Vitreous Disorders

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Retina June 2025

Liposome Encapsulation Enhances Ripasudil Therapeutic Efficacy Against Proliferative Vitreoretinal Diseases: Implications in Advanced Ocular Treatment

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Rui Ji; Keijiro Ishikawa; Wei Tan; Kenichiro Mori; Ryotaro Tsukamoto; Naoya Matsunaga; Kohei Kiyohara; Yosuke Fukuda; Iori Wada; Tomoyuki Isobe; Tomohito Tanihara; Yuya Yoshida; Kouta Mayanagi; Kosuke Oyama; Yuma Terada; Kaita Otsuki; Kengo Hamamura; Hiroshi Kikuchi; Shintaro Nakao; Shigeo Yoshida; Ram Kannan; Shigehiro Ohdo; Koh-Hei Sonoda
TAGS: encapsulation, hmga2 protein, lipoma, liposomes, radioimmunoprecipitation assay, ristocetin induced platelet aggregation, vitreoretinal disease, fibrosis, choroidal neovascularization, oryctolagus cuniculus
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):56. https://doi.org/10.1167/iovs.66.6.56

Includes: Supplemental Content

Lens May 2025

RNA-Seq Study of Human Lens Epithelial Cells: Differentially Expressed Genes and Pathways in Steroid, Uveitic, Post-Vitrectomy, and Senile Cataracts

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Carrie Fei; Michael R. Dong; Sean Byars; Jaynish S. Shah; Anthony J. Hall; Lyndell L. Lim
TAGS: after-cataract, cataract, cataract, senile, epithelial cells, genes, lens, crystalline, rna-seq, steroids, vitrectomy, rna
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):4. https://doi.org/10.1167/iovs.66.5.4

Includes: Supplemental Content

Anatomy and Pathology/Oncology March 2025

Vitreous Fibrillar Structure and Interfibrillar Composition in Adult Mice

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Patricia Jaramillo-Garcés; Judit Pampalona; Ana Carretero; Eduard José Cunilleras; David Ramos; Jesús Ruberte
TAGS: fibril, mice, vitreous body, adult
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):60. https://doi.org/10.1167/iovs.66.3.60

Includes: Supplemental Content

Immunology and Microbiology March 2025

An Approach to Predict Intraocular Diseases by Machine Learning Based on Vitreous Humor Immune Mediator Profile

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Risa Sugawara; Yoshihiko Usui; Akira Saito; Naoya Nezu; Hiroyuki Komatsu; Kinya Tsubota; Masaki Asakage; Naoyuki Yamakawa; Yoshihiro Wakabayashi; Masahiro Sugimoto; Masahiko Kuroda; Hiroshi Goto
TAGS: biological response modifiers, immune mediator, machine learning, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):38. https://doi.org/10.1167/iovs.66.3.38

Clinical and Epidemiologic Research February 2025

Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy

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Ying-Yi Chen; Chung-May Yang; Chang-Hao Yang; Tzyy-Chang Ho; Yi-Ting Hsieh; Tso-Ting Lai; Tzu-Hsun Tsai; Shu-Yi Huang
TAGS: ceramides, vitreous body, diabetic retinopathy, proliferative diabetic retinopathy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):28. https://doi.org/10.1167/iovs.66.2.28

Genetics February 2025

Gene Variant Spectrum in Probands With Familial Exudative Vitreoretinopathy Using an Expanded Panel

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Sarah van der Ende; Karen Bedard; Karin Wallace; Michael P. Mackley; Mathew Nightingale; Daniel Gaston; M. Jill Beis; Marissa A. Leblanc; Roxanne Gillett; Alex V. Levin; Ian H. Clark; Élise Héon; Rajeev H. Muni; Elias I. Traboulsi; Christopher J. Lyons; Christopher R. McMaster; Johane M. Robitaille; on behalf of The FEVR Consortium
TAGS: familial exudative vitreoretinopathies, genes, proband
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):23. https://doi.org/10.1167/iovs.66.2.23

Includes: Supplemental Content

Genetics February 2025

Genotype–Phenotype Spectrum of eyeGENE Patients With Familial Exudative Vitreoretinopathy: Novel Variants in Norrin/β-Catenin Signaling Pathway Genes

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Fulya Yaylacıoğlu Tuncay; Melissa J. Reeves; Sairah Yousaf; Ehsan Ullah; Bin Guan; Kerry E. Goetz; Santa J. Tumminia; Robert B. Hufnagel
TAGS: cohort studies, familial exudative vitreoretinopathies, genes, genotype, phenotype, signal pathway, signal transduction pathways, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):9. https://doi.org/10.1167/iovs.66.2.9

Includes: Supplemental Content

Letters to the Editor December 2024

Letter to the Editor: Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus

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Yang Pan; Takeshi Iwata
TAGS: age-related macular degeneration, genetic risk, htra1 gene, proteins, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):27. https://doi.org/10.1167/iovs.65.14.27

Letters to the Editor December 2024

Author Response: Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus

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Brandi L. Williams; Moussa A. Zouache; Gregory S. Hageman
TAGS: age-related macular degeneration, genetic risk, htra1 gene, proteins, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):26. https://doi.org/10.1167/iovs.65.14.26

Retina December 2024

Epiretinal Membrane: Correlations Among Clinical, Immunohistochemical, and Biochemical Features and Their Prognostic Implications

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Hyun Seung Yang; Suho Choi; Soojin Kim; Chan Hong Min; Dongwoo Kim; Youngseop Lee; Minji Kim; Donghoon Koo; Jaiyoung Ryu; Jeongmin Kim
TAGS: body tissue, cytokine, epiretinal membrane, patient prognosis, postoperative care, preoperative care, prognostic factors, surgical procedures, operative, n-cadherins, proteins
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):25. https://doi.org/10.1167/iovs.65.14.25

Physiology and Pharmacology November 2024

Exposure to Silicone Oil Endotamponades Induces VEGF Antibody Aggregation and Loss of Functionality

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Sabrina Wohlfart; Jonathan Herth; Manuel Ben Böhmann; Giulia Pander; Lorenz Herbster; Walter Mier; Gerd Uwe Auffarth; Philipp Uhl; Maximilian Hammer
TAGS: antibodies, anti-vascular endothelial growth factor therapy, bevacizumab, silicone oils, trastuzumab, vascular endothelial growth factor a, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):56. https://doi.org/10.1167/iovs.65.13.56

Includes: Supplemental Content

Immunology and Microbiology November 2024

Age-Associated Alterations in the Metabolome of Human Vitreous in Bacterial Endophthalmitis

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Sreyasi Maiti; Lakshminarayanan Gowtham; Dhanwini Rudraprasad; Vivek P. Dave; Joveeta Joseph
TAGS: bacterial endophthalmitis, endophthalmitis, metabolic disturbance, metabolites, metabolome, vitreous body, metabolomics, older adult
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):6. https://doi.org/10.1167/iovs.65.13.6

Includes: Supplemental Content

Retina November 2024

Midperipheral Microvascular Defects and Their Associations With Vitreoretinal Abnormalities in Early-Stage Familial Exudative Vitreoretinopathy

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Juan Zhang; Lu Ruan; Chen Jiang; Qian Yang; Qing Chang; Xin Huang
TAGS: familial exudative vitreoretinopathies
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):4. https://doi.org/10.1167/iovs.65.13.4

Includes: Supplemental Content

Retina October 2024

A First-Passage Model of Intravitreal Drug Delivery and Residence Time—Influence of Ocular Geometry, Individual Variability, and Injection Location

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Patricia Lamirande; Eamonn A. Gaffney; Michael Gertz; Philip K. Maini; Jessica R. Crawshaw; Antonello Caruso
TAGS: drug delivery systems, eye, injections, vitreous body, immunoglobulin g, molecule, drug elimination routes, drug excretion
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):21. https://doi.org/10.1167/iovs.65.12.21

Includes: Supplemental Content

Anatomy and Pathology/Oncology June 2024

Aqueous VEGF-A Levels as a Liquid Biopsy Biomarker of Retinoblastoma Vitreous Seed Response to Therapy

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Anthony B. Daniels; Kamakshi L. Sishtla; Carley M. Bogan; Janene M. Pierce; Sheau-Chiann Chen; Liya Xu; Jesse L. Berry; Timothy W. Corson
TAGS: biological markers, eye, oryctolagus cuniculus, retinoblastoma, seeds, vascular endothelial growth factor a, vitreous body, chemotherapy regimen, aqueous humor, transplantation, heterologous
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):18. https://doi.org/10.1167/iovs.65.6.18

Includes: Supplemental Content

Retina May 2024

Light Scattering by Vitreous of Humans With Vision Degrading Myodesopsia From Floaters

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Alba M. Paniagua-Diaz; Justin H. Nguyen; Pablo Artal; Wei Gui; J. Sebag
TAGS: vision, vitreous body, vitreous floaters
Invest. Ophthalmol. Vis. Sci.. 2024; 65(5):20. https://doi.org/10.1167/iovs.65.5.20

Retina April 2024

Short Term Effect of Pre-Operative Anti-VEGF on Angiogenic and Fibrotic Profile of Fibrovascular Membranes of Proliferative Diabetic Retinopathy

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Kaveh Fadakar; Safa Rahmani; Thomas Tedeschi; Jeremy A. Lavine; Amani A. Fawzi
TAGS: angiogenesis, anti-vascular endothelial growth factor therapy, endothelial cells, endothelium, proliferative diabetic retinopathy, tissue membrane, surgical procedures, operative, endothelin-1, gene expression, injections
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):37. https://doi.org/10.1167/iovs.65.4.37

Includes: Supplemental Content

Genetics April 2024

Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus

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Brandi L. Williams; Moussa A. Zouache; Nathan A. Seager; Chris M. Pappas; Jin Liu; Robert A. Anstadt; William C. Hubbard; Julie Thomas; Jill L. Hageman; Jennifer Mohler; Burt T. Richards; Gregory S. Hageman
TAGS: htra1 gene, proteins, vitreous body, genetic risk, enzyme-linked immunosorbent assay, age-related macular degeneration
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):34. https://doi.org/10.1167/iovs.65.4.34

Includes: Supplemental Content

Retina April 2024

Drug Distribution After Intravitreal Injection: A Mathematical Model

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Alessia Ruffini; Alessia Casalucci; Caterina Cara; C. Ross Ethier; Rodolfo Repetto
TAGS: drug distribution, eye, injections, intravitreal injections, mathematical model, vitreous body, intraocular pressure, fluid flow, biological transport
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):9. https://doi.org/10.1167/iovs.65.4.9

Retina April 2024

Early Choriocapillaris Loss in a Porcine Model of RPE Cell Debridement Precedes Pathology That Simulates Advanced Macular Degeneration

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Raymond Iezzi; Brittni A. Scruggs; Jarel Gandhi; Francesca N. Zenti; Noah Shafi; Aubrey Berger; Alan D. Marmorstein
TAGS: debridement, macular degeneration, suidae, retinal pigment cell, pathology
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):8. https://doi.org/10.1167/iovs.65.4.8

Includes: Multimedia, Supplemental Content

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Liposome Encapsulation Enhances Ripasudil Therapeutic Efficacy Against Proliferative Vitreoretinal Diseases: Implications in Advanced Ocular Treatment

RNA-Seq Study of Human Lens Epithelial Cells: Differentially Expressed Genes and Pathways in Steroid, Uveitic, Post-Vitrectomy, and Senile Cataracts

Vitreous Fibrillar Structure and Interfibrillar Composition in Adult Mice

An Approach to Predict Intraocular Diseases by Machine Learning Based on Vitreous Humor Immune Mediator Profile

Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy

Gene Variant Spectrum in Probands With Familial Exudative Vitreoretinopathy Using an Expanded Panel

Genotype–Phenotype Spectrum of eyeGENE Patients With Familial Exudative Vitreoretinopathy: Novel Variants in Norrin/β-Catenin Signaling Pathway Genes

Letter to the Editor: Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus

Author Response: Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus

Epiretinal Membrane: Correlations Among Clinical, Immunohistochemical, and Biochemical Features and Their Prognostic Implications

Exposure to Silicone Oil Endotamponades Induces VEGF Antibody Aggregation and Loss of Functionality

Age-Associated Alterations in the Metabolome of Human Vitreous in Bacterial Endophthalmitis

Midperipheral Microvascular Defects and Their Associations With Vitreoretinal Abnormalities in Early-Stage Familial Exudative Vitreoretinopathy

A First-Passage Model of Intravitreal Drug Delivery and Residence Time—Influence of Ocular Geometry, Individual Variability, and Injection Location

Aqueous VEGF-A Levels as a Liquid Biopsy Biomarker of Retinoblastoma Vitreous Seed Response to Therapy

Light Scattering by Vitreous of Humans With Vision Degrading Myodesopsia From Floaters

Short Term Effect of Pre-Operative Anti-VEGF on Angiogenic and Fibrotic Profile of Fibrovascular Membranes of Proliferative Diabetic Retinopathy

Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus

Drug Distribution After Intravitreal Injection: A Mathematical Model

Early Choriocapillaris Loss in a Porcine Model of RPE Cell Debridement Precedes Pathology That Simulates Advanced Macular Degeneration

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