Pharmacology

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Retina August 2018

Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging

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Ignacio Melgar-Asensio; Irawati Kandela; Fraser Aird; Soesiawati R. Darjatmoko; Cristobal de los Rios; Christine M. Sorenson; Daniel M. Albert; Nader Sheibani; Jack Henkin
TAGS: arginine, drug clearance, drug delivery systems, peptides, oryctolagus cuniculus, vitreous body, diagnostic imaging, eye
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4071-4081. doi: 10.1167/iovs.18-24087

Letters to the Editor August 2018

Comments on Assays Used to Measure VEGF in the Presence of Anti-VEGF Therapeutics

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Eric Wakshull; Robert Avery; Mauricio Maia
TAGS: vascular endothelial growth factor a, therapeutics, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4106-4106. doi: 10.1167/iovs.18-24792

Cornea August 2018

Higher Total Insulin Dose Has Positive Effect on Corneal Nerve Fibers in DM1 Patients

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Gabriela Mahelková; Marie Česká Burdová; Šárka Malá; Lucie Hoskovcová; Dagmar Dotřelová; Kateřina Štechová
TAGS: nerve fibers, cornea, insulin
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3800-3807. doi: 10.1167/iovs.18-24265

Glaucoma August 2018

Resveratrol Delays Retinal Ganglion Cell Loss and Attenuates Gliosis-Related Inflammation From Ischemia-Reperfusion Injury

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Hongdou Luo; Jiejie Zhuang; Piaopiao Hu; Wei Ye; Shanshan Chen; Yulian Pang; Ningfeng Li; Cong Deng; Xu Zhang
TAGS: apoptosis, inflammation, gliosis, reperfusion injury, wounds and injuries, retina, resveratrol, attenuation, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3879-3888. doi: 10.1167/iovs.18-23806

Cornea July 2018

Modulating Contact Lens Discomfort With Anti-Inflammatory Approaches: A Randomized Controlled Trial

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Laura E. Downie; Anne Gad; Chinn Yi Wong; John Henry V. Gray; Weiguang Zeng; David C. Jackson; Algis J. Vingrys
TAGS: anti-inflammatory agents, cytokine, inflammation, omega-3 fatty acids, fish oils, contact lenses, interleukin-17, placebos, randomized controlled trial, signs and symptoms, interleukin-6, topical corticosteroid, outcome measures
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3755-3766. doi: 10.1167/iovs.18-24758

Includes: Supplemental Content

Cornea July 2018

Therapeutic Effects of a Novel Phenylphthalimide Analog for Corneal Neovascularization and Retinal Vascular Leakage

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Bing Wang; Pui-Kai Li; Jian-xing Ma; Danyang Chen
TAGS: vascular endothelial growth factor a, alkalies, eye, thalidomide, diabetes mellitus, retina, cornea, angiogenesis inhibitors, rats, streptozocin, intravitreal injections, corneal neovascularization, burns
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3630-3642. doi: 10.1167/iovs.18-24015

Includes: Supplemental Content

Cornea July 2018

0.005% Preservative-Free Latanoprost Induces Dry Eye-Like Ocular Surface Damage via Promotion of Inflammation in Mice

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Yiran Yang; Caihong Huang; Xiang Lin; Yang Wu; Weijie Ouyang; Liying Tang; Sihao Ye; Yuhong Wang; Wei Li; Xiaobo Zhang; Zuguo Liu
TAGS: inflammation, administration, topical, dry eye syndromes, mice, latanoprost, eyedrops
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3375-3384. doi: 10.1167/iovs.18-24013

Includes: Supplemental Content

Retinal Cell Biology June 2018

D- cis -Diltiazem Can Produce Oxidative Stress in Healthy Depolarized Rods In Vivo

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Bruce A. Berkowitz; Robert H. Podolsky; Benjamin Farrell; Hojun Lee; Christopher Trepanier; Ali M. Berri; Kristin Dernay; Emma Graffice; Fatema Shafie-Khorassani; Timothy S. Kern; Robin Roberts
TAGS: oxidative stress, diltiazem, magnetic resonance imaging, rod photoreceptors, mice, retina
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2999-3010. doi: 10.1167/iovs.18-23829

Cornea June 2018

Bacterial Coaggregation and Cohesion Among Isolates From Contact Lens Cases

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Ananya Datta; Fiona Stapleton; Mark D. P. Willcox
TAGS: staphylococcus, bacteria, contact lens storage case
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2729-2735. doi: 10.1167/iovs.17-23155

Retinal Cell Biology June 2018

Anti-CD160, Alone or in Combination With Bevacizumab, Is a Potent Inhibitor of Ocular Neovascularization in Rabbit and Monkey Models

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Thierry Menguy; Anne Briaux; Elisabeth Jeunesse; Jérôme Giustiniani; Alexandre Calcei; Thierry Guyon; Jacques Mizrahi; Hélène Haegel; Vanessa Duong; Vincent Soler; Pierre Brousset; Armand Bensussan; Isabelle Raymond Letron; Philippe Le Bouteiller
TAGS: vascular endothelial growth factor a, angiogenesis inhibitors, monoclonal antibodies, cercopithecidae, choroidal neovascularization, fibroblast growth factor 2, injection of therapeutic agent, lasers, neovascularization, pathologic, oryctolagus cuniculus, immunoglobulin g, cornea, bevacizumab, transverse spin relaxation rate, anti-vascular endothelial growth factor therapy, coefficient of determination
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2687-2698. doi: 10.1167/iovs.18-24024

Includes: Supplemental Content

Clinical and Epidemiologic Research May 2018

A CCR2/5 Inhibitor, PF-04634817, Is Inferior to Monthly Ranibizumab in the Treatment of Diabetic Macular Edema

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Jeremy D. Gale; Brian Berger; Steven Gilbert; Serghei Popa; Marla B. Sultan; Ronald A. Schachar; Douglas Girgenti; Christelle Perros-Huguet
TAGS: safety, macular edema, diabetic, ranibizumab
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2659-2669. doi: 10.1167/iovs.17-22731

Includes: Supplemental Content

Glaucoma May 2018

FOXC1 Regulates Expression of Prostaglandin Receptors Leading to an Attenuated Response to Latanoprost

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Lance P. Doucette; Tim Footz; Michael A. Walter
TAGS: phenotype, prostaglandins, glaucoma, prostaglandin receptor, proteins, latanoprost, rna, rna, small interfering, attenuation
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2548-2554. doi: 10.1167/iovs.17-23223

Includes: Supplemental Content

Glaucoma May 2018

Effect of Timolol on Optineurin Aggregation in Transformed Induced Pluripotent Stem Cells Derived From Patient With Familial Glaucoma

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Satoshi Inagaki; Kazuhide Kawase; Michinori Funato; Junko Seki; Chizuru Kawase; Kazuki Ohuchi; Tsubasa Kameyama; Shiori Ando; Arisu Sato; Wataru Morozumi; Shinsuke Nakamura; Masamitsu Shimazawa; Daisuke Iejima; Takeshi Iwata; Tetsuya Yamamoto; Hideo Kaneko; Hideaki Hara
TAGS: timolol, glaucoma, stem cells, pluripotent, optn gene
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2293-2304. doi: 10.1167/iovs.17-22975

Includes: Supplemental Content

Clinical and Epidemiologic Research May 2018

Clinical Outcomes of Fixed Versus As-Needed Use of Artificial Tears in Dry Eye Disease: A 6-Week, Observer-Masked Phase 4 Clinical Trial

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Penny Asbell; Algis J. Vingrys; Jacqueline Tan; Abayomi Ogundele; Laura E. Downie; Gary Jerkins; Lee Shettle
TAGS: phase iv trial, dry eye syndromes, treatment outcome, ocular lubricants
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2275-2280. doi: 10.1167/iovs.17-23733

Includes: Supplemental Content

Physiology and Pharmacology April 2018

Endothelial Protein C–Targeting Liposomes Show Enhanced Uptake and Improved Therapeutic Efficacy in Human Retinal Endothelial Cells

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Anthoula Arta; Anne Z. Eriksen; Fredrik Melander; Paul Kempen; Michael Larsen; Thomas L. Andresen; Andrew J. Urquhart
TAGS: endothelial cells, liposomes, endothelial protein c receptor
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):2119-2132. doi: 10.1167/iovs.18-23800

Includes: Supplemental Content

Retina April 2018

Targeted Drug Delivery in the Suprachoroidal Space by Swollen Hydrogel Pushing

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Jae Hwan Jung; Patcharin Desit; Mark R. Prausnitz
TAGS: hydrogel, injection of therapeutic agent, oryctolagus cuniculus, eye
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):2069-2079. doi: 10.1167/iovs.17-23758

Includes: Supplemental Content

Lens April 2018

Pharmacokinetics of Caffeine in the Lens Capsule/Epithelium After Peroral Intake: A Pilot Randomized Controlled Study

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Martin Kronschläger; Thomas Stimpfl; Manuel Ruiß; Nino Hirnschall; Christoph Leisser; Oliver Findl
TAGS: caffeine, epithelium, lens capsule, crystalline, lens, crystalline, lens (device), pharmacokinetics
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1855-1860. doi: 10.1167/iovs.18-23963

Clinical and Epidemiologic Research April 2018

Plasma Concentrations of Lutein and Zeaxanthin, Macular Pigment Optical Density, and Their Associations With Cognitive Performances Among Older Adults

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Soufiane Ajana; Daniela Weber; Catherine Helmer; Bénédicte M. Merle; Wolfgang Stuetz; Jean-François Dartigues; Marie-Bénédicte Rougier; Jean-François Korobelnik; Tilman Grune; Cécile Delcourt; Catherine Féart
TAGS: plasma drug concentration, cognition, lutein, mental processes, optics, plasma, elderly, cognitive ability, macular pigment
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1828-1835. doi: 10.1167/iovs.17-22656

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2018

Bevacizumab Promotes T-Cell–Mediated Collagen Deposition in the Mouse Model of Conjunctival Scarring

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Li-Fong Seet; Li Zhen Toh; Stephanie Chu; Sharon N. Finger; Florent Ginhoux; Wanjin Hong; Tina T. Wong
TAGS: vascular endothelial growth factor a, cicatrix, collagen, t-lymphocyte, blister, conjunctiva, mice, bevacizumab, collagen synthesis
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1682-1692. doi: 10.1167/iovs.17-22694

Cornea March 2018

The Role of 2% Rebamipide Eye Drops Related to Conjunctival Differentiation in Superoxide Dismutase-1 ( Sod1 ) Knockout Mice

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Takashi Kojima; Cem Simsek; Ayako Igarashi; Kazue Aoki; Kazunari Higa; Takahiko Shimizu; Murat Dogru; Kazuo Tsubota; Jun Shimazaki
TAGS: epithelium, goblet cells, mice, knockout, rna, messenger, conjunctiva, mice, eyedrops, rebamipide, sod1 gene, superoxide dismutase 1
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1675-1681. doi: 10.1167/iovs.17-23213

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Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging

Comments on Assays Used to Measure VEGF in the Presence of Anti-VEGF Therapeutics

Higher Total Insulin Dose Has Positive Effect on Corneal Nerve Fibers in DM1 Patients

Resveratrol Delays Retinal Ganglion Cell Loss and Attenuates Gliosis-Related Inflammation From Ischemia-Reperfusion Injury

Modulating Contact Lens Discomfort With Anti-Inflammatory Approaches: A Randomized Controlled Trial

Therapeutic Effects of a Novel Phenylphthalimide Analog for Corneal Neovascularization and Retinal Vascular Leakage

0.005% Preservative-Free Latanoprost Induces Dry Eye-Like Ocular Surface Damage via Promotion of Inflammation in Mice

D- cis -Diltiazem Can Produce Oxidative Stress in Healthy Depolarized Rods In Vivo

Bacterial Coaggregation and Cohesion Among Isolates From Contact Lens Cases

Anti-CD160, Alone or in Combination With Bevacizumab, Is a Potent Inhibitor of Ocular Neovascularization in Rabbit and Monkey Models

A CCR2/5 Inhibitor, PF-04634817, Is Inferior to Monthly Ranibizumab in the Treatment of Diabetic Macular Edema

FOXC1 Regulates Expression of Prostaglandin Receptors Leading to an Attenuated Response to Latanoprost

Effect of Timolol on Optineurin Aggregation in Transformed Induced Pluripotent Stem Cells Derived From Patient With Familial Glaucoma

Clinical Outcomes of Fixed Versus As-Needed Use of Artificial Tears in Dry Eye Disease: A 6-Week, Observer-Masked Phase 4 Clinical Trial

Endothelial Protein C–Targeting Liposomes Show Enhanced Uptake and Improved Therapeutic Efficacy in Human Retinal Endothelial Cells

Targeted Drug Delivery in the Suprachoroidal Space by Swollen Hydrogel Pushing

Pharmacokinetics of Caffeine in the Lens Capsule/Epithelium After Peroral Intake: A Pilot Randomized Controlled Study

Plasma Concentrations of Lutein and Zeaxanthin, Macular Pigment Optical Density, and Their Associations With Cognitive Performances Among Older Adults

Bevacizumab Promotes T-Cell–Mediated Collagen Deposition in the Mouse Model of Conjunctival Scarring

The Role of 2% Rebamipide Eye Drops Related to Conjunctival Differentiation in Superoxide Dismutase-1 ( Sod1 ) Knockout Mice

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