Ocular Oncology Special Issue

Guest Editor: Martine J. Jager, Leiden University

Accepted papers will be published as ready in the current monthly issue as well as added to this special issue page.

Treatment of Conjunctival Melanoma Cell Lines With a Light-Activated Virus-Like Drug Conjugate Induces Immunogenic Cell Death Open Access
Sen Ma, Ruben V. Huis In't Veld, Elisabet de los Pinos, Ferry A. Ossendorp, Martine J. Jager
Investigative Ophthalmology & Visual Science November 2024, Vol.65, 3. https://doi.org/10.1167/iovs.65.13.3
Quantitative Perfusion-Weighted Magnetic Resonance Imaging in Uveal Melanoma Open Access
Lisa Klaassen, Myriam G. Jaarsma-Coes, Marina Marinkovic, Gregorius P. M. Luyten, Coen R. N. Rasch, Teresa A. Ferreira, Jan-Willem M. Beenakker
Investigative Ophthalmology & Visual Science September 2024, Vol.65, 17. https://doi.org/10.1167/iovs.65.11.17
Aqueous VEGF-A Levels as a Liquid Biopsy Biomarker of Retinoblastoma Vitreous Seed Response to Therapy Open Access
Anthony B. Daniels, Kamakshi L. Sishtla, Carley M. Bogan, Janene M. Pierce, Sheau-Chiann Chen, Liya Xu, Jesse L. Berry, Timothy W. Corson
Investigative Ophthalmology & Visual Science June 2024, Vol.65, 18. https://doi.org/10.1167/iovs.65.6.18
Radiation-Induced DNA Damage in Uveal Melanoma Is Influenced by Dose Delivery and Chromosome 3 Status Open Access
Aysegül Tura, Yingda Zhu, Siranush Vardanyan, Michelle Prasuhn, Vinodh Kakkassery, Julia Lüke, Hartmut Merz, Frank Paulsen, Dirk Rades, Florian Cremers, Karl-Ulrich Bartz-Schmidt, Salvatore Grisanti
Investigative Ophthalmology & Visual Science June 2024, Vol.65, 7. https://doi.org/10.1167/iovs.65.6.7
Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastoma Open Access
Roxana M. Hicks, Xunda Ji, Yihua Zou, Sadia Sultana, Riffat Rashid, Sadik T. Sherief, Nathalie Cassoux, Juan L. Garcia Leon, Rosdali Y. Diaz Coronado, Arturo M. Z. López, Tatiana L. Ushakova, Vladimir G. Polyakov, Soma R. Roy, Alia Ahmad, M. Ashwin Reddy, Mandeep S. Sagoo, Lamis Al Harby, Jesse L. Berry, Ashley Polski, Nicholas J. Astbury, Covadonga Bascaran, Sharon Blum, Richard Bowman, Matthew J. Burton, Nir Gomel, Naama Keren-Froim, Shiran Madgar, Marcia Zondervan, Swathi Kaliki, Ido D. Fabian, Andrew W. Stacey
Investigative Ophthalmology & Visual Science April 2024, Vol.65, 39. https://doi.org/10.1167/iovs.65.4.39
Histologic and Genomic Analysis of Conjunctival SCC in African and American Cohorts Reveal UV Light and HPV Signatures and High Tumor Mutation Burden Open Access
Frederico O. Gleber-Netto, Priyadharsini Nagarajan, Oded Sagiv, Curtis R. Pickering, Neil Gross, Jing Ning, Melisachew M. Yeshi, Yonas Mitku, Michael T. Tetzlaff, Bita Esmaeli
Investigative Ophthalmology & Visual Science April 2024, Vol.65, 24. https://doi.org/10.1167/iovs.65.4.24
The Pediatric and Young Adult Choroidal and Ciliary Body Melanoma Genetic Study, A Survey by the European Ophthalmic Oncology Group Open Access
Natasha M. van Poppelen, Nathalie Cassoux, Joni A. Turunen, Nicole C. Naus, Robert M. Verdijk, Jolanda Vaarwater, Victoria Cohen, Vasilios P. Papastefanou, Hayyam Kiratli, Svetlana V. Saakyan, Alexander Y. Tsygankov, Iwona Rospond-Kubiak, Hardeep S. Mudhar, Sachin M. Salvi, Jens F. Kiilgaard, Steffen Heegaard, Alexandre P. Moulin, Maria A. Saornil, Ciro Garciá-Alvarez, Maria Fili, Nils A. Eide, Peter Meyer, Tero T. Kivelä, Annelies de Klein, Emine Kilic, Rana'a T. Al-Jamal
Investigative Ophthalmology & Visual Science April 2024, Vol.65, 12. https://doi.org/10.1167/iovs.65.4.12
Impact of Nintedanib and Anti-Angiogenic Agents on Uveal Melanoma Cell Behavior Open Access
Vera E. Pawlik, Svenja R. Sonntag, Salvatore Grisanti, Aysegül Tura, Vinodh Kakkassery, Mahdy Ranjbar
Investigative Ophthalmology & Visual Science February 2024, Vol.65, 30. https://doi.org/10.1167/iovs.65.2.30
Mass Spectrometry-Based Profiling of Histone Post-Translational Modifications in Uveal Melanoma Tissues, Human Melanocytes, and Uveal Melanoma Cell Lines – A Pilot Study Open Access
Martina C. Herwig-Carl, Amit Sharma, Verena Tischler, Natalie Pelusi, Karin U. Loeffler, Frank G. Holz, Michael Zeschnigk, Solange Landreville, Claudia Auw-Haedrich, Roberta Noberini, Tiziana Bonaldi
Investigative Ophthalmology & Visual Science February 2024, Vol.65, 27. https://doi.org/10.1167/iovs.65.2.27
Evaluation of Circulating Tumor DNA as a Liquid Biomarker in Uveal Melanoma Open Access
Daniel P. de Bruyn, Natasha M. van Poppelen, Tom Brands, Susanne C. van den Boom, Ellis Eikenboom, Anja Wagner, Monique M. van Veghel-Plandsoen, Geert Geeven, Berna Beverloo, Caroline M. van Rij, Robert M. Verdijk, Nicole C. Naus, Mette M. Bagger, Jens F. Kiilgaard, Annelies de Klein, Erwin Brosens, Emine Kiliç
Investigative Ophthalmology & Visual Science February 2024, Vol.65, 11. https://doi.org/10.1167/iovs.65.2.11
Correction Method for Optical Scaling of Fundoscopy Images: Development, Validation, and First Implementation Open Access
Lennart J. Pors, Corné Haasjes, Luc van Vught, Noor P. Hoes, Gregorius P. M. Luyten, Gwyneth A. van Rijn, T. H. Khanh Vu, Coen R. N. Rasch, Nanda Horeweg, Jan-Willem M. Beenakker
Investigative Ophthalmology & Visual Science January 2024, Vol.65, 43. https://doi.org/10.1167/iovs.65.1.43
Tumor Pigmentation Does Not Affect Light-Activated Belzupacap Sarotalocan Treatment but Influences Macrophage Polarization in a Murine Melanoma Model Open Access
Sen Ma, Ruben V. Huis in't Veld, Yang Hao, Zili Gu, Cadmus Rich, Maria Chiara Gelmi, Aat A. Mulder, Peter A. van Veelen, T. Khanh H. Vu, Thorbald van Hall, Ferry A. Ossendorp, Martine J. Jager
Investigative Ophthalmology & Visual Science January 2024, Vol.65, 42. https://doi.org/10.1167/iovs.65.1.42
Heterogeneous Expression Patterns of the Minichromosome Maintenance Complex Members in Retinoblastoma Unveil Its Clinical Significance Open Access
Junjie Tang, Yaoming Liu, Zhihui Zhang, Yi Ren, Yujun Ma, Yinghao Wang, Jinmiao Li, Yang Gao, Cheng Li, Chao Cheng, Shicai Su, Shuxia Chen, Ping Zhang, Rong Lu
Investigative Ophthalmology & Visual Science January 2024, Vol.65, 31. https://doi.org/10.1167/iovs.65.1.31
The Potential of Aqueous Humor Sampling in Diagnosis, Prognosis, and Treatment of Retinoblastoma Open Access
Anbukkarasi Muniyandi, Nathan R. Jensen, Nirupama Devanathan, Helen Dimaras, Timothy W. Corson
Investigative Ophthalmology & Visual Science January 2024, Vol.65, 18. https://doi.org/10.1167/iovs.65.1.18
Expression of GNAQ, BAP1, SF3B1, and EIF1AX Proteins in the Aqueous Humor of Eyes Affected by Uveal Melanoma Open Access
Giulia Midena, Raffaele Parrozzani, Luisa Frizziero, Graziana Esposito, Alessandra Micera, Edoardo Midena
Investigative Ophthalmology & Visual Science January 2024, Vol.65, 15. https://doi.org/10.1167/iovs.65.1.15
PRAME Expression: A Target for Cancer Immunotherapy and a Prognostic Factor in Uveal Melanoma Open Access
Maria Chiara Gelmi, Gulçin Gezgin, Pieter A. van der Velden, Gregorius P. M. Luyten, Sietse J. Luk, Mirjam H. M. Heemskerk, Martine J. Jager
Investigative Ophthalmology & Visual Science December 2023, Vol.64, 36. https://doi.org/10.1167/iovs.64.15.36
The Use of rAAV2-RB1–Mediated Gene Therapy in Retinoblastoma Open Access
Hanhan Shi, Xiaoyu He, Zhi Yang; Qili Liao, Jing Ruan; Shengfang Ge, Peiwei Chai, Renbing Jia; Jiayan Fan; Xuyang Wen, Xianqun Fan
Investigative Ophthalmology & Visual Science December 2023, Vol.64, 31. https://doi.org/10.1167/iovs.64.15.31
Establishment and Comprehensive Characterization of a Novel Preclinical Platform of Metastatic Retinoblastoma for Therapeutic Developments Open Access
Santiago Zugbi, Rosario Aschero, Daiana Ganiewich, María B. Cancela, Ursula Winter, Daniela Ottaviani, Claudia Sampor; Milagros Dinardi; Ana V. Torbidoni; Marcela Mena; Leire Balaguer-Lluna; Gabriela Lamas; Mariana Sgroi; Eduardo Lagomarsino, Fabiana Lubieniecki, Adriana Fandiño, François Radvanyi, David H. Abramson, Osvaldo Podhajcer, Andrea S. Llera, Eduardo G. Cafferata, Guillermo Chantada, Angel M. Carcaboso, Paula Schaiquevich
Investigative Ophthalmology & Visual Science December 2023, Vol.64, 16. https://doi.org/10.1167/iovs.64.15.27
Establishment and Characterization of a TP53-Mutated Eyelid Sebaceous Carcinoma Cell Line Open Access
Xiang Gu, Ziyue Huang, Jie Chen, Yingxiu Luo, Shengfang Ge, Renbing Jia, Xin Song, Peiwei Chai, Shiqiong Xu, Xianqun Fan
Investigative Ophthalmology & Visual Science December 2023, Vol.64, 16. https://doi.org/10.1167/iovs.64.15.16
Vitreous Humor Proteomic Profile in Patients With Vitreoretinal Lymphoma Open Access
Hiroyuki Komatsu, Yoshihiko Usui, Kinya Tsubota, Risa Fujii, Takefumi Yamaguchi, Kazuichi Maruyama, Ryo Wakita, Masaki Asakage, Kazuki Hamada, Naoyuki Yamakawa, Naoya Nezu, Koji Ueda; Hiroshi Goto
Investigative Ophthalmology & Visual Science December 2023, Vol.64, 2. https://doi.org/10.1167/iovs.64.15.2
Next-Generation Sequencing of Vitreoretinal Lymphoma by Vitreous Liquid Biopsy: Diagnostic Potential and Genotype/Phenotype Correlation Open Access
Jay Jiyong Kwak, Kwang Seob Lee, Junwon Lee, Yong Joon Kim, Eun Young Choi, Suk Ho Byeon, Won Seok Chang, Yu Ri Kim, Jin Seok Kim, Saeam Shin, Seung-Tae Lee, Sung Soo Kim, Christopher Seungkyu Lee
Investigative Ophthalmology & Visual Science November 2023, Vol.64, 27. https://doi.org/10.1167/iovs.64.14.27
Cross-Platform Identification and Validation of Uveal Melanoma Vitreous Protein Biomarkers Open Access
Gabriel Velez, Julian Wolf, Antoine Dufour, Prithvi Mruthyunjaya, Vinit B. Mahajan
Investigative Ophthalmology & Visual Science November 2023, Vol.64, 14. https://doi.org/10.1167/iovs.64.14.14
Polarization-Diversity Optical Coherence Tomography Assessment of Choroidal Nevi Open Access
Yusi Miao, Hoyoung Jung, Destiny Hsu, Jun Song, Shuibin Ni, Da Ma, Yifan Jian, Shuichi Makita, Yoshiaki Yasuno, Marinko V. Sarunic, Kirk A. J. Stephenson, Katherine Paton, Zaid Mammo, Myeong Jin Ju
Investigative Ophthalmology & Visual Science November 2023, Vol.64, 6. https://doi.org/10.1167/iovs.64.14.6
Incidence and Mortality of Conjunctival Melanoma in Australia (1982 to 2014) Open Access
Aaron B. Beasley, David B. Preen, Samuel McLenachan, Elin S. Gray, Fred K. Chen
Investigative Ophthalmology & Visual Science November 2023, Vol.64, 2. https://doi.org/10.1167/iovs.64.14.2
Worldwide Incidence of Ocular Melanoma and Correlation With Pigmentation-Related Risk Factors Open Access
Mike Wu, Serdar Yavuzyiğitoğlu, Erwin Brosens, Wishal D. Ramdas, Emine Kiliç, on behalf of the Rotterdam Ocular Melanoma Study Group (ROMS)
Investigative Ophthalmology & Visual Science October 2023, Vol.64, 45. https://doi.org/10.1167/iovs.64.13.45
Tumor Profiles of Late Presentation Uveal Ring Melanoma With Novel Characteristics – A Case Series Open Access
Joevy Z. Lim, Alexandra Z. Crawford, Charles N. J. McGhee
Investigative Ophthalmology & Visual Science October 2023, Vol.64, 44. https://doi.org/10.1167/iovs.64.13.44
Release of Cell-Free Tumor DNA in the Plasma of Uveal Melanoma Patients Under Radiotherapy Open Access
Viktoria Kim, Maja Guberina, Nikolaos E. Bechrakis, Dietmar R. Lohmann, Michael Zeschnigk, Claudia H. D. Le Guin
Investigative Ophthalmology & Visual Science October 2023, Vol.64, 35. https://doi.org/10.1167/iovs.64.13.35
Optical Density Ratio of Subretinal Fluid in Choroidal Melanomas Versus Choroidal Naevi Assessed by Optical Coherence Tomography Open Access
Zachary Mahoun, Denis Malaise, Livia Lumbroso-Le Rouic, Christine Levy-Gabriel, Nathalie Cassoux, Alexandre Matet
Investigative Ophthalmology & Visual Science October 2023, Vol.64, 1. https://doi.org/10.1167/iovs.64.13.1
Pharmacokinetics of Orbital Topotecan After Ophthalmic Artery Chemosurgery and Intravenous Infusion in the Swine Model Open Access
Flavio Requejo, Javier Opezzo, Alan Vater, Marcelo Asprea, Eduardo Lagomarsino, Claudia Sampor, Adriana Fandiño, Guillermo Chantada, Jasmine H. Francis, David H. Abramson, Paula Schaiquevich
Investigative Ophthalmology & Visual Science September 2023, Vol.64, 3. https://doi.org/10.1167/iovs.64.12.3
Adjuvant Chemotherapy Improves Survival for Children With Massive Choroidal Invasion of Retinoblastoma Open Access
Zhao Xun Feng, Junyang Zhao, Nan Zhang, Mei Jin, Brenda Gallie
Investigative Ophthalmology & Visual Science August 2023, Vol.64, 27. https://doi.org/10.1167/iovs.64.11.27
Identifying Treatment Resistance Related Pathways by Analyzing Serum Extracellular Vesicles of Patients With Resistant Versus Regressed Retinoblastoma Open Access
Radhika Manukonda, Saumya Jakati, Jyothi Attem, Dilip K. Mishra, Tirupathi Rao Mocherla, Mamatha M. Reddy, Khushboo Gulati, Krishna Mohan Poluri, Geeta K. Vemuganti, Swathi Kaliki
Investigative Ophthalmology & Visual Science August 2023, Vol.64, 26. https://doi.org/10.1167/iovs.64.11.26
Clinical Applications of Machine Learning in the Management of Intraocular Cancers: A Narrative Review Open Access
Anirudha S. Chandrabhatla, Taylor M. Horgan, Caroline C. Cotton, Naveen K. Ambati, Yevgeniy Eugene Shildkrot
Investigative Ophthalmology & Visual Science July 2023, Vol.64, 29. https://doi.org/10.1167/iovs.64.10.29
Conditional Metastasis of Uveal Melanoma in 8091 Patients over Half-Century (51 Years) by Age Group: Assessing the Entire Population and the Extremes of Age Open Access
Carol L. Shields, Annika G. Samuelson, Glenn J. Oh, Joseph D. DeSimone, Zaynab L. Sajjadi, Zeynep Bas, Nicholas E. Kalafatis, Sara E. Lally, Jerry A. Shields, Philip W. Dockery
Investigative Ophthalmology & Visual Science July 2023, Vol.64, 7. https://doi.org/10.1167/iovs.64.10.7
CD63/81 Small Extracellular Vesicles in the Aqueous Humor are Retinoblastoma Associated Open Access
Sarah Pike, Chen-Ching Peng, Paolo Neviani, Jesse L. Berry, Liya Xu
Investigative Ophthalmology & Visual Science July 2023, Vol.64, 5. https://doi.org/10.1167/iovs.64.10.5
Randomized Trial of Treat-and-Extend Intravitreal Aflibercept for Radiation Retinopathy: 1-Year Outcomes Open Access
Stephanie Trejo Corona, Cecilia Villanueva Boone, Amna M. Ali, Chelsey Moore, Alexandra Brown, Jose Munoz, Thomas Aaberg, Jr., Amy C. Schefler, on behalf of the ARRT Study Group
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 35. https://doi.org/10.1167/iovs.64.7.35
Immune Checkpoint Inhibitor Therapy for Orbital and Ocular Adnexal Squamous Cell Carcinomas: International Society of Ocular Oncology President's Lecture, 2022 Open Access
Bita Esmaeli
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 29. https://doi.org/10.1167/iovs.64.7.29
The Potential of Artemisinins as Novel Treatment for Thyroid Eye Disease by Inhibiting Adipogenesis in Orbital Fibroblasts Open Access
Yan Guo, Yanglei Cheng, Hai Li, Hongyu Guan, Haipeng Xiao, Yanbing Li
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 28. https://doi.org/10.1167/iovs.64.7.28
In Vitro Testing of the Virus-Like Drug Conjugate Belzupacap Sarotalocan (AU-011) on Uveal Melanoma Suggests BAP1-Related Immunostimulatory Capacity Open Access
Sen Ma, Ruben V. Huis In't Veld, Alexander Houy, Marc-Henri Stern, Cadmus Rich, Ferry A. Ossendorp, Martine J. Jager
Investigative Ophthalmology & Visual Science June 2023, Vol.64, 10. https://doi.org/10.1167/iovs.64.7.10
AURKB Enhances Chromosomal Remodeling of Telomeric Genes and Accelerates Tumorigenesis of Uveal Melanoma Open Access
Huixue Wang, Hui Pan, Xiaolin Huang
Investigative Ophthalmology & Visual Science April 2023, Vol.64, 23. https://doi.org/10.1167/iovs.64.4.23
Cytogenetic Abnormalities for Predicting the Risk of Metastases in Choroidal and Ciliary Body Melanoma Open Access
An-Ning Chao, Kalpana Rose, Hilary Racher, Filiberto Altomare, Hatem Krema
Investigative Ophthalmology & Visual Science January 2023, Vol.64, 15. https://doi.org/10.1167/iovs.64.1.15
Detectability of Plasma-Derived Circulating Tumor DNA Panel in Patients Undergoing Primary Treatment for Uveal Melanoma Open Access
Jasmine H. Francis, Christopher A. Barker, A. Rose Brannon, Julia Canestraro, Melissa Robbins, Christina E. Swartzwelder, Sara Levine, Crystal Law, Michael F. Berger, Alexander Shoushtari, David H. Abramson
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 17. https://doi.org/10.1167/iovs.63.13.17
Preclinical Evaluation of Trabectedin in Combination With Targeted Inhibitors for Treatment of Metastatic Uveal Melanoma Open Access
Kseniya Glinkina, Fariba Nemati, Amina F. A. S. Teunisse, Maria Chiara Gelmi, Vesnie Etienne, Muriel J. Kuipers, Samar Alsafadi, Martine J. Jager, Didier Decaudin, Aart G. Jochemsen
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 14. https://doi.org/10.1167/iovs.63.13.14

Ocular Oncology Special Issue

Guest Editor: Martine J. Jager, Leiden University

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