Vitreous Disorders

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Lecture April 2019

Discovering Mechanisms in the Changing and Diverse Pathology of Retinopathy of Prematurity: The Weisenfeld Award Lecture

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M. Elizabeth Hartnett
TAGS: vascular endothelial growth factor a, signal transduction, awards and prizes, neovascularization, pathologic, retinopathy of prematurity, pathology, retina, vitreous neovascularization
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1286-1297. doi: 10.1167/iovs.18-25525

Immunology and Microbiology April 2019

Mycoplasma Ocular Infection in Subretinal Graft Transplantation of iPS Cells-Derived Retinal Pigment Epithelial Cells

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Kenichi Makabe; Sunao Sugita; Ayumi Hono; Hiroyuki Kamao; Masayo Takahashi
TAGS: cercopithecidae, tissue transplants, mycoplasma, transplantation, retinal pigment cell, idiopathic pneumonia syndrome, mycoplasma infections
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1298-1308. doi: 10.1167/iovs.18-26222

Includes: Supplemental Content

Physiology and Pharmacology February 2019

1 H NMR Spectroscopy Characterization of Porcine Vitreous Humor in Physiological and Photoreceptor Degeneration Conditions

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Alberto Elmi; Domenico Ventrella; Luca Laghi; Giacomo Carnevali; Chenglin Zhu; Grazia Pertile; Francesca Barone; Fabio Benfenati; Maria Laura Bacci
TAGS: photoreceptors, spectrum analysis, suidae, vitreous body, tissue degeneration, molecule
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):741-747. doi: 10.1167/iovs.18-25675

Includes: Supplemental Content

Retina January 2019

VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site

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Peter H. Tang; Gabriel Velez; Stephen H. Tsang; Alexander G. Bassuk; Vinit B. Mahajan
TAGS: mutation, exons, gelatinase a, surgical procedures, operative, vitreous body, eye, retina, cytokinesis, tissue degeneration, histopathology tests, proteolysis, proteins, splice-site mutation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):282-293. doi: 10.1167/iovs.18-25624

Includes: Supplemental Content

Genetics January 2019

Germline Mutations in CTNNB1 Associated With Syndromic FEVR or Norrie Disease

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Wenmin Sun; Xueshan Xiao; Shiqiang Li; Xiaoyun Jia; Panfeng Wang; Qingjiong Zhang
TAGS: mutation, germ-line mutation, familial exudative vitreoretinopathy, congenital progressive oculo-acoustico-cerebral degeneration, beta catenin
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):93-97. doi: 10.1167/iovs.18-25142

Includes: Supplemental Content

Anatomy and Pathology/Oncology December 2018

Color and Temporal Frequency Sensitive Eye Growth in Chick

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Frances Rucker; Stephanie Britton; Christopher Taylor
TAGS: color, light, lighting, eye, photopsia, luminance, refraction
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6003-6013. doi: 10.1167/iovs.18-25322

Retina December 2018

Optical Coherence Tomography Angiography in Familial Exudative Vitreoretinopathy: Clinical Features and Phenotype-Genotype Correlation

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Chonglin Chen; Chengxi Liu; Zhirong Wang; Limei Sun; Xiujuan Zhao; Songshan Li; Xiaoling Luo; Aiyuan Zhang; Victor Chong; Lin Lu; Xiaoyan Ding
TAGS: angiogram, phenotype, genotype, signs and symptoms, optical coherence tomography, familial exudative vitreoretinopathy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5726-5734. doi: 10.1167/iovs.18-25377

Retina November 2018

Morphologic, Biomechanical, and Compositional Features of the Internal Limiting Membrane in Pathologic Myopic Foveoschisis

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Lu Chen; Yantao Wei; Xuezhi Zhou; Zhaotian Zhang; Wei Chi; Li Gong; Xintong Jiang; Shaochong Zhang
TAGS: western blotting, astrocytes, collagen, collagen type iv, fluorescent antibody technique, gliosis, tissue membrane, microscopy, atomic force, surgical procedures, operative, body tissue, eye, proteins, mass or substance concentration per volume, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5569-5578. doi: 10.1167/iovs.18-24676

Genetics November 2018

Spectrum of Variants in 389 Chinese Probands With Familial Exudative Vitreoretinopathy

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Jia-Kai Li; Yian Li; Xiang Zhang; Chun-Li Chen; Yu-Qing Rao; Ping Fei; Qi Zhang; Peiquan Zhao; Jing Li
TAGS: cohort studies, genes, proband, chinese people, chinese (other dialects), familial exudative vitreoretinopathy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5368-5381. doi: 10.1167/iovs.17-23541

Includes: Supplemental Content

Retinal Cell Biology October 2018

Altered Decorin Biology in Proliferative Vitreoretinopathy: A Mechanistic and Cohort Study

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Ghazala Begum; Jenna O'Neill; Rishika Chaudhary; Karen Blachford; David R. J. Snead; Martin Berry; Robert A. H. Scott; Ann Logan; Richard J. Blanch
TAGS: cell culture techniques, fibronectins, cohort studies, vitreoretinopathy, proliferative, vitreous body, epithelial to mesenchymal transition, laminin, collagen, fibrosis, enzyme-linked immunosorbent assay, radiation recall dermatitis
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4929-4936. doi: 10.1167/iovs.18-24299

Includes: Supplemental Content

Anatomy and Pathology/Oncology September 2018

Targeting the Platelet-Derived Growth Factor-beta Stimulatory Circuitry to Control Retinoblastoma Seeds

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Zachary K. Goldsmith; William Coppess; Andrew S. Irvine; Kelley Yuan; Samuel R. Barsh; Madison K. Ritter; Matthew W. McEwen; Jacqueline Flores-Otero; Aileen Garcia-Vargas; Magaly Martinez-Ferrer; Rachel C. Brennan; Vanessa M. Morales-Tirado; Matthew W. Wilson
TAGS: signal transduction, cell culture techniques, western blotting, enzyme-linked immunosorbent assay, blood platelets, cell proliferation, flow cytometry, cell lines, cell survival, platelet-derived growth factor, platelet-derived growth factor receptor, retinoblastoma, rna, messenger, seeds, spheroids, cellular, vitreous body, diagnostic imaging, eye, neoplasms, rna, small interfering, nuclear translocation, proto-oncogene proteins c-akt, did not receive therapy or drug
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4486-4495. doi: 10.1167/iovs.18-24359

Retina August 2018

Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging

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Ignacio Melgar-Asensio; Irawati Kandela; Fraser Aird; Soesiawati R. Darjatmoko; Cristobal de los Rios; Christine M. Sorenson; Daniel M. Albert; Nader Sheibani; Jack Henkin
TAGS: arginine, drug clearance, drug delivery systems, peptides, oryctolagus cuniculus, vitreous body, diagnostic imaging, eye
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4071-4081. doi: 10.1167/iovs.18-24087

Retina July 2018

Vitreous Cytokine Expression and a Murine Model Suggest a Key Role of Microglia in the Inflammatory Response to Retinal Detachment

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Lee Kiang; Bing X. Ross; Jingyu Yao; Sumathi Shanmugam; Chris A. Andrews; Sean Hansen; Cagri G. Besirli; David N. Zacks; Steven F. Abcouwer
TAGS: cytokine, microglia, retinal detachment, rna, messenger, vitreous body, mice, retina, inflammatory response
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3767-3778. doi: 10.1167/iovs.18-24489

Includes: Supplemental Content

Biochemistry and Molecular Biology July 2018

Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells

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David W. Sant; Vladimir Camarena; Sushmita Mustafi; Yiwen Li; Zachary Wilkes; Derek Van Booven; Rong Wen; Gaofeng Wang
TAGS: vascular endothelial growth factor a, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3608-3618. doi: 10.1167/iovs.18-24101

Includes: Supplemental Content

Special Issue June 2018

The Proteomic Landscape in the Vitreous of Patients With Age-Related and Diabetic Retinal Disease

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Christian Schori; Christian Trachsel; Jonas Grossmann; Ioanna Zygoula; Daniel Barthelmes; Christian Grimm
TAGS: diabetes mellitus, enzyme-linked immunosorbent assay, proteome, retinal diseases, vitreous body, proteins, proteomics, exudative age-related macular degeneration
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD31-AMD40. doi: 10.1167/iovs.18-24122

Includes: Supplemental Content

Immunology and Microbiology May 2018

Comparison of Aqueous and Vitreous Lymphocyte Populations From Two Rat Models of Experimental Uveitis

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Kathryn L. Pepple; Leslie Wilson; Russell N. Van Gelder
TAGS: b-lymphocytes, lymphocyte, t-lymphocyte, uveitis, vitreous body, eye, fluid flow
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2504-2511. doi: 10.1167/iovs.18-24192

Includes: Supplemental Content

Retina February 2018

Enhanced Expression of NLRP3 Inflammasome-Related Inflammation in Diabetic Retinopathy

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Hui Chen; Xiongze Zhang; Nanying Liao; Lan Mi; Yuting Peng; Bing Liu; Shaochong Zhang; Feng Wen
TAGS: inflammation, diabetic retinopathy, interleukin-18, vitreous body, inflammasomes, nlr family, pyrin domain-containing 3 protein
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):978-985. doi: 10.1167/iovs.17-22816

Anatomy and Pathology/Oncology January 2018

The Adenosine Receptor Antagonist, 7-Methylxanthine, Alters Emmetropizing Responses in Infant Macaques

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Li-Fang Hung; Baskar Arumugam; Lisa Ostrin; Nimesh Patel; Klaus Trier; Monica Jong; Earl L. Smith III
TAGS: anisometropia, cercopithecidae, infant, lens, crystalline, lens (device), macaca, myopia, refractive errors, vision, vitreous body, cornea, eye, methylxanthine, adenosine receptor antagonist, symbols
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):472-486. doi: 10.1167/iovs.17-22337

Retina November 2017

Mutation Spectrum of the LRP5 , NDP , and TSPAN12 Genes in Chinese Patients With Familial Exudative Vitreoretinopathy

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Miao Tang; Limei Sun; Andina Hu; Miner Yuan; Yu Yang; Xuening Peng; Xiaoyan Ding
TAGS: mutation, genes, chinese people, chinese (other dialects), familial exudative vitreoretinopathy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5949-5957. doi: 10.1167/iovs.17-22577

Includes: Supplemental Content

Retina November 2017

Visual Function Response to Ocriplasmin for the Treatment of Vitreomacular Traction and Macular Hole: The OASIS Study

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Benedicte Lescrauwaet; Luc Duchateau; Thomas Verstraeten; Timothy L. Jackson
TAGS: vision, macular holes, oasis trial, vitreomacular traction syndrome, ocriplasmin
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5842-5848. doi: 10.1167/iovs.17-22363

Includes: Supplemental Content

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Discovering Mechanisms in the Changing and Diverse Pathology of Retinopathy of Prematurity: The Weisenfeld Award Lecture

Mycoplasma Ocular Infection in Subretinal Graft Transplantation of iPS Cells-Derived Retinal Pigment Epithelial Cells

1 H NMR Spectroscopy Characterization of Porcine Vitreous Humor in Physiological and Photoreceptor Degeneration Conditions

VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site

Germline Mutations in CTNNB1 Associated With Syndromic FEVR or Norrie Disease

Color and Temporal Frequency Sensitive Eye Growth in Chick

Optical Coherence Tomography Angiography in Familial Exudative Vitreoretinopathy: Clinical Features and Phenotype-Genotype Correlation

Morphologic, Biomechanical, and Compositional Features of the Internal Limiting Membrane in Pathologic Myopic Foveoschisis

Spectrum of Variants in 389 Chinese Probands With Familial Exudative Vitreoretinopathy

Altered Decorin Biology in Proliferative Vitreoretinopathy: A Mechanistic and Cohort Study

Targeting the Platelet-Derived Growth Factor-beta Stimulatory Circuitry to Control Retinoblastoma Seeds

Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging

Vitreous Cytokine Expression and a Murine Model Suggest a Key Role of Microglia in the Inflammatory Response to Retinal Detachment

Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells

The Proteomic Landscape in the Vitreous of Patients With Age-Related and Diabetic Retinal Disease

Comparison of Aqueous and Vitreous Lymphocyte Populations From Two Rat Models of Experimental Uveitis

Enhanced Expression of NLRP3 Inflammasome-Related Inflammation in Diabetic Retinopathy

The Adenosine Receptor Antagonist, 7-Methylxanthine, Alters Emmetropizing Responses in Infant Macaques

Mutation Spectrum of the LRP5 , NDP , and TSPAN12 Genes in Chinese Patients With Familial Exudative Vitreoretinopathy

Visual Function Response to Ocriplasmin for the Treatment of Vitreomacular Traction and Macular Hole: The OASIS Study

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