Nanotechnology and Regenerative Medicine

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Biochemistry and Molecular Biology June 2025

Three-Dimensional Culture of Orbital Fibroblasts From Thyroid Eye Disease Induce In Vivo-Like Tissue Remodeling and Fibrosis

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Xiaoli Bao; Zhihui Xu; Xi Wang; Te Zhang; Huijing Ye; Huasheng Yang
TAGS: body tissue, fibroblasts, fibrosis, graves' ophthalmopathy, tissue remodeling, spheroids, cellular, genes, polymerase chain reaction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):67. https://doi.org/10.1167/iovs.66.6.67

Includes: Supplemental Content

Retina June 2025

Allogenic Transplantation of RPE Strips Lacking MHC Class II Can Avoid Rejection in Nonhuman Primate Eyes

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Atsuta Ozaki; Sunao Sugita; Masaaki Ishida; Mitsuhiro Nishida; Kyoko Iseki; Noriko Sakai; Naoko Hayashi; Takashi Shiina; Satoshi Yokota; Shin-ichiro Ito; Masashi Fujihara; Mineo Kondo; Masayo Takahashi; Yasuo Kurimoto; Michiko Mandai
TAGS: cercopithecidae, eye, genes, mhc class ii, rejection (psychology), transplantation, primates, retinal pigment cell, tissue transplants
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):53. https://doi.org/10.1167/iovs.66.6.53

Includes: Supplemental Content

Genetics June 2025

Investigating the Immunogenic Potential of Variations in Host Cell Protein Levels in Clinical-Grade AAV8 Products

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Immanuel P. Seitz; Eduardo Rodríguez-Bocanegra; Kirsten Bucher; Felix F. Reichel; Stylianos Michalakis; Dimitri Romanovsky; Martin Biel; Bernd Wissinger; Karl-Ulrich Bartz-Schmidt; Tobias Peters; Manuel D. Fischer; on behalf of the RD-CURE Consortium
TAGS: disease vectors, proteins, spatial vectors, cytokine, thp-1 cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):38. https://doi.org/10.1167/iovs.66.6.38

Includes: Supplemental Content

Cornea June 2025

SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction

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Yizhou Li; Feijia Xie; Lingling Yang; Xiaolei Wang; Yangyang Zhang; Hongqi Ge; Min Wang; Rui Cao; Qingjun Zhou; Ya Li
TAGS: cornea, epithelium, mice, stem cells, taurine, wound healing, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):25. https://doi.org/10.1167/iovs.66.6.25

Includes: Supplemental Content

Review May 2025

Recent Advances in Stem Cells of Corneal Epithelia

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Yijian Li; Yong Liu
TAGS: cornea, corneal epithelium, epithelium, heterogeneity, stem cells, mice, adult stem cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):45. https://doi.org/10.1167/iovs.66.5.45

Biochemistry and Molecular Biology May 2025

Distinct Transcriptomic Profiles of Cultured Anterior and Posterior Populations of Human Infant Scleral Fibroblasts: Including Dopamine Receptors

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Jiali Guan; Guangliang Hong; Zhong Liu; Yingfeng Zheng; Jiangping He; Dajiang Qin; He Li
TAGS: fibroblasts, sclera, infant, single-cell rna-seq, dopamine receptors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):29. https://doi.org/10.1167/iovs.66.5.29

Includes: Supplemental Content

Biochemistry and Molecular Biology May 2025

Nicotinamide N-Methyltransferase in the Inflammatory Pathogenesis of Graves’ Orbitopathy

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Dayoon Cho; Soo Hyun Choi; Jin Sook Yoon; JaeSang Ko
TAGS: cytokine, fibroblasts, inflammation, methyltransferase, niacinamide, pathogenesis, body tissue, western blotting, cyclooxygenase-2
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):3. https://doi.org/10.1167/iovs.66.5.3

Includes: Supplemental Content

Cornea April 2025

Prox1 Protein in Corneal Limbal Lymphatic Vessels Maintains Limbal Stem Cell Stemness and Regulates Corneal Injury Repair

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An Wang; Zongyuan Li; Yilin Jiang; Mingxiong Chen; Hanrui Yu; Zhao Li; Shengshu Sun; Ge Bai; Qun Wang; Yifei Huang; Liqiang Wang
TAGS: alkalies, burns, cornea, corneal injuries, limbal stem cells, lymphatic vessels, prospero-related homeobox 1 protein, recovery of function, epithelium, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):81. https://doi.org/10.1167/iovs.66.4.81

Includes: Supplemental Content

Cornea April 2025

Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells

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Min Wang; Rong Chen; Yao Wang; Ya Li; Qingjun Zhou; Rui Cao; Yizhou Li; Hongqi Ge; Xiaolei Wang; Lingling Yang
TAGS: cornea, keratins, limbal stem cells, proteins, stress, epithelium, mice, corneal epithelium, rna, messenger, rna-seq
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):55. https://doi.org/10.1167/iovs.66.4.55

Includes: Supplemental Content

Cornea April 2025

Antigen Presentation by Extracellular Vesicles in the Acute Phase of Corneal Transplantation

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Toshiki Shimizu; Takahiko Hayashi; Junki Kurita; Kentaro Yuda; Nobuhisa Mizuki; Satoru Yamagami
TAGS: antigen processing and presentation, extracellular vesicles, keratoplasty, tissue transplants, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):38. https://doi.org/10.1167/iovs.66.4.38

Includes: Supplemental Content

Retina April 2025

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

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Xing Wei; Sisi Ma; Yunyu Zhou; Haoliang Cui; Shan Zhang; Duanyang Wang; Yingying Fu; Wei Li; Huihui Han; Yamei Li; Wuyi Li; Huixin Liu; Zixi Sun; Xiaoxu Han; Xuan Zou; Hui Li; Cheng Wang; Ruifang Sui
TAGS: electroretinography, mice, gene therapy, capsid
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):37. https://doi.org/10.1167/iovs.66.4.37

Includes: Supplemental Content

Immunology and Microbiology April 2025

Role of SerpinA3 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts

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Min Seok Kim; Soo Hyun Choi; Hyun Young Park; Sun Young Jang; JaeSang Ko; Jae-woo Kim; Jin Sook Yoon
TAGS: body tissue, fibroblasts, pathogenesis, hyaluronan
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):20. https://doi.org/10.1167/iovs.66.4.20

Includes: Supplemental Content

Glaucoma April 2025

Effects of Verteporfin on Interstitial Fluid Flow-Induced Fibrotic Transdifferentiation of Human Tenon Fibroblasts

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Janne Frömmichen; Emma Bungert; Jeanne Ströble; Moritz Gläser; Charlotte Gottwald; Kosovare Zeqiri; Thomas Reinhard; Jan Lübke; Günther Schlunck; Cornelius Jakob Wiedenmann
TAGS: fibroblasts, fibrosis, fluid flow, interstitial fluid, verteporfin, actins, cell transdifferentiation, connective tissue growth factor
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):17. https://doi.org/10.1167/iovs.66.4.17

Cornea March 2025

The Spatial Transcriptomic Atlas of Human Limbus and Vital Niche Microenvironment Regulating the Fate of Limbal Epithelial Stem Cells

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Shiding Li; Hao Sun; Fei Fang; Siyi Zhang; Junzhao Chen; Chunyi Shao; Yao Fu; Liangbo Chen
TAGS: body tissue, cell communication, cornea, epithelial stem cells, epithelium, fluorescent antibody technique, genes, rna, small cytoplasmic, transcriptomics, melanocytes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):52. https://doi.org/10.1167/iovs.66.3.52

Includes: Supplemental Content

Cornea March 2025

Corneal Keratocytes, Fibroblasts, and Myofibroblasts Exhibit Distinct Transcriptional Profiles In Vitro

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Kara Poole; Krithika S. Iyer; David W. Schmidtke; W. Matthew Petroll; Victor D. Varner
TAGS: cornea, fibroblasts, genes, keratocytes, myofibroblasts, transcription, genetic, stromal cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):28. https://doi.org/10.1167/iovs.66.3.28

Includes: Supplemental Content

Cornea March 2025

Isolated Mitochondrial Transplantation as a Novel Treatment for Corneal Chemical Burns

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Dan Jiang; Jinjie Yu; Xiaoqing Wu; Xintong Yu; Pinyan Jin; Huikang Zheng; Huiru Liu; Wei Xu; Qizhou Lian; Wei Chen
TAGS: mitochondria, cornea, transplantation, mice, chemical burns
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):14. https://doi.org/10.1167/iovs.66.3.14

Includes: Multimedia, Supplemental Content

Biochemistry and Molecular Biology March 2025

Butyrate Ameliorates Graves’ Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota

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Pingbo Ouyang; Jia Qi; Boding Tong; Yunping Li; Jiamin Cao; Lujue Wang; Tongxin Niu; Xin Qi
TAGS: butyrates, fibroblasts, gastrointestinal microbiome, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):5. https://doi.org/10.1167/iovs.66.3.5

Includes: Supplemental Content

Biochemistry and Molecular Biology February 2025

Extracellular Matrix Stiffness Modulates Myopia Scleral Remodeling Through Integrin/F-Actin/YAP Axis

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Xin Liu; Ying Yuan; Yue Wu; Chengcheng Zhu; Yuying Liu; Bilian Ke
TAGS: actins, integrins, myopia, sclera, fibroblasts, extracellular matrix, caviidae
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):22. https://doi.org/10.1167/iovs.66.2.22

Includes: Supplemental Content

Cornea February 2025

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)

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Hao Chi; Li Ma; Fanxing Zeng; Xiaolei Wang; Peng Peng; Xiaofei Bai; Ting Zhang; Wenhui Yin; Yaoyao Yu; Lingling Yang; Qingjun Zhou; Chao Wei; Weiyun Shi
TAGS: aging, allografting, angiotensin converting enzyme 2, cornea, keratoplasty, navitoclax, rejection (psychology), senolytics, stress, transplant rejection
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):15. https://doi.org/10.1167/iovs.66.2.15

Includes: Supplemental Content

Glaucoma January 2025

Artificial Intelligence in Predicting Ocular Hypertension After Descemet Membrane Endothelial Keratoplasty

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Min Seok Kim; Heesuk Kim; Hyung Keun Lee; Chan Yun Kim; Wungrak Choi
TAGS: artificial intelligence, descemet's membrane endothelial keratoplasty, ocular hypertension, survival analysis, preoperative care, risk factors, tissue transplants, glaucoma, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):61. https://doi.org/10.1167/iovs.66.1.61

Includes: Supplemental Content

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Three-Dimensional Culture of Orbital Fibroblasts From Thyroid Eye Disease Induce In Vivo-Like Tissue Remodeling and Fibrosis

Allogenic Transplantation of RPE Strips Lacking MHC Class II Can Avoid Rejection in Nonhuman Primate Eyes

Investigating the Immunogenic Potential of Variations in Host Cell Protein Levels in Clinical-Grade AAV8 Products

SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction

Recent Advances in Stem Cells of Corneal Epithelia

Distinct Transcriptomic Profiles of Cultured Anterior and Posterior Populations of Human Infant Scleral Fibroblasts: Including Dopamine Receptors

Nicotinamide N-Methyltransferase in the Inflammatory Pathogenesis of Graves’ Orbitopathy

Prox1 Protein in Corneal Limbal Lymphatic Vessels Maintains Limbal Stem Cell Stemness and Regulates Corneal Injury Repair

Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells

Antigen Presentation by Extracellular Vesicles in the Acute Phase of Corneal Transplantation

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

Role of SerpinA3 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts

Effects of Verteporfin on Interstitial Fluid Flow-Induced Fibrotic Transdifferentiation of Human Tenon Fibroblasts

The Spatial Transcriptomic Atlas of Human Limbus and Vital Niche Microenvironment Regulating the Fate of Limbal Epithelial Stem Cells

Corneal Keratocytes, Fibroblasts, and Myofibroblasts Exhibit Distinct Transcriptional Profiles In Vitro

Isolated Mitochondrial Transplantation as a Novel Treatment for Corneal Chemical Burns

Butyrate Ameliorates Graves’ Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota

Extracellular Matrix Stiffness Modulates Myopia Scleral Remodeling Through Integrin/F-Actin/YAP Axis

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)

Artificial Intelligence in Predicting Ocular Hypertension After Descemet Membrane Endothelial Keratoplasty

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