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Clinical and Epidemiologic Research April 2021

Higher Serum Uric Acid Levels Are Associated With an Increased Risk of Vision-Threatening Diabetic Retinopathy in Type 2 Diabetes Patients

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Yanan Hu; Zhulin Chan; Chunxia Li; Ya Shi; Xinping She; Chufeng Gu; Yujie Wang; Chuandi Zhou; Shuzhi Zhao; Zhi Zheng; Haibing Chen
TAGS: diabetes mellitus, type 2, diabetic retinopathy, hyperuricemia, urate measurement, serum, uric acid, vision
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):23. doi: https://doi.org/10.1167/iovs.62.4.23

Includes: Supplemental Content

Visual Neuroscience April 2021

Light Environment Influences Developmental Programming of the Metabolic and Visual Systems in Mice

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Danielle A. Clarkson-Townsend; Katie L. Bales; Carmen J. Marsit; Machelle T. Pardue
TAGS: body weight, circadian rhythm disorders, mice, visual system, blood glucose, vision, glucose tolerance, weight (force), electroretinography
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):22. doi: https://doi.org/10.1167/iovs.62.4.22

Includes: Supplemental Content

Retinal Cell Biology April 2021

Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors

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Yi Chen; Binxin Wu; Jian Feng He; Jingyao Chen; Zi Wei Kang; Dandan Liu; Junjie Luo; Kexin Fang; Xiaoxu Leng; Haibin Tian; Jingying Xu; Caixia Jin; Jieping Zhang; Juan Wang; Jingfa Zhang; Qingjian Ou; Lixia Lu; Furong Gao; Guo-Tong Xu
TAGS: epithelial to mesenchymal transition, retinal pigment cell, signal transduction inhibitor, primary eosinophilic endomyocardial cardiomyopathy
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):21. doi: https://doi.org/10.1167/iovs.62.4.21

Includes: Supplemental Content

Article April 2021

Salience of spatiochromatic patterns

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Amanda C. Hardman; Jasna Martinovic
TAGS: color, luminance, perception, photopsia, spatial frequency
Journal of Vision. 2021; 21(4):7. doi: https://doi.org/10.1167/jov.21.4.7

Articles April 2021

The ROCK Inhibitor Ripasudil Shows an Endothelial Protective Effect in Patients With Low Corneal Endothelial Cell Density After Cataract Surgery

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Hisitaka Fujimoto; Yoshinao Setoguchi; Junichi Kiryu
TAGS: cataract surgery, cornea, endothelial cells, endothelium, surgical procedures, operative, eye, glaucoma
Trans. Vis. Sci. Tech.. 2021; 10(4):18. doi: https://doi.org/10.1167/tvst.10.4.18

Includes: Supplemental Content

Articles April 2021

Automated Quantification of Pathological Fluids in Neovascular Age-Related Macular Degeneration, and Its Repeatability Using Deep Learning

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Irmela Mantel; Agata Mosinska; Ciara Bergin; Maria Sole Polito; Jacopo Guidotti; Stefanos Apostolopoulos; Carlos Ciller; Sandro De Zanet
TAGS: body fluid, datasets, deep learning, exudative age-related macular degeneration, volume, training, spectral domain-optical coherence tomography, pixel
Trans. Vis. Sci. Tech.. 2021; 10(4):17. doi: https://doi.org/10.1167/tvst.10.4.17

Includes: Supplemental Content

Articles April 2021

Strategies to Improve Convolutional Neural Network Generalizability and Reference Standards for Glaucoma Detection From OCT Scans

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Kaveri A. Thakoor; Xinhui Li; Emmanouil Tsamis; Zane Z. Zemborain; Carlos Gustavo De Moraes; Paul Sajda; Donald C. Hood
TAGS: convolutional neural networks, datasets, glaucoma, reference standards, retinal nerve fiber layer, training, maps
Trans. Vis. Sci. Tech.. 2021; 10(4):16. doi: https://doi.org/10.1167/tvst.10.4.16

Includes: Supplemental Content

Articles April 2021

Estimating Ganglion Cell Complex Rates of Change With Bayesian Hierarchical Models

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Vahid Mohammadzadeh; Erica Su; Sepideh Heydar Zadeh; Simon K. Law; Anne L. Coleman; Joseph Caprioli; Robert E. Weiss; Kouros Nouri-Mahdavi
TAGS: eye, ganglia, glaucoma, heterogeneity of variance, trend, inspection
Trans. Vis. Sci. Tech.. 2021; 10(4):15. doi: https://doi.org/10.1167/tvst.10.4.15

Includes: Supplemental Content

Articles April 2021

Longitudinal Development of Refractive Error in Children Treated With Intravitreal Bevacizumab or Laser for Retinopathy of Prematurity

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Michael Simmons; Jingyun Wang; Joel N. Leffler; Shanshan Li; Sarah E. Morale; Angie de la Cruz; Eileen E. Birch
TAGS: anisometropia, bevacizumab, child, lasers, refractive errors, retinopathy of prematurity, visual acuity, myopia, astigmatism
Trans. Vis. Sci. Tech.. 2021; 10(4):14. doi: https://doi.org/10.1167/tvst.10.4.14

Includes: Supplemental Content

Articles April 2021

Can the Macula be Attached if View Is Obscured by a Bullous Retinal Detachment? A Mathematical Consideration

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William E. Smiddy; Lev Kapitanski; Harry W. Flynn
TAGS: macula lutea, mathematics, retina, retinal detachment, fovea centralis
Trans. Vis. Sci. Tech.. 2021; 10(4):13. doi: https://doi.org/10.1167/tvst.10.4.13

Includes: Supplemental Content

Articles April 2021

Evaluating Contrast Sensitivity in Asian Indian Pre-Term Infants With and Without Retinopathy of Prematurity

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Rwituja Thomas; Anand Vinekar; Shwetha Mangalesh; Thirumalesh Basavaraj Mochi; Puja Sarbajna; Bhujang Shetty
TAGS: asian indians, contrast sensitivity, infant, infant, premature, retinopathy of prematurity, visual acuity
Trans. Vis. Sci. Tech.. 2021; 10(4):12. doi: https://doi.org/10.1167/tvst.10.4.12

Includes: Multimedia, Supplemental Content

Cornea April 2021

Tear Film Cytokine Profile of Patients With the Boston Keratoprosthesis Type 1: Comparing Patients With and Without Glaucoma

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Dominique Geoffrion; Marie-Claude Robert; Adriana Di Polo; Robert K. Koenekoop; Younes Agoumi; Mona Harissi-Dagher
TAGS: cytokine, glaucoma, tear film finding, eye
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):20. doi: https://doi.org/10.1167/iovs.62.4.20

Includes: Supplemental Content

Review April 2021

Interleukin-1 and Transforming Growth Factor Beta: Commonly Opposing, but Sometimes Supporting, Master Regulators of the Corneal Wound Healing Response to Injury

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Steven E. Wilson
TAGS: cornea, fibroblasts, interleukin-1, wounds and injuries, myofibroblasts, wound healing, keratocytes, transforming growth factor beta, epithelium
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):8. doi: https://doi.org/10.1167/iovs.62.4.8

Articles April 2021

Validation of a Novel Automated Algorithm to Measure Drusen Volume and Area Using Swept Source Optical Coherence Tomography Angiography

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Xiaoshuang Jiang; Mengxi Shen; Liang Wang; Luis de Sisternes; Mary K. Durbin; William Feuer; Philip J. Rosenfeld; Giovanni Gregori
TAGS: angiogram, drusen, optical coherence tomography, volume, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2021; 10(4):11. doi: https://doi.org/10.1167/tvst.10.4.11

Articles April 2021

Effect of CPAP Therapy on 24-Hour Intraocular Pressure-Related Pattern From Contact Lens Sensors in Obstructive Sleep Apnea Syndrome

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María Jesús Muniesa; Iván Benítez; Juan Ezpeleta; Manuel Sánchez de la Torre; Marta Pazos; Elena Millà; Ferrán Barbé
TAGS: contact lenses, continuous positive airway pressure, intraocular pressure, obstructive sleep apnea, sensor, night time
Trans. Vis. Sci. Tech.. 2021; 10(4):10. doi: https://doi.org/10.1167/tvst.10.4.10

Letters to the Editor April 2021

Author Response: Surface Area of the Exposed Eye

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Ben J. Glasgow
TAGS: eye
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):19. doi: https://doi.org/10.1167/iovs.62.4.19

Letters to the Editor April 2021

Surface Area of the Exposed Eye

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Thomas Millar
TAGS: eye
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):18. doi: https://doi.org/10.1167/iovs.62.4.18

Clinical and Epidemiologic Research April 2021

Rapid Myopic Progression in Childhood Is Associated With Teenage High Myopia

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Carla Lanca; Li-Lian Foo; Marcus Ang; Chuen-Seng Tan; Biten Kathrani; Hla Myint Htoon; Donald Tan; Quan V. Hoang; Noel Brennan; Seang-Mei Saw; Charumathi Sabanayagam
TAGS: adolescent, child, myopia
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):17. doi: https://doi.org/10.1167/iovs.62.4.17

Cornea April 2021

IL-36α Exerts Proinflammatory Effects in A spergillus fumigatus Keratitis of Mice Through the Pathway of IL-36α/IL-36R/NF-κB

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Yawen Niu; Changjie Ren; Xudong Peng; Cui Li; Qiang Xu; Liting Hu; Ziyue Zhang; Guiqiu Zhao; Jing Lin
TAGS: aspergillus fumigatus, cornea, cytokine, keratitis, macrophages, mice, proteins, interleukin-6, rna, messenger, infections
Invest. Ophthalmol. Vis. Sci.. 2021; 62(4):16. doi: https://doi.org/10.1167/iovs.62.4.16

Articles April 2021

Durability of VEGF Suppression With Intravitreal Aflibercept and Brolucizumab: Using Pharmacokinetic Modeling to Understand Clinical Outcomes

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Thomas Eissing; Michael W. Stewart; Cynthia X. Qian; Kay D. Rittenhouse
TAGS: aflibercept, anti-vascular endothelial growth factor therapy, brolucizumab, vascular endothelial growth factor a, treatment outcome, vitreous body, half-life, molar tooth
Trans. Vis. Sci. Tech.. 2021; 10(4):9. doi: https://doi.org/10.1167/tvst.10.4.9

Includes: Supplemental Content

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Higher Serum Uric Acid Levels Are Associated With an Increased Risk of Vision-Threatening Diabetic Retinopathy in Type 2 Diabetes Patients

Light Environment Influences Developmental Programming of the Metabolic and Visual Systems in Mice

Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors

Salience of spatiochromatic patterns

The ROCK Inhibitor Ripasudil Shows an Endothelial Protective Effect in Patients With Low Corneal Endothelial Cell Density After Cataract Surgery

Automated Quantification of Pathological Fluids in Neovascular Age-Related Macular Degeneration, and Its Repeatability Using Deep Learning

Strategies to Improve Convolutional Neural Network Generalizability and Reference Standards for Glaucoma Detection From OCT Scans

Estimating Ganglion Cell Complex Rates of Change With Bayesian Hierarchical Models

Longitudinal Development of Refractive Error in Children Treated With Intravitreal Bevacizumab or Laser for Retinopathy of Prematurity

Can the Macula be Attached if View Is Obscured by a Bullous Retinal Detachment? A Mathematical Consideration

Evaluating Contrast Sensitivity in Asian Indian Pre-Term Infants With and Without Retinopathy of Prematurity

Tear Film Cytokine Profile of Patients With the Boston Keratoprosthesis Type 1: Comparing Patients With and Without Glaucoma

Interleukin-1 and Transforming Growth Factor Beta: Commonly Opposing, but Sometimes Supporting, Master Regulators of the Corneal Wound Healing Response to Injury

Validation of a Novel Automated Algorithm to Measure Drusen Volume and Area Using Swept Source Optical Coherence Tomography Angiography

Effect of CPAP Therapy on 24-Hour Intraocular Pressure-Related Pattern From Contact Lens Sensors in Obstructive Sleep Apnea Syndrome

Author Response: Surface Area of the Exposed Eye

Surface Area of the Exposed Eye

Rapid Myopic Progression in Childhood Is Associated With Teenage High Myopia

IL-36α Exerts Proinflammatory Effects in A spergillus fumigatus Keratitis of Mice Through the Pathway of IL-36α/IL-36R/NF-κB

Durability of VEGF Suppression With Intravitreal Aflibercept and Brolucizumab: Using Pharmacokinetic Modeling to Understand Clinical Outcomes

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