Vitreous Disorders

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Retina August 2018

Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging

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Ignacio Melgar-Asensio; Irawati Kandela; Fraser Aird; Soesiawati R. Darjatmoko; Cristobal de los Rios; Christine M. Sorenson; Daniel M. Albert; Nader Sheibani; Jack Henkin
TAGS: arginine, drug clearance, drug delivery systems, peptides, oryctolagus cuniculus, vitreous body, diagnostic imaging, eye
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4071-4081. doi: 10.1167/iovs.18-24087

Retina July 2018

Vitreous Cytokine Expression and a Murine Model Suggest a Key Role of Microglia in the Inflammatory Response to Retinal Detachment

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Lee Kiang; Bing X. Ross; Jingyu Yao; Sumathi Shanmugam; Chris A. Andrews; Sean Hansen; Cagri G. Besirli; David N. Zacks; Steven F. Abcouwer
TAGS: cytokine, microglia, retinal detachment, rna, messenger, vitreous body, mice, retina, inflammatory response
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3767-3778. doi: 10.1167/iovs.18-24489

Includes: Supplemental Content

Biochemistry and Molecular Biology July 2018

Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells

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David W. Sant; Vladimir Camarena; Sushmita Mustafi; Yiwen Li; Zachary Wilkes; Derek Van Booven; Rong Wen; Gaofeng Wang
TAGS: vascular endothelial growth factor a, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3608-3618. doi: 10.1167/iovs.18-24101

Includes: Supplemental Content

Special Issue June 2018

The Proteomic Landscape in the Vitreous of Patients With Age-Related and Diabetic Retinal Disease

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Christian Schori; Christian Trachsel; Jonas Grossmann; Ioanna Zygoula; Daniel Barthelmes; Christian Grimm
TAGS: diabetes mellitus, enzyme-linked immunosorbent assay, proteome, retinal diseases, vitreous body, proteins, proteomics, exudative age-related macular degeneration
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD31-AMD40. doi: 10.1167/iovs.18-24122

Includes: Supplemental Content

Immunology and Microbiology May 2018

Comparison of Aqueous and Vitreous Lymphocyte Populations From Two Rat Models of Experimental Uveitis

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Kathryn L. Pepple; Leslie Wilson; Russell N. Van Gelder
TAGS: b-lymphocytes, lymphocyte, t-lymphocyte, uveitis, vitreous body, eye, fluid flow
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2504-2511. doi: 10.1167/iovs.18-24192

Includes: Supplemental Content

Retina February 2018

Enhanced Expression of NLRP3 Inflammasome-Related Inflammation in Diabetic Retinopathy

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Hui Chen; Xiongze Zhang; Nanying Liao; Lan Mi; Yuting Peng; Bing Liu; Shaochong Zhang; Feng Wen
TAGS: inflammation, diabetic retinopathy, interleukin-18, vitreous body, inflammasomes, nlr family, pyrin domain-containing 3 protein
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):978-985. doi: 10.1167/iovs.17-22816

Anatomy and Pathology/Oncology January 2018

The Adenosine Receptor Antagonist, 7-Methylxanthine, Alters Emmetropizing Responses in Infant Macaques

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Li-Fang Hung; Baskar Arumugam; Lisa Ostrin; Nimesh Patel; Klaus Trier; Monica Jong; Earl L. Smith III
TAGS: anisometropia, cercopithecidae, infant, lens, crystalline, lens (device), macaca, myopia, refractive errors, vision, vitreous body, cornea, eye, methylxanthine, adenosine receptor antagonist, symbols
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):472-486. doi: 10.1167/iovs.17-22337

Retina November 2017

Mutation Spectrum of the LRP5 , NDP , and TSPAN12 Genes in Chinese Patients With Familial Exudative Vitreoretinopathy

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Miao Tang; Limei Sun; Andina Hu; Miner Yuan; Yu Yang; Xuening Peng; Xiaoyan Ding
TAGS: mutation, genes, chinese people, chinese (other dialects), familial exudative vitreoretinopathy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5949-5957. doi: 10.1167/iovs.17-22577

Includes: Supplemental Content

Retina November 2017

Visual Function Response to Ocriplasmin for the Treatment of Vitreomacular Traction and Macular Hole: The OASIS Study

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Benedicte Lescrauwaet; Luc Duchateau; Thomas Verstraeten; Timothy L. Jackson
TAGS: vision, macular holes, oasis trial, vitreomacular traction syndrome, ocriplasmin
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5842-5848. doi: 10.1167/iovs.17-22363

Includes: Supplemental Content

Clinical and Epidemiologic Research November 2017

Vitreous Fibronectin and Fibrinogen Expression Increased in Eyes With Proliferative Diabetic Retinopathy After Intravitreal Anti-VEGF Therapy

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Qiaoling Wei; Ting Zhang; Rui Jiang; Qing Chang; Yanqiong Zhang; Xin Huang; Xing Gao; Hong Jin; Gezhi Xu
TAGS: vascular endothelial growth factor a, fibrinogen, enzyme-linked immunosorbent assay, fibronectins, diabetic retinopathy, vitreous body, eye, proteins, proteomics, proliferative diabetic retinopathy, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5783-5791. doi: 10.1167/iovs.17-22345

Includes: Supplemental Content

Letters to the Editor November 2017

Comment on: Vitreomacular Adhesion and Its Association With Age-Related Macular Degeneration in a Population-Based Setting: The Alienor Study

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Emilia Maggio; Antonio Polito; Grazia Pertile
TAGS: age-related macular degeneration, vitreomacular adhesions
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5681-5681. doi: 10.1167/iovs.17-22981

Retina October 2017

Assessment of Neurotrophins and Inflammatory Mediators in Vitreous of Patients With Diabetic Retinopathy

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Joseph D. Boss; Pawan Kumar Singh; Hemang K. Pandya; Joaquin Tosi; Chaesik Kim; Asheesh Tewari; Mark S. Juzych; Gary W. Abrams; Ashok Kumar
TAGS: cytokine, tumor necrosis factors, diabetic retinopathy, inflammation mediators, nerve growth factors, nucleus solitarius, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5594-5603. doi: 10.1167/iovs.17-21973

Biochemistry and Molecular Biology October 2017

Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy

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Guohong Zhou; Yajiang Duan; Gaoen Ma; Wenyi Wu; Zhengping Hu; Na Chen; Yewlin Chee; Jing Cui; Arif Samad; Joanne A. Matsubara; Shizuo Mukai; Patricia A. D'Amore; Hetian Lei
TAGS: apoptosis, western blotting, mutation, cell proliferation, oryctolagus cuniculus, vitreoretinopathy, proliferative, vitreous body, epithelial cells, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5361-5367. doi: 10.1167/iovs.17-22045

Physiology and Pharmacology October 2017

Sustaining Intravitreal Residence With L-Arginine Peptide-Conjugated Nanocarriers

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Hao Li; Wenzhong Liu; Christine M. Sorenson; Nader Sheibani; Daniel M. Albert; Thulani Senanayake; Serguei Vinogradov; Jack Henkin; Hao F. Zhang
TAGS: half-life, arginine, diffusion, fluorescence, injection of therapeutic agent, peptides, vitreous body, nanoparticles, drug release
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5142-5150. doi: 10.1167/iovs.17-22160

Includes: Supplemental Content

Retinal Cell Biology September 2017

The Role of Inverted Internal Limiting Membrane Flap in Macular Hole Closure

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Yusuke Shiode; Yuki Morizane; Ryo Matoba; Masayuki Hirano; Shinichiro Doi; Shinji Toshima; Kosuke Takahashi; Ryoichi Araki; Yuki Kanzaki; Mika Hosogi; Tomoko Yonezawa; Atsushi Yoshida; Fumio Shiraga
TAGS: immunohistochemistry, fibroblast growth factor 2, tissue membrane, nerve growth factors, surgical flaps, macular holes, 5-lipoxygenase-activating protein
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4847-4855. doi: 10.1167/iovs.17-21756

Physiology and Pharmacology August 2017

Role of the Fc Region in the Vitreous Half-Life of Anti-VEGF Drugs

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Kwangsic Joo; Sang Jun Park; Yewon Choi; Jung Eun Lee; Young Mi Na; Hye Kyoung Hong; Kyu Hyung Park; Ho Min Kim; Jae-Yong Chung; Se Joon Woo
TAGS: vascular endothelial growth factor a, excretory function, half-life, cd40 ligand, molecular mass, vitreous body, eye, proteins, retina, thyroid hormone associated protein complex, telomeric repeat amplification protocol, anti-vascular endothelial growth factor therapy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4261-4267. doi: 10.1167/iovs.17-21813

Retina August 2017

A Self-Assembling Peptide Gel as a Vitreous Substitute: A Rabbit Study

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Koji Uesugi; Hirokazu Sakaguchi; Yasutaka Hayashida; Ryuhei Hayashi; Koichi Baba; Yuya Suganuma; Hidenori Yokoi; Motokazu Tsujikawa; Kohji Nishida
TAGS: gel, peptides, oryctolagus cuniculus, vitreous substitute
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4068-4075. doi: 10.1167/iovs.17-21536

Includes: Multimedia, Supplemental Content

Special Issue August 2017

Retinal Oximetry Discovers Novel Biomarkers in Retinal and Brain Diseases

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Einar Stefánsson; Olof Birna Olafsdottir; Anna Bryndis Einarsdottir; Thorunn Scheving Eliasdottir; Thor Eysteinsson; Wouter Vehmeijer; Evelien Vandewalle; Toke Bek; Sveinn Hakon Hardarson
TAGS: diabetic retinopathy, biological markers, brain diseases, oximetry, retinal diseases
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO227-BIO233. doi: 10.1167/iovs.17-21776

Glaucoma August 2017

Effects of Vitrectomy and Lensectomy on Older Rhesus Macaques: Oxygen Distribution, Antioxidant Status, and Aqueous Humor Dynamics

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Carla J. Siegfried; Ying-Bo Shui; Baohe Tian; T. Michael Nork; Gregg A. Heatley; Paul L. Kaufman
TAGS: antioxidants, oxygen, cercopithecidae, surgical procedures, operative, vitrectomy, vitreous body, aqueous humor, eye, intraocular pressure, macaca mulatta, macaca
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4003-4014. doi: 10.1167/iovs.17-21890

Includes: Supplemental Content

Retina August 2017

Effect of Methotrexate on an In Vitro Patient-Derived Model of Proliferative Vitreoretinopathy

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Dhanesh Amarnani; Arturo Israel Machuca-Parra; Lindsay L. Wong; Christina K. Marko; James A. Stefater; Tomasz P. Stryjewski; Dean Eliott; Joseph F. Arboleda-Velasquez; Leo A. Kim
TAGS: immunohistochemistry, tissue membrane, methotrexate, vitreoretinopathy, proliferative
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):3940-3949. doi: 10.1167/iovs.16-20912

Includes: Supplemental Content

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Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging

Vitreous Cytokine Expression and a Murine Model Suggest a Key Role of Microglia in the Inflammatory Response to Retinal Detachment

Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells

The Proteomic Landscape in the Vitreous of Patients With Age-Related and Diabetic Retinal Disease

Comparison of Aqueous and Vitreous Lymphocyte Populations From Two Rat Models of Experimental Uveitis

Enhanced Expression of NLRP3 Inflammasome-Related Inflammation in Diabetic Retinopathy

The Adenosine Receptor Antagonist, 7-Methylxanthine, Alters Emmetropizing Responses in Infant Macaques

Mutation Spectrum of the LRP5 , NDP , and TSPAN12 Genes in Chinese Patients With Familial Exudative Vitreoretinopathy

Visual Function Response to Ocriplasmin for the Treatment of Vitreomacular Traction and Macular Hole: The OASIS Study

Vitreous Fibronectin and Fibrinogen Expression Increased in Eyes With Proliferative Diabetic Retinopathy After Intravitreal Anti-VEGF Therapy

Comment on: Vitreomacular Adhesion and Its Association With Age-Related Macular Degeneration in a Population-Based Setting: The Alienor Study

Assessment of Neurotrophins and Inflammatory Mediators in Vitreous of Patients With Diabetic Retinopathy

Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy

Sustaining Intravitreal Residence With L-Arginine Peptide-Conjugated Nanocarriers

The Role of Inverted Internal Limiting Membrane Flap in Macular Hole Closure

Role of the Fc Region in the Vitreous Half-Life of Anti-VEGF Drugs

A Self-Assembling Peptide Gel as a Vitreous Substitute: A Rabbit Study

Retinal Oximetry Discovers Novel Biomarkers in Retinal and Brain Diseases

Effects of Vitrectomy and Lensectomy on Older Rhesus Macaques: Oxygen Distribution, Antioxidant Status, and Aqueous Humor Dynamics

Effect of Methotrexate on an In Vitro Patient-Derived Model of Proliferative Vitreoretinopathy

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