Pharmacology

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Lens September 2019

Resveratrol Inhibits Wound Healing and Lens Fibrosis: A Putative Candidate for Posterior Capsule Opacification Prevention

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Andrew J. O. Smith; Julie A. Eldred; I. Michael Wormstone
TAGS: lens, crystalline, resveratrol, wound healing, lens (device), after-cataract, prevention, fibrosis, epithelial to mesenchymal transition
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3863-3877. doi: 10.1167/iovs.18-26248

Glaucoma September 2019

Peripapillary Choroidal Vascularity Index and Microstructure of Parapapillary Atrophy

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Min Hee Suh; Jun Woo Park; Neha Khandelwal; Rupesh Agrawal
TAGS: atrophy, cortical blindness, antidepressive agents, tricyclic, trichloroacetic acid, spectral-domain optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3768-3775. doi: 10.1167/iovs.18-26286

Retina August 2019

Elevated Steroid Hormone Levels in Active Chronic Central Serous Chorioretinopathy

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Rosa L. Schellevis; Lebriz Altay; Asha Kalisingh; Timo W. F. Mulders; Vasilena Sitnilska; Carel B. Hoyng; Camiel J. F. Boon; Joannes M. M. Groenewoud; Eiko K. de Jong; Anneke I. den Hollander
TAGS: central serous chorioretinopathy, steroid hormone, steroids, hormones
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3407-3413. doi: 10.1167/iovs.19-26781

Includes: Supplemental Content

Retinal Cell Biology August 2019

COMP-Ang1 Stabilizes Hyperglycemic Disruption of Blood-Retinal Barrier Phenotype in Human Retinal Microvascular Endothelial Cells

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Keith D. Rochfort; Lara S. Carroll; Peter Barabas; Timothy M. Curtis; Balamurali K. Ambati; Niall Barron; Philip M. Cummins
TAGS: angiotensin i, hyperglycemia, hyperglycemic agents, endothelial cells, blood-retinal barrier, phenotype
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3547-3555. doi: 10.1167/iovs.19-27644

Includes: Supplemental Content

Letters to the Editor August 2019

Chemical Considerations Regarding the H-Value Methodology and Its Relation With Toxicity Determination

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Girish K. Srivastava; Cristina Andrés-Iglesias; Rosa M. Coco; Ivan Fernandez-Bueno; Jesús Medina; Juan García-Serna; Antonio Dueñas; Fernando Rull; J. Carlos Pastor
TAGS: toxic effect
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3363-3364. doi: 10.1167/iovs.19-26948

Retina July 2019

Apratoxin S4 Inspired by a Marine Natural Product, a New Treatment Option for Ocular Angiogenic Diseases

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Beiying Qiu; Alison Tan; Amutha Barathi Veluchamy; Yong Li; Hannah Murray; Wei Cheng; Chenghao Liu; Joanna Marie Busoy; Qi-Yin Chen; Srivani Sistla; Walter Hunziker; Chui Ming Gemmy Cheung; Tien Yin Wong; Wanjin Hong; Hendrik Luesch; Xiaomeng Wang
TAGS: angiogenesis, mice, natural products, aflibercept, neovascularization, pathologic, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3254-3263. doi: 10.1167/iovs.19-26936

Includes: Supplemental Content

Retinal Cell Biology July 2019

Norgestrel, a Progesterone Analogue, Promotes Significant Long-Term Neuroprotection of Cone Photoreceptors in a Mouse Model of Retinal Disease

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Sarah L. Roche; Oksana Kutsyr; Nicolás Cuenca; Thomas G. Cotter
TAGS: mice, norgestrel, retinal cone
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3221-3235. doi: 10.1167/iovs.19-27246

Includes: Supplemental Content

Physiology and Pharmacology July 2019

Oral Delivery of the P2Y 12 Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4 −/− Mouse Model of Retinal Degeneration

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Wennan Lu; Keith E. Campagno; Huen-Yee Tso; Aurora Cenaj; Alan M. Laties; Leif G. Carlsson; Claire H. Mitchell
TAGS: mice, photoreceptors, retinal degeneration, ticagrelor, antagonists, administration, oral
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3046-3053. doi: 10.1167/iovs.19-27241

Immunology and Microbiology July 2019

Glycyrrhizin Use for Multi-Drug Resistant Pseudomonas aeruginosa : In Vitro and In Vivo Studies

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Linda D. Hazlett; Sandamali A. Ekanayaka; Sharon A. McClellan; Rebecca Francis
TAGS: ciprofloxacin, glycyrrhizic acid, keratitis, pseudomonas aeruginosa
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):2978-2989. doi: 10.1167/iovs.19-27200

Retina May 2019

Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR

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Jakob Grauslund; Ulrik Frydkjaer-Olsen; Tunde Peto; Jimena Fernández-Carneado; Berta Ponsati; Cristina Hernández; José Cunha-Vaz; Rafael Simó; for the EUROCONDOR
TAGS: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, dilatation, pathologic, somatostatin, brimonidine, retinal vascular caliber
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2257-2262. doi: 10.1167/iovs.18-26487

Retina May 2019

Intravitreal Fluocinolone Acetonide May Decelerate Diabetic Retinal Neurodegeneration

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Stephanie K. Lynch; Kyungmoo Lee; Zhi Chen; James C. Folk; Ursula Schmidt-Erfurth; Bianca S. Gerendas; Andreas Wahle; Charles C. Wykoff; Michael D. Abràmoff
TAGS: diabetes mellitus, fluocinolone acetonide, nerve degeneration, left ventricular area fractional change, cyclophosphamide/doxorubicin/fluorouracil protocol, right ventricular fractional area change
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2134-2139. doi: 10.1167/iovs.18-24643

Retinal Cell Biology April 2019

Activation of the BMP4/Smad1 Pathway Promotes Retinal Ganglion Cell Survival and Axon Regeneration

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Adam Thompson; Martin Berry; Ann Logan; Zubair Ahmed
TAGS: rapamycin, peptides, neuronal outgrowth, rna, messenger, retinal ganglion cells, axon, neurites
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1748-1759. doi: 10.1167/iovs.18-26449

Visual Neuroscience April 2019

ON-Type Retinal Ganglion Cells are Preferentially Affected in STZ-Induced Diabetic Mice

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Run-Ze Cui; Lu Wang; Sheng-Nan Qiao; Yong-Chen Wang; Xin Wang; Fei Yuan; Shi-Jun Weng; Xiong-Li Yang; Yong-Mei Zhong
TAGS: diabetes mellitus, streptozocin, mice, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1644-1656. doi: 10.1167/iovs.18-26359

Retina April 2019

Outer Retinal Oxidative Stress Measured In Vivo Using QUEnch-assiSTed (QUEST) OCT

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Bruce A. Berkowitz; Robert H. Podolsky; Karen M. Lins-Childers; Yichao Li; Haohua Qian
TAGS: oxidative stress, diltiazem, mice, apraxia of speech, aneurysms-osteoarthritis syndrome, saline solutions
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1566-1570. doi: 10.1167/iovs.18-26164

Glaucoma April 2019

Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation

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Yan Hu; Arturo O. Barron; Sofya Gindina; Sandeep Kumar; Shravan Chintala; Ashima Nayyar; John Danias
TAGS: alteplase, urokinase, gelatinase b, platelet count measurement, mice, regulation, fibrinolysis pathway
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1571-1580. doi: 10.1167/iovs.18-25698

Clinical and Epidemiologic Research April 2019

The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration

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Emily E. Brown; Jacob D. Ball; Zhaoyi Chen; Gibran S. Khurshid; Mattia Prosperi; John D. Ash
TAGS: metformin, age-related macular degeneration, antidiabetics
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1470-1477. doi: 10.1167/iovs.18-26422

Physiology and Pharmacology April 2019

PARP Inhibitor Protects Against Chronic Hypoxia/Reoxygenation-Induced Retinal Injury by Regulation of MAPKs, HIF1α, Nrf2, and NFκB

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Krisztina Kovacs; Alexandra Vaczy; Katalin Fekete; Petra Kovari; Tamas Atlasz; Dora Reglodi; Robert Gabriel; Ferenc Gallyas; Balazs Sumegi
TAGS: hypoxia, retina, retinal injuries, poly(adp-ribose) polymerase inhibitors, olaparib, hypoxia chronic
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1478-1490. doi: 10.1167/iovs.18-25936

Cornea March 2019

Rapamycin Rescues Endoplasmic Reticulum Stress–Induced Dry Eye Syndrome in Mice

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Bum-Joo Cho; Jin Sun Hwang; Young Joo Shin; Jeong Won Kim; Tae-Young Chung; Joon Young Hyon
TAGS: inflammation, rapamycin, dry eye syndromes, endoplasmic reticulum, mice, stress
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1254-1264. doi: 10.1167/iovs.18-25583

Biochemistry and Molecular Biology March 2019

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

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Kailin Chen; Kairan Lai; Xiaobo Zhang; Zhenwei Qin; Qiuli Fu; Chenqi Luo; Xiuming Jin; Jianghua Hu; Siyu Liu; Ke Yao
TAGS: fibroblasts, conjunctiva, pterygium, proto-oncogene proteins c-akt, bromfenac, hpfs trial
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1156-1164. doi: 10.1167/iovs.18-24743

Includes: Supplemental Content

Cornea March 2019

A New Ophthalmic Pharmaceutical Formulation, Topical Sulglycotide, Enhances the Ocular Mucin Secretion in Desiccation Stress-Mediated Dry Eye Disease

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Hyesook Lee; Sangwon Jeon; Chae Eun Kim; Young-Joon Park; Jaewook Yang
TAGS: dry eye syndromes, cornea, eye, stress, mucins, dosage forms, desiccation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1076-1087. doi: 10.1167/iovs.18-24935

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Resveratrol Inhibits Wound Healing and Lens Fibrosis: A Putative Candidate for Posterior Capsule Opacification Prevention

Peripapillary Choroidal Vascularity Index and Microstructure of Parapapillary Atrophy

Elevated Steroid Hormone Levels in Active Chronic Central Serous Chorioretinopathy

COMP-Ang1 Stabilizes Hyperglycemic Disruption of Blood-Retinal Barrier Phenotype in Human Retinal Microvascular Endothelial Cells

Chemical Considerations Regarding the H-Value Methodology and Its Relation With Toxicity Determination

Apratoxin S4 Inspired by a Marine Natural Product, a New Treatment Option for Ocular Angiogenic Diseases

Norgestrel, a Progesterone Analogue, Promotes Significant Long-Term Neuroprotection of Cone Photoreceptors in a Mouse Model of Retinal Disease

Oral Delivery of the P2Y 12 Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4 −/− Mouse Model of Retinal Degeneration

Glycyrrhizin Use for Multi-Drug Resistant Pseudomonas aeruginosa : In Vitro and In Vivo Studies

Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR

Intravitreal Fluocinolone Acetonide May Decelerate Diabetic Retinal Neurodegeneration

Activation of the BMP4/Smad1 Pathway Promotes Retinal Ganglion Cell Survival and Axon Regeneration

ON-Type Retinal Ganglion Cells are Preferentially Affected in STZ-Induced Diabetic Mice

Outer Retinal Oxidative Stress Measured In Vivo Using QUEnch-assiSTed (QUEST) OCT

Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation

The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration

PARP Inhibitor Protects Against Chronic Hypoxia/Reoxygenation-Induced Retinal Injury by Regulation of MAPKs, HIF1α, Nrf2, and NFκB

Rapamycin Rescues Endoplasmic Reticulum Stress–Induced Dry Eye Syndrome in Mice

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

A New Ophthalmic Pharmaceutical Formulation, Topical Sulglycotide, Enhances the Ocular Mucin Secretion in Desiccation Stress-Mediated Dry Eye Disease

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