Pharmacology

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Immunology and Microbiology July 2025

The Gut Microbial System Responds to Retinal Injury and Modulates the Outcomes by Regulating Innate Immune Activation

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Xuexue Cui; Caijiao Yi; Jian Liu; Jinyan Qi; Wen Deng; Xiangling Yuan; Ruiqi Zhou; Mei Chen; Qiang Xiang; Heping Xu
TAGS: antibiotics, gastrointestinal microbiome, mice, retinal injuries, wounds and injuries, laser injuries, attenuation, lasers
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):6. https://doi.org/10.1167/iovs.66.9.6

Includes: Supplemental Content

Retina July 2025

Retinal Angiogenesis in Methamphetamine Self-Administration Rats

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Minsup Lee; Bo J. Wood; Hyeon Hak Jeong; Hyung W. Nam; Courtney M. Keller; Bonggi Lee; Jae-Il Kim; Kevin S. Murnane; Nicholas E. Goeders; Norman R. Harris
TAGS: angiogenesis, methamphetamine, rats, self administration, retina, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):8. https://doi.org/10.1167/iovs.66.9.8

Physiology and Pharmacology June 2025

Antibiotics-Induced Gut Microbiome Dysbiosis Affects Susceptibility to Minus Lens-Induced Myopia in Mice

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Shin-ichi Ikeda; Deokho Lee; Junhan Chen; Shinji Fukuda; Kazuno Negishi; Kazuo Tsubota; Toshihide Kurihara
TAGS: antibiotics, disease susceptibility, gastrointestinal microbiome, lens (device), lens, crystalline, mice, myopia, dysbiosis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):76. https://doi.org/10.1167/iovs.66.6.76

Cornea June 2025

Human Platelet Lysate Treatment for Exposure Keratopathy: An In Vivo Confocal Microscopy and Anterior Segment OCT Study

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Chia-Ying Tsai; Wei-Lun Huang; Shang-Chih Yang; Bo-Da Huang; Vladlen Klochkov; Shu-Lang Liao; Albert Y. Wu; Wei-Li Chen
TAGS: adrenal corticosteroids, blood platelets, cornea, epithelium, exposure keratoconjunctivitis, glucocorticoids, lysate, microscopy, confocal, mineralocorticoids, anti-inflammatory agents
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):73. https://doi.org/10.1167/iovs.66.6.73

Retina June 2025

Liposome Encapsulation Enhances Ripasudil Therapeutic Efficacy Against Proliferative Vitreoretinal Diseases: Implications in Advanced Ocular Treatment

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Rui Ji; Keijiro Ishikawa; Wei Tan; Kenichiro Mori; Ryotaro Tsukamoto; Naoya Matsunaga; Kohei Kiyohara; Yosuke Fukuda; Iori Wada; Tomoyuki Isobe; Tomohito Tanihara; Yuya Yoshida; Kouta Mayanagi; Kosuke Oyama; Yuma Terada; Kaita Otsuki; Kengo Hamamura; Hiroshi Kikuchi; Shintaro Nakao; Shigeo Yoshida; Ram Kannan; Shigehiro Ohdo; Koh-Hei Sonoda
TAGS: encapsulation, hmga2 protein, lipoma, liposomes, radioimmunoprecipitation assay, ristocetin induced platelet aggregation, vitreoretinal disease, fibrosis, choroidal neovascularization, oryctolagus cuniculus
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):56. https://doi.org/10.1167/iovs.66.6.56

Includes: Supplemental Content

Physiology and Pharmacology June 2025

Modeling the Ocular Pharmacokinetics and Pharmacodynamics of Ranibizumab for Improved Understanding and Data Collection Strategies in Ocular Diseases

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Jessica R. Crawshaw; Eamonn A. Gaffney; Michael Gertz; Philip K. Maini; Antonello Caruso
TAGS: aqueous humor, ranibizumab, vascular endothelial growth factor a, pharmacodynamics, eye diseases, pharmacokinetics, mathematical model
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):20. https://doi.org/10.1167/iovs.66.6.20

Includes: Supplemental Content

Retina June 2025

Anti-VEGF Agents Clearance Through the Aqueous Outflow Pathway in a Rat Model

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Assaf Ben-Arzi; Itay Spector; Yariv Keshet; Orly Gal-Or; Irit Bahar; Assaf Dotan
TAGS: aflibercept, anti-vascular endothelial growth factor therapy, drug clearance, ranibizumab, intravitreal injections, bevacizumab, choroidal neovascularization, mass or substance concentration per volume, eye, antibodies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):1. https://doi.org/10.1167/iovs.66.6.1

Lens May 2025

RNA-Seq Study of Human Lens Epithelial Cells: Differentially Expressed Genes and Pathways in Steroid, Uveitic, Post-Vitrectomy, and Senile Cataracts

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Carrie Fei; Michael R. Dong; Sean Byars; Jaynish S. Shah; Anthony J. Hall; Lyndell L. Lim
TAGS: after-cataract, cataract, cataract, senile, epithelial cells, genes, lens, crystalline, rna-seq, steroids, vitrectomy, rna
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):4. https://doi.org/10.1167/iovs.66.5.4

Includes: Supplemental Content

Retina April 2025

Use of SGLT2 Inhibitors Versus DPP-4 Inhibitors and Age-Related Macular Degeneration in Patients WithType 2 Diabetes: A Multinational Cohort Study

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Ssu-Yu Pan; Chien-Hsiang Weng; Shang-Feng Tsai; Hui-Ju Lin; Jun-Fu Lin; Ching-Heng Lin; I-Jong Wang; Chien-Chih Chou
TAGS: age-related macular degeneration, diabetes mellitus, type 2, dipeptidyl-peptidase iv inhibitors, sodium-glucose transporter 2 inhibitors, diabetes mellitus, cohort studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):58. https://doi.org/10.1167/iovs.66.4.58

Includes: Supplemental Content

Cornea April 2025

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

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Haiqi Xiao; Li Hu; Xiongshi Lin; Linchang Liu; Xing Dong; Liting Yang; Ying Liu; Zhichong Wang; Ying Tian; Shuangyong Wang
TAGS: pax6 transcription factor, soluble fms-like tyrosine kinase 1
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):52. https://doi.org/10.1167/iovs.66.4.52

Includes: Supplemental Content

Glaucoma April 2025

Effects of Verteporfin on Interstitial Fluid Flow-Induced Fibrotic Transdifferentiation of Human Tenon Fibroblasts

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Janne Frömmichen; Emma Bungert; Jeanne Ströble; Moritz Gläser; Charlotte Gottwald; Kosovare Zeqiri; Thomas Reinhard; Jan Lübke; Günther Schlunck; Cornelius Jakob Wiedenmann
TAGS: fibroblasts, fibrosis, fluid flow, interstitial fluid, verteporfin, actins, cell transdifferentiation, connective tissue growth factor
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):17. https://doi.org/10.1167/iovs.66.4.17

Clinical and Epidemiologic Research March 2025

NLRP3 Activation With Bisphosphonate Use and the Risk of Incident Age-Related Macular Degeneration

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Joseph Magagnoli; Tammy Cummings; James W. Hardin; S. Scott Sutton; Jayakrishna Ambati
TAGS: age-related macular degeneration, bisphosphonates, nlr family, pyrin domain-containing 3 protein
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):32. https://doi.org/10.1167/iovs.66.3.32

Includes: Supplemental Content

Cornea March 2025

Reversal of Diabetic Dry Eye by Topical Opioid Receptor Blockade Follows Dual Pathways

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David Diaz; Joseph W. Sassani; Ian S. Zagon; Patricia J. McLaughlin
TAGS: cornea, diabetes mellitus, dry eye syndromes, naltrexone, opioid receptor, rats, corneal epithelium, trigeminal ganglion
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):24. https://doi.org/10.1167/iovs.66.3.24

Includes: Supplemental Content

Letters to the Editor March 2025

Author Response: Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

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Patricia Barreto; Claudia Farinha; Rita Coimbra; Rufino Silva
TAGS: age-related macular degeneration, genetics, statins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):3. https://doi.org/10.1167/iovs.66.3.3

Retina February 2025

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

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Xiaoyan Ding; Xiaodi Zhou; Xinyu Liu; Yanting Lai; Wenjia Yan; Yizhe Cheng; Aohan Hou; Limei Chen; Limei Sun
TAGS: angiogenesis, hypoxia, mice, neovascularization, pathologic, 1-phosphatidylinositol 3-kinase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):40. https://doi.org/10.1167/iovs.66.2.40

Includes: Supplemental Content

Cornea February 2025

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)

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Hao Chi; Li Ma; Fanxing Zeng; Xiaolei Wang; Peng Peng; Xiaofei Bai; Ting Zhang; Wenhui Yin; Yaoyao Yu; Lingling Yang; Qingjun Zhou; Chao Wei; Weiyun Shi
TAGS: aging, allografting, angiotensin converting enzyme 2, cornea, keratoplasty, navitoclax, rejection (psychology), senolytics, stress, transplant rejection
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):15. https://doi.org/10.1167/iovs.66.2.15

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology January 2025

Simvastatin-Induced Ferroptosis in Orbital Fibroblasts in Graves’ Ophthalmopathy

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Lujue Wang; Yuan Li; Tongxin Niu; Jing Deng; Yuxian Shi; Yating Liu; Boding Tong; Xin Qi; Dan Cao; Yongguang Tao; Yunping Li
TAGS: ferroptosis, graves' ophthalmopathy, simvastatin, fibroblasts
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):56. https://doi.org/10.1167/iovs.66.1.56

Letters to the Editor January 2025

Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

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Blondy Kayembe Mulumba; Karen Leffondré; Pierre Joly; Marie-Noëlle Delyfer; Cécile Delcourt
TAGS: age-related macular degeneration, genetics, statins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):25. https://doi.org/10.1167/iovs.66.1.25

Anatomy and Pathology/Oncology January 2025

Leptin Receptor Deficiency–Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome

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Xiaoting Pei; Mengru Ba; Tingting Yang; Shuting Xuan; Duliurui Huang; Di Qi; Dingli Lu; Shenzhen Huang; Zhijie Li
TAGS: diabetes mellitus, diabetes mellitus, type 2, insulin, mice, langer-giedion syndrome, circadian rhythms, dry eye syndromes, gene expression
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):19. https://doi.org/10.1167/iovs.66.1.19

Includes: Supplemental Content

Immunology and Microbiology January 2025

Anti-Inflammatory Effects of Clarstatin, a Shared-Epitope–Antagonistic Cyclic Peptide, on Experimental Autoimmune Uveitis in Mice

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Shira Merzbach; Adi Schumacher-Klinger; Michal Klazas; Amnon Hoffman; Philip Lazarovici; Chaim Gilon; Gabriel Nussbaum; Radgonde Amer
TAGS: anti-inflammatory agents, autoimmunity, cyclic peptides, epitopes, mice, uveitis, mice, inbred c57bl, cd45 antigens, cytokine
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):13. https://doi.org/10.1167/iovs.66.1.13

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The Gut Microbial System Responds to Retinal Injury and Modulates the Outcomes by Regulating Innate Immune Activation

Retinal Angiogenesis in Methamphetamine Self-Administration Rats

Antibiotics-Induced Gut Microbiome Dysbiosis Affects Susceptibility to Minus Lens-Induced Myopia in Mice

Human Platelet Lysate Treatment for Exposure Keratopathy: An In Vivo Confocal Microscopy and Anterior Segment OCT Study

Liposome Encapsulation Enhances Ripasudil Therapeutic Efficacy Against Proliferative Vitreoretinal Diseases: Implications in Advanced Ocular Treatment

Modeling the Ocular Pharmacokinetics and Pharmacodynamics of Ranibizumab for Improved Understanding and Data Collection Strategies in Ocular Diseases

Anti-VEGF Agents Clearance Through the Aqueous Outflow Pathway in a Rat Model

RNA-Seq Study of Human Lens Epithelial Cells: Differentially Expressed Genes and Pathways in Steroid, Uveitic, Post-Vitrectomy, and Senile Cataracts

Use of SGLT2 Inhibitors Versus DPP-4 Inhibitors and Age-Related Macular Degeneration in Patients WithType 2 Diabetes: A Multinational Cohort Study

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

Effects of Verteporfin on Interstitial Fluid Flow-Induced Fibrotic Transdifferentiation of Human Tenon Fibroblasts

NLRP3 Activation With Bisphosphonate Use and the Risk of Incident Age-Related Macular Degeneration

Reversal of Diabetic Dry Eye by Topical Opioid Receptor Blockade Follows Dual Pathways

Author Response: Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)

Simvastatin-Induced Ferroptosis in Orbital Fibroblasts in Graves’ Ophthalmopathy

Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

Leptin Receptor Deficiency–Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome

Anti-Inflammatory Effects of Clarstatin, a Shared-Epitope–Antagonistic Cyclic Peptide, on Experimental Autoimmune Uveitis in Mice

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