Vitreous Disorders

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Retina December 2018

Optical Coherence Tomography Angiography in Familial Exudative Vitreoretinopathy: Clinical Features and Phenotype-Genotype Correlation

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Chonglin Chen; Chengxi Liu; Zhirong Wang; Limei Sun; Xiujuan Zhao; Songshan Li; Xiaoling Luo; Aiyuan Zhang; Victor Chong; Lin Lu; Xiaoyan Ding
TAGS: angiogram, phenotype, genotype, signs and symptoms, optical coherence tomography, familial exudative vitreoretinopathy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5726-5734. doi: 10.1167/iovs.18-25377

Retina November 2018

Morphologic, Biomechanical, and Compositional Features of the Internal Limiting Membrane in Pathologic Myopic Foveoschisis

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Lu Chen; Yantao Wei; Xuezhi Zhou; Zhaotian Zhang; Wei Chi; Li Gong; Xintong Jiang; Shaochong Zhang
TAGS: western blotting, astrocytes, collagen, collagen type iv, fluorescent antibody technique, gliosis, tissue membrane, microscopy, atomic force, surgical procedures, operative, body tissue, eye, proteins, mass or substance concentration per volume, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5569-5578. doi: 10.1167/iovs.18-24676

Genetics November 2018

Spectrum of Variants in 389 Chinese Probands With Familial Exudative Vitreoretinopathy

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Jia-Kai Li; Yian Li; Xiang Zhang; Chun-Li Chen; Yu-Qing Rao; Ping Fei; Qi Zhang; Peiquan Zhao; Jing Li
TAGS: cohort studies, genes, proband, chinese people, chinese (other dialects), familial exudative vitreoretinopathy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5368-5381. doi: 10.1167/iovs.17-23541

Includes: Supplemental Content

Retinal Cell Biology October 2018

Altered Decorin Biology in Proliferative Vitreoretinopathy: A Mechanistic and Cohort Study

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Ghazala Begum; Jenna O'Neill; Rishika Chaudhary; Karen Blachford; David R. J. Snead; Martin Berry; Robert A. H. Scott; Ann Logan; Richard J. Blanch
TAGS: cell culture techniques, fibronectins, cohort studies, vitreoretinopathy, proliferative, vitreous body, epithelial to mesenchymal transition, laminin, collagen, fibrosis, enzyme-linked immunosorbent assay, radiation recall dermatitis
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4929-4936. doi: 10.1167/iovs.18-24299

Includes: Supplemental Content

Anatomy and Pathology/Oncology September 2018

Targeting the Platelet-Derived Growth Factor-beta Stimulatory Circuitry to Control Retinoblastoma Seeds

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Zachary K. Goldsmith; William Coppess; Andrew S. Irvine; Kelley Yuan; Samuel R. Barsh; Madison K. Ritter; Matthew W. McEwen; Jacqueline Flores-Otero; Aileen Garcia-Vargas; Magaly Martinez-Ferrer; Rachel C. Brennan; Vanessa M. Morales-Tirado; Matthew W. Wilson
TAGS: signal transduction, cell culture techniques, western blotting, enzyme-linked immunosorbent assay, blood platelets, cell proliferation, flow cytometry, cell lines, cell survival, platelet-derived growth factor, platelet-derived growth factor receptor, retinoblastoma, rna, messenger, seeds, spheroids, cellular, vitreous body, diagnostic imaging, eye, neoplasms, rna, small interfering, nuclear translocation, proto-oncogene proteins c-akt, did not receive therapy or drug
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4486-4495. doi: 10.1167/iovs.18-24359

Retina August 2018

Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging

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Ignacio Melgar-Asensio; Irawati Kandela; Fraser Aird; Soesiawati R. Darjatmoko; Cristobal de los Rios; Christine M. Sorenson; Daniel M. Albert; Nader Sheibani; Jack Henkin
TAGS: arginine, drug clearance, drug delivery systems, peptides, oryctolagus cuniculus, vitreous body, diagnostic imaging, eye
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4071-4081. doi: 10.1167/iovs.18-24087

Retina July 2018

Vitreous Cytokine Expression and a Murine Model Suggest a Key Role of Microglia in the Inflammatory Response to Retinal Detachment

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Lee Kiang; Bing X. Ross; Jingyu Yao; Sumathi Shanmugam; Chris A. Andrews; Sean Hansen; Cagri G. Besirli; David N. Zacks; Steven F. Abcouwer
TAGS: cytokine, microglia, retinal detachment, rna, messenger, vitreous body, mice, retina, inflammatory response
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3767-3778. doi: 10.1167/iovs.18-24489

Includes: Supplemental Content

Biochemistry and Molecular Biology July 2018

Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells

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David W. Sant; Vladimir Camarena; Sushmita Mustafi; Yiwen Li; Zachary Wilkes; Derek Van Booven; Rong Wen; Gaofeng Wang
TAGS: vascular endothelial growth factor a, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3608-3618. doi: 10.1167/iovs.18-24101

Includes: Supplemental Content

Special Issue June 2018

The Proteomic Landscape in the Vitreous of Patients With Age-Related and Diabetic Retinal Disease

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Christian Schori; Christian Trachsel; Jonas Grossmann; Ioanna Zygoula; Daniel Barthelmes; Christian Grimm
TAGS: diabetes mellitus, enzyme-linked immunosorbent assay, proteome, retinal diseases, vitreous body, proteins, proteomics, exudative age-related macular degeneration
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD31-AMD40. doi: 10.1167/iovs.18-24122

Includes: Supplemental Content

Immunology and Microbiology May 2018

Comparison of Aqueous and Vitreous Lymphocyte Populations From Two Rat Models of Experimental Uveitis

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Kathryn L. Pepple; Leslie Wilson; Russell N. Van Gelder
TAGS: b-lymphocytes, lymphocyte, t-lymphocyte, uveitis, vitreous body, eye, fluid flow
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2504-2511. doi: 10.1167/iovs.18-24192

Includes: Supplemental Content

Retina February 2018

Enhanced Expression of NLRP3 Inflammasome-Related Inflammation in Diabetic Retinopathy

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Hui Chen; Xiongze Zhang; Nanying Liao; Lan Mi; Yuting Peng; Bing Liu; Shaochong Zhang; Feng Wen
TAGS: inflammation, diabetic retinopathy, interleukin-18, vitreous body, inflammasomes, nlr family, pyrin domain-containing 3 protein
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):978-985. doi: 10.1167/iovs.17-22816

Anatomy and Pathology/Oncology January 2018

The Adenosine Receptor Antagonist, 7-Methylxanthine, Alters Emmetropizing Responses in Infant Macaques

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Li-Fang Hung; Baskar Arumugam; Lisa Ostrin; Nimesh Patel; Klaus Trier; Monica Jong; Earl L. Smith III
TAGS: anisometropia, cercopithecidae, infant, lens, crystalline, lens (device), macaca, myopia, refractive errors, vision, vitreous body, cornea, eye, methylxanthine, adenosine receptor antagonist, symbols
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):472-486. doi: 10.1167/iovs.17-22337

Retina November 2017

Mutation Spectrum of the LRP5 , NDP , and TSPAN12 Genes in Chinese Patients With Familial Exudative Vitreoretinopathy

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Miao Tang; Limei Sun; Andina Hu; Miner Yuan; Yu Yang; Xuening Peng; Xiaoyan Ding
TAGS: mutation, genes, chinese people, chinese (other dialects), familial exudative vitreoretinopathy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5949-5957. doi: 10.1167/iovs.17-22577

Includes: Supplemental Content

Retina November 2017

Visual Function Response to Ocriplasmin for the Treatment of Vitreomacular Traction and Macular Hole: The OASIS Study

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Benedicte Lescrauwaet; Luc Duchateau; Thomas Verstraeten; Timothy L. Jackson
TAGS: vision, macular holes, oasis trial, vitreomacular traction syndrome, ocriplasmin
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5842-5848. doi: 10.1167/iovs.17-22363

Includes: Supplemental Content

Clinical and Epidemiologic Research November 2017

Vitreous Fibronectin and Fibrinogen Expression Increased in Eyes With Proliferative Diabetic Retinopathy After Intravitreal Anti-VEGF Therapy

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Qiaoling Wei; Ting Zhang; Rui Jiang; Qing Chang; Yanqiong Zhang; Xin Huang; Xing Gao; Hong Jin; Gezhi Xu
TAGS: vascular endothelial growth factor a, fibrinogen, enzyme-linked immunosorbent assay, fibronectins, diabetic retinopathy, vitreous body, eye, proteins, proteomics, proliferative diabetic retinopathy, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5783-5791. doi: 10.1167/iovs.17-22345

Includes: Supplemental Content

Letters to the Editor November 2017

Comment on: Vitreomacular Adhesion and Its Association With Age-Related Macular Degeneration in a Population-Based Setting: The Alienor Study

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Emilia Maggio; Antonio Polito; Grazia Pertile
TAGS: age-related macular degeneration, vitreomacular adhesions
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5681-5681. doi: 10.1167/iovs.17-22981

Retina October 2017

Assessment of Neurotrophins and Inflammatory Mediators in Vitreous of Patients With Diabetic Retinopathy

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Joseph D. Boss; Pawan Kumar Singh; Hemang K. Pandya; Joaquin Tosi; Chaesik Kim; Asheesh Tewari; Mark S. Juzych; Gary W. Abrams; Ashok Kumar
TAGS: cytokine, tumor necrosis factors, diabetic retinopathy, inflammation mediators, nerve growth factors, nucleus solitarius, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5594-5603. doi: 10.1167/iovs.17-21973

Biochemistry and Molecular Biology October 2017

Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy

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Guohong Zhou; Yajiang Duan; Gaoen Ma; Wenyi Wu; Zhengping Hu; Na Chen; Yewlin Chee; Jing Cui; Arif Samad; Joanne A. Matsubara; Shizuo Mukai; Patricia A. D'Amore; Hetian Lei
TAGS: apoptosis, western blotting, mutation, cell proliferation, oryctolagus cuniculus, vitreoretinopathy, proliferative, vitreous body, epithelial cells, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5361-5367. doi: 10.1167/iovs.17-22045

Physiology and Pharmacology October 2017

Sustaining Intravitreal Residence With L-Arginine Peptide-Conjugated Nanocarriers

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Hao Li; Wenzhong Liu; Christine M. Sorenson; Nader Sheibani; Daniel M. Albert; Thulani Senanayake; Serguei Vinogradov; Jack Henkin; Hao F. Zhang
TAGS: half-life, arginine, diffusion, fluorescence, injection of therapeutic agent, peptides, vitreous body, nanoparticles, drug release
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5142-5150. doi: 10.1167/iovs.17-22160

Includes: Supplemental Content

Retinal Cell Biology September 2017

The Role of Inverted Internal Limiting Membrane Flap in Macular Hole Closure

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Yusuke Shiode; Yuki Morizane; Ryo Matoba; Masayuki Hirano; Shinichiro Doi; Shinji Toshima; Kosuke Takahashi; Ryoichi Araki; Yuki Kanzaki; Mika Hosogi; Tomoko Yonezawa; Atsushi Yoshida; Fumio Shiraga
TAGS: immunohistochemistry, fibroblast growth factor 2, tissue membrane, nerve growth factors, surgical flaps, macular holes, 5-lipoxygenase-activating protein
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4847-4855. doi: 10.1167/iovs.17-21756

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Optical Coherence Tomography Angiography in Familial Exudative Vitreoretinopathy: Clinical Features and Phenotype-Genotype Correlation

Morphologic, Biomechanical, and Compositional Features of the Internal Limiting Membrane in Pathologic Myopic Foveoschisis

Spectrum of Variants in 389 Chinese Probands With Familial Exudative Vitreoretinopathy

Altered Decorin Biology in Proliferative Vitreoretinopathy: A Mechanistic and Cohort Study

Targeting the Platelet-Derived Growth Factor-beta Stimulatory Circuitry to Control Retinoblastoma Seeds

Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging

Vitreous Cytokine Expression and a Murine Model Suggest a Key Role of Microglia in the Inflammatory Response to Retinal Detachment

Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells

The Proteomic Landscape in the Vitreous of Patients With Age-Related and Diabetic Retinal Disease

Comparison of Aqueous and Vitreous Lymphocyte Populations From Two Rat Models of Experimental Uveitis

Enhanced Expression of NLRP3 Inflammasome-Related Inflammation in Diabetic Retinopathy

The Adenosine Receptor Antagonist, 7-Methylxanthine, Alters Emmetropizing Responses in Infant Macaques

Mutation Spectrum of the LRP5 , NDP , and TSPAN12 Genes in Chinese Patients With Familial Exudative Vitreoretinopathy

Visual Function Response to Ocriplasmin for the Treatment of Vitreomacular Traction and Macular Hole: The OASIS Study

Vitreous Fibronectin and Fibrinogen Expression Increased in Eyes With Proliferative Diabetic Retinopathy After Intravitreal Anti-VEGF Therapy

Comment on: Vitreomacular Adhesion and Its Association With Age-Related Macular Degeneration in a Population-Based Setting: The Alienor Study

Assessment of Neurotrophins and Inflammatory Mediators in Vitreous of Patients With Diabetic Retinopathy

Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy

Sustaining Intravitreal Residence With L-Arginine Peptide-Conjugated Nanocarriers

The Role of Inverted Internal Limiting Membrane Flap in Macular Hole Closure

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