surgery
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):20. https://doi.org/10.1167/iovs.66.5.20

Includes: Supplemental Content

Lens May 2025

Cholesterol and Q147E Deamidation Modulates αA-Crystallin Membrane Binding Elucidating Protective Role of Lens Membrane Composition Changes With Aging

PDF

Preston Hazen; Nawal K. Khadka; Laxman Mainali
TAGS: crystallins, lens (device), lens, crystalline, tissue membrane, cholesterol, aging, lipids
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):8. https://doi.org/10.1167/iovs.66.5.8

Clinical and Epidemiologic Research May 2025

Three-Year Change in Subfoveal Choroidal Thickness and Area With Multifocal Contact Lens Wear in the Bifocal Lenses in Nearsighted Kids (BLINK) Study

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Maria K. Walker; David A. Berntsen; Matt L. Robich; Rachel L. Fenton; Anita Ticak; Justina R. Assaad; Hope M. Queener; Stephanie J. Chiu; Sina Farsiu; Donald O. Mutti; Lisa A. Jones-Jordan; Jeffrey J. Walline; for the BLINK Study Group
TAGS: child, choroid, contact lenses, lens (device), lens, crystalline, myopia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):5. https://doi.org/10.1167/iovs.66.5.5

Includes: Supplemental Content

Lens May 2025

RNA-Seq Study of Human Lens Epithelial Cells: Differentially Expressed Genes and Pathways in Steroid, Uveitic, Post-Vitrectomy, and Senile Cataracts

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Carrie Fei; Michael R. Dong; Sean Byars; Jaynish S. Shah; Anthony J. Hall; Lyndell L. Lim
TAGS: after-cataract, cataract, cataract, senile, epithelial cells, genes, lens, crystalline, rna-seq, steroids, vitrectomy, rna
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):4. https://doi.org/10.1167/iovs.66.5.4

Includes: Supplemental Content

Lens April 2025

Macrophage-Hosted Porphyromonas gingivalis Is a Risk Factor for Cataract Development

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Dongzhe Zhang; Junwei Qu; Cuncun Ke; Xiumei Kong; Mengyun Liu; Iqbal Nawaz Khan; Shuxin Huang; Haijiao Tian; Tong Xie; Ke Qiu; Jing Li; Mingli Wang; Hui Li; Fengling Yuan; Weikai Guo; Mingya Cao; Jing Zhang; Keke Zhu; Jin Luo; Fengyan Zhang; Xiukun Cui; Hongmei Mu; Yanzhong Hu
TAGS: body tissue, cataract, epithelium, infections, lens (device), macrophages, risk factors, porphyromonas gingivalis, hypertension, lens, crystalline
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):68. https://doi.org/10.1167/iovs.66.4.68

Includes: Supplemental Content

Lens April 2025

Transcriptome Meta-Analysis Uncovers Cell-Specific Regulatory Relationships in Embryonic, Juvenile, Adult, and Aged Mouse Lens Epithelium and Fibers

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Matthieu Duot; Sarah Y. Coomson; Sanjaya K. Shrestha; M. V. Murali Krishna Nagulla; Yann Audic; Ruteja A. Barve; Hongzhan Huang; Carole Gautier-Courteille; Luc Paillard; Salil A. Lachke
TAGS: datasets, embryo, epithelium, genes, lens epithelium, meta-analysis, mice, lens (device), lens, crystalline, adult
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):42. https://doi.org/10.1167/iovs.66.4.42

Includes: Supplemental Content

Lens April 2025

Elevated Inflammatory Cytokines Persist in the Aqueous Humor Years After Cataract Surgery

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Caili Hao; Emily Fan; Zongbo Wei; Kazi Rafsan Radeen; Neha Purohit; Kailin Li; Sharad Purohit; Xingjun Fan
TAGS: cataract, cataract surgery, chronic inflammation, cytokine, hypertension, surgical procedures, operative, aqueous humor, surgery specialty, donors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):12. https://doi.org/10.1167/iovs.66.4.12

Includes: Supplemental Content

Lens April 2025

In Vivo Brillouin Analysis of Lens Nucleus and Cortex in Adult Myopic Eyes and Their Correlation With Accommodation

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Le Chang; Fen Song; Shijia Qu; Huazheng Cao; Yanan Wu; Lulu Xu; Jing Wang; Ruirui Zhang; Chao Xue; Yan Wang
TAGS: cell nucleus, eye, lens (device), lens, crystalline, myopia, visual accommodation, adult, regression analysis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):6. https://doi.org/10.1167/iovs.66.4.6

Includes: Supplemental Content

Anatomy and Pathology/Oncology March 2025

Lens Thickness-to-Anterior Chamber Depth Ratio: A Biometric Determinant of Chamber Angle Width in Han Chinese Cataract Patients

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Ao Miao; Fan Yang; Tianhui Chen; Dongjin Qian; Yongxiang Jiang; Jie Xu; Tianyu Zheng
TAGS: anterior chamber of eye, biometry, cataract, chinese (other dialects), chinese people, lens (device), lens, crystalline, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):42. https://doi.org/10.1167/iovs.66.3.42

Visual Psychophysics and Physiological Optics March 2025

Age-Related Changes in Mesopic Reading Vision Across Adulthood

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Boris Peñaloza; Traci-Lin Goddin; David S. Friedman; Cynthia Owsley; MiYoung Kwon
TAGS: reading (activity), vision, adult
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):40. https://doi.org/10.1167/iovs.66.3.40

Lens March 2025

Changes in Lens Thickness and Power Before and After Myopia Onset

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Jiaqing Zhang; Ling Jin; Qianyun Chen; Decai Wang; Xiang Chen; Yuting Li; Yabin Qu; Rong Lin; Mingguang He; Ian G. Morgan; Lixia Luo; Yangfa Zeng; Xiaotong Han
TAGS: lens, crystalline, myopia, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):36. https://doi.org/10.1167/iovs.66.3.36

Includes: Supplemental Content

Cornea March 2025

A Novel Model for Cornea Power Shift in Eyes Wearing Orthokeratology Lenses With Different Back Optic Zone Diameters for Myopia Control

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Ting Wang; Xiaoqin Chen; Mengdi Li; Hua Bi; Xiaoyan Yang; Muhan Sun; Yue Liu; Lihua Li; Bin Zhang
TAGS: cornea, eye, lens (device), lens, crystalline, myopia, orthokeratology contact lenses, optics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):29. https://doi.org/10.1167/iovs.66.3.29

Includes: Supplemental Content

Genetics March 2025

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

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Qiu-Yi Huo; Rui-Zheng Zhang; Wan-Nan Jia; Ya-Lei Wang; Xin Shen; Xin-Yao Chen; Tian-Hui Chen; Yan Liu; Ling-Hao Song; Xinyue Wang; Yong Lv; Ze-Xu Chen; Yong-Xiang Jiang
TAGS: biomechanics, cornea, ectopia lentis, fibrillin-1, marfan syndrome, mutation, genotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):23. https://doi.org/10.1167/iovs.66.3.23

Includes: Supplemental Content

Lens February 2025

Depth and Strain-Dependent Structural Responses of Mouse Lens Fiber Cells During Whole Lens Shape Changes

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Sepideh Cheheltani; Mahbubul H. Shihan; Justin Parreno; Sondip K. Biswas; Woo-Kuen Lo; Velia M. Fowler
TAGS: lens (device), lens, crystalline, shape, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):53. https://doi.org/10.1167/iovs.66.2.53

Includes: Supplemental Content

Clinical and Epidemiologic Research February 2025

Peripheral Refraction and Axial Growth Rate After Multifocal or Monofocal Intraocular Lens Implantation in Chinese Pediatric Cataract Patients

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Qiuxuan Du; Ying Zhang; Yusen Huang
TAGS: cataract, cataract, childhood, chinese (other dialects), chinese people, eye, growth rate, intraocular lens implantation procedure, multifocal intraocular lenses, refraction, surgical procedures, operative
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):33. https://doi.org/10.1167/iovs.66.2.33

Cornea February 2025

Contact Lens Wear Alters Transcriptional Responses to Pseudomonas aeruginosa in Both the Corneal Epithelium and the Bacteria

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Naren Gajenthra Kumar; Melinda R. Grosser; Stephanie Wan; Daniel Schator; Eugene Ahn; Eric Jedel; Vincent Nieto; David J. Evans; Suzanne M. J. Fleiszig
TAGS: bacteria, contact lenses, cornea, corneal epithelium, genes, lens (device), lens, crystalline, pseudomonas aeruginosa, transcription, genetic, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):31. https://doi.org/10.1167/iovs.66.2.31

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics January 2025

Dynamic Accommodation Responses in Subjects Wearing Myopia Control Spectacles Modifying Peripheral Refraction

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Zhenghua Lin; Dimitrios Christaras; Raul Duarte-Toledo; Zhikuan Yang; Augusto Arias; Weizhong Lan; Pablo Artal
TAGS: eyeglasses, myopia, optics, refraction, visual accommodation, lens (device), lens, crystalline
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):55. https://doi.org/10.1167/iovs.66.1.55

Lens January 2025

Influence of Lens Power on IOL/Posterior Lens Capsule Interactions and IOL's PCO Potential

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Amjad Chatila; Vicki Ea; Samira Izuagbe; Le Quynh Hoang; Bhavya Vaish; Cynthia M. Co; Trinh M. Luong; Liping Tang
TAGS: adhesions, diopters, incidence, lens (device), lens capsule, crystalline, lens, crystalline, myopia, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):41. https://doi.org/10.1167/iovs.66.1.41

Includes: Supplemental Content

Physiology and Pharmacology January 2025

Broadband Long Wavelength Light Promotes Myopic Eye Growth and Alters Retinal Responses to Light Offset in Chick

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Nina Riddell; Melanie J. Murphy; Sania Zahra; Isabella Robertson-Dixon; Sheila G. Crewther
TAGS: eye, lens (device), lens, crystalline, myopia, white light, blue light, refraction, photopsia, electroretinography, weight gain
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):30. https://doi.org/10.1167/iovs.66.1.30

Includes: Supplemental Content

Lens January 2025

Targeted Activation of OGG1 Inhibits Paraptosis in Lens Epithelial Cells of Early Age-Related Cortical Cataract

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Wenjing Geng; Pengfei Li; Guowei Zhang; Renhao Zhong; Linhui Xu; Lihua Kang; Xi Liu; Miaomiao Wu; Min Ji; Huaijin Guan
TAGS: cataract, cortical cataract, paraptosis, lens, crystalline, lens epithelial cell, lens (device)
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):29. https://doi.org/10.1167/iovs.66.1.29

Includes: Supplemental Content

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LncRNA HOTAIR Interaction With WTAP Promotes m 6 A Methyltransferase Complex Assembly and Posterior Capsule Opacification Formation by Increasing THBS1

Cholesterol and Q147E Deamidation Modulates αA-Crystallin Membrane Binding Elucidating Protective Role of Lens Membrane Composition Changes With Aging

Three-Year Change in Subfoveal Choroidal Thickness and Area With Multifocal Contact Lens Wear in the Bifocal Lenses in Nearsighted Kids (BLINK) Study

RNA-Seq Study of Human Lens Epithelial Cells: Differentially Expressed Genes and Pathways in Steroid, Uveitic, Post-Vitrectomy, and Senile Cataracts

Macrophage-Hosted Porphyromonas gingivalis Is a Risk Factor for Cataract Development

Transcriptome Meta-Analysis Uncovers Cell-Specific Regulatory Relationships in Embryonic, Juvenile, Adult, and Aged Mouse Lens Epithelium and Fibers

Elevated Inflammatory Cytokines Persist in the Aqueous Humor Years After Cataract Surgery

In Vivo Brillouin Analysis of Lens Nucleus and Cortex in Adult Myopic Eyes and Their Correlation With Accommodation

Lens Thickness-to-Anterior Chamber Depth Ratio: A Biometric Determinant of Chamber Angle Width in Han Chinese Cataract Patients

Age-Related Changes in Mesopic Reading Vision Across Adulthood

Changes in Lens Thickness and Power Before and After Myopia Onset

A Novel Model for Cornea Power Shift in Eyes Wearing Orthokeratology Lenses With Different Back Optic Zone Diameters for Myopia Control

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

Depth and Strain-Dependent Structural Responses of Mouse Lens Fiber Cells During Whole Lens Shape Changes

Peripheral Refraction and Axial Growth Rate After Multifocal or Monofocal Intraocular Lens Implantation in Chinese Pediatric Cataract Patients

Contact Lens Wear Alters Transcriptional Responses to Pseudomonas aeruginosa in Both the Corneal Epithelium and the Bacteria

Dynamic Accommodation Responses in Subjects Wearing Myopia Control Spectacles Modifying Peripheral Refraction

Influence of Lens Power on IOL/Posterior Lens Capsule Interactions and IOL's PCO Potential

Broadband Long Wavelength Light Promotes Myopic Eye Growth and Alters Retinal Responses to Light Offset in Chick

Targeted Activation of OGG1 Inhibits Paraptosis in Lens Epithelial Cells of Early Age-Related Cortical Cataract

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