Visual Neuroscience

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Anatomy and Pathology/Oncology August 2018

The Impact of Choroidal Swelling on Optic Nerve Head Deformation

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Andrew J. Feola; Emily S. Nelson; Jerry Myers; C. Ross Ethier; Brian C. Samuels
TAGS: edema, optic disk, body tissue, choroid
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4172-4181. doi: 10.1167/iovs.18-24463

Includes: Supplemental Content

Special Issue August 2018

Determining Optimal Test Parameters for Assessing Dark Adaptation in People With Intermediate Age-Related Macular Degeneration

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Alison M. Binns; Deanna J. Taylor; Laura A. Edwards; David P. Crabb
TAGS: dark adaptation, recovery of function, rod photoreceptors, age-related macular degeneration, bleach
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD114-AMD121. doi: 10.1167/iovs.18-24211

Glaucoma August 2018

Modeling the Origin of the Ocular Pulse and Its Impact on the Optic Nerve Head

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Yuejiao Jin; Xiaofei Wang; Liang Zhang; Jost B. Jonas; Tin Aung; Leopold Schmetterer; Michaël J. A. Girard
TAGS: diastole, optic disk, systole, intraocular pressure, sclera, cardiac cycle, pulse volume
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3997-4010. doi: 10.1167/iovs.17-23454

Includes: Supplemental Content

Glaucoma August 2018

Change of β-Zone Parapapillary Atrophy During Axial Elongation: Boramae Myopia Cohort Study Report 3

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Kyoung Min Lee; Ho-Kyung Choung; Martha Kim; Sohee Oh; Seok Hwan Kim
TAGS: glaucoma, atrophy, cohort studies, myopia, optic disk, eye, hypertrophy, sclera, trunk structure, spectral-domain optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4020-4030. doi: 10.1167/iovs.18-24775

Includes: Supplemental Content

Glaucoma August 2018

Evaluation of Automated Segmentation Algorithms for Optic Nerve Head Structures in Optical Coherence Tomography Images

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Xiangyun J. Duan; Joan L. Jefferys; Harry A. Quigley
TAGS: glaucoma, optic disk, eye, optical coherence tomography, surrogate endpoints
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3816-3826. doi: 10.1167/iovs.18-24469

Glaucoma August 2018

Deep Optic Nerve Head Morphology Is Associated With Pattern of Glaucomatous Visual Field Defect in Open-Angle Glaucoma

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Jong Chul Han; Jae Hwan Choi; Do Young Park; Eun Jung Lee; Changwon Kee
TAGS: open-angle glaucoma, optic disk, eye, glaucomatous visual field defect, morphology, language morphology, scotoma
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3842-3851. doi: 10.1167/iovs.18-24588

Retinal Cell Biology August 2018

Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina

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Kota Sato; Yukihiro Shiga; Yurika Nakagawa; Kosuke Fujita; Koji M. Nishiguchi; Hiroshi Tawarayama; Namie Murayama; Shigeto Maekawa; Takeshi Yabana; Kazuko Omodaka; Shota Katayama; Qiwei Feng; Satoru Tsuda; Toru Nakazawa
TAGS: optic nerve injuries, mice, optic nerve, retina, crispr
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3943-3951. doi: 10.1167/iovs.18-23784

Includes: Supplemental Content

Glaucoma July 2018

Regional Deformation of the Optic Nerve Head and Peripapillary Sclera During IOP Elevation

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Elias Pavlatos; Yanhui Ma; Keyton Clayson; Xueliang Pan; Jun Liu
TAGS: ultrasonography, optic disk, eye, intraocular pressure, sclera, two-dimensional speckle tracking
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3779-3788. doi: 10.1167/iovs.18-24462

Glaucoma July 2018

Diagnostic Accuracy of Three-Dimensional Neuroretinal Rim Thickness for Differentiation of Myopic Glaucoma From Myopia

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Yong Woo Kim; Ki Ho Park
TAGS: glaucoma, eye, false-positive results, neuroretinal rim, myopia, retinal nerve fiber layer
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3655-3666. doi: 10.1167/iovs.18-24283

Includes: Supplemental Content

Retina July 2018

Sustained Connexin43 Mimetic Peptide Release From Loaded Nanoparticles Reduces Retinal and Choroidal Photodamage

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Nasir Mat Nor; Cindy X. Guo; Ilva D. Rupenthal; Ying-Shan Chen; Colin R. Green; Monica L. Acosta
TAGS: eye, retina, inflammation, peptides, choroid, connexin 43, photodamage, injections, body tissue, saline solution, fluorescein-5-isothiocyanate, normal saline, nanoparticles, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3682-3693. doi: 10.1167/iovs.17-22829

Retinal Cell Biology July 2018

Defined Conditions for Differentiation of Functional Retinal Ganglion Cells From Human Pluripotent Stem Cells

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Junwon Lee; Sang-Hwi Choi; Young-Beom Kim; Ikhyun Jun; Jin Jea Sung; Dongjin R. Lee; Yang In Kim; Myung Soo Cho; Suk Ho Byeon; Dae-Sung Kim; Dong-Wook Kim
TAGS: mitochondria, fibroblast growth factor 2, patient isolation, prescriptions, drug, eye, stem cells, pluripotent, pax6 transcription factor, enhanced s-cone syndrome, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3531-3542. doi: 10.1167/iovs.17-23439

Includes: Multimedia, Supplemental Content

Glaucoma June 2018

The Contribution of Sulfated Glycosaminoglycans to the Inflation Response of the Human Optic Nerve Head

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Dan E. Midgett; Joan L. Jefferys; Harry A. Quigley; Thao D. Nguyen
TAGS: buffers, glycosaminoglycans, economic inflation, optic disk, enzymes, eye, catabolism
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):3144-3154. doi: 10.1167/iovs.18-23845

Visual Neuroscience June 2018

Systemic 7,8-Dihydroxyflavone Treatment Protects Immature Retinas Against Hypoxic-Ischemic Injury via Müller Glia Regeneration and MAPK/ERK Activation

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Hsiu-Mei Huang; Chao-Ching Huang; Meng-Han Tsai; Yi-Chieh Poon; Ying-Chao Chang
TAGS: ischemia, hypoxia, mitogen-activated protein kinases, neuroglia, wounds and injuries, retina
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):3124-3135. doi: 10.1167/iovs.18-23792

Includes: Supplemental Content

Glaucoma June 2018

microRNA Profiling in Glaucoma Eyes With Varying Degrees of Optic Neuropathy by Using Next-Generation Sequencing

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Yaoming Liu; Yang Chen; Yayi Wang; Xinyu Zhang; Kai Gao; Shida Chen; Xiulan Zhang
TAGS: hypertension, glaucoma, cataract, open-angle glaucoma, eye, optic nerve disorders, micrornas, massively-parallel genome sequencing
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2955-2966. doi: 10.1167/iovs.17-23599

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology June 2018

Tumor Necrosis Factor Inhibition in the Acute Management of Traumatic Optic Neuropathy

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Brian C. Tse; Galina Dvoriantchikova; Wensi Tao; Ryan A. Gallo; John Y. Lee; Steven Pappas; Roberta Brambilla; Dmitry Ivanov; David T. Tse; Daniel Pelaez
TAGS: tumor necrosis factors, etanercept, optic nerve injuries, wounds and injuries
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2905-2912. doi: 10.1167/iovs.18-24431

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology June 2018

Optic Nerve Sheath Tethering in Adduction Occurs in Esotropia and Hypertropia, But Not in Exotropia

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Soh Youn Suh; Robert A. Clark; Joseph L. Demer
TAGS: magnetic resonance imaging, esotropia, exotropia, hypertropia, eye, optic nerve, optic nerve sheath, gaze, adduction, spinal tethering
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2899-2904. doi: 10.1167/iovs.18-24305

Special Issue June 2018

Perspective on AMD Pathobiology: A Bioenergetic Crisis in the RPE

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Cody R. Fisher; Deborah A. Ferrington
TAGS: mitochondria, dna, mitochondrial, pathology, proteins, bioenergetics, donors
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD41-AMD47. doi: 10.1167/iovs.18-24289

Retina June 2018

Biomechanical Properties of Bruch's Membrane–Choroid Complex and Their Influence on Optic Nerve Head Biomechanics

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Xiaofei Wang; Clarence Ken Guan Teoh; Anita S. Y. Chan; Sathiyan Thangarajoo; Jost B. Jonas; Michaël J. A. Girard
TAGS: biomechanics, bruch's basal membrane, optic disk, rupture, body tissue, choroid, eye, intraocular pressure, sclera, raised intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2808-2817. doi: 10.1167/iovs.17-22069

Includes: Supplemental Content

Physiology and Pharmacology June 2018

Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha 2A -Adrenoceptors In Vitro

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Brittany J. Carr; Koichiro Mihara; Rithwik Ramachandran; Mahmoud Saifeddine; Neil M. Nathanson; William K. Stell; Morley D. Hollenberg
TAGS: atropine, muscarinic antagonists, myopia, adrenergic receptor, antagonists
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2778-2791. doi: 10.1167/iovs.17-22562

Includes: Supplemental Content

Glaucoma June 2018

Mapping the Central 10° Visual Field to the Optic Nerve Head Using the Structure–Function Relationship

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Yuri Fujino; Hiroshi Murata; Masato Matsuura; Mieko Yanagisawa; Nobuyuki Shoji; Kenji Inoue; Junkichi Yamagami; Ryo Asaoka
TAGS: optic disk, visual fields, eye
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2801-2807. doi: 10.1167/iovs.17-23485

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The Impact of Choroidal Swelling on Optic Nerve Head Deformation

Determining Optimal Test Parameters for Assessing Dark Adaptation in People With Intermediate Age-Related Macular Degeneration

Modeling the Origin of the Ocular Pulse and Its Impact on the Optic Nerve Head

Change of β-Zone Parapapillary Atrophy During Axial Elongation: Boramae Myopia Cohort Study Report 3

Evaluation of Automated Segmentation Algorithms for Optic Nerve Head Structures in Optical Coherence Tomography Images

Deep Optic Nerve Head Morphology Is Associated With Pattern of Glaucomatous Visual Field Defect in Open-Angle Glaucoma

Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina

Regional Deformation of the Optic Nerve Head and Peripapillary Sclera During IOP Elevation

Diagnostic Accuracy of Three-Dimensional Neuroretinal Rim Thickness for Differentiation of Myopic Glaucoma From Myopia

Sustained Connexin43 Mimetic Peptide Release From Loaded Nanoparticles Reduces Retinal and Choroidal Photodamage

Defined Conditions for Differentiation of Functional Retinal Ganglion Cells From Human Pluripotent Stem Cells

The Contribution of Sulfated Glycosaminoglycans to the Inflation Response of the Human Optic Nerve Head

Systemic 7,8-Dihydroxyflavone Treatment Protects Immature Retinas Against Hypoxic-Ischemic Injury via Müller Glia Regeneration and MAPK/ERK Activation

microRNA Profiling in Glaucoma Eyes With Varying Degrees of Optic Neuropathy by Using Next-Generation Sequencing

Tumor Necrosis Factor Inhibition in the Acute Management of Traumatic Optic Neuropathy

Optic Nerve Sheath Tethering in Adduction Occurs in Esotropia and Hypertropia, But Not in Exotropia

Perspective on AMD Pathobiology: A Bioenergetic Crisis in the RPE

Biomechanical Properties of Bruch's Membrane–Choroid Complex and Their Influence on Optic Nerve Head Biomechanics

Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha 2A -Adrenoceptors In Vitro

Mapping the Central 10° Visual Field to the Optic Nerve Head Using the Structure–Function Relationship

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