Pharmacology

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Cornea December 2018

Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes

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Kiyokazu Ozaki; Yui Terayama; Tetsuro Matsuura
TAGS: hyperglycemia, diabetes mellitus, type 1, body weight, alloxan, neurons, streptozocin, sural nerve, cornea, mice, nerve lesions
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5868-5875. doi: 10.1167/iovs.18-25693

Retina December 2018

Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability

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Gerard A. Rodrigues; Matthew Mason; Lori-Ann Christie; Candice Hansen; Lisa M. Hernandez; James Burke; Keith A. Luhrs; Thomas C. Hohman
TAGS: angiogenesis, vascular endothelial growth factor a, oryctolagus cuniculus, bevacizumab, ranibizumab, affinity, aflibercept, anti-vascular endothelial growth factor therapy, vascular permeability
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5836-5846. doi: 10.1167/iovs.18-25307

Biochemistry and Molecular Biology November 2018

The Effect of Corticosteroids on Human Choroidal Endothelial Cells: A Model to Study Central Serous Chorioretinopathy

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Joost Brinks; Elon H. C. van Dijk; Mahmoud Habeeb; Aikaterini Nikolaou; Roula Tsonaka; Hendrika A. B. Peters; Hetty C. M. Sips; Arjanneke F. van de Merbel; Eiko K. de Jong; Robbert G. E. Notenboom; Szymon M. Kielbasa; Silvère M. van der Maarel; Paul H. A. Quax; Onno C. Meijer; Camiel J. F. Boon
TAGS: hydrocortisone, endothelial cells, adrenal corticosteroids, glucocorticoids, patient isolation, mineralocorticoids, agonists, antagonists, central serous chorioretinopathy, chronic exertional compartment syndrome
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5682-5692. doi: 10.1167/iovs.18-25054

Includes: Supplemental Content

Special Issue November 2018

Functional Visual Acuity

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Minako Kaido
TAGS: glaucoma, cataract, vision, visual acuity, quality, system of measurement
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES29-DES35. doi: 10.1167/iovs.17-23721

Special Issue November 2018

Autologous Serum and Serum Components

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Akihiro Higuchi
TAGS: dry eye syndromes, eyedrops
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES121-DES129. doi: 10.1167/iovs.17-23760

Retina November 2018

The Influence of Intravitreal Ranibizumab on Inflammation-associated Cytokine Concentrations in Eyes With Diabetic Macular Edema

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Shueh Wen Lim; Esther Bandala-Sanchez; Maria Kolic; Sophie L. Rogers; Annie K. McAuley; Lyndell L. Lim; Sanjeewa S. Wickremasinghe
TAGS: cytokine, vascular endothelial growth factor a, inflammation, eye, macular edema, diabetic, ranibizumab
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5382-5390. doi: 10.1167/iovs.17-23325

Includes: Supplemental Content

Retina November 2018

Intravitreal Injection of AAV Expressing Soluble VEGF Receptor-1 Variant Induces Anti-VEGF Activity and Suppresses Choroidal Neovascularization

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Steven Hyun Seung Lee; Hee Jong Kim; Oh Kyu Shin; Jun-Sub Choi; Jin Kim; Young-Hwa Cho; Joohun Ha; Tae Kwann Park; Joo Yong Lee; Keerang Park; Heuiran Lee
TAGS: vascular endothelial growth factor a, vegfr-1, choroidal neovascularization, mice, bevacizumab, intravitreal injections, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5398-5407. doi: 10.1167/iovs.18-24926

Includes: Supplemental Content

Cornea October 2018

Plasminogen-Dependent Collagenolytic Properties of Staphylococcus aureus in Collagen Gel Cultures of Human Corneal Fibroblasts

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Koji Sugioka; Aya Kodama-Takahshi; Tomoko Sato; Kiyotaka Okada; Junko Murakami; Ah-Mee Park; Hiroshi Mishima; Yoshikazu Shimomura; Shunji Kusaka; Teruo Nishida
TAGS: urokinase, fibroblasts, collagen, gel, plasminogen, cornea, catabolism
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5098-5107. doi: 10.1167/iovs.18-24925

Retina October 2018

How to Ward Off Retinal Toxicity of Perfluorooctane and Other Perfluorocarbon Liquids?

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Dirk-Henning Menz; Nicolas Feltgen; Helge Menz; Bernd-Kristof Müller; Thorsten Lechner; Joachim Dresp; Hans Hoerauf
TAGS: patent foramen ovale, fluorides, fluorocarbons, patients' rooms, safety, cytotoxicity, retinal toxicity, liquids, perfluorooctane
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4841-4846. doi: 10.1167/iovs.18-24698

Immunology and Microbiology September 2018

In Vitro Amoebicidal Activity of Titanium Dioxide/UV-A Combination Against Acanthamoeba

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Gabrielle Gomart; Julie Denis; Tristan Bourcier; Anne Dory; Ahmed Abou-Bacar; Ermanno Candolfi; Arnaud Sauer
TAGS: acanthamoeba, cysts, ultraviolet a radiation, titanium dioxide, trophozoite
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4567-4571. doi: 10.1167/iovs.18-25003

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2018

Inhibitory Effect of Idelalisib, a Selective Phosphatidylinositol 3-Kinase δ Inhibitor, on Adipogenesis in an In Vitro Model of Graves' Orbitopathy

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JaeSang Ko; Ji-Young Kim; Eun Jig Lee; Jin Sook Yoon
TAGS: fibroblasts, 1-phosphatidylinositol 3-kinase, idelalisib
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4477-4485. doi: 10.1167/iovs.18-24509

Includes: Supplemental Content

Retina September 2018

Neuroprotective Effects of FGF2 and Minocycline in Two Animal Models of Inherited Retinal Degeneration

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Johnny Di Pierdomenico; Rebecca Scholz; F. Javier Valiente-Soriano; Maria C. Sánchez-Migallón; Manuel Vidal-Sanz; Thomas Langmann; Marta Agudo-Barriuso; Diego García-Ayuso; María Paz Villegas-Pérez
TAGS: ciliary neurotrophic factor, fibroblast growth factor 2, minocycline, animal model, photoreceptors, retinal degeneration, rats, neuroprotective effect
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4392-4403. doi: 10.1167/iovs.18-24621

Retina August 2018

Mechanistic Evaluation of Panretinal Photocoagulation Versus Aflibercept in Proliferative Diabetic Retinopathy: CLARITY Substudy

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Luke Nicholson; Roxanne Crosby-Nwaobi; Joana C. Vasconcelos; A. Toby Prevost; Jayashree Ramu; Amy Riddell; James W. Bainbridge; Philip G. Hykin; Sobha Sivaprasad
TAGS: oximetry, eye, proliferative diabetic retinopathy, panretinal photocoagulation, aflibercept
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4277-4284. doi: 10.1167/iovs.17-23509

Includes: Supplemental Content

Retina August 2018

Anti-VEGF Monotherapy Versus Photodynamic Therapy and Anti-VEGF Combination Treatment for Neovascular Age-Related Macular Degeneration: A Meta-Analysis

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Yang Gao; Tao Yu; Yue Zhang; Guangfu Dang
TAGS: meta-analysis, combined modality therapy, photochemotherapy, verteporfin, exudative age-related macular degeneration, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4307-4317. doi: 10.1167/iovs.17-23747

Cornea August 2018

Ophthalmic Nonsteroidal Anti-Inflammatory Drugs as a Therapy for Corneal Dystrophies Caused by SLC4A11 Mutation

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Kumari Alka; Joseph R. Casey
TAGS: mutation, anti-inflammatory agents, non-steroidal, hereditary corneal dystrophy, diclofenac, eye, water, nepafenac
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4258-4267. doi: 10.1167/iovs.18-24301

Includes: Supplemental Content

Biochemistry and Molecular Biology August 2018

Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway

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Na Wang; Chen Zou; Shuzhi Zhao; Yunzhi Wang; Changjing Han; Zhi Zheng
TAGS: apoptosis, diabetes mellitus, inflammation, glucose, diabetic retinopathy, rats, angptl3 gene, fenofibrate, integrins
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4210-4217. doi: 10.1167/iovs.18-24155

Retina August 2018

Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging

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Ignacio Melgar-Asensio; Irawati Kandela; Fraser Aird; Soesiawati R. Darjatmoko; Cristobal de los Rios; Christine M. Sorenson; Daniel M. Albert; Nader Sheibani; Jack Henkin
TAGS: arginine, drug clearance, drug delivery systems, peptides, oryctolagus cuniculus, vitreous body, diagnostic imaging, eye
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4071-4081. doi: 10.1167/iovs.18-24087

Letters to the Editor August 2018

Comments on Assays Used to Measure VEGF in the Presence of Anti-VEGF Therapeutics

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Eric Wakshull; Robert Avery; Mauricio Maia
TAGS: vascular endothelial growth factor a, therapeutics, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4106-4106. doi: 10.1167/iovs.18-24792

Cornea August 2018

Higher Total Insulin Dose Has Positive Effect on Corneal Nerve Fibers in DM1 Patients

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Gabriela Mahelková; Marie Česká Burdová; Šárka Malá; Lucie Hoskovcová; Dagmar Dotřelová; Kateřina Štechová
TAGS: nerve fibers, cornea, insulin
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3800-3807. doi: 10.1167/iovs.18-24265

Glaucoma August 2018

Resveratrol Delays Retinal Ganglion Cell Loss and Attenuates Gliosis-Related Inflammation From Ischemia-Reperfusion Injury

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Hongdou Luo; Jiejie Zhuang; Piaopiao Hu; Wei Ye; Shanshan Chen; Yulian Pang; Ningfeng Li; Cong Deng; Xu Zhang
TAGS: apoptosis, inflammation, gliosis, reperfusion injury, wounds and injuries, retina, resveratrol, attenuation, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3879-3888. doi: 10.1167/iovs.18-23806

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Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes

Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability

The Effect of Corticosteroids on Human Choroidal Endothelial Cells: A Model to Study Central Serous Chorioretinopathy

Functional Visual Acuity

Autologous Serum and Serum Components

The Influence of Intravitreal Ranibizumab on Inflammation-associated Cytokine Concentrations in Eyes With Diabetic Macular Edema

Intravitreal Injection of AAV Expressing Soluble VEGF Receptor-1 Variant Induces Anti-VEGF Activity and Suppresses Choroidal Neovascularization

Plasminogen-Dependent Collagenolytic Properties of Staphylococcus aureus in Collagen Gel Cultures of Human Corneal Fibroblasts

How to Ward Off Retinal Toxicity of Perfluorooctane and Other Perfluorocarbon Liquids?

In Vitro Amoebicidal Activity of Titanium Dioxide/UV-A Combination Against Acanthamoeba

Inhibitory Effect of Idelalisib, a Selective Phosphatidylinositol 3-Kinase δ Inhibitor, on Adipogenesis in an In Vitro Model of Graves' Orbitopathy

Neuroprotective Effects of FGF2 and Minocycline in Two Animal Models of Inherited Retinal Degeneration

Mechanistic Evaluation of Panretinal Photocoagulation Versus Aflibercept in Proliferative Diabetic Retinopathy: CLARITY Substudy

Anti-VEGF Monotherapy Versus Photodynamic Therapy and Anti-VEGF Combination Treatment for Neovascular Age-Related Macular Degeneration: A Meta-Analysis

Ophthalmic Nonsteroidal Anti-Inflammatory Drugs as a Therapy for Corneal Dystrophies Caused by SLC4A11 Mutation

Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway

Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging

Comments on Assays Used to Measure VEGF in the Presence of Anti-VEGF Therapeutics

Higher Total Insulin Dose Has Positive Effect on Corneal Nerve Fibers in DM1 Patients

Resveratrol Delays Retinal Ganglion Cell Loss and Attenuates Gliosis-Related Inflammation From Ischemia-Reperfusion Injury

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