Nanotechnology and Regenerative Medicine

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Retina December 2018

In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode–Based Retinal Prosthesis

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Brandon Bosse; Samir Damle; Abraham Akinin; Yi Jing; Dirk-Uwe Bartsch; Lingyun Cheng; Nicholas Oesch; Yu-Hwa Lo; Gert Cauwenberghs; William R. Freeman
TAGS: evoked potentials, visual, oryctolagus cuniculus, silicon, surgical procedures, operative, retina, implantation procedure, nanowires, implants, prostheses, visual prosthesis
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5885-5892. doi: 10.1167/iovs.18-24554

Special Issue November 2018

Regeneration of Lacrimal Gland Function to Maintain the Health of the Ocular Surface

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Tetsuya Kawakita
TAGS: inflammation, stem cells, epithelium, graft-versus-host disease, cicatrix, dry eye syndromes, health, langer-giedion syndrome, animal model, body tissue, wounds and injuries, mice, lacrimal gland, tear production, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES169-DES173. doi: 10.1167/iovs.17-23576

Special Issue November 2018

Advances in Functional Restoration of the Lacrimal Glands

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Masatoshi Hirayama
TAGS: stem cells, epithelium, body tissue, transplantation, lacrimal gland, injection therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES174-DES182. doi: 10.1167/iovs.17-23528

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology October 2018

Loss of CXCR4/CXCL12 Signaling Causes Oculomotor Nerve Misrouting and Development of Motor Trigeminal to Oculomotor Synkinesis

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Mary C. Whitman; Elaine H. Nguyen; Jessica L. Bell; Alan P. Tenney; Alon Gelber; Elizabeth C. Engle
TAGS: signal transduction, axon, embryo, motor neurons, oculomotor nerve, cxcr4 receptors, synkinesis, oculomotor synkinesis, stromal cell-derived factor 1
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5201-5209. doi: 10.1167/iovs.18-25190

Includes: Multimedia, Supplemental Content

Cornea October 2018

Plasminogen-Dependent Collagenolytic Properties of Staphylococcus aureus in Collagen Gel Cultures of Human Corneal Fibroblasts

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Koji Sugioka; Aya Kodama-Takahshi; Tomoko Sato; Kiyotaka Okada; Junko Murakami; Ah-Mee Park; Hiroshi Mishima; Yoshikazu Shimomura; Shunji Kusaka; Teruo Nishida
TAGS: urokinase, fibroblasts, collagen, gel, plasminogen, cornea, catabolism
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5098-5107. doi: 10.1167/iovs.18-24925

Retina October 2018

A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye – Implications for Ocular Gene Therapy

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Shyamtanu Datta; Marian Renwick; Viet Q. Chau; Fang Zhang; Emily R. Nettesheim; Daniel M. Lipinski; John D. Hulleman
TAGS: gene therapy, dihydrofolate reductase, visual acuity, eye, mice, retina, potable water, regulation, proteins
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4909-4920. doi: 10.1167/iovs.18-24987

Includes: Supplemental Content

Perspective October 2018

Accessibility to and Quality of Human Eye Tissue for Research: A Cross-Sectional Survey of ARVO Members

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W. Daniel Stamer; Andrew M. Williams; Stephen Pflugfelder; Sarah E. Coupland
TAGS: research personnel, body tissue, eye, surveys, quality
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4783-4792. doi: 10.1167/iovs.18-25319

Biochemistry and Molecular Biology September 2018

Inhibitory Effect of Idelalisib, a Selective Phosphatidylinositol 3-Kinase δ Inhibitor, on Adipogenesis in an In Vitro Model of Graves' Orbitopathy

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JaeSang Ko; Ji-Young Kim; Eun Jig Lee; Jin Sook Yoon
TAGS: fibroblasts, 1-phosphatidylinositol 3-kinase, idelalisib
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4477-4485. doi: 10.1167/iovs.18-24509

Includes: Supplemental Content

Immunology and Microbiology August 2018

Detection of Complement Activators in Immune Attack Eyes After iPS-Derived Retinal Pigment Epithelial Cell Transplantation

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Sunao Sugita; Kenichi Makabe; Shota Fujii; Masayo Takahashi
TAGS: complement system proteins, eye, transplantation, transcriptional activation, idiopathic pneumonia syndrome, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4198-4209. doi: 10.1167/iovs.18-24769

Includes: Supplemental Content

Cornea August 2018

Resolvin E1 Inhibits Corneal Allograft Rejection in High-Risk Corneal Transplantation

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Han Wang; Qingqing Zhao; Dan Luo; Yizhou Yin; Ting Li; Min Zhao
TAGS: cytokine, keratoplasty, rejection (psychology), tissue transplants, cornea, transplantation, allografting, transplant rejection
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3911-3919. doi: 10.1167/iovs.18-24562

Cornea July 2018

Stemness and Regenerative Potential of Corneal Stromal Stem Cells and Their Secretome After Long-Term Storage: Implications for Ocular Regeneration

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Ajay Kumar; Yi Xu; Enzhi Yang; Yiqin Du
TAGS: stem cells, fibroblasts, fibrosis, wound healing, cornea, stem cell, mesenchymal, keratocytes
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3728-3738. doi: 10.1167/iovs.18-23824

Includes: Supplemental Content

Special Issue July 2018

New Insights Into the Development and Progression of Geographic Atrophy After Full Thickness Autologous Choroidal Graft

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Grazia Pertile; Maurizio Mete; Antonio Peroglio Deiro; Massimo Guerriero; Mauro Sartore; Alessandro Alfano; Antonio Polito
TAGS: atrophy, tissue transplants
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD93-AMD103. doi: 10.1167/iovs.18-24229

Includes: Supplemental Content

Biochemistry and Molecular Biology July 2018

The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation

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Ying Yuan; Min Li; Chi Ho To; Thomas Chuen Lam; Peng Wang; Yunjie Yu; Qingzhong Chen; Xiaojun Hu; Bilian Ke
TAGS: signal transduction pathways, fibroblasts, sclera, signal pathway, rhoa gtp-binding protein, myofibroblast
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3619-3629. doi: 10.1167/iovs.17-23580

Retina July 2018

Sustained Connexin43 Mimetic Peptide Release From Loaded Nanoparticles Reduces Retinal and Choroidal Photodamage

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Nasir Mat Nor; Cindy X. Guo; Ilva D. Rupenthal; Ying-Shan Chen; Colin R. Green; Monica L. Acosta
TAGS: eye, retina, inflammation, peptides, choroid, connexin 43, photodamage, injections, body tissue, saline solution, fluorescein-5-isothiocyanate, normal saline, nanoparticles, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3682-3693. doi: 10.1167/iovs.17-22829

Retinal Cell Biology July 2018

Defined Conditions for Differentiation of Functional Retinal Ganglion Cells From Human Pluripotent Stem Cells

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Junwon Lee; Sang-Hwi Choi; Young-Beom Kim; Ikhyun Jun; Jin Jea Sung; Dongjin R. Lee; Yang In Kim; Myung Soo Cho; Suk Ho Byeon; Dae-Sung Kim; Dong-Wook Kim
TAGS: mitochondria, fibroblast growth factor 2, patient isolation, prescriptions, drug, eye, stem cells, pluripotent, pax6 transcription factor, enhanced s-cone syndrome, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3531-3542. doi: 10.1167/iovs.17-23439

Includes: Multimedia, Supplemental Content

Special Issue July 2018

Stem Cell Treatment for Age-Related Macular Degeneration: the Challenges

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Mandeep S. Singh; Robert E. MacLaren
TAGS: stem cells, age-related macular degeneration, stem cell therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD78-AMD82. doi: 10.1167/iovs.18-24426

Cornea June 2018

Directed Differentiation of Human Corneal Endothelial Cells From Human Embryonic Stem Cells by Using Cell-Conditioned Culture Media

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Xiaoniao Chen; Lingling Wu; Zongjin Li; Ying Dong; Xuetao Pei; Yifei Huang; Liqiang Wang
TAGS: embryonic stem cells, endothelial cells, conditioning (psychology), culture media, culture media, conditioned, cornea, signal pathway, chronic exertional compartment syndrome
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):3028-3036. doi: 10.1167/iovs.17-23627

Glaucoma June 2018

Active Lymphatic Drainage From the Eye Measured by Noninvasive Photoacoustic Imaging of Near-Infrared Nanoparticles

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Yeni H. Yücel; Kirsten Cardinell; Shireen Khattak; Xun Zhou; Michael Lapinski; Fang Cheng; Neeru Gupta
TAGS: fluorescence, injection of therapeutic agent, diagnostic imaging, eye, mice, drainage of lymphatics, nanoparticles
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2699-2707. doi: 10.1167/iovs.17-22850

Includes: Supplemental Content

Retinal Cell Biology May 2018

Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats

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Bryce T. McLelland; Bin Lin; Anuradha Mathur; Robert B. Aramant; Biju B. Thomas; Gabriel Nistor; Hans S. Keirstead; Magdalene J. Seiler
TAGS: organoids, photoreceptors, rats, nude, vision, rats, retina, transplantation
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2586-2603. doi: 10.1167/iovs.17-23646

Includes: Supplemental Content

Cornea May 2018

Labial Salivary Gland Transplantation for Severe Dry Eye in a Rhesus Monkey Model

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Yi Qin; Yingnan Zhang; Qingfeng Liang; Xiaolin Xu; Qian Li; Zhiqiang Pan; Antoine Labbé
TAGS: cytology, dry eye syndromes, macaca mulatta, surgical procedures, operative, tissue transplants, conjunctiva, eye, lip, salivary glands, transplantation
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2478-2486. doi: 10.1167/iovs.18-23966

Includes: Supplemental Content

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In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode–Based Retinal Prosthesis

Regeneration of Lacrimal Gland Function to Maintain the Health of the Ocular Surface

Advances in Functional Restoration of the Lacrimal Glands

Loss of CXCR4/CXCL12 Signaling Causes Oculomotor Nerve Misrouting and Development of Motor Trigeminal to Oculomotor Synkinesis

Plasminogen-Dependent Collagenolytic Properties of Staphylococcus aureus in Collagen Gel Cultures of Human Corneal Fibroblasts

A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye – Implications for Ocular Gene Therapy

Accessibility to and Quality of Human Eye Tissue for Research: A Cross-Sectional Survey of ARVO Members

Inhibitory Effect of Idelalisib, a Selective Phosphatidylinositol 3-Kinase δ Inhibitor, on Adipogenesis in an In Vitro Model of Graves' Orbitopathy

Detection of Complement Activators in Immune Attack Eyes After iPS-Derived Retinal Pigment Epithelial Cell Transplantation

Resolvin E1 Inhibits Corneal Allograft Rejection in High-Risk Corneal Transplantation

Stemness and Regenerative Potential of Corneal Stromal Stem Cells and Their Secretome After Long-Term Storage: Implications for Ocular Regeneration

New Insights Into the Development and Progression of Geographic Atrophy After Full Thickness Autologous Choroidal Graft

The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation

Sustained Connexin43 Mimetic Peptide Release From Loaded Nanoparticles Reduces Retinal and Choroidal Photodamage

Defined Conditions for Differentiation of Functional Retinal Ganglion Cells From Human Pluripotent Stem Cells

Stem Cell Treatment for Age-Related Macular Degeneration: the Challenges

Directed Differentiation of Human Corneal Endothelial Cells From Human Embryonic Stem Cells by Using Cell-Conditioned Culture Media

Active Lymphatic Drainage From the Eye Measured by Noninvasive Photoacoustic Imaging of Near-Infrared Nanoparticles

Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats

Labial Salivary Gland Transplantation for Severe Dry Eye in a Rhesus Monkey Model

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