Visual Neuroscience

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Retina December 2018

Diabetic Nonperfused Areas in Macular and Extramacular Regions on Wide-Field Optical Coherence Tomography Angiography

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Shota Yasukura; Tomoaki Murakami; Kiyoshi Suzuma; Tatsuya Yoshitake; Hideo Nakanishi; Masahiro Fujimoto; Maho Oishi; Akitaka Tsujikawa
TAGS: angiogram, diabetes mellitus, arteriole, optic disk, perfusion, blood capillaries, eye, nonproliferative diabetic retinopathy, optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5893-5903. doi: 10.1167/iovs.18-25108

Includes: Supplemental Content

Retina December 2018

Supernormal Flicker ERGs in Eyes With Central Retinal Vein Occlusion: Clinical Characteristics, Prognosis, and Effects of Anti-VEGF Agent

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Ryohei Miyata; Mineo Kondo; Kumiko Kato; Masahiko Sugimoto; Hisashi Matsubara; Kengo Ikesugi; Shinji Ueno; Shunsuke Yasuda; Hiroko Terasaki
TAGS: electroretinography, eye, central retinal vein occlusion, photopsia, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5854-5861. doi: 10.1167/iovs.18-25087

Includes: Supplemental Content

Glaucoma December 2018

Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma

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Emily Mathieu; Neeru Gupta; Luz A. Paczka-Giorgi; Xun Zhou; Amir Ahari; Rafael Lani; Joseph Hanna; Yeni H. Yücel
TAGS: glaucoma, cerebrospinal fluid, optic nerve
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5876-5884. doi: 10.1167/iovs.18-24521

Glaucoma November 2018

Adrenal and Glucocorticoid Effects on the Circadian Rhythm of Murine Intraocular Pressure

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Shunsuke Tsuchiya; Kazuhisa Sugiyama; Russell N. Van Gelder
TAGS: circadian rhythms, adrenal glands, glucocorticoids, periodicity, rna, messenger, intraocular pressure, iris, mice, immune reconstitution inflammatory syndrome, rhythm
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5641-5647. doi: 10.1167/iovs.18-24785

Retina November 2018

A Controlled Impact of Optic Nerve as a New Model of Traumatic Optic Neuropathy in Mouse

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Ahmed S. Ibrahim; Khaled Elmasry; Ming Wan; Samer Abdulmoneim; Amber Still; Farid Khan; Abraham Khalil; Alan Saul; Md Nasrul Hoda; Mohamed Al-Shabrawey
TAGS: electroretinography, optic nerve injuries, wounds and injuries, eye, mice, optic nerve, velocity
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5548-5557. doi: 10.1167/iovs.18-24773

Includes: Multimedia, Supplemental Content

Glaucoma November 2018

Mesenchymal Stem Cell–Derived Small Extracellular Vesicles Promote Neuroprotection in a Genetic DBA/2J Mouse Model of Glaucoma

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Ben Mead; Zubair Ahmed; Stanislav Tomarev
TAGS: glaucoma, ocular hypertension, genetics, mice, stem cell, mesenchymal, neuroprotection, exosomes, extracellular vesicles
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5473-5480. doi: 10.1167/iovs.18-25310

Includes: Supplemental Content

Visual Neuroscience November 2018

How Ocular Dominance and Binocularity Are Reflected by the Population Receptive Field Properties

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Pieter B. de Best; Noa Raz; Serge O. Dumoulin; Netta Levin
TAGS: ocular dominance, prolactin-releasing hormone, eye, summation, primary visual cortex
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5301-5311. doi: 10.1167/iovs.18-24161

Includes: Supplemental Content

Special Issue November 2018

Slowed Dark Adaptation in Early AMD: Dual Stimulus Reveals Scotopic and Photopic Abnormalities

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Humza J. Tahir; Elena Rodrigo-Diaz; Neil R. A. Parry; Jeremiah M. F. Kelly; David Carden; Tariq M. Aslam; Ian J. Murray
TAGS: retinal cone, dark adaptation, recovery of function, rod photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD202-AMD210. doi: 10.1167/iovs.18-24227

Visual Neuroscience October 2018

Binocular Summation in Postillumination Pupil Response Driven by Melanopsin-Containing Retinal Ganglion Cells

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Marija Zivcevska; Alan Blakeman; Shaobo Lei; Herbert C. Goltz; Agnes M. F. Wong
TAGS: retinal ganglion cells, pupil reaction, melanopsin, summation
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4968-4977. doi: 10.1167/iovs.18-24639

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology October 2018

Loss of CXCR4/CXCL12 Signaling Causes Oculomotor Nerve Misrouting and Development of Motor Trigeminal to Oculomotor Synkinesis

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Mary C. Whitman; Elaine H. Nguyen; Jessica L. Bell; Alan P. Tenney; Alon Gelber; Elizabeth C. Engle
TAGS: signal transduction, axon, embryo, motor neurons, oculomotor nerve, cxcr4 receptors, synkinesis, oculomotor synkinesis, stromal cell-derived factor 1
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5201-5209. doi: 10.1167/iovs.18-25190

Includes: Multimedia, Supplemental Content

Retina October 2018

Ocular Biometric Diurnal Rhythms in Emmetropic and Myopic Adults

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Hannah J. Burfield; Nimesh B. Patel; Lisa A. Ostrin
TAGS: circadian rhythms, adult, biometry, refractive errors, choroid, retina
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5176-5187. doi: 10.1167/iovs.18-25389

Cornea October 2018

Diquafosol Sodium Inhibits Apoptosis and Inflammation of Corneal Epithelial Cells Via Activation of Erk1/2 and RSK: In Vitro and In Vivo Dry Eye Model

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Jin Hyoung Park; Seong-Ho Moon; Dong Hyun Kang; Hyun Jun Um; Soon-Suk Kang; Jae Yong Kim; Hungwon Tchah
TAGS: apoptosis, inflammation, conditioning (psychology), dry eye syndromes, scopolamine, cornea, sodium, corneal epithelial cells
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5108-5115. doi: 10.1167/iovs.17-22925

Physiology and Pharmacology October 2018

Defective Choroidal Blood Flow Baroregulation and Retinal Dysfunction and Pathology Following Sympathetic Denervation of Choroid

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Chunyan Li; Malinda E. C. Fitzgerald; Nobel Del Mar; Corey Haughey; Anton Reiner
TAGS: vascular flow, surgical procedures, operative, visual acuity, choroid, eye, pathology, rats, retina, pathophysiology, sympathectomy, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5032-5044. doi: 10.1167/iovs.18-24954

Visual Neuroscience October 2018

Temporal Frequency Abnormalities in Early-Stage Diabetic Retinopathy Assessed by Electroretinography

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J. Jason McAnany; Jason C. Park
TAGS: diabetes mellitus, diabetic retinopathy, electroretinography, photopsia, nonproliferative diabetic retinopathy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4871-4879. doi: 10.1167/iovs.18-25199

Review October 2018

Ocular Clocks: Adapting Mechanisms for Eye Functions and Health

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Marie-Paule Felder-Schmittbuhl; Ethan D. Buhr; Ouria Dkhissi-Benyahya; David Hicks; Stuart N. Peirson; Christophe P. Ribelayga; Cristina Sandu; Rainer Spessert; Gianluca Tosini
TAGS: dopamine, health, melatonin, photoreceptors, vision, eye, mice, retina, rhythm, body tissue, circadian clocks, regulation, clock gene
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4856-4870. doi: 10.1167/iovs.18-24957

Retinal Cell Biology September 2018

AAV2-mediated GRP78 Transfer Alleviates Retinal Neuronal Injury by Downregulating ER Stress and Tau Oligomer Formation

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Yonju Ha; Wei Liu; Hua Liu; Shuang Zhu; Fan Xia; Julia E. Gerson; Nisha A. Azhar; Ronald G. Tilton; Massoud Motamedi; Rakez Kayed; Wenbo Zhang
TAGS: immunohistochemistry, tau proteins, wounds and injuries, mice, retina, stress, transfer technique, oligomers, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4670-4682. doi: 10.1167/iovs.18-24427

Includes: Supplemental Content

Glaucoma September 2018

Effect of Resveratrol on Sirtuins, OPA1, and Fis1 Expression in Adult Zebrafish Retina

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Weiwei Sheng; Ye Lu; Feng Mei; Ning Wang; Zhi-Zhi Liu; Ying-Ying Han; Han-Tsing Wang; Suqi Zou; Hong Xu; Xu Zhang
TAGS: polymerase chain reaction, mitochondria, adult, genes, n-methylaspartate, zebrafish, retina, resveratrol, sirtuins, optic atrophy, autosomal dominant
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4542-4551. doi: 10.1167/iovs.18-24539

Includes: Supplemental Content

Anatomy and Pathology/Oncology September 2018

Targeting the Platelet-Derived Growth Factor-beta Stimulatory Circuitry to Control Retinoblastoma Seeds

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Zachary K. Goldsmith; William Coppess; Andrew S. Irvine; Kelley Yuan; Samuel R. Barsh; Madison K. Ritter; Matthew W. McEwen; Jacqueline Flores-Otero; Aileen Garcia-Vargas; Magaly Martinez-Ferrer; Rachel C. Brennan; Vanessa M. Morales-Tirado; Matthew W. Wilson
TAGS: signal transduction, cell culture techniques, western blotting, enzyme-linked immunosorbent assay, blood platelets, cell proliferation, flow cytometry, cell lines, cell survival, platelet-derived growth factor, platelet-derived growth factor receptor, retinoblastoma, rna, messenger, seeds, spheroids, cellular, vitreous body, diagnostic imaging, eye, neoplasms, rna, small interfering, nuclear translocation, proto-oncogene proteins c-akt, did not receive therapy or drug
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4486-4495. doi: 10.1167/iovs.18-24359

Retina September 2018

Three-Dimensional Microscopy Demonstrates Series and Parallel Organization of Human Peripapillary Capillary Plexuses

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Erandi Chandrasekera; Dong An; Ian L. McAllister; Dao-Yi Yu; Chandrakumar Balaratnasingam
TAGS: microcirculation, blood capillaries
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4327-4344. doi: 10.1167/iovs.18-24105

Retinal Cell Biology September 2018

Caspase-2 Mediates Site-Specific Retinal Ganglion Cell Death After Blunt Ocular Injury

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Chloe N. Thomas; Adam M. Thompson; Eleanor McCance; Martin Berry; Ann Logan; Richard J. Blanch; Zubair Ahmed
TAGS: caspases, eye injuries, photoreceptors, retinal ganglion cells, wounds and injuries, ocular trauma
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4453-4462. doi: 10.1167/iovs.18-24045

Includes: Supplemental Content

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Diabetic Nonperfused Areas in Macular and Extramacular Regions on Wide-Field Optical Coherence Tomography Angiography

Supernormal Flicker ERGs in Eyes With Central Retinal Vein Occlusion: Clinical Characteristics, Prognosis, and Effects of Anti-VEGF Agent

Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma

Adrenal and Glucocorticoid Effects on the Circadian Rhythm of Murine Intraocular Pressure

A Controlled Impact of Optic Nerve as a New Model of Traumatic Optic Neuropathy in Mouse

Mesenchymal Stem Cell–Derived Small Extracellular Vesicles Promote Neuroprotection in a Genetic DBA/2J Mouse Model of Glaucoma

How Ocular Dominance and Binocularity Are Reflected by the Population Receptive Field Properties

Slowed Dark Adaptation in Early AMD: Dual Stimulus Reveals Scotopic and Photopic Abnormalities

Binocular Summation in Postillumination Pupil Response Driven by Melanopsin-Containing Retinal Ganglion Cells

Loss of CXCR4/CXCL12 Signaling Causes Oculomotor Nerve Misrouting and Development of Motor Trigeminal to Oculomotor Synkinesis

Ocular Biometric Diurnal Rhythms in Emmetropic and Myopic Adults

Diquafosol Sodium Inhibits Apoptosis and Inflammation of Corneal Epithelial Cells Via Activation of Erk1/2 and RSK: In Vitro and In Vivo Dry Eye Model

Defective Choroidal Blood Flow Baroregulation and Retinal Dysfunction and Pathology Following Sympathetic Denervation of Choroid

Temporal Frequency Abnormalities in Early-Stage Diabetic Retinopathy Assessed by Electroretinography

Ocular Clocks: Adapting Mechanisms for Eye Functions and Health

AAV2-mediated GRP78 Transfer Alleviates Retinal Neuronal Injury by Downregulating ER Stress and Tau Oligomer Formation

Effect of Resveratrol on Sirtuins, OPA1, and Fis1 Expression in Adult Zebrafish Retina

Targeting the Platelet-Derived Growth Factor-beta Stimulatory Circuitry to Control Retinoblastoma Seeds

Three-Dimensional Microscopy Demonstrates Series and Parallel Organization of Human Peripapillary Capillary Plexuses

Caspase-2 Mediates Site-Specific Retinal Ganglion Cell Death After Blunt Ocular Injury

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