Translational Research

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Translational Research October 2014

The Demethylating Agent 5-Aza Reduces the Growth, Invasiveness, and Clonogenicity of Uveal and Cutaneous Melanoma

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Fatemeh Rajaii; Laura Asnaghi; Raymond Enke; Shannath L. Merbs; James T. Handa; Charles G. Eberhart
TAGS: azacitidine, malignant melanoma, cutaneous, melanoma, demethylating agents, uvea, cell lines, neoplasm metastasis
Invest. Ophthalmol. Vis. Sci.. 2014; 55(10):6178-6186. https://doi.org/10.1167/iovs.14-13933

Includes: Supplemental Content

Translational Research August 2014

Characterization of a Mouse Model With Complete RPE Loss and Its Use for RPE Cell Transplantation

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Madalena Carido; Yu Zhu; Kai Postel; Boris Benkner; Peter Cimalla; Mike O. Karl; Thomas Kurth; François Paquet-Durand; Edmund Koch; Thomas A. Münch; Elly M. Tanaka; Marius Ader
TAGS: mice, retinal pigment cell, tissue degeneration, transplantation, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2014; 55(8):5431-5444. https://doi.org/10.1167/iovs.14-14325

Includes: Supplemental Content

Translational Research July 2014

The Oral Iron Chelator Deferiprone Protects Against Systemic Iron Overload–Induced Retinal Degeneration in Hepcidin Knockout Mice

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Delu Song; Liangliang Zhao; Yafeng Li; Majda Hadziahmetovic; Ying Song; John Connelly; Michael Spino; Joshua L. Dunaief
TAGS: deferiprone, hepcidin, iron chelating agents, iron overload, mice, mice, knockout, retina, retinal degeneration, electroretinography, oxidative stress
Invest. Ophthalmol. Vis. Sci.. 2014; 55(7):4525-4532. https://doi.org/10.1167/iovs.14-14568

Translational Research July 2014

Up-Regulation of VEGF by Retinoic Acid During Hyperoxia Prevents Retinal Neovascularization and Retinopathy

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Liya Wang; Pingling Shi; Zhongzhong Xu; Jing Li; Yanting Xie; Kenneth Mitton; Kimberly Drenser; Qi Yan
TAGS: mice, retinal diseases, retinal neovascularization, tretinoin, vascular endothelial growth factor a, retina, hyperoxia, up-regulation (physiology)
Invest. Ophthalmol. Vis. Sci.. 2014; 55(7):4276-4287. https://doi.org/10.1167/iovs.14-14170

Translational Research June 2014

Spontaneous CNV in a Novel Mutant Mouse Is Associated With Early VEGF-A–Driven Angiogenesis and Late-Stage Focal Edema, Neural Cell Loss, and Dysfunction

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Norihiro Nagai; Pete Lundh von Leithner; Kanako Izumi-Nagai; Brett Hosking; Bo Chang; Ron Hurd; Peter Adamson; Anthony P. Adamis; Richard H. Foxton; Yin Shan Ng; David T. Shima
TAGS: choroidal neovascularization, edema, mice, pathophysiology, vascular endothelial growth factor a, angiogenesis, neurons
Invest. Ophthalmol. Vis. Sci.. 2014; 55(6):3709-3719. https://doi.org/10.1167/iovs.14-13989

Includes: Multimedia, Supplemental Content

Translational Research May 2014

Comparative Study of nJ- and μJ-Energy Level Femtosecond Lasers: Evaluation of Flap Adhesion Strength, Stromal Bed Quality, and Tissue Responses

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Andri K. Riau; Yu-Chi Liu; Nyein C. Lwin; Heng P. Ang; Neil Y. S. Tan; Gary H. F. Yam; Donald T. Tan; Jodhbir S. Mehta
TAGS: 5-lipoxygenase-activating protein, adhesions, femtosecond pulsed lasers, lasers, surgical flaps, body tissue, new jersey, cornea
Invest. Ophthalmol. Vis. Sci.. 2014; 55(5):3186-3194. https://doi.org/10.1167/iovs.14-14434

Includes: Supplemental Content

Translational Research April 2014

Pirfenidone Attenuates the IL-1β–Induced Hyaluronic Acid Increase in Orbital Fibroblasts From Patients With Thyroid-Associated Ophthalmopathy

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Seung Ah Chung; Bo Kyung Jeon; Youn-Hee Choi; Keum Ok Back; Jong Bok Lee; Koung Hoon Kook
TAGS: fibroblasts, pirfenidone, hyaluronic acid, graves' ophthalmopathy, mitogen-activated protein kinases
Invest. Ophthalmol. Vis. Sci.. 2014; 55(4):2276-2283. https://doi.org/10.1167/iovs.13-13759

Translational Research April 2014

Protein Kinase C Inhibitors Sensitize GNAQ Mutant Uveal Melanoma Cells to Ionizing Radiation

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Jasmina Ziva Cerne; Sean Michael Hartig; Mark Patrick Hamilton; Sue Anne Chew; Nicholas Mitsiades; Vassiliki Poulaki; Sean Eric McGuire
TAGS: cell cycle, intraocular melanoma, protein kinase c, protein kinase c inhibitor, proteins, radiation, ionizing, sotrastaurin, cell survival, combined modality therapy, dna damage
Invest. Ophthalmol. Vis. Sci.. 2014; 55(4):2130-2139. https://doi.org/10.1167/iovs.13-13468

Includes: Supplemental Content

Editorial March 2014

Training the Next Physician Scientists

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David C. Beebe
TAGS: physicians, training
Invest. Ophthalmol. Vis. Sci.. 2014; 55(3):1856. https://doi.org/10.1167/iovs.14-14269

Translational Research March 2014

Hypoxia–Reoxygenation Affects Whole-Genome Expression in the Newborn Eye

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Embjørg J. Wollen; Przemko Kwinta; Miroslaw Bik-Multanowski; Anna Madetko-Talowska; Yngve Sejersted; Marianne S. Wright; Clara-Cecilie Günther; Ståle Nygård; Ola Didrik Saugstad; Jacek J. Pietrzyk
TAGS: gene expression, genome, hypoxia, newborn, genes, eye
Invest. Ophthalmol. Vis. Sci.. 2014; 55(3):1393-1401. https://doi.org/10.1167/iovs.13-13159

Includes: Supplemental Content

Translational Research March 2014

Sildenafil Attenuates Vaso-Obliteration and Neovascularization in a Mouse Model of Retinopathy of Prematurity

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Amani A. Fawzi; Jonathan C. Chou; Gina A. Kim; Stuart D. Rollins; Joann M. Taylor; Kathryn N. Farrow
TAGS: mice, neovascularization, pathologic, sildenafil
Invest. Ophthalmol. Vis. Sci.. 2014; 55(3):1493-1501. https://doi.org/10.1167/iovs.13-13207

Translational Research February 2014

Ocular Pharmacokinetics of Intravitreally Administered Brimonidine and Dexamethasone in Animal Models With and Without Blood–Retinal Barrier Breakdown

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Jie Shen; Chandra Durairaj; Ton Lin; Yan Liu; James Burke
TAGS: animal model, brimonidine, cercopithecidae, choroidal neovascularization, dexamethasone, intravitreal injections, oryctolagus cuniculus, pharmacokinetics, blood-retinal barrier, retina
Invest. Ophthalmol. Vis. Sci.. 2014; 55(2):1056-1066. https://doi.org/10.1167/iovs.13-13650

Translational Research January 2014

Effect of Coadministration of Neuronal Growth Factors on Neuroglial Differentiation of Bone Marrow–Derived Stem Cells in the Ischemic Retina

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Nitza Goldenberg-Cohen; Bat-Chen R. Avraham-Lubin; Tamilla Sadikov; Nadir Askenasy
TAGS: bone marrow, brain-derived neurotrophic factor, ciliary neurotrophic factor, growth factor, ischemia, retina, stem cells, neural development, donors
Invest. Ophthalmol. Vis. Sci.. 2014; 55(1):502-512. https://doi.org/10.1167/iovs.13-12223

Translational Research January 2014

Biocompatible Reverse Thermal Gel Sustains the Release of Intravitreal Bevacizumab In Vivo

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Britta M. Rauck; Thomas R. Friberg; Carlos A. Medina Mendez; Daewon Park; Veeral Shah; Richard A. Bilonick; Yadong Wang
TAGS: bevacizumab, gel, eye
Invest. Ophthalmol. Vis. Sci.. 2014; 55(1):469-476. https://doi.org/10.1167/iovs.13-13120

Includes: Supplemental Content

Translational Research January 2014

Swine Cone and Rod Precursors Arise Sequentially and Display Sequential and Transient Integration and Differentiation Potential Following Transplantation

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Wei Wang; Liang Zhou; Sang Joon Lee; Yongqing Liu; Juan Fernandez de Castro; Douglas Emery; Eric Vukmanic; Henry J. Kaplan; Douglas C. Dean
TAGS: embryo, retina, retinal cone, rod photoreceptors, suidae, transplantation, immunohistochemistry, opsin
Invest. Ophthalmol. Vis. Sci.. 2014; 55(1):301-309. https://doi.org/10.1167/iovs.13-12600

Includes: Supplemental Content

Translational Research November 2013

Hydrogen Peroxide Accumulation in the Choroid During Intermittent Hypoxia Increases Risk of Severe Oxygen-Induced Retinopathy in Neonatal Rats

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Kay D. Beharry; Charles L. Cai; Poonam Sharma; Vadim Bronshtein; Gloria B. Valencia; Douglas R. Lazzaro; Jacob V. Aranda
TAGS: choroid, hydrogen peroxide, hypoxia, mitochondria, newborn, oxygen, rats, retina, retinal diseases, blood gas
Invest. Ophthalmol. Vis. Sci.. 2013; 54(12):7644-7657. https://doi.org/10.1167/iovs.13-13040

Translational Research November 2013

Orbital Fibroblasts From Thyroid Eye Disease Patients Differ in Proliferative and Adipogenic Responses Depending on Disease Subtype

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Ajay E. Kuriyan; Collynn F. Woeller; Charles W. O'Loughlin; Richard P. Phipps; Steven E. Feldon
TAGS: fibroblasts, graves' ophthalmopathy, cyclooxygenase inhibitors
Invest. Ophthalmol. Vis. Sci.. 2013; 54(12):7370-7377. https://doi.org/10.1167/iovs.13-12741

Translational Research October 2013

Computational Model for Oxygen Transport and Consumption in Human Vitreous

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Benjamen A. Filas; Ying-Bo Shui; David C. Beebe
TAGS: lens, crystalline, oxygen, oxygen transport, vitreous body, computer simulation, lens (device), liquefaction, oxygen consumption, retina
Invest. Ophthalmol. Vis. Sci.. 2013; 54(10):6549-6559. https://doi.org/10.1167/iovs.13-12609

Translational Research October 2013

Phagocytosis of Photoreceptor Outer Segments by Transplanted Human Neural Stem Cells as a Neuroprotective Mechanism in Retinal Degeneration

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Nicolás Cuenca; Laura Fernández-Sánchez; Trevor J. McGill; Bin Lu; Shaomei Wang; Raymond Lund; Stephen Huhn; Alexandra Capela
TAGS: neural stem cells, phagocytosis, photoreceptors, retinal degeneration, transplantation, retina, did not receive therapy or drug
Invest. Ophthalmol. Vis. Sci.. 2013; 54(10):6745-6756. https://doi.org/10.1167/iovs.13-12860

Includes: Supplemental Content

Translational Research September 2013

Subretinal Gene Therapy of Mice With Bardet-Biedl Syndrome Type 1

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Seongjin Seo; Robert F. Mullins; Alina V. Dumitrescu; Sajag Bhattarai; Daniel Gratie; Kai Wang; Edwin M. Stone; Val Sheffield; Arlene V. Drack
TAGS: bardet-biedl syndrome, eye, gene therapy, mice, retina, electroretinography, spatial vectors, proteins, toxic effect
Invest. Ophthalmol. Vis. Sci.. 2013; 54(9):6118-6132. https://doi.org/10.1167/iovs.13-11673

Includes: Supplemental Content

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The Demethylating Agent 5-Aza Reduces the Growth, Invasiveness, and Clonogenicity of Uveal and Cutaneous Melanoma

Characterization of a Mouse Model With Complete RPE Loss and Its Use for RPE Cell Transplantation

The Oral Iron Chelator Deferiprone Protects Against Systemic Iron Overload–Induced Retinal Degeneration in Hepcidin Knockout Mice

Up-Regulation of VEGF by Retinoic Acid During Hyperoxia Prevents Retinal Neovascularization and Retinopathy

Spontaneous CNV in a Novel Mutant Mouse Is Associated With Early VEGF-A–Driven Angiogenesis and Late-Stage Focal Edema, Neural Cell Loss, and Dysfunction

Comparative Study of nJ- and μJ-Energy Level Femtosecond Lasers: Evaluation of Flap Adhesion Strength, Stromal Bed Quality, and Tissue Responses

Pirfenidone Attenuates the IL-1β–Induced Hyaluronic Acid Increase in Orbital Fibroblasts From Patients With Thyroid-Associated Ophthalmopathy

Protein Kinase C Inhibitors Sensitize GNAQ Mutant Uveal Melanoma Cells to Ionizing Radiation

Training the Next Physician Scientists

Hypoxia–Reoxygenation Affects Whole-Genome Expression in the Newborn Eye

Sildenafil Attenuates Vaso-Obliteration and Neovascularization in a Mouse Model of Retinopathy of Prematurity

Ocular Pharmacokinetics of Intravitreally Administered Brimonidine and Dexamethasone in Animal Models With and Without Blood–Retinal Barrier Breakdown

Effect of Coadministration of Neuronal Growth Factors on Neuroglial Differentiation of Bone Marrow–Derived Stem Cells in the Ischemic Retina

Biocompatible Reverse Thermal Gel Sustains the Release of Intravitreal Bevacizumab In Vivo

Swine Cone and Rod Precursors Arise Sequentially and Display Sequential and Transient Integration and Differentiation Potential Following Transplantation

Hydrogen Peroxide Accumulation in the Choroid During Intermittent Hypoxia Increases Risk of Severe Oxygen-Induced Retinopathy in Neonatal Rats

Orbital Fibroblasts From Thyroid Eye Disease Patients Differ in Proliferative and Adipogenic Responses Depending on Disease Subtype

Computational Model for Oxygen Transport and Consumption in Human Vitreous

Phagocytosis of Photoreceptor Outer Segments by Transplanted Human Neural Stem Cells as a Neuroprotective Mechanism in Retinal Degeneration

Subretinal Gene Therapy of Mice With Bardet-Biedl Syndrome Type 1

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