Nanotechnology and Regenerative Medicine

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Biochemistry and Molecular Biology October 2019

Therapeutic Effect of Curcumin, a Plant Polyphenol Extracted From Curcuma longae , in Fibroblasts From Patients With Graves' Orbitopathy

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Jihei Sara Lee; Jinjoo Kim; Eun Jig Lee; Jin Sook Yoon
TAGS: curcumin, fibroblasts, polyphenols, plants
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4129-4140. doi: 10.1167/iovs.19-27376

Physiology and Pharmacology September 2019

In Vivo Fluorescence Visualization of Anterior Chamber Injected Human Corneal Endothelial Cells Labeled With Quantum Dots

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Munetoyo Toda; Hiroshi Yukawa; Jun Yamada; Morio Ueno; Shigeru Kinoshita; Yoshinobu Baba; Junji Hamuro
TAGS: anterior chamber of eye, cornea, endothelial cells, eye, fluorescence, mice, quantum dots, diagnostic imaging, injections
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):4008-4020. doi: 10.1167/iovs.19-27788

Includes: Supplemental Content

Cornea September 2019

Effects of Amniotic Membrane–Derived Fibroblast Supernatant on Corneal Epithelium

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Kazunari Higa; Junko Higuchi; Reona Kimoto; Yoshiyuki Satake; Takefumi Yamaguchi; Daisuke Tomida; Jun Shimazaki
TAGS: amnion, cornea, corneal epithelium, epithelium, fibroblasts, wound healing, oryctolagus cuniculus, antibodies, flow cytometry
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3718-3726. doi: 10.1167/iovs.19-27041

Cornea August 2019

Induction of Fibroblast Senescence During Mouse Corneal Wound Healing

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Xiaolei Wang; Mingli Qu; Jing Li; Patrik Danielson; Lingling Yang; Qingjun Zhou
TAGS: aging, cornea, fibroblasts, mice, wound healing, myofibroblasts
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3669-3679. doi: 10.1167/iovs.19-26983

Includes: Supplemental Content

Retina August 2019

Rescue of M-cone Function in Aged Opn1mw −/− Mice, a Model for Late-Stage Blue Cone Monochromacy

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Wen-Tao Deng; Jie Li; Ping Zhu; Beau Freedman; W. Clay Smith; Wolfgang Baehr; William W. Hauswirth
TAGS: gene therapy, mice, retinal cone, opsin
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3644-3651. doi: 10.1167/iovs.19-27079

Cornea August 2019

Small Molecule Modulation of the Integrated Stress Response Governs the Keratoconic Phenotype In Vitro

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Uri Simcha Soiberman; Ahmed Elsayed Mahmoud Shehata; Michelle Xiaoyi Lu; Tempest Young; Yassine J. Daoud; Shukti Chakravarti; Albert S. Jun; James William Foster
TAGS: keratoconus, phenotype, regulation, small molecule, stress response, fibroblasts, proteins, cell count, collagen synthesis, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3422-3431. doi: 10.1167/iovs.19-27151

Includes: Supplemental Content

Cornea July 2019

Modulation of Contact Inhibition by ZO-1/ZONAB Gene Transfer—A New Strategy to Increase the Endothelial Cell Density of Corneal Grafts

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Daniel Kampik; Mark Basche; Anastasios Georgiadis; Ulrich F. O. Luhmann; D. Frank Larkin; Alexander J. Smith; Robin R. Ali
TAGS: contact inhibition, cornea, endothelial cells, endothelium, keratoplasty, gene therapy, gene transfer techniques
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3170-3177. doi: 10.1167/iovs.18-26260

Includes: Supplemental Content

Cornea July 2019

Differentiation Capacity of Human Mesenchymal Stem Cells into Keratocyte Lineage

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Aurelie Dos Santos; Alis Balayan; Martha L. Funderburgh; John Ngo; James L. Funderburgh; Sophie X. Deng
TAGS: keratocytes, stem cell, mesenchymal, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3013-3023. doi: 10.1167/iovs.19-27008

Includes: Supplemental Content

Cornea July 2019

Inhibition by Epigallocatechin Gallate of IL-1–Induced Urokinase-Type Plasminogen Activator Expression and Collagen Degradation by Corneal Fibroblasts

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Koji Sugioka; Koji Yoshida; Junko Murakami; Motoki Itahashi; Hiroshi Mishima; Teruo Nishida; Shunji Kusaka
TAGS: catabolism, collagen, cornea, fibroblasts, urokinase, interleukin-1, plasmin
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):2895-2903. doi: 10.1167/iovs.19-27306

Cornea June 2019

Magnetic Human Corneal Endothelial Cell Transplant: Delivery, Retention, and Short-Term Efficacy

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Xin Xia; Melissa Atkins; Roopa Dalal; Olga Kuzmenko; Kun-Che Chang; Catalina B. Sun; C. Andres Benatti; Dillon J. Rak; Michael Nahmou; Noelia J. Kunzevitzky; Jeffrey L. Goldberg
TAGS: endothelial cells, oryctolagus cuniculus, cornea, transplantation, cell therapy, injections
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2438-2448. doi: 10.1167/iovs.18-26001

Includes: Supplemental Content

Cornea May 2019

MMP14-Containing Exosomes Cleave VEGFR1 and Promote VEGFA-Induced Migration and Proliferation of Vascular Endothelial Cells

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Kyu-Yeon Han; Jin-Hong Chang; Dimitri T. Azar
TAGS: endothelial cells, proteins, exosomes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2321-2329. doi: 10.1167/iovs.18-26277

Immunology and Microbiology April 2019

Mycoplasma Ocular Infection in Subretinal Graft Transplantation of iPS Cells-Derived Retinal Pigment Epithelial Cells

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Kenichi Makabe; Sunao Sugita; Ayumi Hono; Hiroyuki Kamao; Masayo Takahashi
TAGS: cercopithecidae, tissue transplants, mycoplasma, transplantation, retinal pigment cell, idiopathic pneumonia syndrome, mycoplasma infections
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1298-1308. doi: 10.1167/iovs.18-26222

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2019

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

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Kailin Chen; Kairan Lai; Xiaobo Zhang; Zhenwei Qin; Qiuli Fu; Chenqi Luo; Xiuming Jin; Jianghua Hu; Siyu Liu; Ke Yao
TAGS: fibroblasts, conjunctiva, pterygium, proto-oncogene proteins c-akt, bromfenac, hpfs trial
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1156-1164. doi: 10.1167/iovs.18-24743

Includes: Supplemental Content

Cornea February 2019

A Novel Tissue-Engineered Corneal Stromal Equivalent Based on Amniotic Membrane and Keratocytes

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Xin Che; Han Wu; Changkai Jia; Huimin Sun; Shangkun Ou; Junqi Wang; M. Vimalin Jeyalatha; Xin He; Jingwen Yu; Chengyou Zuo; Zuguo Liu; Wei Li
TAGS: amnion, corneal stroma, keratoplasty, body tissue, cornea, central serous chorioretinopathy, keratocytes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):517-527. doi: 10.1167/iovs.18-24869

Includes: Multimedia, Supplemental Content

Glaucoma January 2019

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway

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Yiwen Wang; Deborah Osakue; Enzhi Yang; Yi Zhou; Haiyan Gong; Xiaobo Xia; Yiqin Du
TAGS: stress response, stem cells, endoplasmic reticulum, trabecular meshwork, stress
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):265-273. doi: 10.1167/iovs.18-25477

Includes: Supplemental Content

Biochemistry and Molecular Biology January 2019

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

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Sun Woong Kim; Hye-In Kim; Bikash Thapa; Selikem Nuwromegbe; Keunwook Lee
TAGS: signal transduction, fibroblasts, pterygium, myofibroblasts, proto-oncogene proteins c-akt, hpfs trial, mechanistic target of rapamycin complex 2, mtor serine-threonine kinases
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):82-92. doi: 10.1167/iovs.18-25376

Cornea January 2019

Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro

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Sheyla González; Denise Oh; Elfren R. Baclagon; Jie J. Zheng; Sophie X. Deng
TAGS: signal transduction, stem cells, molecule, small molecule, regulation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):107-112. doi: 10.1167/iovs.18-25740

Retina December 2018

In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode–Based Retinal Prosthesis

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Brandon Bosse; Samir Damle; Abraham Akinin; Yi Jing; Dirk-Uwe Bartsch; Lingyun Cheng; Nicholas Oesch; Yu-Hwa Lo; Gert Cauwenberghs; William R. Freeman
TAGS: evoked potentials, visual, oryctolagus cuniculus, silicon, surgical procedures, operative, retina, implantation procedure, nanowires, implants, prostheses, visual prosthesis
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5885-5892. doi: 10.1167/iovs.18-24554

Special Issue November 2018

Regeneration of Lacrimal Gland Function to Maintain the Health of the Ocular Surface

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Tetsuya Kawakita
TAGS: inflammation, stem cells, epithelium, graft-versus-host disease, cicatrix, dry eye syndromes, health, langer-giedion syndrome, animal model, body tissue
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES169-DES173. doi: 10.1167/iovs.17-23576

Special Issue November 2018

Advances in Functional Restoration of the Lacrimal Glands

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Masatoshi Hirayama
TAGS: stem cells, epithelium, body tissue, transplantation, lacrimal gland, injection therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES174-DES182. doi: 10.1167/iovs.17-23528

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Therapeutic Effect of Curcumin, a Plant Polyphenol Extracted From Curcuma longae , in Fibroblasts From Patients With Graves' Orbitopathy

In Vivo Fluorescence Visualization of Anterior Chamber Injected Human Corneal Endothelial Cells Labeled With Quantum Dots

Effects of Amniotic Membrane–Derived Fibroblast Supernatant on Corneal Epithelium

Induction of Fibroblast Senescence During Mouse Corneal Wound Healing

Rescue of M-cone Function in Aged Opn1mw −/− Mice, a Model for Late-Stage Blue Cone Monochromacy

Small Molecule Modulation of the Integrated Stress Response Governs the Keratoconic Phenotype In Vitro

Modulation of Contact Inhibition by ZO-1/ZONAB Gene Transfer—A New Strategy to Increase the Endothelial Cell Density of Corneal Grafts

Differentiation Capacity of Human Mesenchymal Stem Cells into Keratocyte Lineage

Inhibition by Epigallocatechin Gallate of IL-1–Induced Urokinase-Type Plasminogen Activator Expression and Collagen Degradation by Corneal Fibroblasts

Magnetic Human Corneal Endothelial Cell Transplant: Delivery, Retention, and Short-Term Efficacy

MMP14-Containing Exosomes Cleave VEGFR1 and Promote VEGFA-Induced Migration and Proliferation of Vascular Endothelial Cells

Mycoplasma Ocular Infection in Subretinal Graft Transplantation of iPS Cells-Derived Retinal Pigment Epithelial Cells

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

A Novel Tissue-Engineered Corneal Stromal Equivalent Based on Amniotic Membrane and Keratocytes

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro

In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode–Based Retinal Prosthesis

Regeneration of Lacrimal Gland Function to Maintain the Health of the Ocular Surface

Advances in Functional Restoration of the Lacrimal Glands

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