Pharmacology

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Visual Neuroscience April 2019

ON-Type Retinal Ganglion Cells are Preferentially Affected in STZ-Induced Diabetic Mice

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Run-Ze Cui; Lu Wang; Sheng-Nan Qiao; Yong-Chen Wang; Xin Wang; Fei Yuan; Shi-Jun Weng; Xiong-Li Yang; Yong-Mei Zhong
TAGS: diabetes mellitus, streptozocin, mice, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1644-1656. doi: 10.1167/iovs.18-26359

Retina April 2019

Outer Retinal Oxidative Stress Measured In Vivo Using QUEnch-assiSTed (QUEST) OCT

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Bruce A. Berkowitz; Robert H. Podolsky; Karen M. Lins-Childers; Yichao Li; Haohua Qian
TAGS: oxidative stress, diltiazem, mice, apraxia of speech, aneurysms-osteoarthritis syndrome, saline solutions
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1566-1570. doi: 10.1167/iovs.18-26164

Glaucoma April 2019

Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation

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Yan Hu; Arturo O. Barron; Sofya Gindina; Sandeep Kumar; Shravan Chintala; Ashima Nayyar; John Danias
TAGS: alteplase, urokinase, gelatinase b, platelet count measurement, mice, regulation, fibrinolysis pathway
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1571-1580. doi: 10.1167/iovs.18-25698

Clinical and Epidemiologic Research April 2019

The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration

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Emily E. Brown; Jacob D. Ball; Zhaoyi Chen; Gibran S. Khurshid; Mattia Prosperi; John D. Ash
TAGS: metformin, age-related macular degeneration, antidiabetics
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1470-1477. doi: 10.1167/iovs.18-26422

Physiology and Pharmacology April 2019

PARP Inhibitor Protects Against Chronic Hypoxia/Reoxygenation-Induced Retinal Injury by Regulation of MAPKs, HIF1α, Nrf2, and NFκB

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Krisztina Kovacs; Alexandra Vaczy; Katalin Fekete; Petra Kovari; Tamas Atlasz; Dora Reglodi; Robert Gabriel; Ferenc Gallyas; Balazs Sumegi
TAGS: hypoxia, retina, retinal injuries, poly(adp-ribose) polymerase inhibitors, olaparib, hypoxia chronic
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1478-1490. doi: 10.1167/iovs.18-25936

Cornea March 2019

Rapamycin Rescues Endoplasmic Reticulum Stress–Induced Dry Eye Syndrome in Mice

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Bum-Joo Cho; Jin Sun Hwang; Young Joo Shin; Jeong Won Kim; Tae-Young Chung; Joon Young Hyon
TAGS: inflammation, rapamycin, dry eye syndromes, endoplasmic reticulum, mice, stress
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1254-1264. doi: 10.1167/iovs.18-25583

Biochemistry and Molecular Biology March 2019

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

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Kailin Chen; Kairan Lai; Xiaobo Zhang; Zhenwei Qin; Qiuli Fu; Chenqi Luo; Xiuming Jin; Jianghua Hu; Siyu Liu; Ke Yao
TAGS: fibroblasts, conjunctiva, pterygium, proto-oncogene proteins c-akt, bromfenac, hpfs trial
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1156-1164. doi: 10.1167/iovs.18-24743

Includes: Supplemental Content

Cornea March 2019

A New Ophthalmic Pharmaceutical Formulation, Topical Sulglycotide, Enhances the Ocular Mucin Secretion in Desiccation Stress-Mediated Dry Eye Disease

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Hyesook Lee; Sangwon Jeon; Chae Eun Kim; Young-Joon Park; Jaewook Yang
TAGS: dry eye syndromes, cornea, eye, stress, mucins, dosage forms, desiccation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1076-1087. doi: 10.1167/iovs.18-24935

Retina February 2019

Longitudinal In Vivo Characterization of the Streptozotocin-Induced Diabetic Mouse Model: Focus on Early Inner Retinal Responses

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Jurgen Sergeys; Isabelle Etienne; Inge Van Hove; Evy Lefevere; Ingeborg Stalmans; Jean H. M. Feyen; Lieve Moons; Tine Van Bergen
TAGS: diabetes mellitus, streptozocin, mice
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):807-822. doi: 10.1167/iovs.18-25372

Includes: Supplemental Content

Retina February 2019

Stimulation of Retinal Pigment Epithelium With an α7 nAChR Agonist Leads to Müller Glia Dependent Neurogenesis in the Adult Mammalian Retina

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Mark K. Webster; Betty J. Barnett; Megan L. Stanchfield; Joshua R. Paris; Sarah E. Webster; Cynthia A. Cooley-Themm; Edward M. Levine; Deborah C. Otteson; Cindy L. Linn
TAGS: cell cycle, adult, bromodeoxyuridine, mammals, neuroglia, neurons, mice, retina, agonists, eyedrops, reentry, neural development, retinal pigment epithelium
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):570-579. doi: 10.1167/iovs.18-25722

Biochemistry and Molecular Biology December 2018

The Effect of Prostaglandin Analogue Bimatoprost on Thyroid-Associated Orbitopathy

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Catherine J. Choi; Wensi Tao; Ravi Doddapaneni; Zenith Acosta-Torres; Nathan W. Blessing; Bradford W. Lee; Daniel Pelaez; Sara T. Wester
TAGS: prostaglandins, synthetic, bimatoprost
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5912-5923. doi: 10.1167/iovs.18-25134

Cornea December 2018

Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes

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Kiyokazu Ozaki; Yui Terayama; Tetsuro Matsuura
TAGS: hyperglycemia, diabetes mellitus, type 1, body weight, alloxan, neurons, streptozocin, sural nerve, cornea, mice, nerve lesions
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5868-5875. doi: 10.1167/iovs.18-25693

Retina December 2018

Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability

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Gerard A. Rodrigues; Matthew Mason; Lori-Ann Christie; Candice Hansen; Lisa M. Hernandez; James Burke; Keith A. Luhrs; Thomas C. Hohman
TAGS: angiogenesis, vascular endothelial growth factor a, oryctolagus cuniculus, bevacizumab, ranibizumab, affinity, aflibercept, anti-vascular endothelial growth factor therapy, vascular permeability
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5836-5846. doi: 10.1167/iovs.18-25307

Biochemistry and Molecular Biology November 2018

The Effect of Corticosteroids on Human Choroidal Endothelial Cells: A Model to Study Central Serous Chorioretinopathy

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Joost Brinks; Elon H. C. van Dijk; Mahmoud Habeeb; Aikaterini Nikolaou; Roula Tsonaka; Hendrika A. B. Peters; Hetty C. M. Sips; Arjanneke F. van de Merbel; Eiko K. de Jong; Robbert G. E. Notenboom; Szymon M. Kielbasa; Silvère M. van der Maarel; Paul H. A. Quax; Onno C. Meijer; Camiel J. F. Boon
TAGS: hydrocortisone, endothelial cells, adrenal corticosteroids, glucocorticoids, patient isolation, mineralocorticoids, agonists, antagonists, central serous chorioretinopathy, chronic exertional compartment syndrome
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5682-5692. doi: 10.1167/iovs.18-25054

Includes: Supplemental Content

Special Issue November 2018

Functional Visual Acuity

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Minako Kaido
TAGS: glaucoma, cataract, vision, visual acuity, quality, system of measurement
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES29-DES35. doi: 10.1167/iovs.17-23721

Special Issue November 2018

Autologous Serum and Serum Components

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Akihiro Higuchi
TAGS: dry eye syndromes, eyedrops
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES121-DES129. doi: 10.1167/iovs.17-23760

Retina November 2018

The Influence of Intravitreal Ranibizumab on Inflammation-associated Cytokine Concentrations in Eyes With Diabetic Macular Edema

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Shueh Wen Lim; Esther Bandala-Sanchez; Maria Kolic; Sophie L. Rogers; Annie K. McAuley; Lyndell L. Lim; Sanjeewa S. Wickremasinghe
TAGS: cytokine, vascular endothelial growth factor a, inflammation, eye, macular edema, diabetic, ranibizumab
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5382-5390. doi: 10.1167/iovs.17-23325

Includes: Supplemental Content

Retina November 2018

Intravitreal Injection of AAV Expressing Soluble VEGF Receptor-1 Variant Induces Anti-VEGF Activity and Suppresses Choroidal Neovascularization

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Steven Hyun Seung Lee; Hee Jong Kim; Oh Kyu Shin; Jun-Sub Choi; Jin Kim; Young-Hwa Cho; Joohun Ha; Tae Kwann Park; Joo Yong Lee; Keerang Park; Heuiran Lee
TAGS: vascular endothelial growth factor a, vegfr-1, choroidal neovascularization, mice, bevacizumab, intravitreal injections, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5398-5407. doi: 10.1167/iovs.18-24926

Includes: Supplemental Content

Cornea October 2018

Plasminogen-Dependent Collagenolytic Properties of Staphylococcus aureus in Collagen Gel Cultures of Human Corneal Fibroblasts

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Koji Sugioka; Aya Kodama-Takahshi; Tomoko Sato; Kiyotaka Okada; Junko Murakami; Ah-Mee Park; Hiroshi Mishima; Yoshikazu Shimomura; Shunji Kusaka; Teruo Nishida
TAGS: urokinase, fibroblasts, collagen, gel, plasminogen, cornea, catabolism
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5098-5107. doi: 10.1167/iovs.18-24925

Retina October 2018

How to Ward Off Retinal Toxicity of Perfluorooctane and Other Perfluorocarbon Liquids?

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Dirk-Henning Menz; Nicolas Feltgen; Helge Menz; Bernd-Kristof Müller; Thorsten Lechner; Joachim Dresp; Hans Hoerauf
TAGS: patent foramen ovale, fluorides, fluorocarbons, patients' rooms, safety, cytotoxicity, retinal toxicity, liquids, perfluorooctane
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4841-4846. doi: 10.1167/iovs.18-24698

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ON-Type Retinal Ganglion Cells are Preferentially Affected in STZ-Induced Diabetic Mice

Outer Retinal Oxidative Stress Measured In Vivo Using QUEnch-assiSTed (QUEST) OCT

Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation

The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration

PARP Inhibitor Protects Against Chronic Hypoxia/Reoxygenation-Induced Retinal Injury by Regulation of MAPKs, HIF1α, Nrf2, and NFκB

Rapamycin Rescues Endoplasmic Reticulum Stress–Induced Dry Eye Syndrome in Mice

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

A New Ophthalmic Pharmaceutical Formulation, Topical Sulglycotide, Enhances the Ocular Mucin Secretion in Desiccation Stress-Mediated Dry Eye Disease

Longitudinal In Vivo Characterization of the Streptozotocin-Induced Diabetic Mouse Model: Focus on Early Inner Retinal Responses

Stimulation of Retinal Pigment Epithelium With an α7 nAChR Agonist Leads to Müller Glia Dependent Neurogenesis in the Adult Mammalian Retina

The Effect of Prostaglandin Analogue Bimatoprost on Thyroid-Associated Orbitopathy

Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes

Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability

The Effect of Corticosteroids on Human Choroidal Endothelial Cells: A Model to Study Central Serous Chorioretinopathy

Functional Visual Acuity

Autologous Serum and Serum Components

The Influence of Intravitreal Ranibizumab on Inflammation-associated Cytokine Concentrations in Eyes With Diabetic Macular Edema

Intravitreal Injection of AAV Expressing Soluble VEGF Receptor-1 Variant Induces Anti-VEGF Activity and Suppresses Choroidal Neovascularization

Plasminogen-Dependent Collagenolytic Properties of Staphylococcus aureus in Collagen Gel Cultures of Human Corneal Fibroblasts

How to Ward Off Retinal Toxicity of Perfluorooctane and Other Perfluorocarbon Liquids?

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