Nanotechnology and Regenerative Medicine

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Biochemistry and Molecular Biology September 2022

Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts

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Jiale Diao; Xinxin Chen; Pei Mou; Xiaoye Ma; Ruili Wei
TAGS: berberine, fibroblasts, fibrosis, graves' ophthalmopathy, tissue remodeling, inflammation, western blotting, proteins, enzyme-linked immunosorbent assay, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):6. doi: https://doi.org/10.1167/iovs.63.10.6

Includes: Supplemental Content

Cornea July 2022

Labial Mucosa Stem Cells: Isolation, Characterization, and Their Potential for Corneal Epithelial Reconstruction

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Kirill E. Zhurenkov; Elga I. Alexander-Sinkler; Ilya O. Gavrilyik; Natalia M. Yartseva; Svetlana A. Aleksandrova; Tatiana V. Mashel; Julia I. Khorolskaya; Miralda I. Blinova; Alexei N. Kulikov; Sergei V. Churashov; Valery F. Chernysh; Natalia A. Mikhailova
TAGS: cornea, epithelium, lip, mucous membrane, oryctolagus cuniculus, patient isolation, reconstructive surgical procedures, social isolation, stem cells, tissue transplants
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):16. doi: https://doi.org/10.1167/iovs.63.8.16

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2022

Potential Therapeutic Role of Bone Morphogenic Protein 7 (BMP7) in the Pathogenesis of Graves’ Orbitopathy

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Bo Yi Kim; Soo Hyun Choi; Ji-Young Kim; JaeSang Ko; Jong In Yook; Hyun Sil Kim; Eun Jig Lee; Don O. Kikkawa; Jin Sook Yoon
TAGS: body tissue, bone morphogenetic proteins, fibroblasts, molecule, pathogenesis, proteins, tumor necrosis factors, western blotting, cytokine, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2022; 63(6):7. doi: https://doi.org/10.1167/iovs.63.6.7

Includes: Supplemental Content

Glaucoma June 2022

Potential Mechanisms of Intraocular Pressure Reduction by Micropulse Transscleral Cyclophotocoagulation in Rabbit Eyes

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Hotaka Nemoto; Megumi Honjo; Michiaki Okamoto; Koichiro Sugimoto; Makoto Aihara
TAGS: cardiac progenitor cells, ciliary body, eye, intraocular pressure, lasers, oryctolagus cuniculus, photocoagulation of ciliary body, fibronectins, sclera
Invest. Ophthalmol. Vis. Sci.. 2022; 63(6):3. doi: https://doi.org/10.1167/iovs.63.6.3

Retinal Cell Biology April 2022

Retinal Neuroprotective Effect of Mesenchymal Stem Cells Secretome Through Modulation of Oxidative Stress, Autophagy, and Programmed Cell Death

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Ricardo Usategui-Martín; Kevin Puertas-Neyra; Nadia Galindo-Cabello; Leticia A. Hernández-Rodríguez; Fernando González-Pérez; José Carlos Rodríguez-Cabello; Rogelio González-Sarmiento; José Carlos Pastor; Ivan Fernandez-Bueno
TAGS: apoptosis, autophagy, genes, necroptosis, nerve degeneration, neuroprotective effect, oxidative stress, proteins, rna, messenger, secretome
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):27. doi: https://doi.org/10.1167/iovs.63.4.27

Includes: Supplemental Content

Retinal Cell Biology April 2022

Identification of CD157-Positive Vascular Endothelial Stem Cells in Mouse Retinal and Choroidal Vessels: Fluorescence-Activated Cell Sorting Analysis

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Taku Wakabayashi; Hisamichi Naito; Tomohiro Iba; Kohji Nishida; Nobuyuki Takakura
TAGS: cell separation, choroid, endothelium, fluorescence, mice, retina, stem cells, electroconvulsive therapy, cd31 antigens, epidural cortical stimulation
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):5. doi: https://doi.org/10.1167/iovs.63.4.5

Includes: Supplemental Content

Cornea April 2022

Defining the Role of Mitochondrial Fission in Corneal Myofibroblast Differentiation

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Kye-Im Jeon; Ankita Kumar; Kaitlin T. Wozniak; Keith Nehrke; Krystel R. Huxlin
TAGS: cornea, fibroblasts, fibrosis, mitochondria, myofibroblasts, phosphorylation
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):2. doi: https://doi.org/10.1167/iovs.63.4.2

Includes: Supplemental Content

Retina March 2022

AAV8 -Mediated Gene Therapy Rescues Retinal Degeneration Phenotype in a Tlcd3b Knockout Mouse Model

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Xinye Qian; Hehe Liu; Shangyi Fu; Jiaxiong Lu; Yu-Ting Hung; Cassidy Turner; Haiwei Gu; Rui Chen
TAGS: gene therapy, mice, phenotype, photoreceptors, retinal degeneration, mice, knockout, retina, ceramides, tissue degeneration, injections
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):11. doi: https://doi.org/10.1167/iovs.63.3.11

Includes: Supplemental Content

Visual Neuroscience January 2022

Retinal Dopamine D2 Receptors Participate in the Development of Myopia in Mice

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Furong Huang; Ziheng Shu; Qin Huang; Kaijie Chen; Wenjun Yan; Wenjing Wu; Jinglei Yang; Qiongsi Wang; Fengjiao Wang; Chunlan Zhang; Jia Qu; Xiangtian Zhou
TAGS: mice, myopia, retina, dopamine d2 receptor, fibroblasts
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):24. doi: https://doi.org/10.1167/iovs.63.1.24

Includes: Supplemental Content

Anatomy and Pathology/Oncology November 2021

Carboplatin- and Etoposide-Loaded Lactoferrin Protein Nanoparticles for Targeting Cancer Stem Cells in Retinoblastoma In Vitro

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Revu V. L. Narayana; Pritikana Jana; Neha Tomar; Varsha Prabhu; Rohini M. Nair; Radhika Manukonda; Swathi Kaliki; Sarah E. Coupland; Jodi Alexander; Helen Kalirai; Anand K. Kondapi; Geeta K. Vemuganti
TAGS: cancer stem cells, carboplatin, culture media, conditioned, etoposide, lactoferrin, nanoparticles, proteins, retinoblastoma, drug release, cytotoxicity
Invest. Ophthalmol. Vis. Sci.. 2021; 62(14):13. doi: https://doi.org/10.1167/iovs.62.14.13

Includes: Supplemental Content

Editorial November 2021

The 2021 National Eye Institute Strategic Plan: Driving Innovation in Eye and Vision Research

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Michael F. Chiang
TAGS: eye, vision research
Invest. Ophthalmol. Vis. Sci.. 2021; 62(14):2. doi: https://doi.org/10.1167/iovs.62.14.2

Retinal Cell Biology October 2021

Transplanted Mouse Embryonic Stem Cell–Derived Retinal Ganglion Cells Integrate and Form Synapses in a Retinal Ganglion Cell-Depleted Mouse Model

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You-Ren Wu; Tomoyo Hashiguchi; Junki Sho; Shih-Hwa Chiou; Masayo Takahashi; Michiko Mandai
TAGS: embryonic stem cells, mice, n-methylaspartate, retina, retinal ganglion cells, tissue transplants, transplantation, stem cells, synapses, neurites
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):26. doi: https://doi.org/10.1167/iovs.62.13.26

Includes: Supplemental Content

Retina September 2021

Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy

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Bhubanananda Sahu; Laura Moreno Leon; Wei Zhang; Nikita Puranik; Ramesh Periasamy; Hemant Khanna; Michael Volkert
TAGS: gene therapy, injections, mice, nerve degeneration, oxidative stress, retinal degeneration, retinal diseases, photoreceptors, caspases, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):8. doi: https://doi.org/10.1167/iovs.62.12.8

Includes: Supplemental Content

Retinal Cell Biology July 2021

Optic Nerve Engraftment of Neural Stem Cells

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Jiun L. Do; Salam Allahwerdy; Ryan Caezar C. David; Robert N. Weinreb; Mark H. Tuszynski; Derek S. Welsbie
TAGS: neural stem cells, optic nerve, axon
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):30. doi: https://doi.org/10.1167/iovs.62.9.30

Anatomy and Pathology/Oncology July 2021

Transcriptomic Profiling of Control and Thyroid-Associated Orbitopathy (TAO) Orbital Fat and TAO Orbital Fibroblasts Undergoing Adipogenesis

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Dong Won Kim; Kamil Taneja; Thanh Hoang; Clayton P. Santiago; Timothy J. McCulley; Shannath L. Merbs; Nicholas R. Mahoney; Seth Blackshaw; Fatemeh Rajaii
TAGS: adipocytes, fibroblasts, genes, orbital fat, rna-seq, small nuclear rna, thyroid
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):24. doi: https://doi.org/10.1167/iovs.62.9.24

Includes: Supplemental Content

Cornea June 2021

Ex Vivo–Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice

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Jun Zhu; Takenori Inomata; Keiichi Fujimoto; Koichiro Uchida; Kenta Fujio; Ken Nagino; Maria Miura; Naoko Negishi; Yuichi Okumura; Yasutsugu Akasaki; Kunihiko Hirosawa; Mizu Kuwahara; Atsuko Eguchi; Hurramhon Shokirova; Ai Yanagawa; Akie Midorikawa-Inomata; Akira Murakami
TAGS: cornea, keratoplasty, myeloid-derived suppressor cells, mice, rejection (psychology), transplant rejection
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):3. doi: https://doi.org/10.1167/iovs.62.7.3

Includes: Supplemental Content

Retina April 2021

Subretinal Rather Than Intravitreal Adeno-Associated Virus–Mediated Delivery of a Complement Alternative Pathway Inhibitor Is Effective in a Mouse Model of RPE Damage

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Balasubramaniam Annamalai; Nathaniel Parsons; Crystal Nicholson; Elisabeth Obert; Bryan Jones; Bärbel Rohrer
TAGS: complement system proteins, familial hypercholesterolemia, family history, mice, adeno-associated virus
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):11. doi: https://doi.org/10.1167/iovs.62.4.11

Biochemistry and Molecular Biology April 2021

Transcriptome Landscape of Epithelial to Mesenchymal Transition of Human Stem Cell–Derived RPE

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Srinivasa R. Sripathi; Ming-Wen Hu; Melissa M. Liu; Jun Wan; Jie Cheng; Yukan Duan; Joseph L. Mertz; Karl J. Wahlin; Julien Maruotti; Cynthia A. Berlinicke; Jiang Qian; Donald J. Zack
TAGS: epithelial to mesenchymal transition, dissociation, tumor necrosis factors, gene expression profiling
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):1. doi: https://doi.org/10.1167/iovs.62.4.1

Includes: Supplemental Content

Retinal Cell Biology March 2021

Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells

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Lorena Teixeira Frasson; Barbara Dalmaso; Priscilla Sayami Akamine; Edna Teruko Kimura; Dânia Emi Hamassaki; Carolina Beltrame Del Debbio
TAGS: hmga2 protein, micrornas, stem cells, ciliary epithelium, adult, newborn
Invest. Ophthalmol. Vis. Sci.. 2021; 62(3):31. doi: https://doi.org/10.1167/iovs.62.3.31

Includes: Supplemental Content

Immunology and Microbiology February 2021

Characterization of Gene Therapy Associated Uveitis Following Intravitreal Adeno-Associated Virus Injection in Mice

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Gayathri Tummala; Adam Crain; Jessica Rowlan; Kathryn L. Pepple
TAGS: adeno-associated virus, eye, gene therapy, inflammation, injections, intravitreal injections, mice, uveitis, spatial vectors, flow cytometry
Invest. Ophthalmol. Vis. Sci.. 2021; 62(2):41. doi: https://doi.org/10.1167/iovs.62.2.41

Includes: Supplemental Content

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Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts

Labial Mucosa Stem Cells: Isolation, Characterization, and Their Potential for Corneal Epithelial Reconstruction

Potential Therapeutic Role of Bone Morphogenic Protein 7 (BMP7) in the Pathogenesis of Graves’ Orbitopathy

Potential Mechanisms of Intraocular Pressure Reduction by Micropulse Transscleral Cyclophotocoagulation in Rabbit Eyes

Retinal Neuroprotective Effect of Mesenchymal Stem Cells Secretome Through Modulation of Oxidative Stress, Autophagy, and Programmed Cell Death

Identification of CD157-Positive Vascular Endothelial Stem Cells in Mouse Retinal and Choroidal Vessels: Fluorescence-Activated Cell Sorting Analysis

Defining the Role of Mitochondrial Fission in Corneal Myofibroblast Differentiation

AAV8 -Mediated Gene Therapy Rescues Retinal Degeneration Phenotype in a Tlcd3b Knockout Mouse Model

Retinal Dopamine D2 Receptors Participate in the Development of Myopia in Mice

Carboplatin- and Etoposide-Loaded Lactoferrin Protein Nanoparticles for Targeting Cancer Stem Cells in Retinoblastoma In Vitro

The 2021 National Eye Institute Strategic Plan: Driving Innovation in Eye and Vision Research

Transplanted Mouse Embryonic Stem Cell–Derived Retinal Ganglion Cells Integrate and Form Synapses in a Retinal Ganglion Cell-Depleted Mouse Model

Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy

Optic Nerve Engraftment of Neural Stem Cells

Transcriptomic Profiling of Control and Thyroid-Associated Orbitopathy (TAO) Orbital Fat and TAO Orbital Fibroblasts Undergoing Adipogenesis

Ex Vivo–Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice

Subretinal Rather Than Intravitreal Adeno-Associated Virus–Mediated Delivery of a Complement Alternative Pathway Inhibitor Is Effective in a Mouse Model of RPE Damage

Transcriptome Landscape of Epithelial to Mesenchymal Transition of Human Stem Cell–Derived RPE

Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells

Characterization of Gene Therapy Associated Uveitis Following Intravitreal Adeno-Associated Virus Injection in Mice

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