Retinal Imaging

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Multidisciplinary Ophthalmic Imaging July 2025

Superficial Retinal Intercapillary Oxygen Diffusion and Perfusion Deficit Alterations in Patients With Coronary Artery Disease

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Natasa Jeremic; Meltem Esengönül; Azin Zarghami; Maximilian Pawloff; Matthias Hasun; Markus Schreiner; Reinhard Windhager; Alexander Niessner; Andreas Pollreisz; Hrvoje Bogunovic; Ursula Schmidt-Erfurth
TAGS: coronary arteriosclerosis, oxygen diffusion, perfusion, comorbidity, artifacts
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):27. https://doi.org/10.1167/iovs.66.9.27

Includes: Supplemental Content

Genetics July 2025

A Phenotypic Study of CRB1 Retinopathy Secondary to the Variant p.(Pro836Thr) Prevalent in Those of Black African Ancestry

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Wendy M. Wong; Anthony G. Robson; Rebecca A. Baker; Gavin Arno; Joseph Van Aerschot; Siying Lin; Mariya Moosajee; Michel Michaelides; Omar A. Mahroo; Andrew R. Webster
TAGS: phenotype, retinal diseases, electroretinography, retinal dystrophies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):3. https://doi.org/10.1167/iovs.66.9.3

Includes: Supplemental Content

Genetics June 2025

Clinical and Biochemical Characterization of Specific GUCY2D Alleles Associated With a Rare Form of Night Blindness

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Rola Ba-Abbad; Igor V. Peshenko; Malena Daich Varela; Siying Lin; Gavin Arno; Omar A. Mahroo; Catherine Egan; Anthony G. Robson; Elena V. Olshevskaya; Alexander M. Dizhoor; Andrew R. Webster
TAGS: alleles, night blindness, retinal cone, electroretinography, rod photoreceptors, phenotype, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):22. https://doi.org/10.1167/iovs.66.6.22

Includes: Supplemental Content

Genetics June 2025

Investigating the Immunogenic Potential of Variations in Host Cell Protein Levels in Clinical-Grade AAV8 Products

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Immanuel P. Seitz; Eduardo Rodríguez-Bocanegra; Kirsten Bucher; Felix F. Reichel; Stylianos Michalakis; Dimitri Romanovsky; Martin Biel; Bernd Wissinger; Karl-Ulrich Bartz-Schmidt; Tobias Peters; Manuel D. Fischer; on behalf of the RD-CURE Consortium
TAGS: disease vectors, proteins, spatial vectors, cytokine, thp-1 cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):38. https://doi.org/10.1167/iovs.66.6.38

Includes: Supplemental Content

Physiology and Pharmacology June 2025

Impact of Second-Generation PDE 5 Inhibitor, Avanafil, on Retinal Function: Studies From Ex Vivo ERG

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Sama Saeid; Frans Vinberg; Ari Koskelainen
TAGS: avanafil, electroretinography, phosphodiesterase 5 inhibitors, rod photoreceptors, phototransduction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):14. https://doi.org/10.1167/iovs.66.6.14

Retina May 2025

Clic6 Deficiency Triggers Aberrant Apical Microvilli in RPE

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Sangwan Park; Naran Suvarnpradip; Niusha Kasiri; Glenn Yiu; Sara M. Thomasy; Denise M. Imai; K. C. Kent Lloyd; Brian C. Leonard; Ala Moshiri
TAGS: mice, microvilli, precipitating factors, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):44. https://doi.org/10.1167/iovs.66.5.44

Includes: Supplemental Content

Retina May 2025

Peptide Lv Deficiency Adversely Impacts the Structural and Functional Integrity of the Neural Retina

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Kofi Owusu-Ansah; Dylan L. Pham; Brower C. Strong; Lora Liberoni; Travis W. Hein; Lih Kuo; Michael Lee Ko; Gladys Yi-Ping Ko
TAGS: neural retina, peptides, personal integrity, adult, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):37. https://doi.org/10.1167/iovs.66.5.37

Includes: Supplemental Content

Retina May 2025

High Resolution Imaging and Fixation Analysis of Eccentric Preferred Retinal Loci in Macular Diseases

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Olubayo U. Kolawole; Ethan Bensinger; Jessica Wong; Nicholas Rinella; Katharina G. Foote; Hao Zhou; Ruikang K. Wang; Jacque L. Duncan; Austin Roorda
TAGS: diagnostic imaging, eye, macular disorders, atrophoderma maculatum, retinal cone, fovea centralis, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):18. https://doi.org/10.1167/iovs.66.5.18

Includes: Supplemental Content

Immunology and Microbiology May 2025

Comparative Efficacy of Interleukin-7 and -15 Blockade in Alleviating Experimental Chronic Uveitis and Suppressing Pathogenic Memory CD4 + T Cells

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Qiurong Zhu; Maryam Shayan; Rachel M. Huckfeldt; Yihe Chen
TAGS: interleukin-15, interleukin-7, memory, t-lymphocytes, uveitis, mice, neutralization
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):9. https://doi.org/10.1167/iovs.66.5.9

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging April 2025

Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study

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Yan-Jie Li; Zeng-Yu Zhang; Tian-Yue Liu; Hai-Yan Liu; Lu-Lu Shi; Rong-Xia Cao; Chao-Ran Lv; Zeng-Hui Zhang
TAGS: angiogram, fluid flow, microcirculation, optical coherence tomography, retina, thyroid carcinoma, papillary, carcinoma, perfusion, inflammation, inspection
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):73. https://doi.org/10.1167/iovs.66.4.73

Retina April 2025

Retinal Pigment Epithelium Specific Metabolic Phenotypes Are Regulated by High-Mobility Group Protein N1

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Toshiaki Abe; Reiko Daigaku; Xie Yuting; Yasukazu Daigaku; Nobuhiro Nagai; Hirokazu Kaji; Aya Katsuyama; Yuki Katsukura; Yasuko Izumida; Atsuko Suzuki; Shinji Yamada; Yao-Wen Chang; Keiko Terada; Sei-ichi Ishiguro; Noriko Osumi; Hiroshi Kunikata; Toru Nakazawa
TAGS: hmgn1 protein, mice, proteins, mobility, metabolism
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):70. https://doi.org/10.1167/iovs.66.4.70

Includes: Supplemental Content

Retina April 2025

Assessment of Ocular Magnification in Relation to Biometric Parameters and Measurement Techniques: A Prospective Study

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Serhat Ermiş; Ece Özal; Emrullah Şimşek; Özlem Taştan; Murat Karapapak
TAGS: biometry, magnification, prospective studies, fovea centralis, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):57. https://doi.org/10.1167/iovs.66.4.57

Retina April 2025

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

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Xing Wei; Sisi Ma; Yunyu Zhou; Haoliang Cui; Shan Zhang; Duanyang Wang; Yingying Fu; Wei Li; Huihui Han; Yamei Li; Wuyi Li; Huixin Liu; Zixi Sun; Xiaoxu Han; Xuan Zou; Hui Li; Cheng Wang; Ruifang Sui
TAGS: electroretinography, mice, gene therapy, capsid
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):37. https://doi.org/10.1167/iovs.66.4.37

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics April 2025

Arabic Reading Performance With a Chromatic Acuity Chart

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Balsam Alabdulkader; Ali Almustanyir; Norah Alsalem; Essam Almutleb; Mosaad Alhassan; Jeffery K. Hovis
TAGS: arabic, reading (activity), luminance, color
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):3. https://doi.org/10.1167/iovs.66.4.3

Visual Psychophysics and Physiological Optics March 2025

Diversity of Peripheral Refraction Patterns—Have These Been Oversimplified?

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Megha Antony; Rakesh Maldoddi; David A. Atchison; Pavan Kumar Verkicharla
TAGS: refraction, myopia, hyperopia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):58. https://doi.org/10.1167/iovs.66.3.58

Includes: Supplemental Content

Retina March 2025

Artificial Intelligence Versus Rules-Based Approach for Segmenting NonPerfusion Area in a DRCR Retina Network Optical Coherence Tomography Angiography Dataset

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Tristan T. Hormel; Wesley T. Beaulieu; Jie Wang; Jennifer K. Sun; Yali Jia
TAGS: nasopharyngeal aspirate, retina, angiogram, optical coherence tomography, datasets, artificial intelligence
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):22. https://doi.org/10.1167/iovs.66.3.22

Includes: Supplemental Content

Visual Neuroscience February 2025

Retinal Responses to Short- and Longer-Term Predominant ON or OFF Stimulation in Emmetropes and Myopes

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Sandra Wagner; Annemarie Settele; Torsten Strasser
TAGS: electroretinography, eye, myopia, reading (activity), refractive errors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):66. https://doi.org/10.1167/iovs.66.2.66

Includes: Supplemental Content

Visual Neuroscience February 2025

Temporal Transformation of the Rod Single-Photon Response in the Retinal Circuitry

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Haruhisa Okawa; Alapakkam P. Sampath
TAGS: ganglia, photons, rod photoreceptors, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):52. https://doi.org/10.1167/iovs.66.2.52

Retina February 2025

Accessible LED Lightbox for Light-induced Retinal Damage in Pigmented Mice

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Hunter L. Aliff; Alexis B. Crockett; Micah A. Chrenek; John M. Nickerson; Jeffrey H. Boatright; Oxana Tseytlin; Matthew Johnson; Hayley G. Bockius; Sierra G. Kuzak; Visvanathan Ramamurthy
TAGS: mice, mice, inbred c57bl, erg protein, human, electroretinography, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):49. https://doi.org/10.1167/iovs.66.2.49

Includes: Supplemental Content

Retina February 2025

Preconception Paternal Alcohol Consumption Elicits Postnatal Changes in Neural Retinas of the Offspring

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Kofi Owusu-Ansah; Kara N. Thomas; Kelsey Cox; Dylan L. Pham; Wei-Lin Chen; Michael Lee Ko; Michael C. Golding; Gladys Yi-Ping Ko
TAGS: alcohol drinking, ethanol, neural retina, offspring, retina, mice, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):16. https://doi.org/10.1167/iovs.66.2.16

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Superficial Retinal Intercapillary Oxygen Diffusion and Perfusion Deficit Alterations in Patients With Coronary Artery Disease

A Phenotypic Study of CRB1 Retinopathy Secondary to the Variant p.(Pro836Thr) Prevalent in Those of Black African Ancestry

Clinical and Biochemical Characterization of Specific GUCY2D Alleles Associated With a Rare Form of Night Blindness

Investigating the Immunogenic Potential of Variations in Host Cell Protein Levels in Clinical-Grade AAV8 Products

Impact of Second-Generation PDE 5 Inhibitor, Avanafil, on Retinal Function: Studies From Ex Vivo ERG

Clic6 Deficiency Triggers Aberrant Apical Microvilli in RPE

Peptide Lv Deficiency Adversely Impacts the Structural and Functional Integrity of the Neural Retina

High Resolution Imaging and Fixation Analysis of Eccentric Preferred Retinal Loci in Macular Diseases

Comparative Efficacy of Interleukin-7 and -15 Blockade in Alleviating Experimental Chronic Uveitis and Suppressing Pathogenic Memory CD4 + T Cells

Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study

Retinal Pigment Epithelium Specific Metabolic Phenotypes Are Regulated by High-Mobility Group Protein N1

Assessment of Ocular Magnification in Relation to Biometric Parameters and Measurement Techniques: A Prospective Study

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

Arabic Reading Performance With a Chromatic Acuity Chart

Diversity of Peripheral Refraction Patterns—Have These Been Oversimplified?

Artificial Intelligence Versus Rules-Based Approach for Segmenting NonPerfusion Area in a DRCR Retina Network Optical Coherence Tomography Angiography Dataset

Retinal Responses to Short- and Longer-Term Predominant ON or OFF Stimulation in Emmetropes and Myopes

Temporal Transformation of the Rod Single-Photon Response in the Retinal Circuitry

Accessible LED Lightbox for Light-induced Retinal Damage in Pigmented Mice

Preconception Paternal Alcohol Consumption Elicits Postnatal Changes in Neural Retinas of the Offspring

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