Nanotechnology and Regenerative Medicine

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Biochemistry and Molecular Biology July 2020

Glycogen Synthase Kinase-3β Mediates Proinflammatory Cytokine Secretion and Adipogenesis in Orbital Fibroblasts from Patients with Graves’ Orbitopathy

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Jihei Sara Lee; Min Kyoung Chae; Don O. Kikkawa; Eun Jig Lee; Jin Sook Yoon
TAGS: cytokine, fibroblasts, glycogen (starch) synthase, phosphotransferases, bodily secretions, body tissue, adipocytes
Invest. Ophthalmol. Vis. Sci.. 2020; 61(8):51. doi: https://doi.org/10.1167/iovs.61.8.51

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology July 2020

Retinoic Acid Potentiates Orbital Tissues for Inflammation Through NF-κB and MCP-1

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Shelby P. Unsworth; Curtis J. Heisel; Christina F. Tingle; Niharika Rajesh; Phillip E. Kish; Alon Kahana
TAGS: inflammation, monocyte chemoattractant protein-1, orbital infections, inflammations and irritations, retinoids, tretinoin, body tissue, fibroblasts
Invest. Ophthalmol. Vis. Sci.. 2020; 61(8):17. doi: https://doi.org/10.1167/iovs.61.8.17

Includes: Supplemental Content

Retina July 2020

Combined Transplantation With Human Mesenchymal Stem Cells Improves Retinal Rescue Effect of Human Fetal RPE Cells in Retinal Degeneration Mouse Model

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Ting Pan; Han Shen; Songtao Yuan; Guohua Lu; Yi Zhang; Hanxue Wang; Yazhi Zhao; Xincheng Sun; Qinghuai Liu
TAGS: cell transplantation, fetus, mice, retinal degeneration, retinal pigment cell, sinus histiocytosis, stem cell, mesenchymal, transplantation, dirty bombs, erg protein, human
Invest. Ophthalmol. Vis. Sci.. 2020; 61(8):9. doi: https://doi.org/10.1167/iovs.61.8.9

Includes: Supplemental Content

Glaucoma June 2020

Prostaglandin F2α Agonists Negatively Modulate the Size of 3D Organoids from Primary Human Orbital Fibroblasts

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Kaku Itoh; Fumihito Hikage; Yosuke Ida; Hiroshi Ohguro
TAGS: agonists, fibroblasts, organoids, prostaglandins, prostaglandins, synthetic
Invest. Ophthalmol. Vis. Sci.. 2020; 61(6):13. doi: https://doi.org/10.1167/iovs.61.6.13

Includes: Supplemental Content

Biochemistry and Molecular Biology May 2020

Gypenosides Protect Orbital Fibroblasts in Graves Ophthalmopathy via Anti-Inflammation and Anti-Fibrosis Effects

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Haoyu Li; Chao Ma; Wei Liu; Jianfeng He; Kaijun Li
TAGS: fibroblasts, fibrosis, graves' ophthalmopathy, inflammation
Invest. Ophthalmol. Vis. Sci.. 2020; 61(5):64. doi: https://doi.org/10.1167/iovs.61.5.64

Includes: Supplemental Content

Cornea May 2020

Agrin Promotes Limbal Stem Cell Proliferation and Corneal Wound Healing Through Hippo-Yap Signaling Pathway

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Lulu Hou; Wenbin Fu; Ying Liu; Qun Wang; Liqiang Wang; Yifei Huang
TAGS: agrin, cornea, stem cells, wound healing, signal pathway, signal transduction pathways
Invest. Ophthalmol. Vis. Sci.. 2020; 61(5):7. doi: https://doi.org/10.1167/iovs.61.5.7

Biochemistry and Molecular Biology March 2020

Therapeutic Effect of Guggulsterone in Primary Cultured Orbital Fibroblasts Obtained From Patients with Graves’ Orbitopathy

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Bo Ram Kim; Jinjoo Kim; Jong Eun Lee; Eun Jig Lee; Jin Sook Yoon
TAGS: fibroblasts, hyaluronan
Invest. Ophthalmol. Vis. Sci.. 2020; 61(3):39. doi: https://doi.org/10.1167/iovs.61.3.39

Includes: Supplemental Content

Retina February 2020

Inhibition of mTOR via an AAV-Delivered shRNA Tested in a Rat OIR Model as a Potential Antiangiogenic Gene Therapy

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Steven Hyun Seung Lee; HeeSoon Chang; Ji Hyun Kim; Hee Jong Kim; Jun-Sub Choi; Sunho Chung; Ha-Na Woo; Kyoung Jin Lee; Keerang Park; Joo Yong Lee; Heuiran Lee
TAGS: angiogenesis inhibitors, gene therapy, mtor serine-threonine kinases, retinal neovascularization, spatial vectors, viruses
Invest. Ophthalmol. Vis. Sci.. 2020; 61(2):45. doi: https://doi.org/10.1167/iovs.61.2.45

Biochemistry and Molecular Biology February 2020

Characteristics of Hyaluronan Synthesis Inhibition by 4-Methylumbelliferone in Orbital Fibroblasts

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Erika Galgoczi; Florence Jeney; Monika Katko; Annamaria Erdei; Annamaria Gazdag; Livia Sira; Miklos Bodor; Eszter Berta; Bernadett Ujhelyi; Zita Steiber; Ferenc Gyory; Endre V. Nagy
TAGS: fibroblasts, hyaluronan, hymecromone
Invest. Ophthalmol. Vis. Sci.. 2020; 61(2):27. doi: https://doi.org/10.1167/iovs.61.2.27

Review February 2020

Fibrocytes, Wound Healing, and Corneal Fibrosis

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Rodrigo Carlos de Oliveira; Steven E. Wilson
TAGS: cicatrix, cornea, fibrosis, wound healing, wounds and injuries, myofibroblasts, body tissue
Invest. Ophthalmol. Vis. Sci.. 2020; 61(2):28. doi: https://doi.org/10.1167/iovs.61.2.28

Cornea January 2020

Development of Transparent Acellular Dermal Matrix as Tissue-Engineered Stroma Substitute for Central Lamellar Keratoplasty

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Yuexin Wang; Jiahui Ma; Xiaodan Jiang; Ziyuan Liu; Jiarui Yang; Xuemin Li
TAGS: body tissue, cornea, keratoplasty, transparency, tissue transplants, collagen, transplantation, postoperative care
Invest. Ophthalmol. Vis. Sci.. 2020; 61(1):5. doi: https://doi.org/10.1167/iovs.61.1.5

Biochemistry and Molecular Biology November 2019

Antifibrotic Effects of Sakuraso-Saponin in Primary Cultured Pterygium Fibroblasts in Comparison With Mitomycin C

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Hun Lee; Hana Jeong; Chang Mok Lee; Jin-A Shin; Sung-Wuk Jang; Jae Hyuck Lee; So Young Park; Jae Yong Kim; Hungwon Tchah
TAGS: fibroblasts, hpfs trial, mitomycin, pterygium, cell motility, recurrence
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4784-4791. doi: https://doi.org/10.1167/iovs.19-27153

Biochemistry and Molecular Biology November 2019

P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts

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Minhong Xiang; Lijuan Mo; Yueping Zhan; Hang Wen; Huanming Zhou; Wanhong Miao
TAGS: cell aging, conjunctivochalasis, fibroblasts, signal transduction, mitogen-activated protein kinases, conjunctiva, body tissue
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4643-4651. doi: https://doi.org/10.1167/iovs.19-27617

Includes: Supplemental Content

Biochemistry and Molecular Biology October 2019

TSHR Signaling Stimulates Proliferation Through PI3K/Akt and Induction of miR-146a and miR-155 in Thyroid Eye Disease Orbital Fibroblasts

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Collynn F. Woeller; Elisa Roztocil; Christine Hammond; Steven E. Feldon
TAGS: micrornas, phosphoinositide 3-kinase, proto-oncogene proteins c-akt, signal transduction, thyrotropin, thyrotropin receptor, fibroblasts, graves' ophthalmopathy
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4336-4345. doi: https://doi.org/10.1167/iovs.19-27865

Cornea October 2019

Stimulation of Phagocytic Activity in Cultured Human Corneal Fibroblasts by Plasminogen

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Tomoko Sato; Koji Sugioka; Aya Kodama-Takahashi; Junko Murakami; Akio Saito; Hiroshi Mishima; Teruo Nishida; Shunji Kusaka
TAGS: cornea, fibroblasts, plasminogen, phagocytosis, cell-derived microparticles
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4205-4214. doi: https://doi.org/10.1167/iovs.19-27736

Biochemistry and Molecular Biology October 2019

Therapeutic Effect of Curcumin, a Plant Polyphenol Extracted From Curcuma longae , in Fibroblasts From Patients With Graves' Orbitopathy

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Jihei Sara Lee; Jinjoo Kim; Eun Jig Lee; Jin Sook Yoon
TAGS: curcumin, fibroblasts, polyphenols, plants
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4129-4140. doi: https://doi.org/10.1167/iovs.19-27376

Physiology and Pharmacology September 2019

In Vivo Fluorescence Visualization of Anterior Chamber Injected Human Corneal Endothelial Cells Labeled With Quantum Dots

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Munetoyo Toda; Hiroshi Yukawa; Jun Yamada; Morio Ueno; Shigeru Kinoshita; Yoshinobu Baba; Junji Hamuro
TAGS: anterior chamber of eye, cornea, endothelial cells, eye, fluorescence, mice, quantum dots, diagnostic imaging, injections
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):4008-4020. doi: https://doi.org/10.1167/iovs.19-27788

Includes: Supplemental Content

Cornea September 2019

Effects of Amniotic Membrane–Derived Fibroblast Supernatant on Corneal Epithelium

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Kazunari Higa; Junko Higuchi; Reona Kimoto; Yoshiyuki Satake; Takefumi Yamaguchi; Daisuke Tomida; Jun Shimazaki
TAGS: amnion, cornea, corneal epithelium, epithelium, fibroblasts, wound healing, oryctolagus cuniculus, antibodies, flow cytometry
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3718-3726. doi: https://doi.org/10.1167/iovs.19-27041

Cornea August 2019

Induction of Fibroblast Senescence During Mouse Corneal Wound Healing

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Xiaolei Wang; Mingli Qu; Jing Li; Patrik Danielson; Lingling Yang; Qingjun Zhou
TAGS: aging, cornea, fibroblasts, mice, wound healing, myofibroblasts
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3669-3679. doi: https://doi.org/10.1167/iovs.19-26983

Includes: Supplemental Content

Retina August 2019

Rescue of M-cone Function in Aged Opn1mw −/− Mice, a Model for Late-Stage Blue Cone Monochromacy

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Wen-Tao Deng; Jie Li; Ping Zhu; Beau Freedman; W. Clay Smith; Wolfgang Baehr; William W. Hauswirth
TAGS: gene therapy, mice, retinal cone, opsin
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3644-3651. doi: https://doi.org/10.1167/iovs.19-27079

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Glycogen Synthase Kinase-3β Mediates Proinflammatory Cytokine Secretion and Adipogenesis in Orbital Fibroblasts from Patients with Graves’ Orbitopathy

Retinoic Acid Potentiates Orbital Tissues for Inflammation Through NF-κB and MCP-1

Combined Transplantation With Human Mesenchymal Stem Cells Improves Retinal Rescue Effect of Human Fetal RPE Cells in Retinal Degeneration Mouse Model

Prostaglandin F2α Agonists Negatively Modulate the Size of 3D Organoids from Primary Human Orbital Fibroblasts

Gypenosides Protect Orbital Fibroblasts in Graves Ophthalmopathy via Anti-Inflammation and Anti-Fibrosis Effects

Agrin Promotes Limbal Stem Cell Proliferation and Corneal Wound Healing Through Hippo-Yap Signaling Pathway

Therapeutic Effect of Guggulsterone in Primary Cultured Orbital Fibroblasts Obtained From Patients with Graves’ Orbitopathy

Inhibition of mTOR via an AAV-Delivered shRNA Tested in a Rat OIR Model as a Potential Antiangiogenic Gene Therapy

Characteristics of Hyaluronan Synthesis Inhibition by 4-Methylumbelliferone in Orbital Fibroblasts

Fibrocytes, Wound Healing, and Corneal Fibrosis

Development of Transparent Acellular Dermal Matrix as Tissue-Engineered Stroma Substitute for Central Lamellar Keratoplasty

Antifibrotic Effects of Sakuraso-Saponin in Primary Cultured Pterygium Fibroblasts in Comparison With Mitomycin C

P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts

TSHR Signaling Stimulates Proliferation Through PI3K/Akt and Induction of miR-146a and miR-155 in Thyroid Eye Disease Orbital Fibroblasts

Stimulation of Phagocytic Activity in Cultured Human Corneal Fibroblasts by Plasminogen

Therapeutic Effect of Curcumin, a Plant Polyphenol Extracted From Curcuma longae , in Fibroblasts From Patients With Graves' Orbitopathy

In Vivo Fluorescence Visualization of Anterior Chamber Injected Human Corneal Endothelial Cells Labeled With Quantum Dots

Effects of Amniotic Membrane–Derived Fibroblast Supernatant on Corneal Epithelium

Induction of Fibroblast Senescence During Mouse Corneal Wound Healing

Rescue of M-cone Function in Aged Opn1mw −/− Mice, a Model for Late-Stage Blue Cone Monochromacy

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