Visual Neuroscience

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Visual Neuroscience March 2025

Modulation of All- Trans Retinoic Acid by Light and Dopamine in the Murine Eye

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Sarah Talwar; Reece Mazade; Melissa Bentley-Ford; Jianshi Yu; Nageswara Pilli; Maureen A. Kane; C. Ross Ethier; Machelle T. Pardue
TAGS: eye, mice, tretinoin, retinoids, lighting, dopamine, light exposure
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):37. https://doi.org/10.1167/iovs.66.3.37

Retina March 2025

The Combination of Retinal Neurovascular Unit Changes With Carotid Artery Stenosis Enhances the Prediction of Ischemic Stroke

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Zhifan Chen; Shuoxin Liao; Guangzhong Chen; Changmao Li; Chunling Liu; Junbin Liu; Guangyu Wu; Zheng Lyu; Mengya Liu; Xiyu Wu; Guixian Ma; Qianli Meng
TAGS: carotid stenosis, ischemic stroke
Trans. Vis. Sci. Tech.. 2025; 14(3):14. https://doi.org/10.1167/tvst.14.3.14

Includes: Supplemental Content

Article March 2025

Low-priority items are held in visual working memory: Evidence from flexible allocation in a two-alternative forced-choice (2AFC) paradigm

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Holly A. Lockhart; Stephen M. Emrich
TAGS: color, memory, precision, visual working memory
Journal of Vision. 2025; 25(3):5. https://doi.org/10.1167/jov.25.3.5

Includes: Supplemental Content

Article February 2025

Pupil dilation underlies the peripheral drift illusion

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George Mather; Patrick Cavanagh
TAGS: illusions, mydriasis, pupil dilation, saccades, pupil
Journal of Vision. 2025; 25(2):13. https://doi.org/10.1167/jov.25.2.13

Visual Neuroscience February 2025

Retinal Responses to Short- and Longer-Term Predominant ON or OFF Stimulation in Emmetropes and Myopes

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Sandra Wagner; Annemarie Settele; Torsten Strasser
TAGS: electroretinography, eye, myopia, reading (activity), refractive errors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):66. https://doi.org/10.1167/iovs.66.2.66

Includes: Supplemental Content

Retina February 2025

Clinical, Genetic, Imaging and Electrophysiological Findings in a Cohort of Patients With GUCA1A -Associated Retinopathy

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Gilad Allon; Siying Lin; Anthony G. Robson; Gavin Arno; Magella M. Neveu; Pirro G. Hysi; Michel Michaelides; Andrew R. Webster; Omar A. Mahroo
TAGS: cohort studies, diagnostic imaging, genetics, retinal diseases, visual acuity, electrophysiology, family, eye, vision
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):50. https://doi.org/10.1167/iovs.66.2.50

Retina February 2025

Accessible LED Lightbox for Light-induced Retinal Damage in Pigmented Mice

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Hunter L. Aliff; Alexis B. Crockett; Micah A. Chrenek; John M. Nickerson; Jeffrey H. Boatright; Oxana Tseytlin; Matthew Johnson; Hayley G. Bockius; Sierra G. Kuzak; Visvanathan Ramamurthy
TAGS: mice, mice, inbred c57bl, erg protein, human, electroretinography, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):49. https://doi.org/10.1167/iovs.66.2.49

Includes: Supplemental Content

Retina February 2025

Effect of Dync1h1 on Phototransduction Protein Transport and the Development and Maintenance of Photoreceptor Cells in Zebrafish

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Xuebin Zhou; Jinfeng Cao; Jianan Xie; Wanqing Tong; Bo Jia; Jinling Fu
TAGS: photoreceptors, phototransduction, proteins, retina, zebrafish, protein transport, retinal degeneration, apoptosis, fluorescent antibody technique
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):38. https://doi.org/10.1167/iovs.66.2.38

Includes: Supplemental Content

Retina February 2025

Topography of Slowed Dark Adaptation in Pseudoxanthoma Elasticum: PROPXE Study Report 1

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Kristina Pfau; Georg Ansari; Stephan Michels; Chantal Dysli; Sandra Liakopoulos; Jana Burghaus-Zhang; Mayss Al-Sheikh; Justus G. Garweg; Mathieu Quinodoz; Karolina Kaminska; Francesca Cancellieri; Carlo Rivolta; Sharon F. Terry; Nicolas Feltgen; Maximilian Pfau
TAGS: dark adaptation, pseudoxanthoma elasticum, study report, rod photoreceptors, calcification, retinal cone
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):17. https://doi.org/10.1167/iovs.66.2.17

Includes: Supplemental Content

Artificial Intelligence February 2025

RetOCTNet: Deep Learning–Based Segmentation of OCT Images Following Retinal Ganglion Cell Injury

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Gabriela Sanchez-Rodriguez; Linjiang Lou; Machelle T. Pardue; Andrew J. Feola
TAGS: datasets, deep learning, retinal ganglion cells, wounds and injuries, retinal nerve fiber layer, optic disk, eye, training
Trans. Vis. Sci. Tech.. 2025; 14(2):4. https://doi.org/10.1167/tvst.14.2.4

Includes: Supplemental Content

Glaucoma January 2025

SIRT4 Protects Retina Against Excitotoxic Injury by Promoting OPA1-Mediated Müller Glial Cell Mitochondrial Fusion and GLAST Expression

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Qian Ying; Hongdou Luo; Zhi Xie; Yi Huang; Haijian Hu; Ming Jin; Ke Xu; Yulian Pang; Yuning Song; Xu Zhang
TAGS: glutamate, glutamates, mitochondria, neuroglia, optic atrophy, autosomal dominant, proteins, retina, wounds and injuries, n-methylaspartate, retinal injuries
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):62. https://doi.org/10.1167/iovs.66.1.62

Artificial Intelligence January 2025

Noninvasive Anemia Detection and Hemoglobin Estimation from Retinal Images Using Deep Learning: A Scalable Solution for Resource-Limited Settings

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Rehana Khan; Vinod Maseedupally; Kaveri A. Thakoor; Rajiv Raman; Maitreyee Roy
TAGS: anemia, hemoglobin, deep learning, resource-limited settings
Trans. Vis. Sci. Tech.. 2025; 14(1):20. https://doi.org/10.1167/tvst.14.1.20

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology January 2025

Eye Movements and the Intraorbital Subarachnoid Space: Potential Contribution of Altered Cerebrospinal Fluid Pumping in Optic Neuropathies

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Joseph L. Demer; Robert A. Clark; Soh Youn Suh; JoAnn A. Giaconi; Kouros Nouri-Mahdavi; Simon K. Law; Laura Bonelli; Anthony C. Arnold; Peter Quiros; Anne L. Coleman; Joseph Caprioli
TAGS: adduction, cerebrospinal fluid, eye, eye movement, magnetic resonance imaging, open-angle glaucoma, optic nerve, optic nerve disorders, subarachnoid space, volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):53. https://doi.org/10.1167/iovs.66.1.53

Physiology and Pharmacology January 2025

Broadband Long Wavelength Light Promotes Myopic Eye Growth and Alters Retinal Responses to Light Offset in Chick

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Nina Riddell; Melanie J. Murphy; Sania Zahra; Isabella Robertson-Dixon; Sheila G. Crewther
TAGS: eye, lens (device), lens, crystalline, myopia, white light, blue light, refraction, photopsia, electroretinography, weight gain
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):30. https://doi.org/10.1167/iovs.66.1.30

Includes: Supplemental Content

Retina January 2025

Anti-Syndecan 2 Antibody Treatment Reduces Edema Formation and Inflammation of Murine Laser-Induced CNV

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Federico Corti; Filippo Locri; Flavia Plastino; Paola Perrotta; Krisztina Zsebo; Emma Ristori; Xiangyun Yin; Eric Song; Helder André; Michael Simons
TAGS: antibodies, choroidal neovascularization, edema, inflammation, lasers, mice, syndecan, vascular endothelial growth factor a, anti-vascular endothelial growth factor therapy, intravitreal injections
Trans. Vis. Sci. Tech.. 2025; 14(1):10. https://doi.org/10.1167/tvst.14.1.10

Includes: Supplemental Content

Cornea January 2025

Mustard Gas Induced Corneal Injury Involves Ferroptosis and p38 MAPK Signaling

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Nishant R. Sinha; Alexandria C. Hofmann; Laila A. Suleiman; Maxwell T. Jeffrey; William C. Jeffrey; Rajnish Kumar; Ratnakar Tripathi; Rajiv R. Mohan
TAGS: corneal injuries, ferroptosis, mitogen-activated protein kinase p38, mustard gas, signal transduction, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):23. https://doi.org/10.1167/iovs.66.1.23

Includes: Supplemental Content

Anatomy and Pathology/Oncology January 2025

Leptin Receptor Deficiency–Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome

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Xiaoting Pei; Mengru Ba; Tingting Yang; Shuting Xuan; Duliurui Huang; Di Qi; Dingli Lu; Shenzhen Huang; Zhijie Li
TAGS: diabetes mellitus, diabetes mellitus, type 2, insulin, mice, langer-giedion syndrome, circadian rhythms, dry eye syndromes, gene expression
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):19. https://doi.org/10.1167/iovs.66.1.19

Includes: Supplemental Content

Physiology and Pharmacology January 2025

Chronic Jet Lag Disrupts Circadian Rhythms and Induces Hyperproliferation in Murine Lacrimal Glands via ROS Accumulation

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Shenzhen Huang; Wenxiao Zhang; Mengru Ba; Shuting Xuan; Duliurui Huang; Di Qi; Xiaoting Pei; Dingli Lu; Zhijie Li
TAGS: circadian rhythm disorders, circadian rhythms, jet lag syndrome, mice, gene expression, rhythm, genes, cell proliferation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):12. https://doi.org/10.1167/iovs.66.1.12

Includes: Supplemental Content

Cornea January 2025

RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway

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Yan Shen; Jiajia Wang; Yiqin Dai; Xichen Wan; Jing Zhang; Qihua Le
TAGS: corneal epithelium, epithelial stem cells, signal pathway, signal transduction pathways, wounds and injuries, proteins, mice, wound healing, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):8. https://doi.org/10.1167/iovs.66.1.8

Includes: Supplemental Content

Retina January 2025

Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens

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Deng Pan; Ge Hu; Jiayue Li; Zixu Wang; Yaoxing Chen; Jing Cao
TAGS: autophagy, chickens, stress, retina, blue light, endoplasmic reticulum, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):3. https://doi.org/10.1167/iovs.66.1.3

Includes: Supplemental Content

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Modulation of All- Trans Retinoic Acid by Light and Dopamine in the Murine Eye

The Combination of Retinal Neurovascular Unit Changes With Carotid Artery Stenosis Enhances the Prediction of Ischemic Stroke

Low-priority items are held in visual working memory: Evidence from flexible allocation in a two-alternative forced-choice (2AFC) paradigm

Pupil dilation underlies the peripheral drift illusion

Retinal Responses to Short- and Longer-Term Predominant ON or OFF Stimulation in Emmetropes and Myopes

Clinical, Genetic, Imaging and Electrophysiological Findings in a Cohort of Patients With GUCA1A -Associated Retinopathy

Accessible LED Lightbox for Light-induced Retinal Damage in Pigmented Mice

Effect of Dync1h1 on Phototransduction Protein Transport and the Development and Maintenance of Photoreceptor Cells in Zebrafish

Topography of Slowed Dark Adaptation in Pseudoxanthoma Elasticum: PROPXE Study Report 1

RetOCTNet: Deep Learning–Based Segmentation of OCT Images Following Retinal Ganglion Cell Injury

SIRT4 Protects Retina Against Excitotoxic Injury by Promoting OPA1-Mediated Müller Glial Cell Mitochondrial Fusion and GLAST Expression

Noninvasive Anemia Detection and Hemoglobin Estimation from Retinal Images Using Deep Learning: A Scalable Solution for Resource-Limited Settings

Eye Movements and the Intraorbital Subarachnoid Space: Potential Contribution of Altered Cerebrospinal Fluid Pumping in Optic Neuropathies

Broadband Long Wavelength Light Promotes Myopic Eye Growth and Alters Retinal Responses to Light Offset in Chick

Anti-Syndecan 2 Antibody Treatment Reduces Edema Formation and Inflammation of Murine Laser-Induced CNV

Mustard Gas Induced Corneal Injury Involves Ferroptosis and p38 MAPK Signaling

Leptin Receptor Deficiency–Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome

Chronic Jet Lag Disrupts Circadian Rhythms and Induces Hyperproliferation in Murine Lacrimal Glands via ROS Accumulation

RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway

Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens

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