Nanotechnology and Regenerative Medicine

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Immunology and Microbiology August 2018

Detection of Complement Activators in Immune Attack Eyes After iPS-Derived Retinal Pigment Epithelial Cell Transplantation

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Sunao Sugita; Kenichi Makabe; Shota Fujii; Masayo Takahashi
TAGS: complement system proteins, eye, transplantation, transcriptional activation, idiopathic pneumonia syndrome, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4198-4209. doi: 10.1167/iovs.18-24769

Includes: Supplemental Content

Cornea August 2018

Resolvin E1 Inhibits Corneal Allograft Rejection in High-Risk Corneal Transplantation

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Han Wang; Qingqing Zhao; Dan Luo; Yizhou Yin; Ting Li; Min Zhao
TAGS: cytokine, keratoplasty, rejection (psychology), tissue transplants, cornea, transplantation, allografting, transplant rejection
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3911-3919. doi: 10.1167/iovs.18-24562

Cornea July 2018

Stemness and Regenerative Potential of Corneal Stromal Stem Cells and Their Secretome After Long-Term Storage: Implications for Ocular Regeneration

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Ajay Kumar; Yi Xu; Enzhi Yang; Yiqin Du
TAGS: stem cells, fibroblasts, fibrosis, wound healing, cornea, stem cell, mesenchymal, keratocytes
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3728-3738. doi: 10.1167/iovs.18-23824

Includes: Supplemental Content

Special Issue July 2018

New Insights Into the Development and Progression of Geographic Atrophy After Full Thickness Autologous Choroidal Graft

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Grazia Pertile; Maurizio Mete; Antonio Peroglio Deiro; Massimo Guerriero; Mauro Sartore; Alessandro Alfano; Antonio Polito
TAGS: atrophy, tissue transplants
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD93-AMD103. doi: 10.1167/iovs.18-24229

Includes: Supplemental Content

Biochemistry and Molecular Biology July 2018

The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation

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Ying Yuan; Min Li; Chi Ho To; Thomas Chuen Lam; Peng Wang; Yunjie Yu; Qingzhong Chen; Xiaojun Hu; Bilian Ke
TAGS: signal transduction pathways, fibroblasts, sclera, signal pathway, rhoa gtp-binding protein, myofibroblast
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3619-3629. doi: 10.1167/iovs.17-23580

Retina July 2018

Sustained Connexin43 Mimetic Peptide Release From Loaded Nanoparticles Reduces Retinal and Choroidal Photodamage

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Nasir Mat Nor; Cindy X. Guo; Ilva D. Rupenthal; Ying-Shan Chen; Colin R. Green; Monica L. Acosta
TAGS: eye, retina, inflammation, peptides, choroid, connexin 43, photodamage, injections, body tissue, saline solution, fluorescein-5-isothiocyanate, normal saline, nanoparticles, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3682-3693. doi: 10.1167/iovs.17-22829

Retinal Cell Biology July 2018

Defined Conditions for Differentiation of Functional Retinal Ganglion Cells From Human Pluripotent Stem Cells

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Junwon Lee; Sang-Hwi Choi; Young-Beom Kim; Ikhyun Jun; Jin Jea Sung; Dongjin R. Lee; Yang In Kim; Myung Soo Cho; Suk Ho Byeon; Dae-Sung Kim; Dong-Wook Kim
TAGS: mitochondria, fibroblast growth factor 2, patient isolation, prescriptions, drug, eye, stem cells, pluripotent, pax6 transcription factor, enhanced s-cone syndrome, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3531-3542. doi: 10.1167/iovs.17-23439

Includes: Multimedia, Supplemental Content

Special Issue July 2018

Stem Cell Treatment for Age-Related Macular Degeneration: the Challenges

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Mandeep S. Singh; Robert E. MacLaren
TAGS: stem cells, age-related macular degeneration, stem cell therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD78-AMD82. doi: 10.1167/iovs.18-24426

Cornea June 2018

Directed Differentiation of Human Corneal Endothelial Cells From Human Embryonic Stem Cells by Using Cell-Conditioned Culture Media

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Xiaoniao Chen; Lingling Wu; Zongjin Li; Ying Dong; Xuetao Pei; Yifei Huang; Liqiang Wang
TAGS: embryonic stem cells, endothelial cells, conditioning (psychology), culture media, culture media, conditioned, cornea, signal pathway, chronic exertional compartment syndrome
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):3028-3036. doi: 10.1167/iovs.17-23627

Glaucoma June 2018

Active Lymphatic Drainage From the Eye Measured by Noninvasive Photoacoustic Imaging of Near-Infrared Nanoparticles

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Yeni H. Yücel; Kirsten Cardinell; Shireen Khattak; Xun Zhou; Michael Lapinski; Fang Cheng; Neeru Gupta
TAGS: fluorescence, injection of therapeutic agent, diagnostic imaging, eye, mice, drainage of lymphatics, nanoparticles
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2699-2707. doi: 10.1167/iovs.17-22850

Includes: Supplemental Content

Retinal Cell Biology May 2018

Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats

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Bryce T. McLelland; Bin Lin; Anuradha Mathur; Robert B. Aramant; Biju B. Thomas; Gabriel Nistor; Hans S. Keirstead; Magdalene J. Seiler
TAGS: organoids, photoreceptors, rats, nude, vision, rats, retina, transplantation
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2586-2603. doi: 10.1167/iovs.17-23646

Includes: Supplemental Content

Cornea May 2018

Labial Salivary Gland Transplantation for Severe Dry Eye in a Rhesus Monkey Model

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Yi Qin; Yingnan Zhang; Qingfeng Liang; Xiaolin Xu; Qian Li; Zhiqiang Pan; Antoine Labbé
TAGS: cytology, dry eye syndromes, macaca mulatta, surgical procedures, operative, tissue transplants, conjunctiva, eye, lip, salivary glands, transplantation
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2478-2486. doi: 10.1167/iovs.18-23966

Includes: Supplemental Content

Glaucoma May 2018

Mechanical Strain Induces Distinct Human Scleral Fibroblast Lineages: Differential Roles in Cell Proliferation, Apoptosis, Migration, and Differentiation

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Chen Qiu; Minjie Chen; Jing Yao; Xinghuai Sun; Jianjiang Xu; Rong Zhang; Xin Wang; Gang Li; Shaohong Qian
TAGS: apoptosis, cell proliferation, fibroblasts, sclera
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2401-2410. doi: 10.1167/iovs.18-23855

Includes: Supplemental Content

Cornea March 2018

Visualizing the Fate of Transplanted K14-Confetti Corneal Epithelia in a Mouse Model of Limbal Stem Cell Deficiency

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Alexander Richardson; Mijeong Park; Stephanie L. Watson; Denis Wakefield; Nick Di Girolamo
TAGS: corneal epithelium, mice, transplantation, limbal stem cell deficiency, donors, corneal epithelial cells
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1630-1640. doi: 10.1167/iovs.17-23557

Includes: Supplemental Content

Glaucoma March 2018

Induced Pluripotent Stem Cells Promote Retinal Ganglion Cell Survival After Transplant

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Suqian Wu; Kun-Che Chang; Michael Nahmou; Jeffrey L. Goldberg
TAGS: coculture techniques, retinal ganglion cells, retina, transplantation, stem cells, pluripotent
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1571-1576. doi: 10.1167/iovs.17-23648

Cornea March 2018

Human Conjunctival Epithelial Sheets Grown on Poly(Lactic-Co-Glycolic) Acid Membranes and Cocultured With Human Tenon's Fibroblasts for Corneal Repair

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Soyoung Hong; Je Hwan Yun; Eun-Soon Kim; Ji Seon Kim; Hungwon Tchah; Changmo Hwang
TAGS: positron-emission tomography, epithelium, fibroblasts, coculture techniques, tissue membrane, conjunctiva, cornea, pet animal
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1475-1485. doi: 10.1167/iovs.17-22719

Includes: Supplemental Content

Retina March 2018

Allogeneic iPSC-Derived RPE Cell Graft Failure Following Transplantation Into the Subretinal Space in Nonhuman Primates

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Trevor J. McGill; Jonathan Stoddard; Lauren M. Renner; Ilhem Messaoudi; Kapil Bharti; Shoukhrat Mitalipov; Andreas Lauer; David J. Wilson; Martha Neuringer
TAGS: primates, tissue transplants, diagnostic imaging, transplantation, idiopathic pneumonia syndrome, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1374-1383. doi: 10.1167/iovs.17-22467

Cornea February 2018

Novel Combination BMP7 and HGF Gene Therapy Instigates Selective Myofibroblast Apoptosis and Reduces Corneal Haze In Vivo

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Suneel Gupta; Michael K. Fink; Arkasubhra Ghosh; Ratnakar Tripathi; Prashant R. Sinha; Ajay Sharma; Nathan P. Hesemann; Shyam S. Chaurasia; Elizabeth A. Giuliano; Rajiv R. Mohan
TAGS: apoptosis, gene therapy, fibrosis, corneal opacity, genes, oryctolagus cuniculus, cornea, myofibroblast
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):1045-1057. doi: 10.1167/iovs.17-23308

Retinal Cell Biology February 2018

Culture Systems of Dissociated Mouse and Human Pluripotent Stem Cell–Derived Retinal Ganglion Cells Purified by Two-Step Immunopanning

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Wataru Kobayashi; Akishi Onishi; Hung-Ya Tu; Yuji Takihara; Michiru Matsumura; Kazuko Tsujimoto; Masaru Inatani; Toru Nakazawa; Masayo Takahashi
TAGS: immunohistochemistry, organoids, retinal ganglion cells, mice, retina, stem cells, pluripotent, neuronal outgrowth
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):776-787. doi: 10.1167/iovs.17-22406

Includes: Supplemental Content

Cornea February 2018

Preoperative Aqueous Cytokine Levels are Associated With Endothelial Cell Loss After Descemet's Stripping Automated Endothelial Keratoplasty

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Hiroyuki Yazu; Takefumi Yamaguchi; Naohiko Aketa; Kazunari Higa; Terumasa Suzuki; Yukari Yagi-Yaguchi; Yoshiyuki Satake; Takayuki Abe; Kazuo Tsubota; Jun Shimazaki
TAGS: cytokine, endothelial cells, keratoplasty, endothelium, postoperative care, preoperative care, proteins, descemet stripping endothelial keratoplasty
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):612-620. doi: 10.1167/iovs.17-23049

Includes: Supplemental Content

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Detection of Complement Activators in Immune Attack Eyes After iPS-Derived Retinal Pigment Epithelial Cell Transplantation

Resolvin E1 Inhibits Corneal Allograft Rejection in High-Risk Corneal Transplantation

Stemness and Regenerative Potential of Corneal Stromal Stem Cells and Their Secretome After Long-Term Storage: Implications for Ocular Regeneration

New Insights Into the Development and Progression of Geographic Atrophy After Full Thickness Autologous Choroidal Graft

The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation

Sustained Connexin43 Mimetic Peptide Release From Loaded Nanoparticles Reduces Retinal and Choroidal Photodamage

Defined Conditions for Differentiation of Functional Retinal Ganglion Cells From Human Pluripotent Stem Cells

Stem Cell Treatment for Age-Related Macular Degeneration: the Challenges

Directed Differentiation of Human Corneal Endothelial Cells From Human Embryonic Stem Cells by Using Cell-Conditioned Culture Media

Active Lymphatic Drainage From the Eye Measured by Noninvasive Photoacoustic Imaging of Near-Infrared Nanoparticles

Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats

Labial Salivary Gland Transplantation for Severe Dry Eye in a Rhesus Monkey Model

Mechanical Strain Induces Distinct Human Scleral Fibroblast Lineages: Differential Roles in Cell Proliferation, Apoptosis, Migration, and Differentiation

Visualizing the Fate of Transplanted K14-Confetti Corneal Epithelia in a Mouse Model of Limbal Stem Cell Deficiency

Induced Pluripotent Stem Cells Promote Retinal Ganglion Cell Survival After Transplant

Human Conjunctival Epithelial Sheets Grown on Poly(Lactic-Co-Glycolic) Acid Membranes and Cocultured With Human Tenon's Fibroblasts for Corneal Repair

Allogeneic iPSC-Derived RPE Cell Graft Failure Following Transplantation Into the Subretinal Space in Nonhuman Primates

Novel Combination BMP7 and HGF Gene Therapy Instigates Selective Myofibroblast Apoptosis and Reduces Corneal Haze In Vivo

Culture Systems of Dissociated Mouse and Human Pluripotent Stem Cell–Derived Retinal Ganglion Cells Purified by Two-Step Immunopanning

Preoperative Aqueous Cytokine Levels are Associated With Endothelial Cell Loss After Descemet's Stripping Automated Endothelial Keratoplasty

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